DK150302C - METHOD OF ANALOGUE FOR THE PREPARATION OF SPIRO-HYDANTOIN COMPOUNDS OR PHARMACOLOGICAL ACCEPTABLE BASES - Google Patents

METHOD OF ANALOGUE FOR THE PREPARATION OF SPIRO-HYDANTOIN COMPOUNDS OR PHARMACOLOGICAL ACCEPTABLE BASES

Info

Publication number: DK150302C
Authority: DK; Denmark
Prior art keywords: spiro; analogue; preparation; acceptable bases; hydantoin compounds
Prior art date: 1976-10-18

Application number

DK461377A

Other languages

Danish (da)

Other versions

DK461377A (en

DK150302B (en

Inventor

Reinhard Sarges

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-18

Filing date

1977-10-17

Publication date

1987-09-28

1977-02-11 Priority claimed from US05/767,803 external-priority patent/US4117230A/en

1977-10-17 Application filed by Pfizer filed Critical Pfizer

1978-04-19 Publication of DK461377A publication Critical patent/DK461377A/en

1987-02-02 Publication of DK150302B publication Critical patent/DK150302B/en

1987-09-28 Application granted granted Critical

1987-09-28 Publication of DK150302C publication Critical patent/DK150302C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK461377A 1976-10-18 1977-10-17 METHOD OF ANALOGUE FOR THE PREPARATION OF SPIRO-HYDANTOIN COMPOUNDS OR PHARMACOLOGICAL ACCEPTABLE BASES DK150302C (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US73306276A	1976-10-18	1976-10-18
US73306276		1976-10-18
US76780377		1977-02-11
US05/767,803 US4117230A (en)	1976-10-18	1977-02-11	Hydantoin derivatives as therapeutic agents

Publications (3)

Publication Number	Publication Date
DK461377A DK461377A (en)	1978-04-19
DK150302B DK150302B (en)	1987-02-02
DK150302C true DK150302C (en)	1987-09-28

Family

ID=27112515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK461377A DK150302C (en)	1976-10-18	1977-10-17	METHOD OF ANALOGUE FOR THE PREPARATION OF SPIRO-HYDANTOIN COMPOUNDS OR PHARMACOLOGICAL ACCEPTABLE BASES

Country Status (29)

Country	Link
JP (3)	JPS5353653A (en)
AR (1)	AR220901A1 (en)
AT (1)	AT356136B (en)
AU (1)	AU504978B2 (en)
BG (1)	BG28847A3 (en)
CA (1)	CA1088945A (en)
CH (1)	CH625511A5 (en)
DD (1)	DD131931A5 (en)
DE (4)	DE2759927C2 (en)
DK (1)	DK150302C (en)
ES (1)	ES463267A1 (en)
FI (1)	FI62307C (en)
FR (1)	FR2367754A1 (en)
GB (1)	GB1566171A (en)
GR (1)	GR70201B (en)
HK (1)	HK53881A (en)
IE (1)	IE45805B1 (en)
IL (1)	IL53094A0 (en)
KE (1)	KE3167A (en)
LU (1)	LU78330A1 (en)
MX (1)	MX4899E (en)
MY (1)	MY8200157A (en)
NL (1)	NL167434C (en)
NO (1)	NO148453C (en)
NZ (1)	NZ185358A (en)
PH (1)	PH15639A (en)
PT (1)	PT67164B (en)
SE (1)	SE437024B (en)
YU (1)	YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives
US4283409A (en) *	1979-10-29	1981-08-11	Pfizer Inc.	Imidazolone derivatives
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) *	1982-01-20	1983-12-12	Eisai Co Ltd	Remedy containing hydantoin derivative
JPS59500617A (en) *	1982-04-15	1984-04-12	アルコン・ラボラトリ−ズ・インコ−ポレ−テッド	Hydantoin therapeutic agent
HU193191B (en) *	1982-12-06	1987-08-28	Pfizer	Process for preparing spiro-hetero-azolones
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
HU198051B (en) *	1984-10-30	1989-07-28	Pfizer	Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives
JPS61200991A (en) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
MX12896A (en) *	1987-09-04	1993-06-01	Pfizer	PROCEDURE FOR PREPARING A SPYRO-HETEROAZOLON COMPOUND
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CA2482035A1 (en) *	2002-04-18	2003-10-30	University Of Virginia Patent Foundation	Novel sodium channel blockers
FR2955107B1 (en)	2010-01-08	2012-03-02	Servier Lab	NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB818724A (en) *	1956-10-18	1959-08-19	Ici Ltd	Hydantoin derivatives
DE1135915B (en) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2449030A1 (en) *	1974-10-11	1976-05-20	Schering Ag	NEW PYRIDINE DERIVATIVES
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents

1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/en not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/en unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 YU YU2442/77A patent/YU40821B/en unknown
- 1977-10-10 IL IL53094A patent/IL53094A0/en not_active IP Right Cessation
- 1977-10-14 DE DE2759927A patent/DE2759927C2/en not_active Expired
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-14 FI FI773060A patent/FI62307C/en not_active IP Right Cessation
- 1977-10-14 DE DE2759543A patent/DE2759543C2/en not_active Expired
- 1977-10-14 DE DE2746244A patent/DE2746244C2/en not_active Expired
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-15 ES ES463267A patent/ES463267A1/en not_active Expired
- 1977-10-17 LU LU78330A patent/LU78330A1/en unknown
- 1977-10-17 FR FR7731216A patent/FR2367754A1/en active Granted
- 1977-10-17 CH CH1262677A patent/CH625511A5/en not_active IP Right Cessation
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-17 NL NL7711358.A patent/NL167434C/en not_active IP Right Cessation
- 1977-10-17 PT PT67164A patent/PT67164B/en unknown
- 1977-10-17 MX MX776490U patent/MX4899E/en unknown
- 1977-10-17 NO NO773548A patent/NO148453C/en unknown
- 1977-10-17 JP JP12437177A patent/JPS5353653A/en active Granted
- 1977-10-17 DK DK461377A patent/DK150302C/en not_active IP Right Cessation
- 1977-10-18 BG BG037604A patent/BG28847A3/en unknown
- 1977-10-18 AT AT745977A patent/AT356136B/en not_active IP Right Cessation
- 1977-10-18 AR AR269623A patent/AR220901A1/en active
- 1977-10-18 DD DD7700201582A patent/DD131931A5/en unknown
1978
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/en not_active Expired
- 1978-11-25 JP JP53145926A patent/JPS607997B2/en not_active Expired
1981
- 1981-10-09 KE KE3167A patent/KE3167A/en unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/en unknown
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/en unknown

Also Published As

Publication number	Publication date
DE2746244C2 (en)	1983-05-19
IE45805B1 (en)	1982-12-01
JPS5534132B2 (en)	1980-09-04
FR2367754A1 (en)	1978-05-12
PT67164A (en)	1977-11-01
SE437024B (en)	1985-02-04
CA1088945A (en)	1980-11-04
CH625511A5 (en)	1981-09-30
NL167434B (en)	1981-07-16
ATA745977A (en)	1979-09-15
DK461377A (en)	1978-04-19
YU40821B (en)	1986-06-30
NL167434C (en)	1981-12-16
FI62307C (en)	1982-12-10
FI62307B (en)	1982-08-31
BG28847A3 (en)	1980-07-15
IE45805L (en)	1978-04-18
DE2759927C2 (en)	1986-12-04
NO148453C (en)	1983-10-12
FR2367754B1 (en)	1982-07-09
DE2759542C2 (en)	1988-07-07
AT356136B (en)	1980-04-10
JPS5940388B2 (en)	1984-09-29
JPS5495575A (en)	1979-07-28
SE7711053L (en)	1978-04-19
AR220901A1 (en)	1980-12-15
JPS5495570A (en)	1979-07-28
YU244277A (en)	1982-08-31
AU504978B2 (en)	1979-11-01
PH15639A (en)	1983-03-11
MY8200157A (en)	1982-12-31
PT67164B (en)	1979-03-20
NO773548L (en)	1978-04-19
JPS5353653A (en)	1978-05-16
DE2759543C2 (en)	1987-04-09
NL7711358A (en)	1978-04-20
DD131931A5 (en)	1978-08-09
IL53094A0 (en)	1977-12-30
MX4899E (en)	1982-12-14
NZ185358A (en)	1979-06-08
HK53881A (en)	1981-11-13
DE2746244A1 (en)	1978-04-20
KE3167A (en)	1981-11-06
JPS607997B2 (en)	1985-02-28
FI773060A (en)	1978-04-19
GR70201B (en)	1982-08-31
LU78330A1 (en)	1979-06-01
AU2943177A (en)	1979-04-12
DK150302B (en)	1987-02-02
GB1566171A (en)	1980-04-30
ES463267A1 (en)	1978-07-16
NO148453B (en)	1983-07-04

Publication	Publication Date	Title
DK150302C (en)	1987-09-28	METHOD OF ANALOGUE FOR THE PREPARATION OF SPIRO-HYDANTOIN COMPOUNDS OR PHARMACOLOGICAL ACCEPTABLE BASES
DK142372C (en)	1981-03-23	PROCEDURE FOR THE PREPARATION OF ANDROSTAN-17-ON DERIVATIVES
DK30277A (en)	1977-07-27	PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PHENYLAMIDINES
DK148477C (en)	1986-04-01	METHOD OF ANALOGUE FOR THE PREPARATION OF TETRAHYDROPYRIDINYLIN DERIVATIVE OR ADDITIONAL SALTS THEREOF
DK146542C (en)	1984-04-09	METHOD OF ANALOGUE FOR THE PREPARATION OF DAUNOSAMINYLANTHRACYCLIONS
DK46777A (en)	1977-08-06	METHOD FOR THE PREPARATION OF META-ARYLOXYBENZALDEHYDE
DK113476A (en)	1976-09-18	METHOD FOR THE PREPARATION OF AMOXICILLINTRIHYDRATE
DK244577A (en)	1977-12-04	PROCEDURE FOR THE PREPARATION OF HYDANTO INTERVENTIVES
DK178677A (en)	1977-10-25	PROCEDURE FOR THE PREPARATION OF ADENIN DERIVATIVES
DK271977A (en)	1977-12-22	PROCEDURE FOR THE PREPARATION OF DISPEPTIDE DERIVATIVES
DK339677A (en)	1978-01-29	PROCEDURE FOR THE PREPARATION OF 2-BENZYLPYRROLIDINES
DK145263C (en)	1983-03-07	METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZOTHIAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK46577A (en)	1977-08-13	PROCEDURE FOR THE PREPARATION OF TETRAHYDROECHINOCANDIN DERIVATIVES
DK118177A (en)	1977-09-18	PROCEDURE FOR THE PREPARATION OF ISOBUTYRAMID DERIVATIVES
DK144377A (en)	1977-10-03	PROCEDURE FOR THE PREPARATION OF ACYLCYANIDES
DK88777A (en)	1977-09-02	PROCEDURE FOR THE PREPARATION OF SUBSTITUTED AZAPURINES
DK146718C (en)	1984-05-21	METHOD OF ANALOGUE FOR THE PREPARATION OF BENZOBICYCLONONES
DK271377A (en)	1977-12-22	PROCEDURE FOR THE PREPARATION OF SUBSTITUTED ARYLACETAMIDOCEPHALOSPORINES
DK216977A (en)	1977-11-22	PROCEDURE FOR THE PREPARATION OF IMIDAZOBENZOXAZINES
DK144277A (en)	1977-10-03	PROCEDURE FOR THE PREPARATION OF ACYLCYANIDES
DK143752C (en)	1982-03-15	METHOD OF ANALOGUE FOR PREPARING PYRIDOBENZODIAZEPINON OR PHARMACOLOGICAL ACCEPTABLE SALTS THEREOF
DK264377A (en)	1978-01-02	PROCEDURE FOR THE PREPARATION OF 1ALFA-HYDROXYCHOLESTEROL DERIVATIVES
DK147280C (en)	1984-12-03	METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-BENZO (B) BICYCLO (3,3,1) NONENDER DERIVATIVES
DK143750C (en)	1982-03-29	METHOD OF ANALOGUE FOR THE PREPARATION OF 1,2,3,4-TETRAHYDROISOQUINOLINES
DK196577A (en)	1977-11-06	PROCEDURE FOR THE PREPARATION OF CHOLECYSTOKININ-PANCREOZYMIN-OCTAPEPTIDAMIDE SULFATESTER

Legal Events

Date	Code	Title	Description
1994-06-20	PBP	Patent lapsed