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DK145666C - METHOD FOR PREPARING 17ALFA- (3-IODBENZOYLOXY) -9ALFA-CHLOR-4-PREGNANCY-3,20-DIONES OR THEIR D-HOME ANALOGUE - Google Patents

METHOD FOR PREPARING 17ALFA- (3-IODBENZOYLOXY) -9ALFA-CHLOR-4-PREGNANCY-3,20-DIONES OR THEIR D-HOME ANALOGUE

Info

Publication number
DK145666C
DK145666C DK477778A DK477778A DK145666C DK 145666 C DK145666 C DK 145666C DK 477778 A DK477778 A DK 477778A DK 477778 A DK477778 A DK 477778A DK 145666 C DK145666 C DK 145666C
Authority
DK
Denmark
Prior art keywords
iodbenzoyloxy
9alfa
17alfa
diones
chlor
Prior art date
Application number
DK477778A
Other languages
Danish (da)
Other versions
DK145666B (en
DK477778A (en
Inventor
Ulrich Kerb
Manfred Stahnke
Rudolf Wiechert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2748442A external-priority patent/DE2748442C3/en
Priority claimed from DE19772748443 external-priority patent/DE2748443A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK477778A publication Critical patent/DK477778A/en
Publication of DK145666B publication Critical patent/DK145666B/en
Application granted granted Critical
Publication of DK145666C publication Critical patent/DK145666C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK477778A 1977-10-26 1978-10-26 METHOD FOR PREPARING 17ALFA- (3-IODBENZOYLOXY) -9ALFA-CHLOR-4-PREGNANCY-3,20-DIONES OR THEIR D-HOME ANALOGUE DK145666C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2748442A DE2748442C3 (en) 1977-10-26 1977-10-26 17? - (3-iodobenzoyloxy) -9? -chlor4-pregnen-3.20-dione, intermediates and process for their preparation, 9? -chlor-17α, 21-dihydroxy-1,4-pregnadiene-3,20-dione and drugs containing it
DE2748443 1977-10-26
DE19772748443 DE2748443A1 (en) 1977-10-26 1977-10-26 17-Iodo:benzoyloxy-9-chloro-D-homo-4-pregnene-3,20-di:one derivs. - prepd. by reacting 9-unsubstituted cpds. with iodo-benzene di:chloride under UV light, used esp. as pharmaceutical intermediates
DE2748442 1977-10-26

Publications (3)

Publication Number Publication Date
DK477778A DK477778A (en) 1979-04-27
DK145666B DK145666B (en) 1983-01-17
DK145666C true DK145666C (en) 1983-07-18

Family

ID=25772982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK477778A DK145666C (en) 1977-10-26 1978-10-26 METHOD FOR PREPARING 17ALFA- (3-IODBENZOYLOXY) -9ALFA-CHLOR-4-PREGNANCY-3,20-DIONES OR THEIR D-HOME ANALOGUE

Country Status (6)

Country Link
EP (1) EP0001737B1 (en)
JP (1) JPS5470253A (en)
BG (1) BG28719A3 (en)
DD (1) DD138981A5 (en)
DK (1) DK145666C (en)
HU (1) HU177759B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197406A (en) * 1978-05-12 1980-04-08 Hoffmann-La Roche Inc. D-Homosteroids
US4252729A (en) * 1978-05-12 1981-02-24 Hoffmann-La Roche Inc. Steroids and process for their manufacture
JP2545522B2 (en) * 1985-10-23 1996-10-23 アルコン・ラボラトーリーズ，インコーポレイテッド Tetrahydro angiogenesis inhibitor steroids
EP3006453A1 (en) 2014-10-08 2016-04-13 Cosmo Technologies Ltd. 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1081888B (en) * 1956-12-31 1960-05-19 Searle & Co Process for the production of? -3-keto-9 ª ‡ -halogen steroids

Also Published As

Publication number Publication date
JPS6227076B2 (en) 1987-06-12
BG28719A3 (en) 1980-06-16
DK145666B (en) 1983-01-17
DK477778A (en) 1979-04-27
EP0001737A1 (en) 1979-05-16
EP0001737B1 (en) 1981-01-07
JPS5470253A (en) 1979-06-05
DD138981A5 (en) 1979-12-05
HU177759B (en) 1981-12-28

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