DK148280C - Analogifremgangsmaade til fremstilling af thienothiazinderivater - Google Patents

Analogifremgangsmaade til fremstilling af thienothiazinderivater

Info

Publication number: DK148280C
Authority: DK; Denmark
Prior art keywords: preparation; analogy procedure; thienothiazine derivatives; thienothiazine; derivatives
Prior art date: 1977-09-06

Application number

DK392778A

Other languages

English (en)

Other versions

DK392778A (da

DK148280B (da

Inventor

Dieter Binder

Otto Hromatka

Rudolf Dr Pfister

Paul Dr Zeller

Original Assignee

Chemie Linz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-09-06

Filing date

1978-09-05

Publication date

1985-11-18

1978-09-05 Application filed by Chemie Linz Ag filed Critical Chemie Linz Ag

1979-03-07 Publication of DK392778A publication Critical patent/DK392778A/da

1985-05-28 Publication of DK148280B publication Critical patent/DK148280B/da

1985-11-18 Application granted granted Critical

1985-11-18 Publication of DK148280C publication Critical patent/DK148280C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK392778A 1977-09-06 1978-09-05 Analogifremgangsmaade til fremstilling af thienothiazinderivater DK148280C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
LU78083		1977-09-06
LU78083		1977-09-06
CH790878		1978-07-21
CH790878		1978-07-21

Publications (3)

Publication Number	Publication Date
DK392778A DK392778A (da)	1979-03-07
DK148280B DK148280B (da)	1985-05-28
DK148280C true DK148280C (da)	1985-11-18

Family

ID=25702440

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK392778A DK148280C (da)	1977-09-06	1978-09-05	Analogifremgangsmaade til fremstilling af thienothiazinderivater

Country Status (28)

Country	Link
US (1)	US4180662A (da)
EP (1)	EP0001113B1 (da)
JP (1)	JPS5448792A (da)
AR (1)	AR222472A1 (da)
AT (1)	AT364851B (da)
AU (1)	AU518216B2 (da)
BR (1)	BR7805845A (da)
CA (1)	CA1103246A (da)
CS (1)	CS202019B2 (da)
DE (2)	DE2838851A1 (da)
DK (1)	DK148280C (da)
ES (1)	ES473074A1 (da)
FI (1)	FI63587C (da)
GB (1)	GB2003877B (da)
GR (1)	GR73066B (da)
HK (1)	HK1085A (da)
HU (1)	HU176979B (da)
IE (1)	IE47261B1 (da)
IL (1)	IL55465A (da)
IT (1)	IT1099046B (da)
LU (1)	LU90207I2 (da)
MC (1)	MC1212A1 (da)
NL (1)	NL7809015A (da)
NO (1)	NO149174C (da)
NZ (1)	NZ188320A (da)
PH (1)	PH13949A (da)
PT (1)	PT68515A (da)
SE (1)	SE7809348L (da)

Families Citing this family (52)

