[go: up one dir, main page]

DK1456346T3 - Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor - Google Patents

Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor

Info

Publication number
DK1456346T3
DK1456346T3 DK02714955.8T DK02714955T DK1456346T3 DK 1456346 T3 DK1456346 T3 DK 1456346T3 DK 02714955 T DK02714955 T DK 02714955T DK 1456346 T3 DK1456346 T3 DK 1456346T3
Authority
DK
Denmark
Prior art keywords
receptor
gene expression
expression system
invertebrate
retinoid
Prior art date
Application number
DK02714955.8T
Other languages
English (en)
Inventor
Subba Reddy Palli
Marianna Zinovjevna Kapitskaya
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26953897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1456346(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intrexon Corp filed Critical Intrexon Corp
Application granted granted Critical
Publication of DK1456346T3 publication Critical patent/DK1456346T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK02714955.8T 2001-02-20 2002-02-20 Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor DK1456346T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26979901P 2001-02-20 2001-02-20
US29481401P 2001-05-31 2001-05-31
PCT/US2002/005235 WO2002066613A2 (en) 2001-02-20 2002-02-20 Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system

Publications (1)

Publication Number Publication Date
DK1456346T3 true DK1456346T3 (da) 2012-05-29

Family

ID=26953897

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02714955.8T DK1456346T3 (da) 2001-02-20 2002-02-20 Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor

Country Status (11)

Country Link
US (2) US9493540B2 (da)
EP (1) EP1456346B1 (da)
JP (3) JP4955904B2 (da)
AT (1) ATE545705T1 (da)
AU (2) AU2002247184B2 (da)
CA (1) CA2441444C (da)
DK (1) DK1456346T3 (da)
ES (1) ES2385598T3 (da)
MX (1) MXPA03007493A (da)
PT (1) PT1456346E (da)
WO (1) WO2002066613A2 (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
JP4994563B2 (ja) * 2001-02-20 2012-08-08 イントレキソン コーポレーション 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用
DK1456346T3 (da) * 2001-02-20 2012-05-29 Intrexon Corp Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor
EP1572862B1 (en) * 2001-02-20 2012-08-01 Intrexon Corporation Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
DK1373470T3 (da) 2001-02-20 2013-07-29 Intrexon Corp Hidtil ukendte substitutionsmutantreceptorer og deres anvendelse i et cellekernereceptorbaseret inducerbart genekspressionssystem
MXPA04002808A (es) 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de mosca blanca, polipeptidos, y sus usos.
MXPA04002810A (es) * 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos.
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) * 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP2043662B1 (en) 2006-07-26 2015-09-09 Intrexon Corporation Methods and compositions for treating disease
DK2167458T3 (da) 2007-05-29 2018-06-18 Intrexon Corp Kirale diacylhydrazin-ligander til modulering af ekspressionen af eksogene gener via et ecdyson-receptor-kompleks
CA2698212A1 (en) * 2007-08-23 2009-02-26 Intrexon Corporation Methods and compositions for diagnosing disease
NZ584848A (en) 2007-09-28 2012-09-28 Intrexon Corp Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
MX2010003720A (es) 2007-10-08 2010-10-20 Intrexon Corp Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer.
WO2009114201A2 (en) 2008-03-14 2009-09-17 Intrexon Corporation Steroidal ligands and their use in gene switch modulation
JP5272898B2 (ja) 2009-05-29 2013-08-28 ソニー株式会社 信号処理装置、信号処理方法、および受信システム
AU2011232435B2 (en) 2010-03-23 2016-01-28 Intrexon Corporation Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
EP3450568A3 (en) 2011-03-04 2019-04-24 Intrexon Corporation Vectors conditionally expressing protein
EP2699688A1 (en) 2011-04-20 2014-02-26 The Trustees Of The University Of Pennsylvania Regimens and compositions for aav-mediated passive immunization of airborne pathogens
WO2014144380A1 (en) 2013-03-15 2014-09-18 Intrexon Corporation Boron-containing diacylhydrazines
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
EP3842528A1 (en) 2013-09-18 2021-06-30 Kymab Limited Methods, cells and organisms
CN107406373B (zh) 2014-09-17 2020-04-28 英特瑞克斯顿股份有限公司 含硼的二酰基肼化合物
US11535665B2 (en) 2015-05-13 2022-12-27 The Trustees Of The University Of Pennsylvania AAV-mediated expression of anti-influenza antibodies and methods of use thereof
WO2017062953A1 (en) 2015-10-10 2017-04-13 Intrexon Corporation Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
WO2017083750A1 (en) 2015-11-11 2017-05-18 Intrexon Corporation Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
IL321834A (en) 2016-06-08 2025-08-01 Precigen Inc Cd33 specific chimeric antigen receptors
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
CN110139933B (zh) 2016-11-09 2024-03-08 英特瑞克斯顿股份有限公司 共济蛋白表达构建体
CN118406655A (zh) 2017-01-10 2024-07-30 普瑞赛格恩公司 通过新基因开关表达系统调节多肽的表达
US10786568B2 (en) 2017-02-28 2020-09-29 The Trustees Of The University Of Pennsylvania AAV mediated influenza vaccines
SMT202400080T1 (it) 2017-02-28 2024-05-14 Univ Pennsylvania Vettore di clade f di virus adenoassociato (aav) e relativi usi
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
CN110997920A (zh) 2017-06-07 2020-04-10 英特拉克森公司 新型细胞标签的表达
CN112088015A (zh) 2018-03-06 2020-12-15 普莱西根股份有限公司 人乳头瘤病毒疫苗及其用途
IL277128B2 (en) 2018-03-06 2025-11-01 Precigen Inc Hepatitis b vaccines and uses of the same
CA3099958A1 (en) 2018-04-16 2019-10-24 The Trustees Of The University Of Pennsylvania Compositions and methods for treating duchenne muscular dystrophy
WO2020206056A1 (en) 2019-04-04 2020-10-08 Greenvenus Llc Peptides and methods of plant protection
CN116670152A (zh) 2020-12-01 2023-08-29 宾夕法尼亚州大学信托人 具有组织特异性靶向基序的新型组合物和含有其的组合物
CA3216004A1 (en) 2021-04-23 2022-10-27 The Trustees Of The University Of Pennsylvania Novel compositions with brain-specific targeting motifs and compositions containing same
US20240384298A1 (en) 2021-10-02 2024-11-21 The Trustees Of The University Of Pennsylvania Novel aav capsids and compositions containing same
JP2025504910A (ja) 2022-01-25 2025-02-19 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 心臓形質導入の改善及び肝臓の脱標的化のためのaavカプシド
WO2024130070A2 (en) 2022-12-17 2024-06-20 The Trustees Of The University Of Pennsylvania Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof
AU2023398931A1 (en) 2022-12-17 2025-07-10 The Trustees Of The University Of Pennsylvania Recombinant aav mutant vectors with cardiac and skeletal muscle-specific targeting motifs and compositions containing same
TW202516019A (zh) 2023-06-29 2025-04-16 賓州大學委員會 具中樞神經系統靶向模體的突變aav及含有其之組成物
WO2025102034A1 (en) 2023-11-10 2025-05-15 The Trustees Of The University Of Pennsylvania Gene therapy for barth syndrome
WO2025106661A1 (en) 2023-11-14 2025-05-22 The Trustees Of The University Of Pennsylvania Compositions with cardiac and skeletal musclespecific targeting motifs and uses thereof

