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DK1379219T3 - Store, poröse partikler fremstillet ved at regulere fugtigheden under en spröjtetörringsproces - Google Patents

Store, poröse partikler fremstillet ved at regulere fugtigheden under en spröjtetörringsproces

Info

Publication number
DK1379219T3
DK1379219T3 DK02728839T DK02728839T DK1379219T3 DK 1379219 T3 DK1379219 T3 DK 1379219T3 DK 02728839 T DK02728839 T DK 02728839T DK 02728839 T DK02728839 T DK 02728839T DK 1379219 T3 DK1379219 T3 DK 1379219T3
Authority
DK
Denmark
Prior art keywords
regulating
drying process
spray drying
porous particles
particles made
Prior art date
Application number
DK02728839T
Other languages
English (en)
Inventor
Donghao Chen
Lloyd Johnston
Jeffrey Mintzes
Richard P Batycky
Original Assignee
Alkermes Inc
Penn State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274976&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1379219(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Inc, Penn State Res Found filed Critical Alkermes Inc
Application granted granted Critical
Publication of DK1379219T3 publication Critical patent/DK1379219T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Glanulating (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Silicon Compounds (AREA)
DK02728839T 2001-04-18 2002-04-17 Store, poröse partikler fremstillet ved at regulere fugtigheden under en spröjtetörringsproces DK1379219T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/837,620 US6848197B2 (en) 2001-04-18 2001-04-18 Control of process humidity to produce large, porous particles
PCT/US2002/012320 WO2002085326A2 (en) 2001-04-18 2002-04-17 Large, porous particles produced controlling humidity during a spray drying process

Publications (1)

Publication Number Publication Date
DK1379219T3 true DK1379219T3 (da) 2009-03-23

Family

ID=25274976

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02728839T DK1379219T3 (da) 2001-04-18 2002-04-17 Store, poröse partikler fremstillet ved at regulere fugtigheden under en spröjtetörringsproces

Country Status (19)

Country Link
US (2) US6848197B2 (da)
EP (1) EP1379219B1 (da)
JP (1) JP4203564B2 (da)
CN (1) CN100522142C (da)
AT (1) ATE418326T1 (da)
AU (1) AU2002258865B2 (da)
CA (1) CA2439818C (da)
CY (1) CY1108803T1 (da)
DE (1) DE60230495D1 (da)
DK (1) DK1379219T3 (da)
ES (1) ES2318007T3 (da)
HK (1) HK1061654A1 (da)
IL (2) IL157569A0 (da)
MX (1) MXPA03009561A (da)
NO (1) NO20034641L (da)
NZ (1) NZ527884A (da)
PL (1) PL371979A1 (da)
PT (1) PT1379219E (da)
WO (1) WO2002085326A2 (da)

