DK109982A - Fremgangsmaade til fremstilling af 2-tertiaer-aminoalkoxymethyl-4-aryl(eller heteroaryl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af 2-tertiaer-aminoalkoxymethyl-4-aryl(eller heteroaryl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf Download PDF

Info

Publication number: DK109982A
Authority: DK; Denmark
Prior art keywords: acceptic; aryl; alkyl; heteroaryl; dihydropyridine
Prior art date: 1981-03-14

Application number

DK109982A

Other languages

English (en)

Other versions

DK155601C (da

DK155601B (da

Inventor

S F Campbell

P E Cross

J K Stubbs

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-14

Filing date

1982-03-12

Publication date

1982-09-15

1982-03-12 Application filed by Pfizer filed Critical Pfizer

1982-09-15 Publication of DK109982A publication Critical patent/DK109982A/da

1989-04-24 Publication of DK155601B publication Critical patent/DK155601B/da

1989-09-11 Application granted granted Critical

1989-09-11 Publication of DK155601C publication Critical patent/DK155601C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK109982A 1981-03-14 1982-03-12 Analogifremgangsmaade til fremstilling af 2-tertiaer-aminoalkoxymethyl-4-aryl(eller heteroaryl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf DK155601C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8108088		1981-03-14
GB8108088		1981-03-14

Publications (3)

Publication Number	Publication Date
DK109982A true DK109982A (da)	1982-09-15
DK155601B DK155601B (da)	1989-04-24
DK155601C DK155601C (da)	1989-09-11

Family

ID=10520395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK109982A DK155601C (da)	1981-03-14	1982-03-12	Analogifremgangsmaade til fremstilling af 2-tertiaer-aminoalkoxymethyl-4-aryl(eller heteroaryl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (24)

Country	Link
US (1)	US4430333A (da)
EP (1)	EP0060674B1 (da)
JP (1)	JPS57206659A (da)
KR (1)	KR860001579B1 (da)
AT (1)	ATE15660T1 (da)
AU (1)	AU529854B2 (da)
CA (1)	CA1205480A (da)
CS (1)	CS228917B2 (da)
DD (1)	DD202430A5 (da)
DE (1)	DE3266272D1 (da)
DK (1)	DK155601C (da)
ES (2)	ES8305330A1 (da)
FI (1)	FI78470C (da)
GR (1)	GR75895B (da)
HU (1)	HU187657B (da)
IE (1)	IE52632B1 (da)
IL (1)	IL65222A (da)
NO (1)	NO159085C (da)
NZ (1)	NZ199990A (da)
PH (1)	PH17585A (da)
PL (2)	PL131190B1 (da)
PT (1)	PT74571B (da)
YU (2)	YU42461B (da)
ZA (1)	ZA821670B (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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DK161312C (da) *	1982-03-11	1991-12-09	Pfizer	Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
ATE50987T1 (de) *	1982-05-10	1990-03-15	Takeda Chemical Industries Ltd	Dihydropyridinderivate, deren herstellung und verwendung.
EP0100189B1 (en) *	1982-07-22	1986-05-28	Pfizer Limited	Dihydropyridine anti-ischaemic and antihypertensive agents
HU192166B (en) *	1982-08-06	1987-05-28	Banyu Pharma Co Ltd	Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
EP0107293A3 (en) *	1982-09-04	1984-06-06	Pfizer Limited	Dihydropyridines
PH19166A (en) *	1982-09-04	1986-01-16	Pfizer	Dihydropyridined,pharmaceutical compositions and method of use
PL140573B1 (en) *	1982-12-21	1987-05-30	Pfizer	Method of obtaining new dihydropyridine derivatives
US4515799A (en) *	1983-02-02	1985-05-07	Pfizer Inc.	Dihydropyridine anti-ischaemic and antihypertensive agents
GB8306666D0 (en) *	1983-03-10	1983-04-13	Pfizer Ltd	Therapeutic agents
US4568677A (en) *	1983-07-23	1986-02-04	Pfizer Inc.	2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