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4985461A (en) 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5117057A (en) 1985-10-21 1992-05-26 Rohm And Haas Company Insecticidal N' substituted-N-N'-disubstituted-hydrazines
US5424333A (en) 1985-10-21 1995-06-13 Rohm And Haas Company Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
FR2593630B1 (fr) 1986-01-27 1988-03-18 Maurice Francois Ecran d'affichage a matrice active a resistance de drain et procedes de fabrication de cet ecran
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5225443A (en) 1986-05-01 1993-07-06 Rohm And Haas Company Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5171671A (en) 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5429952A (en) 1988-02-02 1995-07-04 Biocode, Inc. Marking of products to establish identity and source
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
ATE145007T1 (de) 1988-06-13 1996-11-15 American Biogenetic Sciences Verfahren zur herstellung monoklonaler antikörper mit hilfe eines keimfreien tieres
US4954655A (en) 1989-03-31 1990-09-04 Rohm And Haas Company Preparation of alkylhydrazines
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
DE69132411T2 (de) 1990-02-09 2001-06-07 The Salk Institute For Biological Studies, La Jolla Retinoid-rezeptor-zusammensetzungen und verfahren
ATE220421T1 (de) 1990-02-26 2002-07-15 Univ Leland Stanford Junior Identifizierung und expression von insekten- steroidrezeptor-dns-sequenzen
WO1991014695A1 (en) 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US7119077B1 (en) 1990-03-22 2006-10-10 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
US5641652A (en) 1990-03-22 1997-06-24 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2043775A1 (en) 1990-06-14 1991-12-15 Dat P. Le Dibenzoylakylcyanohydrazines
US5139749A (en) 1990-06-22 1992-08-18 Tas, Inc. Fluidized calcining process
IL100643A (en) 1991-01-25 1996-10-31 Nippon Kayaku Kk History of hydrazine and pesticides containing these histories as an active ingredient
US5668175A (en) 1991-08-23 1997-09-16 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids
CA2114936C (en) 1991-08-23 2004-02-10 Ronald M. Evans Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones
AU2579692A (en) 1991-09-17 1993-04-27 Salk Institute For Biological Studies, The Receptor of the thyroid/steroid hormone receptor superfamily
EP1396541A3 (en) 1991-12-06 2004-11-24 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors
CA2106382A1 (en) 1992-01-24 1993-07-25 Mark Leid Heterodimeric nuclear receptors proteins, genes encoding same, and usage thereof
US5530028A (en) 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
DK0705279T3 (da) 1993-05-27 2003-06-10 Selectide Corp Topologisk adskilte, kodende fastfase-biblioteker
WO1995013373A1 (en) 1993-11-10 1995-05-18 Arch Development Corporation Ubiquitous nuclear receptor: compositions and methods
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
US6326166B1 (en) 1995-12-29 2001-12-04 Massachusetts Institute Of Technology Chimeric DNA-binding proteins
CA2210248A1 (en) 1995-01-13 1996-07-18 Ronald M. Evans Allosteric control of nuclear hormone receptors
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
ATE293699T1 (de) 1995-03-03 2005-05-15 Syngenta Participations Ag Kontrolle der pflanzengenexpression durch rezeptor-vermittelte transaktivation in gegenwart von einem chemischen ligand
TR199701436T1 (xx) 1995-05-26 1998-03-21 Zeneca Limited Bir ekdison resept�r�n� i�eren bir gen anahtar�.
US5939442A (en) 1995-06-07 1999-08-17 The Salk Institute For Biological Studies Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
US6266622B1 (en) 1995-12-13 2001-07-24 Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
GB9606126D0 (en) 1996-03-22 1996-05-22 British Biotech Pharm Biosensors
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
