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DK125021B - Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser. - Google Patents

Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser.

Info

Publication number
DK125021B
DK125021B DK2571AA DK2571A DK125021B DK 125021 B DK125021 B DK 125021B DK 2571A A DK2571A A DK 2571AA DK 2571 A DK2571 A DK 2571A DK 125021 B DK125021 B DK 125021B
Authority
DK
Denmark
Prior art keywords
tetrahydro
phenyl
preparation
acid addition
addition salts
Prior art date
Application number
DK2571AA
Other languages
Danish (da)
English (en)
Inventor
A Rheiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK125021B publication Critical patent/DK125021B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK2571AA 1970-01-06 1971-01-05 Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser. DK125021B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH10370A CH527194A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten

Publications (1)

Publication Number Publication Date
DK125021B true DK125021B (da) 1972-12-18

Family

ID=4179328

Family Applications (1)

Application Number Title Priority Date Filing Date
DK2571AA DK125021B (da) 1970-01-06 1971-01-05 Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser.

Country Status (19)

Country Link
JP (1) JPS5515476B1 (sv)
AT (1) AT303041B (sv)
BE (1) BE761219A (sv)
CA (1) CA999866A (sv)
CH (2) CH538477A (sv)
DE (1) DE2062001C2 (sv)
DK (1) DK125021B (sv)
ES (1) ES387016A1 (sv)
FI (1) FI49503C (sv)
FR (1) FR2081412B1 (sv)
GB (1) GB1335261A (sv)
IE (1) IE34859B1 (sv)
IL (1) IL35916A (sv)
NL (1) NL171444C (sv)
NO (1) NO135315C (sv)
PH (1) PH9682A (sv)
SE (3) SE386672B (sv)
YU (1) YU33660B (sv)
ZA (1) ZA708590B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
ZA844402B (en) * 1983-06-23 1986-01-29 Mcneil Pharmaceutical Hexahydropyrrolo(2,1-a)isoquinoline derivatives
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
AU781179B2 (en) 1999-11-03 2005-05-12 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
RU2293728C2 (ru) * 1999-11-03 2007-02-20 Эймр Текнолоджи, Инк. Производные тетрагидроизохинолина, содержащая их фармацевтическая композиция, способ ингибирования синаптического захвата допамина и способ лечения
EP1113007A1 (en) 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
MXPA03000275A (es) 2000-07-11 2004-12-13 Albany Molecular Res Inc Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
MX2007000428A (es) 2004-07-15 2008-03-05 Amr Technology Inc Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina.
JP2008543880A (ja) 2005-06-17 2008-12-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ナフチリジン化合物
UA95454C2 (uk) 2005-07-15 2011-08-10 Амр Текнолоджи, Інк. Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
KR20120023072A (ko) 2009-05-12 2012-03-12 브리스톨-마이어스 스큅 컴퍼니 （Ｓ）-7-（〔1,2,4〕트리아졸〔1,5-ａ〕피리딘-6-일）-4-（3,4-디클로로페닐）-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
MX2011011907A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc 7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma.
MX2011011901A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (de) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen

Also Published As

Publication number Publication date
DE2062001A1 (de) 1971-07-15
FI49503C (sv) 1975-07-10
NO135315C (sv) 1977-03-23
SE368401B (sv) 1974-07-01
IL35916A0 (en) 1971-02-25
SE399879B (sv) 1978-03-06
GB1335261A (en) 1973-10-24
JPS5515476B1 (sv) 1980-04-23
YU33660B (en) 1977-12-31
CA999866A (en) 1976-11-16
NL171444C (nl) 1983-04-05
IE34859B1 (en) 1975-09-03
FR2081412B1 (sv) 1974-04-12
NL7018956A (sv) 1971-07-08
IL35916A (en) 1973-11-28
IE34859L (en) 1971-07-06
PH9682A (en) 1976-02-10
AT303041B (de) 1972-11-10
ZA708590B (en) 1971-09-29
CH527194A (de) 1972-08-31
NL171444B (nl) 1982-11-01
YU1971A (en) 1977-06-30
CH538477A (de) 1973-06-30
FI49503B (sv) 1975-04-01
FR2081412A1 (sv) 1971-12-03
BE761219A (fr) 1971-07-05
ES387016A1 (es) 1976-05-01
NO135315B (sv) 1976-12-13
DE2062001C2 (de) 1986-10-16
SE386672B (sv) 1976-08-16

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