US4603135A (en) *	1983-10-17	1986-07-29	Takeda Chemical Industries, Ltd.	Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates
US5137889A (en) *	1983-12-02	1992-08-11	Otsuka Pharmaceutical Co., Ltd.	Dihydropyridine derivatives and process for preparing the same
JPS60120861A (ja) *	1983-12-02	1985-06-28	Otsuka Pharmaceut Co Ltd	ジヒドロピリジン誘導体
EP0168841B1 (en) *	1983-12-19	1988-09-28	Pfizer Limited	Dihydropyridine intermediate
GB8401288D0 (en) *	1984-01-18	1984-02-22	Pfizer Ltd	Therapeutic agents
US4755512A (en) *	1984-04-11	1988-07-05	Bristol-Myers Company	Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities
US4895846A (en) *	1984-04-11	1990-01-23	Bristol-Myers Company	Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties
GB8412208D0 (en) *	1984-05-12	1984-06-20	Pfizer Ltd	Quinolone inotropic agents
GB8414518D0 (en) *	1984-06-07	1984-07-11	Pfizer Ltd	Therapeutic agents
GB8415386D0 (en) *	1984-06-15	1984-07-18	Pfizer Ltd	Therapeutic agents
GB8421039D0 (en) *	1984-08-17	1984-09-19	Wyeth John & Brother Ltd	Heterocyclic compounds
GR851819B (da) *	1984-08-17	1985-11-26	Wyeth John & Brother Ltd
US4652573A (en) *	1985-03-14	1987-03-24	Nelson Research & Development Co.	Calcium antagonist N-hetero ester 1,4-dihydropyridines
IT1204421B (it) *	1986-06-27	1989-03-01	Boehringer Biochemia Srl	2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
DE3628215C2 (de) *	1985-08-21	1996-09-19	Glaxo Spa	1,4-Dihydro-2-alkylenamino-3,5-dicarbonester-4-(2-propenyl)-phenyl-pyridine, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
DE3675747D1 (de) *	1985-08-21	1991-01-03	Glaxo Spa	1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung.
DE3531498A1 (de) *	1985-09-04	1987-03-05	Bayer Ag	Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US4849436A (en) *	1986-03-11	1989-07-18	Nelson Research & Development Co.	1,4-dihydropyridines
GB8608335D0 (en) *	1986-04-04	1986-05-08	Pfizer Ltd	Pharmaceutically acceptable salts
FR2602231B1 (fr) *	1986-08-04	1988-10-28	Adir	Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
WO1988001266A1 (en) *	1986-08-14	1988-02-25	Byk Gulden Lomberg Chemische Fabrik Gmbh	New piperidines
IT1213555B (it) *	1986-12-11	1989-12-20	Boehringer Biochemia Srl	2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
US4920225A (en) *	1986-12-22	1990-04-24	Laboratoires Syntex S.A.	Resolution of 1,4-dihydropyridine derivatives
JPH0688973B2 (ja) *	1987-03-12	1994-11-09	京都薬品工業株式会社	１，４−ジヒドロピリジン誘導体
GB8710493D0 (en) *	1987-05-02	1987-06-03	Pfizer Ltd	Dihydropyridines
IT1205114B (it) *	1987-05-29	1989-03-15	Boehringer Biochemia Srl	2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
US4978533A (en) *	1988-11-01	1990-12-18	Pharmaconsult, Inc.	Liquid nifidipine composition
US5635503A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Company	Dihydropyridine npy antagonists: piperazine derivatives
ES2151850B1 (es) *	1998-10-26	2001-08-16	Esteve Quimica Sa	Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
US6653481B2 (en) *	2000-12-29	2003-11-25	Synthon Bv	Process for making amlodipine
CA2433288C (en) *	2000-12-29	2006-06-13	Pfizer Limited	Process for making amlodipine maleate
US20040072879A1 (en) *	2002-10-10	2004-04-15	Dr. Reddy's Laboratories Limited	Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
WO2016155815A1 (en)	2015-04-01	2016-10-06	Ceva Sante Animale	Oral solid dosage form of amlodipine and veterinary uses thereof
KR102719122B1 (ko) *	2019-06-19	2024-10-17	현대자동차주식회사	차량의 통합열관리모듈