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DE2838377A1 (de) *	1978-09-02	1980-03-20	Thomae Gmbh Dr K	Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung
AU5811280A (en) *	1979-06-13	1980-12-18	F. Hoffmann-La Roche Ag	Thiazine derivatives
JPS58109492A (ja) *	1981-12-22	1983-06-29	Mitsui Toatsu Chem Inc	チエノチアジン誘導体およびそれを含有する医薬組成物
ATE26720T1 (de) *	1982-09-09	1987-05-15	Hoffmann La Roche	Thieno(2,3-e)-1,2-thiazin-derivate.
GR80576B (en) *	1983-10-17	1984-11-29	Fujisawa Pharmaceutical Co	Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) *	1983-12-21	1985-11-05	Pfizer Inc.	Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
DE3346526C2 (de) *	1983-12-22	1986-12-11	A. Nattermann & Cie GmbH, 5000 Köln	Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
JPS60184077A (ja) *	1984-02-23	1985-09-19	フアイザー・インコーポレーテツド	抗炎症性オキシム前駆薬
US4656265A (en) *	1984-06-21	1987-04-07	Pfizer Inc.	Cyclic prodrugs of antiinflammatory oxicams
US4623486A (en)	1985-05-29	1986-11-18	Pfizer Inc.	[4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) *	1985-06-03	1986-09-09	Pfizer Inc.	Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4914101A (en) *	1987-06-10	1990-04-03	Pfizer Inc.	3,4-Dihydro-2-alkyl-3-oxo-n-aryl-2H-(1)benzo-thieno(3,2-e)-1,2-thiazine-4-carboxamide-1,1-dioxides
NZ226477A (en) *	1987-10-29	1990-07-26	Cl Pharma	Substituted thieno (2,3-e)-1,2 thiazine derivatives and pharmaceutical compositions
ATA39088A (de)	1988-02-18	1990-06-15	Binder Dieter Dr	Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung
AT390060B (de) *	1988-05-02	1990-03-12	Cl Pharma	Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern
JPH01316314A (ja) *	1988-06-16	1989-12-21	Taisho Pharmaceut Co Ltd	湿布剤
JPH01316315A (ja) *	1988-06-16	1989-12-21	Taisho Pharmaceut Co Ltd	硬膏剤
AT400437B (de) *	1993-12-14	1995-12-27	Chem Pharm Forsch Gmbh	Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
AT400568B (de) *	1994-05-18	1996-01-25	Chem Pharm Forsch Gmbh	Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
DE4141218A1 (de) *	1991-12-13	1993-06-17	Luitpold Werk Chem Pharm	Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
AT399880B (de)	1992-07-03	1995-08-25	Chem Pharm Forsch Gmbh	Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400845B (de) *	1993-12-06	1996-03-25	Chem Pharm Forsch Gmbh	Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) *	1993-12-14	1995-06-21	Chemisch Pharmazeutische Forschungsgesellschaft m.b.H.	Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
DE19747625A1 (de) *	1997-10-29	1999-05-06	Bayer Ag	Verfahren zur Herstellung von 3,5-Dimethylisoxazol-4-sulfochlorid
IT1308633B1 (it)	1999-03-02	2002-01-09	Nicox Sa	Nitrossiderivati.
DE19933260A1 (de) *	1999-07-15	2001-01-18	Bayer Ag	Substituierte Thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
EP2206709A3 (en) *	2001-06-11	2011-06-29	Virochem Pharma Inc.	Thiophene derivatives as antiviral agents for flavivirus infection
US8329924B2 (en) *	2001-06-11	2012-12-11	Vertex Pharmaceuticals (Canada) Incorporated	Compounds and methods for the treatment or prevention of Flavivirus infections
CN1171892C (zh) *	2001-06-25	2004-10-20	李晶	具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
ES2345438T3 (es) *	2002-12-10	2010-09-23	Virochem Pharma Inc.	Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.
AT413944B (de) *	2003-05-27	2006-07-15	Binder Eva Dkfm	Verwendung von oxicam-verbindungen
CN1266155C (zh) *	2003-08-01	2006-07-26	浙江震元制药有限公司	6－氯－4－羟基－2－甲基－2H－噻吩并（2，3－e）－1，2－噻嗪－1，1－二氧化物－3－羧酸酯的合成方法
DE102004010812A1 (de) *	2004-03-05	2005-09-22	Bayer Cropscience Ag	Unkrautbekämpfungsverfahren
EP1751115A4 (en)	2004-05-23	2010-10-20	Gerard M Housey	THERAMUTEINMODULATOREN
KR20080016597A (ko) *	2005-05-13	2008-02-21	바이로켐 파마 인코포레이티드	플라비바이러스 감염의 예방 또는 치료용 화합물 및 그의예방 또는 치료 방법
US8431110B2 (en)	2005-05-23	2013-04-30	Hmi Medical Innovations, Llc.	Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
US20090275070A1 (en) *	2005-11-23	2009-11-05	Housey Gerard M	Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
WO2008044095A1 (en)	2006-10-11	2008-04-17	Techfields Biochem Co. Ltd	Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate
US20090238763A1 (en)	2006-07-09	2009-09-24	Chongxi Yu	High penetration compositions and uses thereof
US20090221703A1 (en)	2006-07-09	2009-09-03	Chongxi Yu	High penetration composition and uses thereof
CN102675279A (zh) *	2006-11-15	2012-09-19	Viro化学制药公司	用于治疗或预防黄病毒属感染的噻吩类似物
MX377501B (es)	2007-06-04	2025-03-10	Techfields Inc	Profarmacos de nsaias con el piel y membranas con indices de penetracion muy altos y nuevos usos medicinales.
CN101314598B (zh) *	2008-07-14	2012-03-21	浙江工业大学	5-氯-2-羧酸甲酯-3-甲胺基磺酰噻吩的合成新工艺
AU2009322112B2 (en)	2008-12-04	2016-12-15	Chongxi Yu	High penetration compositions and their applications
KR20220130239A (ko)	2012-01-18	2022-09-26	테크필즈 파마 코., 엘티디.	폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물
ITUB20152229A1 (it) *	2015-07-16	2017-01-16	Edmond Pharma Srl	Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam
CN108218895B (zh) *	2018-04-13	2019-06-18	北京金城泰尔制药有限公司沧州分公司	一锅法合成氯诺昔康中间体的方法
CN112125792B (zh) *	2020-09-24	2022-07-12	万华化学集团股份有限公司	一种联产羟基香茅醛和羟基香茅醇的方法
CN112645925A (zh) *	2020-12-25	2021-04-13	北京金城泰尔制药有限公司	氯诺昔康中间体5-氯-3-甲基磺酰胺噻吩-2-羧酸甲酯的合成方法
CN112661742A (zh) *	2020-12-25	2021-04-16	北京金城泰尔制药有限公司	氯诺昔康金属化活性中间体的合成方法
CN114213434A (zh) *	2021-12-29	2022-03-22	北京金城泰尔制药有限公司	氯诺昔康晶型及其制备方法
CN115894525B (zh) *	2023-01-04	2024-09-20	河北国龙制药有限公司	一种氯诺昔康中间体的合成方法

