ATA745977A - PROCESS FOR MANUFACTURING NEW SPIRO HYDANTOIN - Google Patents

PROCESS FOR MANUFACTURING NEW SPIRO HYDANTOIN

Info

Publication number: ATA745977A
Authority: AT; Austria
Prior art keywords: manufacturing new; new spiro; spiro hydantoin; hydantoin; manufacturing
Prior art date: 1976-10-18

Application number

AT745977A

Other languages

German (de)

Other versions

AT356136B (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-18

Filing date

1977-10-18

Publication date

1979-09-15

1977-02-11 Priority claimed from US05/767,803 external-priority patent/US4117230A/en

1977-10-18 Application filed by Pfizer filed Critical Pfizer

1979-09-15 Publication of ATA745977A publication Critical patent/ATA745977A/en

1980-04-10 Application granted granted Critical

1980-04-10 Publication of AT356136B publication Critical patent/AT356136B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT745977A 1976-10-18 1977-10-18 METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES AT356136B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73306276A	1976-10-18	1976-10-18
US05/767,803 US4117230A (en)	1976-10-18	1977-02-11	Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number	Publication Date
ATA745977A true ATA745977A (en)	1979-09-15
AT356136B AT356136B (en)	1980-04-10

Family

ID=27112515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT745977A AT356136B (en)	1976-10-18	1977-10-18	METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES

Country Status (29)

Country	Link
JP (3)	JPS5353653A (en)
AR (1)	AR220901A1 (en)
AT (1)	AT356136B (en)
AU (1)	AU504978B2 (en)
BG (1)	BG28847A3 (en)
CA (1)	CA1088945A (en)
CH (1)	CH625511A5 (en)
DD (1)	DD131931A5 (en)
DE (4)	DE2759927C2 (en)
DK (1)	DK150302C (en)
ES (1)	ES463267A1 (en)
FI (1)	FI62307C (en)
FR (1)	FR2367754A1 (en)
GB (1)	GB1566171A (en)
GR (1)	GR70201B (en)
HK (1)	HK53881A (en)
IE (1)	IE45805B1 (en)
IL (1)	IL53094A0 (en)
KE (1)	KE3167A (en)
LU (1)	LU78330A1 (en)
MX (1)	MX4899E (en)
MY (1)	MY8200157A (en)
NL (1)	NL167434C (en)
NO (1)	NO148453C (en)
NZ (1)	NZ185358A (en)
PH (1)	PH15639A (en)
PT (1)	PT67164B (en)
SE (1)	SE437024B (en)
YU (1)	YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives
US4283409A (en) *	1979-10-29	1981-08-11	Pfizer Inc.	Imidazolone derivatives
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) *	1982-01-20	1983-12-12	Eisai Co Ltd	Remedy containing hydantoin derivative
JPS59500617A (en) *	1982-04-15	1984-04-12	アルコン・ラボラトリ−ズ・インコ−ポレ−テッド	Hydantoin therapeutic agent
HU193191B (en) *	1982-12-06	1987-08-28	Pfizer	Process for preparing spiro-hetero-azolones
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
HU198051B (en) *	1984-10-30	1989-07-28	Pfizer	Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives
JPS61200991A (en) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
MX12896A (en) *	1987-09-04	1993-06-01	Pfizer	PROCEDURE FOR PREPARING A SPYRO-HETEROAZOLON COMPOUND
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CA2482035A1 (en) *	2002-04-18	2003-10-30	University Of Virginia Patent Foundation	Novel sodium channel blockers
FR2955107B1 (en)	2010-01-08	2012-03-02	Servier Lab	NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB818724A (en) *	1956-10-18	1959-08-19	Ici Ltd	Hydantoin derivatives
DE1135915B (en) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2449030A1 (en) *	1974-10-11	1976-05-20	Schering Ag	NEW PYRIDINE DERIVATIVES
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents

