DK1456346T3 - Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor - Google Patents
Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptorInfo
- Publication number
- DK1456346T3 DK1456346T3 DK02714955.8T DK02714955T DK1456346T3 DK 1456346 T3 DK1456346 T3 DK 1456346T3 DK 02714955 T DK02714955 T DK 02714955T DK 1456346 T3 DK1456346 T3 DK 1456346T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor
- gene expression
- expression system
- invertebrate
- retinoid
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 4
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 title 1
- 102000034527 Retinoid X Receptors Human genes 0.000 abstract 1
- 108010038912 Retinoid X Receptors Proteins 0.000 abstract 1
- 108010057988 ecdysone receptor Proteins 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 238000012188 high-throughput screening assay Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- High Energy & Nuclear Physics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26979901P | 2001-02-20 | 2001-02-20 | |
| US29481401P | 2001-05-31 | 2001-05-31 | |
| PCT/US2002/005235 WO2002066613A2 (en) | 2001-02-20 | 2002-02-20 | Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1456346T3 true DK1456346T3 (da) | 2012-05-29 |
Family
ID=26953897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02714955.8T DK1456346T3 (da) | 2001-02-20 | 2002-02-20 | Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9493540B2 (da) |
| EP (1) | EP1456346B1 (da) |
| JP (3) | JP4955904B2 (da) |
| AT (1) | ATE545705T1 (da) |
| AU (2) | AU2002247184B2 (da) |
| CA (1) | CA2441444C (da) |
| DK (1) | DK1456346T3 (da) |
| ES (1) | ES2385598T3 (da) |
| MX (1) | MXPA03007493A (da) |
| PT (1) | PT1456346E (da) |
| WO (1) | WO2002066613A2 (da) |
Families Citing this family (49)
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|---|---|---|---|---|
| US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
| US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
| JP4994563B2 (ja) * | 2001-02-20 | 2012-08-08 | イントレキソン コーポレーション | 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用 |
| DK1456346T3 (da) * | 2001-02-20 | 2012-05-29 | Intrexon Corp | Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor |
| EP1572862B1 (en) * | 2001-02-20 | 2012-08-01 | Intrexon Corporation | Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system |
| DK1373470T3 (da) | 2001-02-20 | 2013-07-29 | Intrexon Corp | Hidtil ukendte substitutionsmutantreceptorer og deres anvendelse i et cellekernereceptorbaseret inducerbart genekspressionssystem |
| MXPA04002808A (es) | 2001-09-26 | 2005-06-06 | Rheogene Holdings Inc | Acidos nucleicos receptores de ecdisona de mosca blanca, polipeptidos, y sus usos. |
| MXPA04002810A (es) * | 2001-09-26 | 2005-06-06 | Rheogene Holdings Inc | Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos. |
| US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7935510B2 (en) * | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| EP2043662B1 (en) | 2006-07-26 | 2015-09-09 | Intrexon Corporation | Methods and compositions for treating disease |
| DK2167458T3 (da) | 2007-05-29 | 2018-06-18 | Intrexon Corp | Kirale diacylhydrazin-ligander til modulering af ekspressionen af eksogene gener via et ecdyson-receptor-kompleks |
| CA2698212A1 (en) * | 2007-08-23 | 2009-02-26 | Intrexon Corporation | Methods and compositions for diagnosing disease |
| NZ584848A (en) | 2007-09-28 | 2012-09-28 | Intrexon Corp | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
| MX2010003720A (es) | 2007-10-08 | 2010-10-20 | Intrexon Corp | Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer. |
| WO2009114201A2 (en) | 2008-03-14 | 2009-09-17 | Intrexon Corporation | Steroidal ligands and their use in gene switch modulation |
| JP5272898B2 (ja) | 2009-05-29 | 2013-08-28 | ソニー株式会社 | 信号処理装置、信号処理方法、および受信システム |
