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DE69524740D1 - Thymidin-kinase-mutanten - Google Patents

Thymidin-kinase-mutanten

Info

Publication number
DE69524740D1
DE69524740D1 DE69524740T DE69524740T DE69524740D1 DE 69524740 D1 DE69524740 D1 DE 69524740D1 DE 69524740 T DE69524740 T DE 69524740T DE 69524740 T DE69524740 T DE 69524740T DE 69524740 D1 DE69524740 D1 DE 69524740D1
Authority
DE
Germany
Prior art keywords
thymidine kinase
mutations
increases
amino acid
binding site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69524740T
Other languages
English (en)
Other versions
DE69524740T2 (de
Inventor
A Loeb
E Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Application granted granted Critical
Publication of DE69524740D1 publication Critical patent/DE69524740D1/de
Publication of DE69524740T2 publication Critical patent/DE69524740T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69524740T 1994-05-02 1995-05-02 Thymidin-kinase-mutanten Expired - Fee Related DE69524740T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23759294A 1994-05-02 1994-05-02
PCT/US1995/005561 WO1995030007A1 (en) 1994-05-02 1995-05-02 Thymidine kinase mutants

Publications (2)

Publication Number Publication Date
DE69524740D1 true DE69524740D1 (de) 2002-01-31
DE69524740T2 DE69524740T2 (de) 2002-08-14

Family

ID=22894372

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524740T Expired - Fee Related DE69524740T2 (de) 1994-05-02 1995-05-02 Thymidin-kinase-mutanten

Country Status (9)

Country Link
US (1) US5877010A (de)
EP (1) EP0758387B1 (de)
JP (1) JPH10503641A (de)
CN (1) CN1151186A (de)
AT (1) ATE211174T1 (de)
AU (1) AU2434195A (de)
CA (1) CA2189543A1 (de)
DE (1) DE69524740T2 (de)
WO (1) WO1995030007A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
FR2736931B1 (fr) * 1995-07-17 1997-09-19 Univ Paris Curie Sequences regulatrices issues du gene cd4 et a expression specifique dans les lymphocytes t matures
FR2744731B1 (fr) * 1996-02-09 1998-05-22 Rhone Poulenc Rorer Sa Nouveaux variants de la thymidine kinase, sequences d'acides nucleiques correspondantes et leur utilisation en therapie genique
IL125597A0 (en) * 1996-02-09 1999-03-12 Rhone Poulenc Rorer Sa Variants of thymidine kinase related nucleic acids sequences and their use in genic therapy
FR2751988B1 (fr) * 1996-08-01 1998-09-11 Rhone Poulenc Rorer Sa Nouveaux variants de la thymidine kinase, sequences d'acides nucleiques correspondantes et leur utilisation en therapie genique
FR2746016B1 (fr) * 1996-03-15 1998-04-17 Combinaisons d'enzymes pour la destruction de cellules proliferatives
GB9700154D0 (en) 1997-01-07 1997-02-26 Primapharma Ltd Peptides
EP1914304A1 (de) * 1998-10-14 2008-04-23 Darwin Molecular Corporation Thymidinkinasemutanten und Fusionsproteine mit Thymidinkinase- und Guanylatkinaseaktivität
EP2386630A1 (de) * 1997-10-14 2011-11-16 Darwin Molecular Corporation Thymidinkinasemutanten und Fusionsproteine mit Thymidinkinase- und Guanylatkinaseaktivität
US7098191B2 (en) * 1997-11-03 2006-08-29 The Arizona Board Of Reagents Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US6709858B1 (en) * 1997-11-03 2004-03-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US6461869B1 (en) * 1999-07-20 2002-10-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Purging leukemia cells from hematopoietic stem cells
GB0008966D0 (en) 2000-04-13 2000-05-31 Imp College Innovations Ltd Vectors for gene therapy
NZ522216A (en) * 2000-05-12 2004-05-28 Wolfgang Knecht Novel deoxynucleoside kinase enzyme variants which decrease the lethal dose of nucleoside analogues
CN1662647A (zh) * 2002-05-23 2005-08-31 沃尔夫冈·克内希特 植物胸苷激酶及其用途
WO2003100045A1 (en) * 2002-05-23 2003-12-04 Wolfgang Knecht Plant thymidine kinases and their use
KR100903729B1 (ko) * 2003-07-09 2009-06-19 헨리 포드 헬쓰 시스템 신규한 아데노바이러스를 이용한 암 치료 방법 및 조성물
US7815902B2 (en) * 2003-07-09 2010-10-19 Henry Ford Health System Methods and compositions for cancer therapy using a novel adenovirus
WO2005117993A2 (en) * 2004-06-04 2005-12-15 Genvec, Inc. Method of using adenoviral vectors with improved safety and efficacy for the treatment of cancer
GB0413702D0 (en) 2004-06-18 2004-07-21 Molmed Spa Thymidine kinase
WO2009012170A1 (en) * 2007-07-13 2009-01-22 California Institute Of Technology Targeting the absence: homozygous dna deletions as signposts for cancer therapy
US9925276B2 (en) * 2013-03-14 2018-03-27 Epeius Biotechnologies Corporation Thymidine kinase gene
CN104357466B (zh) * 2014-11-07 2017-04-19 重庆医科大学 一种单纯疱疹病毒胸苷激酶突变体及其制备方法和用途
US20210085756A1 (en) 2017-07-26 2021-03-25 Medizinische Universität Wien Superactive mutant thymidine kinase for use in cancer therapy
WO2019108777A1 (en) 2017-11-29 2019-06-06 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
EP3733854A4 (de) * 2017-12-28 2021-12-01 Bionoxx Inc. Onkolytisches virus mit verbesserter sicherheit und antikrebswirkung