1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/en not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/en unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 YU YU2442/77A patent/YU40821B/en unknown
- 1977-10-10 IL IL53094A patent/IL53094A0/en not_active IP Right Cessation
- 1977-10-14 DE DE2759927A patent/DE2759927C2/en not_active Expired
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-14 FI FI773060A patent/FI62307C/en not_active IP Right Cessation
- 1977-10-14 DE DE2759543A patent/DE2759543C2/en not_active Expired
- 1977-10-14 DE DE2746244A patent/DE2746244C2/en not_active Expired
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-15 ES ES463267A patent/ES463267A1/en not_active Expired
- 1977-10-17 LU LU78330A patent/LU78330A1/en unknown
- 1977-10-17 FR FR7731216A patent/FR2367754A1/en active Granted
- 1977-10-17 CH CH1262677A patent/CH625511A5/en not_active IP Right Cessation
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-17 NL NL7711358.A patent/NL167434C/en not_active IP Right Cessation
- 1977-10-17 PT PT67164A patent/PT67164B/en unknown
- 1977-10-17 MX MX776490U patent/MX4899E/en unknown
- 1977-10-17 NO NO773548A patent/NO148453C/en unknown
- 1977-10-17 JP JP12437177A patent/JPS5353653A/en active Granted
- 1977-10-17 DK DK461377A patent/DK150302C/en not_active IP Right Cessation
- 1977-10-18 BG BG037604A patent/BG28847A3/en unknown
- 1977-10-18 AT AT745977A patent/AT356136B/en not_active IP Right Cessation
- 1977-10-18 AR AR269623A patent/AR220901A1/en active
- 1977-10-18 DD DD7700201582A patent/DD131931A5/en unknown
1978
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/en not_active Expired
- 1978-11-25 JP JP53145926A patent/JPS607997B2/en not_active Expired
1981
- 1981-10-09 KE KE3167A patent/KE3167A/en unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/en unknown
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/en unknown

Also Published As

Publication number	Publication date
DE2746244C2 (en)	1983-05-19
IE45805B1 (en)	1982-12-01
JPS5534132B2 (en)	1980-09-04
FR2367754A1 (en)	1978-05-12
PT67164A (en)	1977-11-01
SE437024B (en)	1985-02-04
CA1088945A (en)	1980-11-04
CH625511A5 (en)	1981-09-30
NL167434B (en)	1981-07-16
DK461377A (en)	1978-04-19
YU40821B (en)	1986-06-30
NL167434C (en)	1981-12-16
FI62307C (en)	1982-12-10
FI62307B (en)	1982-08-31
BG28847A3 (en)	1980-07-15
IE45805L (en)	1978-04-18
DE2759927C2 (en)	1986-12-04
NO148453C (en)	1983-10-12
DK150302C (en)	1987-09-28
FR2367754B1 (en)	1982-07-09
DE2759542C2 (en)	1988-07-07
AT356136B (en)	1980-04-10
JPS5940388B2 (en)	1984-09-29
JPS5495575A (en)	1979-07-28
SE7711053L (en)	1978-04-19
AR220901A1 (en)	1980-12-15
JPS5495570A (en)	1979-07-28
YU244277A (en)	1982-08-31
AU504978B2 (en)	1979-11-01
PH15639A (en)	1983-03-11
MY8200157A (en)	1982-12-31
PT67164B (en)	1979-03-20
NO773548L (en)	1978-04-19
JPS5353653A (en)	1978-05-16
DE2759543C2 (en)	1987-04-09
NL7711358A (en)	1978-04-20
DD131931A5 (en)	1978-08-09
IL53094A0 (en)	1977-12-30
MX4899E (en)	1982-12-14
NZ185358A (en)	1979-06-08
HK53881A (en)	1981-11-13
DE2746244A1 (en)	1978-04-20
KE3167A (en)	1981-11-06
JPS607997B2 (en)	1985-02-28
FI773060A (en)	1978-04-19
GR70201B (en)	1982-08-31
LU78330A1 (en)	1979-06-01
AU2943177A (en)	1979-04-12
DK150302B (en)	1987-02-02
GB1566171A (en)	1980-04-30
ES463267A1 (en)	1978-07-16
NO148453B (en)	1983-07-04

