[go: up one dir, main page]

DK1145009T3 - Method for detecting analytes in a test sample and measuring carrier therefore - Google Patents

Method for detecting analytes in a test sample and measuring carrier therefore

Info

Publication number
DK1145009T3
DK1145009T3 DK00905017T DK00905017T DK1145009T3 DK 1145009 T3 DK1145009 T3 DK 1145009T3 DK 00905017 T DK00905017 T DK 00905017T DK 00905017 T DK00905017 T DK 00905017T DK 1145009 T3 DK1145009 T3 DK 1145009T3
Authority
DK
Denmark
Prior art keywords
detection fields
substrate
sample
detecting analytes
test sample
Prior art date
Application number
DK00905017T
Other languages
Danish (da)
Inventor
Peter Becker
Heinrich Hoerber
Original Assignee
Europ Lab Molekularbiolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19938839A external-priority patent/DE19938839A1/en
Application filed by Europ Lab Molekularbiolog filed Critical Europ Lab Molekularbiolog
Application granted granted Critical
Publication of DK1145009T3 publication Critical patent/DK1145009T3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00536—Sheets in the shape of disks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The invention relates to a method of detecting analytes in a sample. According to said method, analyte-specific binders (15) are immobilized on a plurality of detection fields (5, 7) on one of the planar faces of a disk-shaped substrate (3). The sample is contacted with said detection fields (5, 7) and the presence or/and the quantity of the analytes (17) to be detected is determined by optically evaluating the detection fields (5, 7). According to the invention, a substrate (3) is used that is produced from an optically transparent material. The detection fields (5, 7) are arranged along at least one spiral line (27) distributed across the substrate (3). After the sample has been contacted with the detection fields (5, 7), a reflecting layer (21) is flatly applied on the substrate (3) on the planar face carrying the detection fields (5, 7). Alternatively, a magnetic read-out of the substrate can be made instead of the optical read-out.
DK00905017T 1999-02-03 2000-02-03 Method for detecting analytes in a test sample and measuring carrier therefore DK1145009T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19904288 1999-02-03
DE19938839A DE19938839A1 (en) 1999-02-03 1999-08-17 Method for the detection of analytes in a measurement sample and measurement carrier therefor

Publications (1)

Publication Number Publication Date
DK1145009T3 true DK1145009T3 (en) 2004-09-13

Family

ID=26051652

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00905017T DK1145009T3 (en) 1999-02-03 2000-02-03 Method for detecting analytes in a test sample and measuring carrier therefore

Country Status (8)

Country Link
EP (1) EP1145009B1 (en)
AT (1) ATE266200T1 (en)
AU (1) AU762899B2 (en)
CA (2) CA2384337A1 (en)
DE (1) DE50006325D1 (en)
DK (1) DK1145009T3 (en)
ES (1) ES2220400T3 (en)
WO (1) WO2000046600A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001147230A (en) * 1999-11-19 2001-05-29 Hitachi Software Eng Co Ltd Biochip reading apparatus end labelled reagent
WO2002041004A2 (en) * 2000-11-16 2002-05-23 Burstein Technologies, Inc. Optical biodiscs with reflective layers
WO2004018992A2 (en) * 2002-08-21 2004-03-04 Datascope Investment Corporation Method and composition for forming a protective coating on an assay substrate and substrate produced by the same
WO2005124349A1 (en) * 2004-06-12 2005-12-29 Auburn University Cd-rom based optical biosensors
EP1856525A4 (en) * 2005-03-10 2015-12-09 Raustech Pty Ltd Disc substrates for combinatorial chemistry

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005326A1 (en) * 1994-08-17 1996-02-22 Fox John S Method and apparatus for magnetically detecting proteins and nucleic acids
GB9418981D0 (en) * 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
JP2002514046A (en) * 1996-07-08 2002-05-14 バースタイン テクノロジーズ，インコーポレイティド Devices and methods for cleavable signaling factors
WO1998012559A1 (en) * 1996-09-20 1998-03-26 Demers James P Spatially addressable combinatorial chemical arrays in cd-rom format

Also Published As

Publication number Publication date
EP1145009B1 (en) 2004-05-06
WO2000046600A3 (en) 2001-11-01
WO2000046600A2 (en) 2000-08-10
ES2220400T3 (en) 2004-12-16
AU762899B2 (en) 2003-07-10
EP1145009A2 (en) 2001-10-17
AU2669600A (en) 2000-08-25
DE50006325D1 (en) 2004-06-09
CA2361700A1 (en) 2000-08-10
CA2384337A1 (en) 2000-08-10
ATE266200T1 (en) 2004-05-15

Similar Documents

Publication Publication Date Title
US4496654A (en) Detection of HCG with solid phase support having avidin coating
US6607922B2 (en) Immunochromatographic assay method and apparatus
NZ306051A (en) Testing using electrochemiluminescence
DE69936916D1 (en) LIGANDEN BINDING TEST AND KIT WITH A SEPARATION ZONE FOR DISTURBING SAMPLE COMPONENTS
HUP0103577A2 (en) Optical disc-based assay devices and methods
DK1111386T3 (en) Test strip to determine an analyte in a liquid sample
DK0820522T3 (en) Assays and devices for detecting extrahepatic biliary atresia
WO1992019957A3 (en) Method for optically measuring chemical analytes
DK405586D0 (en) MULTI ZONE ANALYST ELEMENT FOR SPECIFIC BINDING ANALYSIS DETERMINING AN ANALYT IN A LIQUID TEST MEDIUM
DE69941688D1 (en) IMMUNOASSAYS USING SERS (SURFACE ENHANCED RAMAN SCATTERING)
DK0728309T3 (en) Analytical devices and their manufacture
DK0533719T3 (en) Method for Detecting and / or Determining Hormones
NO20003709L (en) Method for detecting an analyte, and enclosing means and kits for use therein
NO813483L (en) TESTING DEVICE FOR DETERMINING A LIGAND IN OR THE LIGAND BONDING CAPACITY OF A LIQUID TEST, PROCEDURE FOR ITS PREPARATION AND ANALYTICAL METHOD USING THE DEVICE
DK1145009T3 (en) Method for detecting analytes in a test sample and measuring carrier therefore
DE69808895D1 (en) INCREASED PERFORMANCE OF BINDING ASSAYS USING MORE THAN ONE MARKING AGENT
DE69114247D1 (en) ANALYTICAL TEST.
TR200402398T3 (en) Transcobalamin II test method
SU879418A1 (en) Method of toxic substance analysis
DE50007429D1 (en) Diffusion-controlling sensor layer
KR20060020229A (en) Detection device and method for biocombination using bridge circuit
ES2004066A6 (en) A kit for qualitative and quantitative analysis of antigens, antibodies and/or microorganisms or other cells
Tam et al. Photothermal Measurement of the Contact Resistance Between an Opaque Film and a Substrate
Hartman Optical Biosensors for Microbiological Analysis
DK397489D0 (en) METHOD FOR DETECTING AND QUANTIFYING THE QUANTITY OF COMPLEMENT COMPONENTS IN A BIOLOGICAL TEST USING ANTIBODIES AGAINST C1 ESTERASE INHIBITOR AND A SYNTHETIC SUBSTRATE