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GB1308533A (en)	1969-06-02	1973-02-21	Pfizer	Benzothiazine dioxides as anti-thombotic agents
US3787324A (en)	1971-03-01	1974-01-22	Warner Lambert Co	4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3821211A (en) *	1972-03-10	1974-06-28	Warner Lambert Co	Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolycarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
CA1010990A (en)	1973-06-06	1977-05-24	Leopold H. O'donnell	Video tape recording animation system
CA1066711A (en) *	1974-08-26	1979-11-20	Hoffmann-La Roche Limited	Thiophene derivatives
IL47877A (en) *	1974-08-26	1978-10-31	Sparamedica Ag	Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
MC1135A1 (fr) *	1976-02-23	1977-11-18	Hoffmann La Roche	Derives de thiazine

1978
- 1978-08-30 AU AU39389/78A patent/AU518216B2/en not_active Expired
- 1978-08-31 MC MC781322A patent/MC1212A1/xx unknown
- 1978-08-31 IL IL55465A patent/IL55465A/xx active IP Right Grant
- 1978-08-31 US US05/938,274 patent/US4180662A/en not_active Expired - Lifetime
- 1978-09-01 NL NL7809015A patent/NL7809015A/xx not_active Application Discontinuation
- 1978-09-01 NZ NZ188320A patent/NZ188320A/xx unknown
- 1978-09-04 HU HU78HO2099A patent/HU176979B/hu unknown
- 1978-09-04 PH PH21565A patent/PH13949A/en unknown
- 1978-09-04 GR GR57146A patent/GR73066B/el unknown
- 1978-09-05 AT AT0642178A patent/AT364851B/de not_active IP Right Cessation
- 1978-09-05 PT PT68515A patent/PT68515A/pt unknown
- 1978-09-05 CS CS785744A patent/CS202019B2/cs unknown
- 1978-09-05 CA CA310,603A patent/CA1103246A/en not_active Expired
- 1978-09-05 NO NO783032A patent/NO149174C/no unknown
- 1978-09-05 DK DK392778A patent/DK148280C/da active
- 1978-09-05 JP JP10820378A patent/JPS5448792A/ja active Granted
- 1978-09-05 ES ES473074A patent/ES473074A1/es not_active Expired
- 1978-09-05 IE IE1788/78A patent/IE47261B1/en not_active IP Right Cessation
- 1978-09-05 GB GB7835571A patent/GB2003877B/en not_active Expired
- 1978-09-05 SE SE7809348A patent/SE7809348L/xx unknown
- 1978-09-06 DE DE19782838851 patent/DE2838851A1/de not_active Withdrawn
- 1978-09-06 BR BR7805845A patent/BR7805845A/pt unknown
- 1978-09-06 AR AR273600A patent/AR222472A1/es active
- 1978-09-06 FI FI782737A patent/FI63587C/fi not_active IP Right Cessation
- 1978-09-06 IT IT27396/78A patent/IT1099046B/it active Protection Beyond IP Right Term
- 1978-09-06 EP EP78100832A patent/EP0001113B1/de not_active Expired
- 1978-09-06 DE DE7878100832T patent/DE2861316D1/de not_active Expired
1985
- 1985-01-03 HK HK10/85A patent/HK1085A/xx not_active IP Right Cessation
1998
- 1998-01-30 LU LU90207C patent/LU90207I2/fr unknown