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288641A (en) * 1984-06-04 1994-02-22 Arch Development Corporation Herpes Simplex virus as a vector
EP0274560A3 (de) * 1986-12-18 1990-03-21 Ajinomoto Co., Inc. Menschlicher, das hämatopoietische Zellwachstum aktivierender Faktor
JPH03504079A (ja) * 1988-03-21 1991-09-12 カイロン　コーポレイション 組換えレトロウィルス
EP0454781B1 (de) * 1989-01-23 1998-12-16 Chiron Corporation Rekombinante zellen für therapien von infektionen und hyperprolieferative störungen und deren herstellung
EP0487587A1 (de) * 1989-08-18 1992-06-03 Chiron Corporation Rekombinante retroviren um vektorkonstruktionen an zielzellen zu liefern
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
CA2039921A1 (en) * 1990-04-16 1991-10-17 Xandra O. Breakefield Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
CA2051288C (en) * 1990-09-14 2002-02-05 Robert L. Martuza Viral targeted destruction of neoplastic cells
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
EP0659209A1 (de) * 1991-07-26 1995-06-28 The University Of Rochester Krebstherapie unter verwendung maligner zellen
US5529774A (en) * 1991-08-13 1996-06-25 The Regents Of The University Of California In vivo transfer of the HSV-TK gene implanted retroviral producer cells
CA2099247A1 (fr) * 1991-10-30 1993-05-01 David Klatzmann Cellules transformees pour la prevention ou le traitement de maladies induites par des virus, notamment retrovirus pathogenes
FR2683226B1 (fr) * 1991-10-30 1995-06-09 Univ Paris Curie Cellules piegees a l'egard d'antigenes provoquant le dysfonctionnement du systeme immunitaire, medicaments pour la prevention ou le traitement de maladies induites par ces dysfonctionnements.
WO1993010218A1 (en) * 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
CA2134763A1 (en) * 1992-05-01 1993-11-11 Kenneth W. Culver Bystander effect tumoricidal therapy
US5401835A (en) * 1992-07-31 1995-03-28 Chishti; Athar H. Human erythroid p55 nucleic acids
FR2699191B1 (fr) * 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.
EP0716614A4 (de) * 1993-09-03 1998-02-04 Us Health Behandlung von menschlichen tumoren durch genetische transformation von menschlichen tumorzellen
GB9323008D0 (en) * 1993-11-05 1994-01-05 Connors Thomas Improvements relating to cancer therapy
FR2712603B1 (fr) * 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
FR2712602B1 (fr) * 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
FI954602A7 (fi) * 1993-11-18 1996-03-18 Viagene Inc Koostumukset ja menetelmät käyttää ehdollisesti letaaleja geenejä

Also Published As

Publication number Publication date
ATE211174T1 (de) 2002-01-15
JPH10503641A (ja) 1998-04-07
CN1151186A (zh) 1997-06-04
EP0758387B1 (de) 2001-12-19
CA2189543A1 (en) 1995-11-09
AU2434195A (en) 1995-11-29
EP0758387A1 (de) 1997-02-19
DE69524740T2 (de) 2002-08-14
US5877010A (en) 1999-03-02
WO1995030007A1 (en) 1995-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee