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DK1240157T3 - Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning - Google Patents

Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning

Info

Publication number
DK1240157T3
DK1240157T3 DK00983349T DK00983349T DK1240157T3 DK 1240157 T3 DK1240157 T3 DK 1240157T3 DK 00983349 T DK00983349 T DK 00983349T DK 00983349 T DK00983349 T DK 00983349T DK 1240157 T3 DK1240157 T3 DK 1240157T3
Authority
DK
Denmark
Prior art keywords
indol
benzyl
substituted
acid derivatives
glyoxylic acid
Prior art date
Application number
DK00983349T
Other languages
English (en)
Inventor
Eckhard Guenther
Peter Emig
Dietmar Reichert
Baut Guillaume Le
Bernd Nickel
Gerald Bacher
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Application granted granted Critical
Publication of DK1240157T3 publication Critical patent/DK1240157T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
DK00983349T 1999-12-23 2000-12-19 Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning DK1240157T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (1)

Publication Number Publication Date
DK1240157T3 true DK1240157T3 (da) 2004-06-14

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00983349T DK1240157T3 (da) 1999-12-23 2000-12-19 Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning

Country Status (31)

Country Link
US (1) US6432987B2 (da)
EP (1) EP1240157B1 (da)
JP (1) JP2003519137A (da)
KR (1) KR100747425B1 (da)
CN (1) CN1283637C (da)
AR (1) AR027098A1 (da)
AT (1) ATE259364T1 (da)
AU (1) AU772745B2 (da)
BG (1) BG106924A (da)
BR (1) BR0016712A (da)
CA (1) CA2395259A1 (da)
CO (1) CO5251472A1 (da)
CZ (1) CZ20022094A3 (da)
DE (2) DE19962300A1 (da)
DK (1) DK1240157T3 (da)
ES (1) ES2215768T3 (da)
HK (1) HK1054038B (da)
HU (1) HUP0203716A3 (da)
IL (1) IL150235A0 (da)
MX (1) MXPA02006229A (da)
NO (1) NO324750B1 (da)
NZ (2) NZ519977A (da)
PL (1) PL195014B1 (da)
PT (1) PT1240157E (da)
RU (1) RU2266280C2 (da)
SK (1) SK8752002A3 (da)
TR (1) TR200400601T4 (da)
TW (1) TWI284128B (da)
UA (1) UA75060C2 (da)
WO (1) WO2001047913A2 (da)
ZA (1) ZA200204896B (da)

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DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
BRPI0410998A (pt) * 2003-06-05 2006-07-04 Zentaris Gmbh derivados de indol com efeito de indução de apoptose
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
SG146624A1 (en) 2003-09-11 2008-10-30 Kemia Inc Cytokine inhibitors
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
KR101238525B1 (ko) 2004-12-31 2013-02-28 레디 유에스 테라퓨틱스 인코포레이티드 Ｃｅｔｐ 저해제로서의 신규 벤질아민 유도체
US8242149B2 (en) * 2005-03-11 2012-08-14 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
KR20090054984A (ko) 2006-08-07 2009-06-01 아이언우드 파마슈티컬스, 인코포레이티드 인돌 화합물
CA2670778A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
WO2010127099A2 (en) 2009-04-29 2010-11-04 Amarin Corporation Plc Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
US9199967B2 (en) 2011-08-18 2015-12-01 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors
CN103958511A (zh) 2011-09-27 2014-07-30 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物