| AU2011232435B2 (en) | 2010-03-23 | 2016-01-28 | Intrexon Corporation | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
| EP3450568A3 (en) | 2011-03-04 | 2019-04-24 | Intrexon Corporation | Vectors conditionally expressing protein |
| EP2699688A1 (en) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| WO2014144380A1 (en) | 2013-03-15 | 2014-09-18 | Intrexon Corporation | Boron-containing diacylhydrazines |
| US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
| EP3842528A1 (en) | 2013-09-18 | 2021-06-30 | Kymab Limited | Methods, cells and organisms |
| CN107406373B (zh) | 2014-09-17 | 2020-04-28 | 英特瑞克斯顿股份有限公司 | 含硼的二酰基肼化合物 |
| US11535665B2 (en) | 2015-05-13 | 2022-12-27 | The Trustees Of The University Of Pennsylvania | AAV-mediated expression of anti-influenza antibodies and methods of use thereof |
| WO2017062953A1 (en) | 2015-10-10 | 2017-04-13 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| WO2017083750A1 (en) | 2015-11-11 | 2017-05-18 | Intrexon Corporation | Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies |
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| SMT202400080T1 (it) | 2017-02-28 | 2024-05-14 | Univ Pennsylvania | Vettore di clade f di virus adenoassociato (aav) e relativi usi |
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| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| CA3099958A1 (en) | 2018-04-16 | 2019-10-24 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating duchenne muscular dystrophy |
| WO2020206056A1 (en) | 2019-04-04 | 2020-10-08 | Greenvenus Llc | Peptides and methods of plant protection |
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| TW202516019A (zh) | 2023-06-29 | 2025-04-16 | 賓州大學委員會 | 具中樞神經系統靶向模體的突變aav及含有其之組成物 |
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-
2002
- 2002-02-20 DK DK02714955.8T patent/DK1456346T3/da active
- 2002-02-20 MX MXPA03007493A patent/MXPA03007493A/es active IP Right Grant
- 2002-02-20 WO PCT/US2002/005235 patent/WO2002066613A2/en not_active Ceased
- 2002-02-20 ES ES02714955T patent/ES2385598T3/es not_active Expired - Lifetime
- 2002-02-20 AU AU2002247184A patent/AU2002247184B2/en not_active Ceased
- 2002-02-20 US US10/468,200 patent/US9493540B2/en not_active Expired - Fee Related
- 2002-02-20 JP JP2002566320A patent/JP4955904B2/ja not_active Expired - Fee Related
- 2002-02-20 AT AT02714955T patent/ATE545705T1/de active
- 2002-02-20 PT PT02714955T patent/PT1456346E/pt unknown
- 2002-02-20 EP EP02714955A patent/EP1456346B1/en not_active Revoked
- 2002-02-20 CA CA2441444A patent/CA2441444C/en not_active Expired - Fee Related
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2008
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- 2008-11-28 JP JP2008304207A patent/JP5345372B2/ja not_active Expired - Fee Related
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2013
- 2013-06-17 JP JP2013126817A patent/JP5887301B2/ja not_active Expired - Fee Related
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2016
- 2016-10-04 US US15/285,195 patent/US20170096672A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1456346B1 (en) | 2012-02-15 |
| US9493540B2 (en) | 2016-11-15 |
| US20170096672A1 (en) | 2017-04-06 |
| AU2008221578A1 (en) | 2008-10-16 |
| US20120167239A1 (en) | 2012-06-28 |
| AU2008221578B2 (en) | 2012-05-03 |
| ATE545705T1 (de) | 2012-03-15 |
| JP2009131259A (ja) | 2009-06-18 |
| CA2441444A1 (en) | 2002-08-29 |
| WO2002066613A2 (en) | 2002-08-29 |
| PT1456346E (pt) | 2012-05-02 |
| AU2002247184B2 (en) | 2008-06-19 |
| MXPA03007493A (es) | 2004-10-15 |
| JP4955904B2 (ja) | 2012-06-20 |
| JP5887301B2 (ja) | 2016-03-16 |
| JP2013236634A (ja) | 2013-11-28 |
| JP5345372B2 (ja) | 2013-11-20 |
| CA2441444C (en) | 2013-09-03 |
| EP1456346A2 (en) | 2004-09-15 |
| EP1456346A4 (en) | 2006-12-20 |
| ES2385598T3 (es) | 2012-07-27 |
| WO2002066613A3 (en) | 2004-07-15 |
| JP2004533214A (ja) | 2004-11-04 |
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