DK1003781T3 - Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse - Google Patents

Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse

Info

Publication number: DK1003781T3
Authority: DK; Denmark
Prior art keywords: interleukin; preparation; binding proteins; proteins; binding
Prior art date: 1997-08-14

Application number

DK98938877.2T

Other languages

English (en)

Inventor

Daniela Novick

Charles Dinarello

Menachem Rubinstein

Soo Hyun Kim

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-14

Filing date

1998-08-13

Publication date

2010-01-25

1997-08-14 Priority claimed from IL12155497A external-priority patent/IL121554A0/xx

1997-08-27 Priority claimed from IL12163997A external-priority patent/IL121639A0/xx

1998-08-13 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

2010-01-25 Application granted granted Critical

2010-01-25 Publication of DK1003781T3 publication Critical patent/DK1003781T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Zoology (AREA)
Toxicology (AREA)
Cell Biology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Transplantation (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)

DK98938877.2T 1997-08-14 1998-08-13 Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse DK1003781T3 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
IL12155497A IL121554A0 (en)	1997-08-14	1997-08-14	Interleukin-18 binding proteins their preparation and use
IL12163997A IL121639A0 (en)	1997-08-14	1997-08-27	Interleukin-18 binding proteins their preparation and use
IL12186097A IL121860A0 (en)	1997-08-14	1997-09-29	Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en)	1997-08-14	1997-11-06	Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en)	1997-08-14	1998-07-22	Interleukin-18 binding proteins their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en)	1997-08-14	1998-08-13	Interleukin-18 binding proteins, their preparation and use

Publications (1)

Publication Number	Publication Date
DK1003781T3 true DK1003781T3 (da)	2010-01-25

Family

ID=27517687

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98938877.2T DK1003781T3 (da)	1997-08-14	1998-08-13	Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse

Country Status (29)

Country	Link
US (4)	US6605280B1 (da)
EP (1)	EP1003781B1 (da)
JP (1)	JP4272348B2 (da)
KR (1)	KR100687388B1 (da)
CN (1)	CN1243021C (da)
AR (2)	AR013422A1 (da)
AT (1)	ATE443719T1 (da)
AU (1)	AU755794B2 (da)
BG (1)	BG65519B1 (da)
BR (1)	BRPI9811940B8 (da)
CA (1)	CA2298855C (da)
CY (1)	CY1109664T1 (da)
CZ (1)	CZ300818B6 (da)
DE (2)	DE69841175D1 (da)
DK (1)	DK1003781T3 (da)
EA (1)	EA003675B1 (da)
EE (1)	EE05538B1 (da)
ES (1)	ES2149149T3 (da)
HK (1)	HK1028773A1 (da)
HU (1)	HU226698B1 (da)
IL (5)	IL121860A0 (da)
NO (1)	NO327240B1 (da)
NZ (1)	NZ502392A (da)
PL (1)	PL206070B1 (da)
PT (1)	PT1003781E (da)
SI (1)	SI1003781T1 (da)
SK (1)	SK287194B6 (da)
UA (1)	UA75862C2 (da)
WO (1)	WO1999009063A1 (da)