WO1997038117A1 (en) 1996-04-05 1997-10-16 The Salk Institute For Biological Studies Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6610828B1 (en) 1996-05-24 2003-08-26 Syngenta Limited Heliothis ecdysone receptor
US6025483A (en) 1996-06-05 2000-02-15 The Regents Of The University Of California Maize and cauliflower apetalai gene products and nucleic acid molecules encoding same
US5919667A (en) 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
AU6007798A (en) 1997-02-14 1998-09-08 New Zealand Pastoral Agriculture Research Institute Limited Insect ecdysteroid receptors
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
CA2296093A1 (en) 1997-07-10 1999-01-21 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression
JP2003524368A (ja) 1997-08-26 2003-08-19 アリアド ジーン セラピューティクス インコーポレイテッド ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、dna結合ドメインまたはリガンド結合ドメインを含む融合蛋白
US7101681B1 (en) 1997-11-21 2006-09-05 Amgen, Inc. Nuclear hormone receptor drug screens
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US6410245B1 (en) 1998-04-01 2002-06-25 Affymax, Inc. Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
JP2002510790A (ja) 1998-04-06 2002-04-09 ブンセン ラッシュ ラボラトリーズ インコーポレーテッド 指向的進化バイオセンサ
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US6117639A (en) 1998-08-31 2000-09-12 Vertex Pharmaceuticals Incorporated Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
JP2002525053A (ja) 1998-09-10 2002-08-13 パイオニア ハイ−ブレッド インターナショナル, インコーポレイテッド エクジソンレセプターおよびそれらの使用のための方法
WO2000018903A2 (en) 1998-09-29 2000-04-06 The Johns Hopkins University Inducible genetic suppression of cellular excitability
US5989863A (en) 1998-10-14 1999-11-23 Incyte Pharmaceuticals, Inc. Human ankyrin family protein
WO2000071743A1 (fr) 1999-05-25 2000-11-30 Eisai Co., Ltd. Methode bihybride dans une cellule de mammifere
US7173722B1 (en) 1999-05-25 2007-02-06 Silverbrook Research Pty Ltd Method and system for printing a photograph
CA2377804A1 (en) 1999-07-01 2001-01-11 Commonwealth Scientific And Industrial Research Organisation Novel genetic sequences encoding steroid and juvenile hormone receptor polypeptides and uses therefor
US7057015B1 (en) 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
AU2001241682A1 (en) * 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
WO2001070816A2 (en) 2000-03-22 2001-09-27 Rohm And Haas Company Ecdysone receptor-based inducible gene expression system
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US20020037514A1 (en) * 2000-03-24 2002-03-28 Klein Elliott S. Identification of nuclear receptor-dependent coregulator recruitment
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
JP4994563B2 (ja) 2001-02-20 2012-08-08 イントレキソン コーポレーション 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用
DK1373470T3 (da) 2001-02-20 2013-07-29 Intrexon Corp Hidtil ukendte substitutionsmutantreceptorer og deres anvendelse i et cellekernereceptorbaseret inducerbart genekspressionssystem
EP1572862B1 (en) 2001-02-20 2012-08-01 Intrexon Corporation Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
DK1456346T3 (da) * 2001-02-20 2012-05-29 Intrexon Corp Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor
MXPA04002810A (es) 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos.
MXPA04002808A (es) 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de mosca blanca, polipeptidos, y sus usos.
WO2003105489A1 (en) 2002-06-07 2003-12-18 The Trustees Of Columbia University Method and device for online dynamic semantic video compression and video indexing
US20050228016A1 (en) 2002-06-13 2005-10-13 Enrique Michelotti Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
US8115059B1 (en) 2005-07-22 2012-02-14 University Of Kentucky Research Foundation Gene expression modulation system for use in plants and method for modulating gene expression in plants
US8471890B1 (en) 2009-12-30 2013-06-25 Insors Integrated Communications Adaptive video communication channel