Also Published As

Publication number	Publication date
IL55465A0 (en)	1978-10-31
ATA642178A (de)	1981-04-15
HU176979B (hu)	1981-06-28
LU90207I2 (fr)	1998-04-29
BR7805845A (pt)	1979-04-24
US4180662A (en)	1979-12-25
DE2861316D1 (en)	1982-01-14
IL55465A (en)	1982-02-28
HK1085A (en)	1985-01-11
NZ188320A (en)	1981-01-23
EP0001113A1 (de)	1979-03-21
DK392778A (da)	1979-03-07
DE2838851A1 (de)	1979-03-22
JPS6149318B2 (da)	1986-10-29
AR222472A1 (es)	1981-05-29
CA1103246A (en)	1981-06-16
NO149174C (no)	1984-02-29
JPS5448792A (en)	1979-04-17
NO783032L (no)	1979-03-07
EP0001113B1 (de)	1981-11-11
NO149174B (no)	1983-11-21
ES473074A1 (es)	1979-10-16
IE47261B1 (en)	1984-02-08
AU518216B2 (en)	1981-09-17
AT364851B (de)	1981-11-25
GR73066B (da)	1984-01-30
GB2003877B (en)	1982-03-17
IT7827396A0 (it)	1978-09-06
AU3938978A (en)	1980-03-06
MC1212A1 (fr)	1979-05-18
FI782737A7 (fi)	1979-03-07
GB2003877A (en)	1979-03-21
PT68515A (en)	1978-10-01
SE7809348L (sv)	1979-03-07
IT1099046B (it)	1985-09-18
PH13949A (en)	1980-11-04
IE781788L (en)	1979-03-06
FI63587C (fi)	1983-07-11
FI63587B (fi)	1983-03-31
CS202019B2 (en)	1980-12-31
NL7809015A (nl)	1979-03-08
DK148280B (da)	1985-05-28

Publication	Publication Date	Title
DK148280C (da)	1985-11-18	Analogifremgangsmaade til fremstilling af thienothiazinderivater
DK155367C (da)	1989-08-14	Analogifremgangsmaade til fremstilling af 2-nitroimidazolderivater
DK63178A (da)	1978-08-12	Fremgangsmaade til fremstilling af pyrrodinderivater
DK536178A (da)	1979-06-23	Fremgangsmaade til fremstilling af stilbenderivater
DK110778A (da)	1978-09-15	Fremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer
DK149954C (da)	1987-06-15	Analogifremgangsmaade til fremstilling af 18-umaettede prostacyklinderivater
DK149858C (da)	1987-06-29	Analogifremgangsmaade til fremstilling af morfinderivater
DK153482C (da)	1988-12-27	Analogifremgangsmaade til fremstilling af 5-cyano-prostacyklinderivater
DK155669C (da)	1989-09-25	Analogifremgangsmaade til fremstilling af pleuromutilinderivater
DK146962C (da)	1984-08-06	Analogifremgangsmaade til fremstilling af indolizinderivater
DK158984C (da)	1991-01-14	Analogifremgangsmaade til fremstilling af carbostyrilderivater
DK154137C (da)	1989-04-10	Analogifremgangsmaade til fremstilling af meta-sulfonamido-benzamidderivater
DK145701C (da)	1983-07-18	Fremgangsmaade til fremstilling af ergotalkaloider
DK156643C (da)	1990-02-05	Analogifremgangsmaade til fremstilling af naphthalensulfonamidderivater
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