DK1399016T3 - Fremgangsmåde til generering af diversitet - Google Patents
Fremgangsmåde til generering af diversitetInfo
- Publication number
- DK1399016T3 DK1399016T3 DK02735612.0T DK02735612T DK1399016T3 DK 1399016 T3 DK1399016 T3 DK 1399016T3 DK 02735612 T DK02735612 T DK 02735612T DK 1399016 T3 DK1399016 T3 DK 1399016T3
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- generating diversity
- diversity
- generating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/879,813 US20020155453A1 (en) | 1998-10-09 | 2001-06-11 | Method for generating diversity |
US10/146,505 US7122339B2 (en) | 1998-10-09 | 2002-05-15 | Method for generating diversity |
PCT/GB2002/002688 WO2002100998A2 (en) | 2001-06-11 | 2002-06-11 | Method for generating diversity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1399016T3 true DK1399016T3 (da) | 2013-12-02 |
Family
ID=26843987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02735612.0T DK1399016T3 (da) | 2001-06-11 | 2002-06-11 | Fremgangsmåde til generering af diversitet |
Country Status (7)
Country | Link |
---|---|
US (3) | US7122339B2 (da) |
EP (1) | EP1399016B1 (da) |
JP (2) | JP4418668B2 (da) |
AU (1) | AU2002310621B2 (da) |
CA (1) | CA2449264C (da) |
DK (1) | DK1399016T3 (da) |
WO (1) | WO2002100998A2 (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7122339B2 (en) * | 1998-10-09 | 2006-10-17 | Medical Research Council | Method for generating diversity |
DE60335191D1 (de) | 2002-07-30 | 2011-01-13 | Japan Science & Tech Agency | Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers |
WO2004076453A1 (en) * | 2003-02-27 | 2004-09-10 | Neurosearch A/S | Novel diazabicyclic aryl derivatives |
JP4639370B2 (ja) * | 2003-09-17 | 2011-02-23 | ミリポア・コーポレイション | 標的被検体を分析するための組成物および方法 |
EP1568765A1 (en) * | 2004-02-23 | 2005-08-31 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Method for genetic diversification in gene conversion active cells |
JP4482693B2 (ja) | 2005-08-29 | 2010-06-16 | 国立大学法人 岡山大学 | 抗体産生細胞の特異的選択方法 |
WO2008133711A2 (en) * | 2006-10-30 | 2008-11-06 | Functional Genetics, Inc. | Random homozygous gene perturbation to enhance antibody production |
CA2678451A1 (en) * | 2007-02-20 | 2008-08-28 | Robert A. Horlick | Somatic hypermutation systems |
EP2152861B1 (en) * | 2007-05-31 | 2017-03-22 | University of Washington | Inducible mutagenesis of target genes |
US7954022B2 (en) | 2008-01-30 | 2011-05-31 | Alcatel-Lucent Usa Inc. | Apparatus and method for controlling dynamic modification of a scan path |
AU2012310880B2 (en) | 2011-09-21 | 2015-12-03 | Fujirebio Inc. | Antibody against affinity complex |
WO2013138518A1 (en) | 2012-03-15 | 2013-09-19 | Omeros Corporation | Composition and method for diversification of target sequences |
GB201223053D0 (en) | 2012-12-20 | 2013-02-06 | Medical Res Council | Receptor |
JP7071740B2 (ja) * | 2017-02-10 | 2022-05-19 | 株式会社カイオム・バイオサイエンス | 抗体可変領域の多様化を促進する方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2685004A1 (fr) | 1991-12-11 | 1993-06-18 | Pasteur Institut | Procede de generation d'une diversite structurale et fonctionnelle dans une sequence peptidique. |
US5750335A (en) * | 1992-04-24 | 1998-05-12 | Massachusetts Institute Of Technology | Screening for genetic variation |
US6027877A (en) | 1993-11-04 | 2000-02-22 | Gene Check, Inc. | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification |
US6146894A (en) * | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
US7122339B2 (en) * | 1998-10-09 | 2006-10-17 | Medical Research Council | Method for generating diversity |
ES2588910T3 (es) * | 1998-10-09 | 2016-11-07 | Medical Research Council | Método para generar diversidad |
WO2003095636A2 (en) * | 2002-05-10 | 2003-11-20 | Medical Research Council | Activation induced deaminase (aid) |
-
2002
- 2002-05-15 US US10/146,505 patent/US7122339B2/en not_active Expired - Lifetime
- 2002-06-11 EP EP02735612.0A patent/EP1399016B1/en not_active Expired - Lifetime
- 2002-06-11 DK DK02735612.0T patent/DK1399016T3/da active
- 2002-06-11 AU AU2002310621A patent/AU2002310621B2/en not_active Expired
- 2002-06-11 JP JP2003503750A patent/JP4418668B2/ja not_active Expired - Lifetime
- 2002-06-11 CA CA2449264A patent/CA2449264C/en not_active Expired - Lifetime
- 2002-06-11 WO PCT/GB2002/002688 patent/WO2002100998A2/en active Application Filing
-
2003
- 2003-12-11 US US10/733,532 patent/US7368259B2/en not_active Expired - Lifetime
-
2008
- 2008-01-28 US US12/011,757 patent/US20080193979A1/en not_active Abandoned
-
2012
- 2012-05-08 JP JP2012106705A patent/JP2012165756A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20080193979A1 (en) | 2008-08-14 |
US7122339B2 (en) | 2006-10-17 |
CA2449264C (en) | 2012-05-29 |
WO2002100998A2 (en) | 2002-12-19 |
CA2449264A1 (en) | 2002-12-19 |
JP2012165756A (ja) | 2012-09-06 |
US7368259B2 (en) | 2008-05-06 |
US20030108889A1 (en) | 2003-06-12 |
JP4418668B2 (ja) | 2010-02-17 |
EP1399016B1 (en) | 2013-08-28 |
AU2002310621B9 (en) | 2002-12-23 |
AU2002310621B2 (en) | 2008-01-17 |
WO2002100998A3 (en) | 2003-09-25 |
JP2005507241A (ja) | 2005-03-17 |
EP1399016A2 (en) | 2004-03-24 |
US20050026246A1 (en) | 2005-02-03 |
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