Also Published As

Publication number Publication date
EP1456346B1 (en) 2012-02-15
US9493540B2 (en) 2016-11-15
US20170096672A1 (en) 2017-04-06
AU2008221578A1 (en) 2008-10-16
US20120167239A1 (en) 2012-06-28
AU2008221578B2 (en) 2012-05-03
ATE545705T1 (de) 2012-03-15
JP2009131259A (ja) 2009-06-18
CA2441444A1 (en) 2002-08-29
WO2002066613A2 (en) 2002-08-29
PT1456346E (pt) 2012-05-02
AU2002247184B2 (en) 2008-06-19
MXPA03007493A (es) 2004-10-15
JP4955904B2 (ja) 2012-06-20
JP5887301B2 (ja) 2016-03-16
JP2013236634A (ja) 2013-11-28
JP5345372B2 (ja) 2013-11-20
CA2441444C (en) 2013-09-03
EP1456346A2 (en) 2004-09-15
EP1456346A4 (en) 2006-12-20
ES2385598T3 (es) 2012-07-27
WO2002066613A3 (en) 2004-07-15
JP2004533214A (ja) 2004-11-04

Similar Documents

Publication Publication Date Title
DK1456346T3 (da) Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor
MXPA03007492A (es) Receptores de retinoide x quimerico y su uso en un sistema de expresion de gen inducible basado en receptor de ecdisona novedoso.
MXPA03007496A (es) Nuevos receptores mutantes de sustitucion y su uso en un sistema de expresion genetica inducible a base de receptores nucleares.
MXPA02009157A (es) Nuevo sistema de expresion genetica inducible a base del receptor de ecdisona.
WO2002066615A3 (en) Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2005108617A3 (en) Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
Hennig et al. Large-scale low-cost NGS library preparation using a robust Tn5 purification and tagmentation protocol
Guisbert et al. Convergence of molecular, modeling, and systems approaches for an understanding of the Escherichia coli heat shock response
Battaglia et al. Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements
Vcelar et al. Karyotype variation of CHO host cell lines over time in culture characterized by chromosome counting and chromosome painting
Vo et al. Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing
BR9607300A (pt) Polinucleotídeo transcrito de rna cdna vetor de dna biologicamente funcional célula hospedeira processo para produzir um polipeptídeo polipeptídeo produto de anticorpo hibridoma e linhagem de célula de hibridoma
ATE400651T1 (de) Verwendung von grünem fluoreszenzprotein
DE60144434D1 (de) Mehrfach-induzierbares genregulierungssystem
Delley et al. Modular barcode beads for microfluidic single cell genomics
DE60034059D1 (de) Zielgerichtete verfahren des wirkstoff screenings unter verwendung von co-kultivierungs verfahren
Arakawa A method to convert mRNA into a gRNA library for CRISPR/Cas9 editing of any organism
DE69524740D1 (de) Thymidin-kinase-mutanten
Baert et al. Phenotypic variability in bioprocessing conditions can be tracked on the basis of on‐line flow cytometry and fits to a scaling law
Ramaswamy et al. Designer ribozymes: programming the tRNA specificity into flexizyme
Han et al. Transposable element profiles reveal cell line identity and loss of heterozygosity in Drosophila cell culture
Morgan et al. Rational engineering of type II restriction endonuclease DNA binding and cleavage specificity
Kuchmina et al. Ethylene production in Synechocystis sp. PCC 6803 promotes phototactic movement
Ha et al. Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium
Pohlschroder et al. Haloferax volcanii: a versatile model for studying archaeal biology