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DK1070077T3 - 15-Leddede ketolid-lactamer med antibakteriel virkning - Google Patents

15-Leddede ketolid-lactamer med antibakteriel virkning

Info

Publication number
DK1070077T3
DK1070077T3 DK99911955T DK99911955T DK1070077T3 DK 1070077 T3 DK1070077 T3 DK 1070077T3 DK 99911955 T DK99911955 T DK 99911955T DK 99911955 T DK99911955 T DK 99911955T DK 1070077 T3 DK1070077 T3 DK 1070077T3
Authority
DK
Denmark
Prior art keywords
ketolide
lactams
jointed
antibacterial action
antibacterial
Prior art date
Application number
DK99911955T
Other languages
Danish (da)
English (en)
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
Zeljko Kelneric
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Application granted granted Critical
Publication of DK1070077T3 publication Critical patent/DK1070077T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK99911955T 1998-04-06 1999-04-02 15-Leddede ketolid-lactamer med antibakteriel virkning DK1070077T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (1)

Publication Number Publication Date
DK1070077T3 true DK1070077T3 (da) 2003-09-22

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99911955T DK1070077T3 (da) 1998-04-06 1999-04-02 15-Leddede ketolid-lactamer med antibakteriel virkning

Country Status (27)

Country Link
US (1) US6110965A (ru)
EP (1) EP1070077B1 (ru)
JP (1) JP2002510701A (ru)
KR (1) KR100600463B1 (ru)
CN (1) CN1141312C (ru)
AR (1) AR019261A1 (ru)
AT (1) ATE241638T1 (ru)
AU (1) AU3046499A (ru)
BG (1) BG64600B1 (ru)
BR (1) BR9910115A (ru)
CA (1) CA2327775C (ru)
DE (1) DE69908338T2 (ru)
DK (1) DK1070077T3 (ru)
EE (1) EE04283B1 (ru)
ES (1) ES2200512T3 (ru)
HK (1) HK1036457A1 (ru)
HR (1) HRP980189B1 (ru)
HU (1) HUP0101817A3 (ru)
IL (2) IL138837A0 (ru)
NO (1) NO317982B1 (ru)
PL (1) PL193742B1 (ru)
PT (1) PT1070077E (ru)
RU (1) RU2211222C2 (ru)
SI (1) SI1070077T1 (ru)
SK (1) SK284169B6 (ru)
UA (1) UA70941C2 (ru)
WO (1) WO1999051616A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
BR0109544A (pt) * 2000-03-28 2003-06-10 Biochemie Gmbh Partìculas granuladas com sabor ocultado
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
JP2005501862A (ja) * 2001-08-21 2005-01-20 ファイザー・プロダクツ・インク １回限りの投与量のアジスロマイシン
AU2003215245A1 (en) 2002-02-15 2003-09-09 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7271154B2 (en) 2002-02-15 2007-09-18 Merckle Gmbh Antibiotic conjugates
AU2003219770B2 (en) 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
US7091187B2 (en) 2002-07-08 2006-08-15 Pliva-Istrazivacki Institut D.O.O. Compounds, compositions and methods for treatment of inflammatory diseases and conditions
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US8080529B2 (en) 2005-01-13 2011-12-20 Glaxo Group Limited Macrolides with anti-inflammatory activity
WO2006120541A1 (en) 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ether linked macrolides useful for the treatment of microbial infections
JP5126685B2 (ja) * 2006-05-01 2013-01-23 大正製薬株式会社 マクロライド誘導体
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
MA32997B1 (fr) * 2009-01-30 2012-01-02 Glaxo Group Ltd Macrolide anti-inflammatoire
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
JP5851516B2 (ja) * 2010-12-09 2016-02-03 ウォックハート リミテッド ケトライド化合物
CA3120148A1 (en) * 2018-11-19 2020-05-28 Zikani Therapeutics, Inc. C10-alkylene substituted 13-membered macrolides and uses thereof
JP2023500897A (ja) * 2019-10-29 2023-01-11 ハイカル リミテッド 実質的に純粋なクラリスロマイシン ９－オキシム（Ｃｌａｒｉｔｈｒｏｍｙｃｉｎ ９－ｏｘｉｍｅ）及びその調製

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
ATE154806T1 (de) * 1993-05-19 1997-07-15 Pfizer Zwischenprodukt für azithromycin

Also Published As

Publication number Publication date
SK284169B6 (sk) 2004-10-05
IL138837A0 (en) 2001-10-31
ES2200512T3 (es) 2004-03-01
CN1301268A (zh) 2001-06-27
EP1070077B1 (en) 2003-05-28
PT1070077E (pt) 2003-10-31
NO317982B1 (no) 2005-01-17
IL138837A (en) 2006-10-05
HUP0101817A2 (hu) 2001-11-28
UA70941C2 (ru) 2004-11-15
EE200000587A (et) 2002-04-15
CA2327775C (en) 2007-08-07
HUP0101817A3 (en) 2003-07-28
US6110965A (en) 2000-08-29
AR019261A1 (es) 2002-02-13
HK1036457A1 (en) 2002-01-04
CA2327775A1 (en) 1999-10-14
CN1141312C (zh) 2004-03-10
SK15022000A3 (sk) 2001-03-12
BG64600B1 (bg) 2005-08-31
BR9910115A (pt) 2000-12-26
NO20005015L (no) 2000-12-04
HRP980189B1 (en) 2004-04-30
AU3046499A (en) 1999-10-25
PL193742B1 (pl) 2007-03-30
RU2211222C2 (ru) 2003-08-27
KR20010034754A (ko) 2001-04-25
NO20005015D0 (no) 2000-10-05
BG104913A (en) 2001-08-31
SI1070077T1 (en) 2004-02-29
EE04283B1 (et) 2004-04-15
KR100600463B1 (ko) 2006-07-13
DE69908338D1 (de) 2003-07-03
WO1999051616A1 (en) 1999-10-14
DE69908338T2 (de) 2004-04-08
ATE241638T1 (de) 2003-06-15
JP2002510701A (ja) 2002-04-09
EP1070077A1 (en) 2001-01-24
HRP980189A2 (en) 2000-12-31
PL343441A1 (en) 2001-08-13

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