DK1283051T3 - Stabile insulinformuleringer - Google Patents

Stabile insulinformuleringer

Info

Publication number: DK1283051T3
Authority: DK; Denmark
Prior art keywords: insulin formulations; stable insulin; stable; formulations; insulin
Prior art date: 1997-06-13

Application number

DK02022956T

Other languages

English (en)

Inventor

Michael Allen Dobbins

Bruce Hill Frank

Dawn Marie Rebhun

Michael Rosario Defelippis

Shun Li

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-13

Filing date

1998-06-12

Publication date

2006-10-16

1998-06-12 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1998-06-12 Priority claimed from EP98304661A external-priority patent/EP0884053B1/en

2006-10-16 Application granted granted Critical

2006-10-16 Publication of DK1283051T3 publication Critical patent/DK1283051T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
238000009472 formulation Methods 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Inorganic Chemistry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02022956T 1997-06-13 1998-06-12 Stabile insulinformuleringer DK1283051T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5308997P	1997-06-13	1997-06-13
EP98304661A EP0884053B1 (en)	1997-06-13	1998-06-12	Stable insulin formulations

Publications (1)

Publication Number	Publication Date
DK1283051T3 true DK1283051T3 (da)	2006-10-16

Family

ID=26151292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02022956T DK1283051T3 (da)	1997-06-13	1998-06-12	Stabile insulinformuleringer

Country Status (4)

Country	Link
EP (1)	EP1283051B1 (da)
CY (1)	CY1105185T1 (da)
DK (1)	DK1283051T3 (da)
SI (1)	SI0884053T1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0413276B8 (pt)	2003-08-05	2021-05-25	Novo Nordisk As	derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
CN101389650B (zh)	2005-12-28	2012-10-10	诺沃-诺迪斯克有限公司	包含酰化胰岛素和锌的组合物以及制备所述组合物的方法
WO2008152106A1 (en)	2007-06-13	2008-12-18	Novo Nordisk A/S	Pharmaceutical formulation comprising an insulin derivative
EP2158927A1 (en)	2008-08-25	2010-03-03	Debiotech S.A.	Drug delivery device with a module for preventing fibrillation downstream of its reservoir
MX2011004357A (es)	2008-10-30	2011-05-23	Novo Nordisk As	Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyeccion menor que a diario.
RU2533217C3 (ru)	2009-06-26	2020-12-21	Ново Нордиск А/С	Препарат, содержащий инсулин, никотинамид и аминокислоту
JP6049625B2 (ja)	2010-10-27	2016-12-21	ノヴォノルディスクアー／エス	様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
US20130331320A1 (en) *	2010-12-14	2013-12-12	Novo Nordisk A/S	Fast-acting insulin in combination with long-acting insulin
CA2821613A1 (en) *	2010-12-14	2012-06-21	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and an amino acid
WO2013186138A1 (en) *	2012-06-14	2013-12-19	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and arginine
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
GB201607918D0 (en)	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5767548A (en) *	1980-10-14	1982-04-24	Shionogi & Co Ltd	Insulin analog and its preparation
FI78616C (fi) *	1982-02-05	1989-09-11	Novo Industri As	Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DK179286D0 (da) *	1986-04-18	1986-04-18	Nordisk Gentofte	Insulinpraeparat
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
AR002976A1 (es) *	1995-03-31	1998-05-27	Lilly Co Eli	Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas

1998
- 1998-06-12 DK DK02022956T patent/DK1283051T3/da active
- 1998-06-12 SI SI9830275T patent/SI0884053T1/xx unknown
- 1998-06-12 EP EP02022956A patent/EP1283051B1/en not_active Expired - Lifetime
2006
- 2006-08-30 CY CY20061101226T patent/CY1105185T1/el unknown

Also Published As

Publication number	Publication date
EP1283051A1 (en)	2003-02-12
SI0884053T1 (en)	2003-02-28
CY1105185T1 (el)	2010-03-03
EP1283051B1 (en)	2006-06-14

Publication	Publication Date	Title
ATE329612T1 (de)	2006-07-15	Stabile insulinformulierungen
DE69808011D1 (de)	2002-10-24	Stabile mikrobizide Formulierung
DK0941067T3 (da)	2003-11-17	Stabile glasagtige pulverformuleringer
NO2006014I1 (no)	2006-11-13	Insulin glulisin
DE69825982D1 (de)	2004-10-07	Spritze
DK0853945T3 (da)	2003-08-04	Flydende gonadotropinholdige formuleringer
MA24473A1 (fr)	1998-10-01	Formulations
NO20002038D0 (no)	2000-04-18	Uløselig insulinsammensetning
FI952931L (fi)	1995-12-17	Insuliinianalogiformulaatioita
DE69813601D1 (de)	2003-05-22	Stabile kosmetische zusammensetzungen
ID30031A (id)	2001-11-01	Formulasi-formulasi agrokimia
ID23546A (id)	2000-05-04	Formulasi-formulasi ziprasidon
NO20001631L (no)	2000-05-30	2-metyl-tieno-benzodiazepin formulering
DE60025198D1 (de)	2006-02-02	Stabile biozidale zusammensetzung
NO20004240D0 (no)	2000-08-24	Formuleringer
ATE224703T1 (de)	2002-10-15	Brauseformulierungen
PT1130966E (pt)	2005-04-29	Formulacoes antiparasitarias
DE69919784D1 (de)	2004-10-07	Spritze
DE69935609D1 (de)	2007-05-03	Formulierungen enthaltend cefuroxim-axetil
DK1283051T3 (da)	2006-10-16	Stabile insulinformuleringer
DE69809016D1 (de)	2002-12-05	Stabile mikrobizide Formulierung
DE69815935D1 (de)	2003-08-07	Stabile pestizide Dispersionen
DE59812037D1 (de)	2004-11-04	Insektizid-enthaltende formulierungen
DE69838558D1 (de)	2007-11-22	Stabile emulsionen
DE69813426D1 (de)	2003-05-22	Stabile Bleichmittelzusammensetzungen