DK1390039T3 - Anvendelse af östrogenforbindelser til forögelse af kvinders libido - Google Patents
Anvendelse af östrogenforbindelser til forögelse af kvinders libidoInfo
- Publication number
- DK1390039T3 DK1390039T3 DK02738950T DK02738950T DK1390039T3 DK 1390039 T3 DK1390039 T3 DK 1390039T3 DK 02738950 T DK02738950 T DK 02738950T DK 02738950 T DK02738950 T DK 02738950T DK 1390039 T3 DK1390039 T3 DK 1390039T3
- Authority
- DK
- Denmark
- Prior art keywords
- progestogen
- formula
- estrogenic component
- progestin
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229940011871 estrogen Drugs 0.000 title 1
- 239000000262 estrogen Substances 0.000 title 1
- 239000000583 progesterone congener Substances 0.000 abstract 4
- 230000001076 estrogenic effect Effects 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 230000000708 anti-progestin effect Effects 0.000 abstract 2
- 239000003418 antiprogestin Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- -1 hydrocarbon carboxylic Chemical class 0.000 abstract 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 abstract 1
- XEZQLSOFXLPSJR-UHFFFAOYSA-N oxane-2-carbaldehyde Chemical compound O=CC1CCCCO1 XEZQLSOFXLPSJR-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201896A EP1260225A1 (de) | 2001-05-18 | 2001-05-18 | Pharmazeutische Zusammensetzung für die Hormonersatztherapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1390039T3 true DK1390039T3 (da) | 2006-07-10 |
Family
ID=8180347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02738950T DK1390039T3 (da) | 2001-05-18 | 2002-05-17 | Anvendelse af östrogenforbindelser til forögelse af kvinders libido |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7723320B2 (de) |
| EP (3) | EP1260225A1 (de) |
| AT (1) | ATE320259T1 (de) |
| CA (1) | CA2447175C (de) |
| DE (1) | DE60209907T2 (de) |
| DK (1) | DK1390039T3 (de) |
| ES (1) | ES2260441T3 (de) |
| PT (1) | PT1390039E (de) |
| WO (1) | WO2002094275A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040214807A1 (en) * | 1993-08-06 | 2004-10-28 | D'amato Robert J. | Estrogenic compounds as anti-mitotic agents |
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US20050192258A1 (en) * | 2000-08-18 | 2005-09-01 | Agoston Gregory E. | Antiangiogenic agents |
| DE60217324T2 (de) | 2001-05-18 | 2007-04-26 | Pantarhei Bioscience B.V. | Pharmazeutische zusammensetzung für die hormonersatztherapie |
| ES2296943T3 (es) | 2001-05-23 | 2008-05-01 | Pantarhei Bioscience B.V. | Sistema de administracion de un medicamento estrogeno tetrahidroxilado destinado a la contracepcion hormonal. |
| US7871995B2 (en) | 2001-05-23 | 2011-01-18 | Pantarhei Bioscience B.V. | Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception |
| DE60216630T2 (de) | 2001-11-15 | 2007-09-20 | Pantarhei Bioscience B.V. | Verwendung von östrogen in kombination mit progestogen für die hormonsubstitutiionstherapie |
| WO2003103685A1 (en) | 2002-06-11 | 2003-12-18 | Pantarhei Bioscience B.V. | A method of treating human skin and a skin care composition for use in such a method |
| EP1511496B1 (de) | 2002-06-11 | 2006-09-27 | Pantarhei Bioscience B.V. | Methode zur behandlung oder prävention immunologischer erkrankungen und pharmazeutische zusammensetzung zur solchen anwendung |
| EP1526856B1 (de) | 2002-07-12 | 2008-01-02 | Pantarhei Bioscience B.V. | Pharmazeutische zusammensetzung enthaltend estetrolderivate und anwendung in der krebsbehandlung |
| ES2298570T3 (es) | 2002-10-23 | 2008-05-16 | Pantarhei Bioscience B.V. | Composiciones farmaceuticas que comprenden derivados de estetrol para el uso en la terapia del cancer. |
| DE60332754D1 (de) | 2002-11-08 | 2010-07-08 | Pantarhei Bioscience Bv | Synthese von oestetrol aus von oestron abgeleiteten steroiden |
| JP2006526025A (ja) * | 2003-05-28 | 2006-11-16 | エントレメッド インコーポレイテッド | 抗血管新生剤 |
| ATE476961T1 (de) * | 2004-03-10 | 2010-08-15 | Bayer Schering Pharma Ag | Flüssige zusammensetzungen als mikroemulsionsvorkonzentrat mit molekular dispergiertem drospirenon |
| MY142989A (en) | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
| US20070004689A1 (en) * | 2004-03-12 | 2007-01-04 | Agoston Gregory E | Antiangiogenic agents |
| US7498322B2 (en) * | 2004-03-12 | 2009-03-03 | Entremed, Inc. | Antiangiogenic agents |
| SI1750766T1 (sl) | 2004-05-11 | 2013-11-29 | Emotional Brain B.V. | Farmacevtske formulacije in njihove uporabe pri zdravljenju spolne disfunkcije pri Ĺľenskah |
| US20060116360A1 (en) * | 2004-11-29 | 2006-06-01 | Fogler William E | Method of administering anti-angiogenic agents and a method of treating disease using same |
| EP1790343A1 (de) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmazeutische Zusammensetzungen und deren Verwendung zur Behandlung sexueller Störungen der Frau |
| WO2007059111A2 (en) * | 2005-11-14 | 2007-05-24 | Entremed, Inc. | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| WO2007109312A2 (en) * | 2006-03-20 | 2007-09-27 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
| EP1925307A1 (de) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Verwendung von 3-alpha-androstanediol zur Behandlung sexueller Dysfunktion |
| WO2008085038A2 (en) | 2007-01-08 | 2008-07-17 | Pantarhei Bioscience B.V. | Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method |
| WO2008094665A1 (en) * | 2007-01-31 | 2008-08-07 | Entremed, Inc. | Method of treating amyloidosis mediated diseases |
| US8518923B2 (en) | 2007-07-19 | 2013-08-27 | Pantarhei Bioscience B.V. | Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation |
| GB0807605D0 (en) * | 2008-04-28 | 2008-06-04 | Diurnal Ltd | Lipid composition |
| US20100155594A1 (en) | 2008-12-23 | 2010-06-24 | Goldman Mildred M | Mass spectrometry assay for estrogenic compounds |
| DK2714710T3 (en) | 2011-06-01 | 2016-06-27 | Estetra Sprl | A process for the preparation of intermediates estetrol |
| BR112013030833B1 (pt) | 2011-06-01 | 2019-09-03 | Estetra S A | processo para a preparação de um composto de fórmula (i) e processo para a preparação de estetrol |
| EP2383279A1 (de) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Herstellungsverfahren für Esterol |
| WO2013034780A2 (en) | 2012-12-20 | 2013-03-14 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol and related compounds |
| JP6254289B2 (ja) | 2013-09-18 | 2017-12-27 | クリスタル ファルマ、エセ、ア、ウＣｒｙｓｔａｌ Ｐｈａｒｍａ，Ｓ．Ａ．Ｕ． | エステトロールの製造プロセス |
| CN103636555A (zh) * | 2013-11-11 | 2014-03-19 | 徐又佳 | 小鼠去势高铁骨质疏松模型构建方法 |
| WO2015086643A1 (en) | 2013-12-12 | 2015-06-18 | Donesta Bioscience B.V. | Orally disintegrating solid dosage unit containing an estetrol component |
| CA2988485A1 (en) | 2015-06-18 | 2016-12-22 | Mithra Pharmaceuticals S.A. | Orodispersible tablet containing estetrol |
| MA44206B1 (fr) | 2015-06-18 | 2021-04-30 | Estetra Sprl | Comprimé orodispersible comprenant estetrol |
| PT3701944T (pt) | 2015-06-18 | 2022-01-11 | Estetra Srl | Dose unitária orodispersível contendo um composto de estetrol |
| GEP20217308B (en) | 2015-06-18 | 2021-10-25 | Estetra Sprl | Orodispersible dosage unit containing an estetrol component |
| CA3178291A1 (en) | 2016-08-05 | 2018-04-12 | Estetra Srl | Method for the management of dysmenorrhea and menstrual pain |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| WO2025061912A1 (en) * | 2023-09-21 | 2025-03-27 | Estetra Srl | Estetrol for use in the treatment of female sexual arousal disorder |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3440320A (en) * | 1964-06-18 | 1969-04-22 | Mortimer D Sackler | Chelated suppository and method of using same |