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WO2003043585A2 (en) 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
CA2472028C (en) 2002-02-01 2010-03-30 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US20040197413A1 (en) * 2003-04-04 2004-10-07 Genteric, Inc. Spray dry coacervation systems and methods
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20060105051A1 (en) * 2004-11-18 2006-05-18 Blair Jackson Manufacture of particles for pulmonary drug delivery by carbon dioxide assisted nebulization
AU2005316687B2 (en) * 2004-12-16 2008-06-26 Alkermes, Inc. Compositions and methods for pulmonary conditions
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
CN101820963B (zh) * 2007-09-24 2013-04-24 吸入科学瑞典股份公司 产生干燥配制物的系统和方法
EP2435025B1 (en) 2009-05-29 2016-07-06 Pearl Therapeutics, Inc. Respiratory delivery of active agents
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
WO2011154014A1 (en) * 2010-06-11 2011-12-15 Gea Process Engineering A/S Controlled humidity drying
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
AU2014228414B2 (en) 2013-03-15 2018-09-13 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
EP3607941A1 (en) 2013-04-30 2020-02-12 Otitopic Inc. Dry powder formulations and methods of use
JP6701086B2 (ja) 2014-02-20 2020-05-27 オティトピック インコーポレイテッド 吸入用の乾燥粉末製剤
MA40910A (fr) 2014-11-07 2017-09-12 Civitas Therapeutics Inc Poudres de rapamycine pour administration pulmonaire
KR101626675B1 (ko) * 2014-11-12 2016-06-01 엘지전자 주식회사 공기조화기 및 그 제어방법
EP3283125B1 (en) 2015-04-17 2021-12-29 CureVac Real Estate GmbH Lyophilization of rna
KR20180002750A (ko) 2015-05-01 2018-01-08 키비타스 테라퓨틱스, 인코포레이티드. 폐 전달용 졸미트립탄 분말
EP3297682B1 (en) 2015-05-20 2021-07-14 CureVac AG Dry powder composition comprising long-chain rna
SG10201910431RA (en) 2015-05-20 2020-01-30 Curevac Ag Dry powder composition comprising long-chain rna
JP2018524346A (ja) 2015-07-02 2018-08-30 サイヴィタス セラピューティックス，インコーポレイテッド 肺送達のためのトリプタン粉末
CH711362B1 (de) * 2015-07-29 2019-11-15 Tecan Schweiz Ag Steuergerät für relative Feuchtigkeit.
WO2018132822A1 (en) 2017-01-16 2018-07-19 Envirostar, Llc Dryer control systems and methods
CA3059449A1 (en) 2017-04-24 2018-11-01 Cocrystal Pharma, Inc. Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
WO2019084293A1 (en) 2017-10-25 2019-05-02 Arizona Board Of Regents On Behalf Of The University Of Arizona COMPOSITIONS AND METHODS FOR ADMINISTERING PHARMACEUTICAL AGENTS
US11667612B2 (en) 2017-10-25 2023-06-06 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents
WO2019143981A1 (en) 2018-01-19 2019-07-25 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents
US20210121462A1 (en) 2018-07-27 2021-04-29 Cocrystal Pharma, Inc. Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication
TWI844564B (zh) 2018-09-10 2024-06-11 美商共結晶製藥公司 流感病毒複製之抑制劑
PL3866778T3 (pl) 2018-10-17 2023-03-27 Cocrystal Pharma, Inc. Kombinacje inhibitorów replikacji wirusa grypy
WO2020112716A1 (en) 2018-11-26 2020-06-04 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
BR112021021775A2 (pt) 2019-04-29 2022-01-04 Insmed Inc Composições de pó seco de pró-fármacos de treprostinil e métodos de uso destas
US20230151034A1 (en) 2020-03-17 2023-05-18 Cocrystal Pharma, Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
EP4132944A1 (en) 2020-04-10 2023-02-15 Cocrystal Pharma, Inc. Inhibitors of norovirus and coronavirus replication
WO2021219230A1 (en) 2020-04-30 2021-11-04 Paolo Fiorina Antiviral treatment
US20240398757A1 (en) 2021-08-03 2024-12-05 Cocrystal Pharma, Inc. Inhibitors for coronaviruses
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof

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US4422900A (en) 1981-11-25 1983-12-27 Olin Corporation Spray drying apparatus for available chlorine-containing compounds
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US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5833647A (en) 1995-10-10 1998-11-10 The Penn State Research Foundation Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery
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US5985320A (en) 1996-03-04 1999-11-16 The Penn State Research Foundation Materials and methods for enhancing cellular internalization
US6387390B1 (en) 1998-10-05 2002-05-14 The Penn State Research Foundation Compositions and methods for enhancing receptor-mediated cellular internalization
AUPN940796A0 (en) 1996-04-23 1996-05-16 F.H. Faulding & Co. Limited Taste masked pharmaceutical compositions
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US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
USRE37053E1 (en) 1996-05-24 2001-02-13 Massachusetts Institute Of Technology Particles incorporating surfactants for pulmonary drug delivery
WO2001000312A1 (en) 1999-06-30 2001-01-04 Inhale Therapeutic Systems, Inc. Spray drying process for preparing dry powders
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
CA2383491A1 (en) 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Large porous particles by spray-drying
ES2243307T3 (es) 1999-09-29 2005-12-01 Glaxo Group Limited Sistema para controlar procesos de secado evaporativo utilizando equivalencia ambiental.
US6848197B2 (en) 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles

Also Published As

Publication number Publication date
CN1503661A (zh) 2004-06-09
JP2005508853A (ja) 2005-04-07
IL157569A (en) 2008-04-13
DE60230495D1 (de) 2009-02-05
PT1379219E (pt) 2009-03-24
US20030017113A1 (en) 2003-01-23
ATE418326T1 (de) 2009-01-15
NZ527884A (en) 2006-02-24
MXPA03009561A (es) 2004-02-12
WO2002085326A3 (en) 2003-04-10
HK1061654A1 (en) 2004-09-30
IL157569A0 (en) 2004-03-28
CA2439818A1 (en) 2002-10-31
JP4203564B2 (ja) 2009-01-07
PL371979A1 (en) 2005-07-11
CY1108803T1 (el) 2012-05-23
CA2439818C (en) 2008-06-17
AU2002258865B2 (en) 2006-01-12
WO2002085326A2 (en) 2002-10-31
US20050058607A1 (en) 2005-03-17
CN100522142C (zh) 2009-08-05
US6848197B2 (en) 2005-02-01
EP1379219B1 (en) 2008-12-24
EP1379219A2 (en) 2004-01-14
ES2318007T3 (es) 2009-05-01
NO20034641D0 (no) 2003-10-17
NO20034641L (no) 2003-10-17
US7469488B2 (en) 2008-12-30

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