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Publication number	Priority date	Publication date	Assignee	Title
US3946028A (en)	1972-09-30	1976-03-23	Bayer Aktiengesellschaft	2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2248150A1 (de)	1972-09-30	1974-04-04	Bayer Ag	Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3946027A (en)	1972-09-30	1976-03-23	Bayer Aktiengesellschaft	3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3943140A (en)	1972-09-30	1976-03-09	Bayer Aktiengesellschaft	2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives
BE843576A (fr)	1975-04-03	1976-12-29		Derives de 1,4-dihydropyridine et leur procede de preparation
GB1552911A (en)	1975-07-02	1979-09-19	Fujisawa Pharmaceutical Co	1,4 dihydropyridine derivatives and the preparation thereof
DE2658183A1 (de)	1976-12-22	1978-07-06	Bayer Ag	In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2715182A1 (de)	1977-04-05	1978-10-19	Bayer Ag	2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4177278A (en)	1977-04-05	1979-12-04	Bayer Aktiengesellschaft	2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
US4307103A (en)	1978-09-08	1981-12-22	Fujisawa Pharmaceutical Co., Ltd.	Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same

1982
- 1982-03-08 CS CS821571A patent/CS228917B2/cs unknown
- 1982-03-09 AT AT82301210T patent/ATE15660T1/de not_active IP Right Cessation
- 1982-03-09 EP EP82301210A patent/EP0060674B1/en not_active Expired
- 1982-03-09 PL PL1982235363A patent/PL131190B1/pl unknown
- 1982-03-09 DE DE8282301210T patent/DE3266272D1/de not_active Expired
- 1982-03-09 PL PL1982238960A patent/PL132199B1/pl unknown
- 1982-03-09 HU HU82722A patent/HU187657B/hu not_active IP Right Cessation
- 1982-03-11 GR GR67557A patent/GR75895B/el unknown
- 1982-03-11 FI FI820840A patent/FI78470C/fi not_active IP Right Cessation
- 1982-03-11 DD DD82238073A patent/DD202430A5/de not_active IP Right Cessation
- 1982-03-11 US US06/357,229 patent/US4430333A/en not_active Expired - Lifetime
- 1982-03-11 IL IL65222A patent/IL65222A/xx not_active IP Right Cessation
- 1982-03-12 ES ES510402A patent/ES8305330A1/es not_active Expired
- 1982-03-12 NO NO820825A patent/NO159085C/no unknown
- 1982-03-12 CA CA000398201A patent/CA1205480A/en not_active Expired
- 1982-03-12 NZ NZ199990A patent/NZ199990A/en unknown
- 1982-03-12 PT PT74571A patent/PT74571B/pt not_active IP Right Cessation
- 1982-03-12 YU YU550/82A patent/YU42461B/xx unknown
- 1982-03-12 ZA ZA821670A patent/ZA821670B/xx unknown
- 1982-03-12 IE IE572/82A patent/IE52632B1/en not_active IP Right Cessation
- 1982-03-12 AU AU81364/82A patent/AU529854B2/en not_active Ceased
- 1982-03-12 DK DK109982A patent/DK155601C/da not_active IP Right Cessation
- 1982-03-12 PH PH26986A patent/PH17585A/en unknown
- 1982-03-13 JP JP57040082A patent/JPS57206659A/ja active Granted
- 1982-03-13 KR KR8201101A patent/KR860001579B1/ko active
- 1982-12-22 ES ES518489A patent/ES8402273A1/es not_active Expired
1984
- 1984-09-10 YU YU1558/84A patent/YU42902B/xx unknown

Also Published As

Publication number	Publication date
ATE15660T1 (de)	1985-10-15
ES510402A0 (es)	1983-04-01
PT74571B (en)	1984-11-27
PL131190B1 (en)	1984-10-31
FI820840L (fi)	1982-09-15
PL132199B1 (en)	1985-02-28
FI78470B (fi)	1989-04-28
DE3266272D1 (en)	1985-10-24
KR860001579B1 (ko)	1986-10-10
NO159085B (no)	1988-08-22
NO820825L (no)	1982-09-15
YU42461B (en)	1988-08-31
YU42902B (en)	1988-12-31
PT74571A (en)	1982-04-01
IL65222A0 (en)	1982-05-31
YU155884A (en)	1985-03-20
HU187657B (en)	1986-02-28
ZA821670B (en)	1983-01-26
PH17585A (en)	1984-10-02
IL65222A (en)	1985-08-30
NZ199990A (en)	1984-07-06
EP0060674B1 (en)	1985-09-18
ES518489A0 (es)	1984-01-16
IE52632B1 (en)	1988-01-06
US4430333A (en)	1984-02-07
JPS6155907B2 (da)	1986-11-29
GR75895B (da)	1984-08-02
JPS57206659A (en)	1982-12-18
DK155601C (da)	1989-09-11
IE820572L (en)	1982-09-14
NO159085C (no)	1988-11-30
ES8402273A1 (es)	1984-01-16
CA1205480A (en)	1986-06-03
CS228917B2 (en)	1984-05-14
ES8305330A1 (es)	1983-04-01
KR830009025A (ko)	1983-12-17
AU8136482A (en)	1982-11-04
PL235363A1 (en)	1983-03-14
PL238960A1 (en)	1983-07-18
DD202430A5 (de)	1983-09-14
FI78470C (fi)	1989-08-10
DK155601B (da)	1989-04-24
AU529854B2 (en)	1983-06-23
YU55082A (en)	1984-12-31
EP0060674A1 (en)	1982-09-22

Publication	Publication Date	Title
DK109982A (da)	1982-09-15	Fremgangsmaade til fremstilling af 2-tertiaer-aminoalkoxymethyl-4-aryl(eller heteroaryl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf
DK333683A (da)	1984-01-23	Fremgangsmaade til fremstilling af 2-heteroaryl-alkoxymethyl-4-(aryl eller heteroaryl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf
DK81383D0 (da)	1983-02-23	Fremgangsmade til fremstilling af 2-aminoalkoxymethyl-4-(aryl eller heteroaryl)-6-methyl-1,4-dihydropyridin-2,5-dicarboxylsyreestere eller syreadditionssalte deraf
DK160984C (da)	1991-11-11	Analogifremgangsmaade til fremstilling af dihydropyridinderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK355784D0 (da)	1984-07-20	2-(heterocyclylalkoxymethyl)-4-(aryl eller heteroaryl)-6-methyl-1,4-dihydropyridin-3,5- dicarboxylsyreestere og deres anvendelse til behandling af cardiovasculaere lidelser samt farmaceutiske praeparater indeholdende disse forbindelser

Legal Events

Date	Code	Title	Description
2001-10-29	PBP	Patent lapsed