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| DE2336434A1 (de) * | 1973-07-13 | 1975-04-17 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| DE2426779A1 (de) * | 1974-05-31 | 1975-12-18 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| DE2336433A1 (de) * | 1973-07-13 | 1975-04-03 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| US4722941A (en) * | 1978-06-07 | 1988-02-02 | Kali-Chemie Pharma Gmbh | Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof |
| US4460372A (en) * | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| US4573996A (en) * | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
| US4624665A (en) * | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
| US4937238A (en) * | 1986-03-04 | 1990-06-26 | The Board Of Regents Of The University Of Nebraska | Prevention of mammary carcinoma |
| US4762717A (en) * | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
| US5223261A (en) * | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
| US5130137A (en) * | 1989-08-09 | 1992-07-14 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders |
| US5063507A (en) * | 1990-09-14 | 1991-11-05 | Plains Cotton Cooperative Association | Goods database employing electronic title or documentary-type title |
| US5340586A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
| US5340585A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
| US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| US5468736A (en) * | 1993-02-25 | 1995-11-21 | The Medical College Of Hampton Road | Hormone replacement therapy |
| NL9301562A (nl) * | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
| DE4344405C2 (de) * | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
| WO1996003929A1 (en) * | 1994-08-04 | 1996-02-15 | Biex, Inc. | Method for prediction of premature delivery using estetrol (e4) as an indicator |
| DE4429374C1 (de) * | 1994-08-12 | 1996-02-01 | Jenapharm Gmbh | Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente |
| DE19739916C2 (de) * | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
| US6214815B1 (en) * | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
| US6936599B2 (en) * | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
-
2001
- 2001-05-18 EP EP01201896A patent/EP1260225A1/de not_active Withdrawn
-
2002
- 2002-05-17 ES ES02738950T patent/ES2260441T3/es not_active Expired - Lifetime
- 2002-05-17 AT AT02738950T patent/ATE320259T1/de not_active IP Right Cessation
- 2002-05-17 WO PCT/NL2002/000316 patent/WO2002094275A1/en not_active Application Discontinuation
- 2002-05-17 DE DE60209907T patent/DE60209907T2/de not_active Expired - Lifetime
- 2002-05-17 DK DK02738950T patent/DK1390039T3/da active
- 2002-05-17 CA CA2447175A patent/CA2447175C/en not_active Expired - Lifetime
- 2002-05-17 EP EP02738950A patent/EP1390039B1/de not_active Expired - Lifetime
- 2002-05-17 US US10/478,264 patent/US7723320B2/en not_active Expired - Lifetime
- 2002-05-17 EP EP06114704A patent/EP1700602A1/de not_active Withdrawn
- 2002-05-17 PT PT02738950T patent/PT1390039E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2260441T3 (es) | 2006-11-01 |
| CA2447175C (en) | 2010-02-16 |
| EP1260225A1 (de) | 2002-11-27 |
| PT1390039E (pt) | 2006-07-31 |
| DE60209907T2 (de) | 2006-08-17 |
| EP1390039A1 (de) | 2004-02-25 |
| US7723320B2 (en) | 2010-05-25 |
| DE60209907D1 (de) | 2006-05-11 |
| ATE320259T1 (de) | 2006-04-15 |
| CA2447175A1 (en) | 2002-11-28 |
| US20040186086A1 (en) | 2004-09-23 |
| WO2002094275A1 (en) | 2002-11-28 |
| EP1390039B1 (de) | 2006-03-15 |
| EP1700602A1 (de) | 2006-09-13 |
| WO2002094275A8 (en) | 2003-02-13 |
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