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BG28719A3 - Method of obtaining of 17- alfa- (3- iodinebenzoiloxy)- 9 alfa chloride- 4- pregnen 3,20- dions and their alfa- homoanaloges - Google Patents

Method of obtaining of 17- alfa- (3- iodinebenzoiloxy)- 9 alfa chloride- 4- pregnen 3,20- dions and their alfa- homoanaloges

Info

Publication number
BG28719A3
BG28719A3 BG040913A BG4091378A BG28719A3 BG 28719 A3 BG28719 A3 BG 28719A3 BG 040913 A BG040913 A BG 040913A BG 4091378 A BG4091378 A BG 4091378A BG 28719 A3 BG28719 A3 BG 28719A3
Authority
BG
Bulgaria
Prior art keywords
alfa
iodinebenzoiloxy
homoanaloges
dions
pregnen
Prior art date
Application number
BG040913A
Other languages
Bulgarian (bg)
Inventor
Ulrich Kerb
Manfred Stahnke
Rudolf Wiechert
Leo Alig
Andor Fuerst
Marcel Mueller
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2748442A external-priority patent/DE2748442C3/en
Priority claimed from DE19772748443 external-priority patent/DE2748443A1/en
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of BG28719A3 publication Critical patent/BG28719A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Метод за получаване на 17 алфа-(3-йодбензоилокси)-9 алфа-хлор-4-прегнен-3.20-диони и техни d-хомоаналози с формула..... Патентните претенции са формулирани в 1 точка.Method for the preparation of 17 alpha-(3-iodobenzoyloxy)-9 alpha-chloro-4-pregnene-3,20-diones and their d-homoanalogues of formula..... The patent claims are formulated in 1 point.

BG040913A 1977-10-26 1978-09-20 Method of obtaining of 17- alfa- (3- iodinebenzoiloxy)- 9 alfa chloride- 4- pregnen 3,20- dions and their alfa- homoanaloges BG28719A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2748442A DE2748442C3 (en) 1977-10-26 1977-10-26 17? - (3-iodobenzoyloxy) -9? -chlor4-pregnen-3.20-dione, intermediates and process for their preparation, 9? -chlor-17α, 21-dihydroxy-1,4-pregnadiene-3,20-dione and drugs containing it
DE19772748443 DE2748443A1 (en) 1977-10-26 1977-10-26 17-Iodo:benzoyloxy-9-chloro-D-homo-4-pregnene-3,20-di:one derivs. - prepd. by reacting 9-unsubstituted cpds. with iodo-benzene di:chloride under UV light, used esp. as pharmaceutical intermediates

Publications (1)

Publication Number Publication Date
BG28719A3 true BG28719A3 (en) 1980-06-16

Family

ID=25772982

Family Applications (1)

Application Number Title Priority Date Filing Date
BG040913A BG28719A3 (en) 1977-10-26 1978-09-20 Method of obtaining of 17- alfa- (3- iodinebenzoiloxy)- 9 alfa chloride- 4- pregnen 3,20- dions and their alfa- homoanaloges

Country Status (6)

Country Link
EP (1) EP0001737B1 (en)
JP (1) JPS5470253A (en)
BG (1) BG28719A3 (en)
DD (1) DD138981A5 (en)
DK (1) DK145666C (en)
HU (1) HU177759B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197406A (en) * 1978-05-12 1980-04-08 Hoffmann-La Roche Inc. D-Homosteroids
US4252729A (en) * 1978-05-12 1981-02-24 Hoffmann-La Roche Inc. Steroids and process for their manufacture
JP2545522B2 (en) * 1985-10-23 1996-10-23 アルコン・ラボラトーリーズ，インコーポレイテッド Tetrahydro angiogenesis inhibitor steroids
EP3006453A1 (en) 2014-10-08 2016-04-13 Cosmo Technologies Ltd. 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1081888B (en) * 1956-12-31 1960-05-19 Searle & Co Process for the production of? -3-keto-9 ª ‡ -halogen steroids

Also Published As

Publication number Publication date
JPS6227076B2 (en) 1987-06-12
DK145666B (en) 1983-01-17
DK477778A (en) 1979-04-27
EP0001737A1 (en) 1979-05-16
EP0001737B1 (en) 1981-01-07
JPS5470253A (en) 1979-06-05
DD138981A5 (en) 1979-12-05
HU177759B (en) 1981-12-28
DK145666C (en) 1983-07-18

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