Publication	Publication Date	Title
ATA815577A (en)	1979-10-15	METHOD FOR MANUFACTURING NEW SPIROL ACTONS
AT353959B (en)	1979-12-10	PROCESS FOR PRODUCING NEW 1-OXADETHIACEPHALOSPORINES
ATA745977A (en)	1979-09-15	PROCESS FOR MANUFACTURING NEW SPIRO HYDANTOIN
AT355571B (en)	1980-03-10	METHOD FOR PRODUCING NEW BIS -PYRIDINIUM COMPOUNDS
ATA348877A (en)	1978-08-15	PROCESS FOR THE PRODUCTION OF NEW N-ACYLATES
AT349634B (en)	1979-04-10	PROCESS FOR THE PRODUCTION OF NEW ANTHRACYCLING LYCOSIDES
DD132663A5 (en)	1978-10-18	PROCESS FOR THE PREPARATION OF NEW PENICILLANSAEUREDERIVATES
AT352279B (en)	1979-09-10	PROCESS FOR THE PRODUCTION OF NEW RIFAMYCINE COMPOUNDS
AT349446B (en)	1979-04-10	PROCESS FOR MANUFACTURING NEW POLYCYCLO-ALIPHATIC DIAMINES
ATA303477A (en)	1978-11-15	PROCESS FOR THE PRODUCTION OF NEW INDAZOLYL- (4 -) - OXY-PROPANOLAMINES
AT347457B (en)	1978-12-27	PROCESS FOR THE PRODUCTION OF NEW INDOLINOSPIROPYRANE COMPOUNDS
AT350736B (en)	1979-06-11	METHOD FOR MANUFACTURING NEW APOVIN-CAMINOLESTERS
AT352280B (en)	1979-09-10	PROCESS FOR THE PRODUCTION OF NEW RIFAMYCINE COMPOUNDS
AT360647B (en)	1981-01-26	METHOD FOR PRODUCING NEW CEPHALOS PORINE COMPOUNDS
AT353411B (en)	1979-11-12	PROCESS FOR THE PRODUCTION OF NEW 4-DEDIMETHYLAMINO-4-ARYLSULFONAMIDO-5A, 6- -ANHYDROTETRACYCLINES
AT354441B (en)	1979-01-10	PROCESS FOR THE PREPARATION OF NEW 1-BENZTHIAZOLYL-IMIDAZOLIDINONES
AT354442B (en)	1979-01-10	PROCESS FOR THE PREPARATION OF NEW 1-THIAZOLYL-IMIDAZOLIDINONES
AT348118B (en)	1979-01-25	PROCESS FOR MANUFACTURING NEW BETALACTAMANTIBIOTICS
AT358189B (en)	1980-08-25	METHOD FOR THE PRODUCTION OF NEW ASPIDOSPERMINE
AT356301B (en)	1980-04-25	METHOD FOR THE PRODUCTION OF NEW D-HOMOSTEROIDS
AT351558B (en)	1979-08-10	PROCESS FOR THE PRODUCTION OF NEW 2-FORMYL-AMINO-PHENYLGUANIDINES
AT352876B (en)	1979-10-10	PROCESS FOR PRODUCING NEW 3-HETEROTHIOMETHYLUREIDOCEPHALOSPORINES
AT351515B (en)	1979-07-25	METHOD FOR PRODUCING NEW POLYEN COMPOUNDS
ATA664076A (en)	1977-10-15	PROCESS FOR PREPARING NEW N-ALKYL -4-NITRO-2-TRIFLUOROMETHYLDIPHENYLAMINES
ATA579676A (en)	1979-07-15	METHOD FOR MANUFACTURING NEW ANTHRANYL OYLOXYALKYL HYDANTOIN

Legal Events

Date	Code	Title	Description
1994-06-15	ELJ	Ceased due to non-payment of the annual fee