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KR950701317A (ko) * 1992-05-08 1995-03-23 오오쓰까 아끼히꼬 인돌 유도체(Indole Derivative)
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
CA2183731C (en) * 1994-02-22 2000-03-21 Alan J. Bitonti Novel indole derivatives useful to treat estrogen-related neoplasms and disorders
EP0675110B1 (en) * 1994-04-01 2002-07-10 Eli Lilly And Company 1H-Indole-3-glyoxylamide sPLA2 inhibitors
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
WO1998037069A1 (fr) * 1997-02-20 1998-08-27 Shionogi & Co., Ltd. Derives d'acide indoldicarboxylique
US5972988A (en) * 1997-03-26 1999-10-26 Eli Lilly And Company Method for treatment of chronic bronchitis using indole compounds
WO1998047507A1 (en) * 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
TW455581B (en) * 1997-06-26 2001-09-21 Lilly Co Eli Process for preparing 4-substituted-1H-indole-3-glyoxamides
CA2301586A1 (en) * 1997-08-28 1999-03-04 William Louis Macias Method for treatment of non-rheumatoid arthritis
EP1007056A1 (en) * 1997-09-26 2000-06-14 Eli Lilly And Company Method for the treatment of cystic fibrosis
CA2309135A1 (en) * 1997-10-27 1999-05-06 Michael Lyle Denney N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors
AU1200799A (en) * 1997-10-27 1999-05-17 Eli Lilly And Company Isopropyl ester prodrugs of indole spla2 inhibitors
DE69830335T2 (de) * 1997-10-27 2006-02-02 Eli Lilly And Co., Indianapolis MORPHOLINO-N-ETHYL ESTER PRODROGEN VON INDOL sPLA 2 HEMMER
WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
EP1039901A1 (en) * 1997-11-14 2000-10-04 Eli Lilly And Company Treatment for alzheimer's disease
BR9908275A (pt) * 1998-02-25 2000-10-24 Genetics Inst Inibidores de enzimas fosfolipase
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
CZ20003985A3 (cs) * 1998-04-28 2001-09-12 Arzneimittelwerk Dresden Gmbh Nový hydroxyindol, způsob jeho přípravy a jeho použití jako inhibitoru fosfodiesterázy 4
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
ATE280155T1 (de) * 1998-05-01 2004-11-15 Lilly Co Eli Inhibitorische ester für spla 2
EP1084108A4 (en) * 1998-05-01 2005-01-12 Lilly Co Eli SPLA 2 INHIBITORS FOR THE TREATMENT OF DISEASES
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action

Also Published As

Publication number Publication date
BR0016712A (pt) 2002-09-03
NO20023039L (no) 2002-08-09
RU2002120462A (ru) 2004-01-10
CN1420880A (zh) 2003-05-28
ZA200204896B (en) 2002-12-20
HUP0203716A3 (en) 2004-05-28
PT1240157E (pt) 2004-06-30
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
JP2003519137A (ja) 2003-06-17
CN1283637C (zh) 2006-11-08
TR200400601T4 (tr) 2004-04-21
NZ519977A (en) 2004-08-27
NO20023039D0 (no) 2002-06-21
EP1240157B1 (de) 2004-02-11
UA75060C2 (en) 2006-03-15
AR027098A1 (es) 2003-03-12
CA2395259A1 (en) 2001-07-05
KR100747425B1 (ko) 2007-08-09
US6432987B2 (en) 2002-08-13
HK1054038B (zh) 2007-04-13
CZ20022094A3 (cs) 2002-10-16
HK1054038A1 (en) 2003-11-14
WO2001047913A3 (de) 2002-04-25
US20010014690A1 (en) 2001-08-16
NO324750B1 (no) 2007-12-03
HUP0203716A2 (hu) 2003-03-28
AU772745B2 (en) 2004-05-06
TWI284128B (en) 2007-07-21
AU2011901A (en) 2001-07-09
ES2215768T3 (es) 2004-10-16
IL150235A0 (en) 2002-12-01
PL355684A1 (en) 2004-05-17
ATE259364T1 (de) 2004-02-15
CO5251472A1 (es) 2003-02-28
EP1240157A2 (de) 2002-09-18
DE50005284D1 (de) 2004-03-18
WO2001047913A2 (de) 2001-07-05
BG106924A (bg) 2003-04-30
RU2266280C2 (ru) 2005-12-20
KR20020063245A (ko) 2002-08-01
NZ533731A (en) 2005-03-24
PL195014B1 (pl) 2007-07-31
DE19962300A1 (de) 2001-06-28

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