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IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) *	1998-06-24	1999-12-24	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	An artificial peptide capable of neutralizing the biological activity of interleukin-18
CA2340579A1 (en) *	1998-09-01	2000-03-09	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	Interleukin 18-binding protein
AR022952A1 (es)	1999-03-19	2002-09-04	Smithkline Beecham Corp	ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
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AU2003299919B2 (en) *	2002-10-08	2009-08-06	Ares Trading S.A.	The use of cytokine able to bind IL-18BP and of inhibiting the activity of a second cytokine
IL152232A0 (en) *	2002-10-10	2003-05-29	Yeda Res & Dev	Promoter to il-18bp, its preparation and use
WO2004097019A1 (ja)	2003-04-30	2004-11-11	Japan Science And Technology Agency	ヒト抗ヒトインターロイキン－１８抗体およびその断片、並びにそれらの利用方法
ES2384241T3 (es) *	2003-05-13	2012-07-02	Merck Serono Sa	Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas
ME01198B (me) *	2003-11-05	2013-03-20	Ares Trading Sa	Prečišćavanje il-18 vezujućeg proteina
US20050100965A1 (en) *	2003-11-12	2005-05-12	Tariq Ghayur	IL-18 binding proteins
US7968684B2 (en) *	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
US7560265B2 (en)	2003-11-12	2009-07-14	The Regents Of The University Of Colorado, A Body Corporate	Compositions for regulation of tumor necrosis factor-alpha
IL159670A0 (en) *	2003-12-31	2004-06-01	Yeda Res & Dev	Use of il-18 binding protein in inflammations
US7553665B2 (en) *	2004-03-01	2009-06-30	Ares Trading S.A.	Process for the cultivation of mammalian cells producing IL-18BP in serum-free cell culture medium
US7557084B2 (en) *	2004-03-31	2009-07-07	Regeneron Pharmaceuticals, Inc.	IL-18 specific polypeptides and therapeutic uses thereof
EP1761552B1 (en)	2004-06-29	2008-09-17	Ares Trading S.A.	Process for the purification of il-18 binding protein
ES2370417T3 (es)	2005-06-03	2011-12-15	Ares Trading S.A.	Producción de una proteína de unión a il-18 recombinante.
CA2610691C (en) *	2005-06-03	2015-12-01	Laboratoires Serono S.A.	Use of il-18bp isoforms for the treatment and/or prevention of neurological inflammatory diseases
PL1891088T3 (pl) *	2005-06-10	2012-03-30	Ares Trading Sa	Sposób oczyszczania białka wiążącego IL-18
CN101003812B (zh) *	2006-01-17	2011-01-05	温州医学院	一种用于制备重组人egf-il18融合蛋白的方法
KR101416078B1 (ko)	2006-05-25	2014-07-07	글락소 그룹 리미티드	변형된 인간화 항인터루킨１８ 항체
WO2010040736A2 (en) *	2008-10-07	2010-04-15	Ablynx Nv	Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
WO2014107530A1 (en) *	2013-01-02	2014-07-10	Wilsa, Inc.	Method and apparatus for conditioning fluids
ES2892923T3 (es)	2013-09-05	2022-02-07	Ab2 Bio Sa	Proteína de unión a IL-18 (IL-18BP) en enfermedades inflamatorias
AU2016227644B2 (en)	2015-03-05	2022-06-16	Ab2 Bio Sa	IL-18 Binding Protein (IL-18BP) and antibodies in inflammatory diseases
EP3943097A1 (en)	2020-07-24	2022-01-26	AB2 Bio SA	Car-t cell therapy
CN117279950A (zh) *	2022-01-28	2023-12-22	和径医药科技（上海）有限公司	一种靶向il-18bp的抗体及其应用
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CN114605521A (zh) *	2022-04-06	2022-06-10	内蒙古农业大学	一种细胞免疫调节蛋白及其应用
CN114891125B (zh) *	2022-06-16	2023-04-11	广东医科大学	一种长效重组白细胞介素-18结合蛋白及其生产方法与应用
WO2025003753A1 (en)	2023-06-26	2025-01-02	Compugen Ltd.	Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer

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1997
- 1997-09-29 IL IL12186097A patent/IL121860A0/xx unknown
- 1997-11-06 IL IL12213497A patent/IL122134A0/xx unknown
1998
- 1998-07-22 IL IL12546398A patent/IL125463A0/xx unknown
- 1998-08-13 JP JP2000509740A patent/JP4272348B2/ja not_active Expired - Lifetime
- 1998-08-13 IL IL13452398A patent/IL134523A0/xx active IP Right Grant
- 1998-08-13 CZ CZ20000490A patent/CZ300818B6/cs not_active IP Right Cessation
- 1998-08-13 PL PL338647A patent/PL206070B1/pl unknown
- 1998-08-13 EE EEP200000073A patent/EE05538B1/xx unknown
- 1998-08-13 ES ES98938877T patent/ES2149149T3/es not_active Expired - Lifetime
- 1998-08-13 CN CNB988081342A patent/CN1243021C/zh not_active Expired - Lifetime
- 1998-08-13 WO PCT/IL1998/000379 patent/WO1999009063A1/en not_active Application Discontinuation
- 1998-08-13 AT AT98938877T patent/ATE443719T1/de active
- 1998-08-13 DE DE69841175T patent/DE69841175D1/de not_active Expired - Lifetime
- 1998-08-13 EA EA200000216A patent/EA003675B1/ru not_active IP Right Cessation
- 1998-08-13 NZ NZ502392A patent/NZ502392A/xx not_active IP Right Cessation
- 1998-08-13 DK DK98938877.2T patent/DK1003781T3/da active
- 1998-08-13 UA UA2000031437A patent/UA75862C2/uk unknown
- 1998-08-13 CA CA2298855A patent/CA2298855C/en not_active Expired - Lifetime
- 1998-08-13 SI SI9830922T patent/SI1003781T1/sl unknown
- 1998-08-13 HU HU0003533A patent/HU226698B1/hu unknown
- 1998-08-13 KR KR1020007001504A patent/KR100687388B1/ko not_active IP Right Cessation
- 1998-08-13 US US09/485,632 patent/US6605280B1/en not_active Expired - Lifetime
- 1998-08-13 AU AU87460/98A patent/AU755794B2/en not_active Expired
- 1998-08-13 DE DE1003781T patent/DE1003781T1/de active Pending
- 1998-08-13 EP EP98938877A patent/EP1003781B1/en not_active Expired - Lifetime
- 1998-08-13 PT PT98938877T patent/PT1003781E/pt unknown
- 1998-08-13 BR BRPI9811940-0 patent/BRPI9811940B8/pt not_active IP Right Cessation
- 1998-08-13 SK SK176-2000A patent/SK287194B6/sk not_active IP Right Cessation
- 1998-08-14 AR ARP980104054A patent/AR013422A1/es active IP Right Grant
2000
- 2000-02-10 BG BG104149A patent/BG65519B1/bg unknown
- 2000-02-11 NO NO20000700A patent/NO327240B1/no not_active IP Right Cessation
- 2000-02-13 IL IL134523A patent/IL134523A/en not_active IP Right Cessation
- 2000-12-19 HK HK00108180A patent/HK1028773A1/xx not_active IP Right Cessation
2003
- 2003-05-08 US US10/434,583 patent/US7101689B2/en not_active Expired - Lifetime
2006
- 2006-03-15 US US11/376,794 patent/US7799541B2/en not_active Expired - Fee Related
2007
- 2007-09-17 AR ARP070104104A patent/AR062867A2/es not_active Application Discontinuation
2009
- 2009-07-29 US US12/511,756 patent/US8436148B2/en not_active Expired - Fee Related
- 2009-11-25 CY CY20091101232T patent/CY1109664T1/el unknown

Also Published As

Publication number	Publication date
NZ502392A (en)	2002-12-20
CZ300818B6 (cs)	2009-08-19
EE05538B1 (et)	2012-04-16
SI1003781T1 (sl)	2009-12-31
CY1109664T1 (el)	2014-08-13
PT1003781E (pt)	2009-10-26
NO327240B1 (no)	2009-05-18
HK1028773A1 (en)	2001-03-02
BG65519B1 (bg)	2008-10-31
DE1003781T1 (de)	2001-01-11
BG104149A (en)	2000-08-31
AR013422A1 (es)	2000-12-27
JP4272348B2 (ja)	2009-06-03
AR062867A2 (es)	2008-12-10
EA003675B1 (ru)	2003-08-28
HU226698B1 (en)	2009-07-28
SK287194B6 (sk)	2010-03-08
BRPI9811940A (pt)	2000-09-05
PL206070B1 (pl)	2010-06-30
HUP0003533A3 (en)	2003-08-28
CN1243021C (zh)	2006-02-22
AU755794B2 (en)	2002-12-19
US20040037829A1 (en)	2004-02-26
EA200000216A1 (ru)	2000-08-28
CA2298855C (en)	2014-05-27
BRPI9811940B8 (pt)	2021-07-06
CZ2000490A3 (cs)	2000-08-16
IL121860A0 (en)	1998-02-22
BRPI9811940B1 (pt)	2011-10-04
ES2149149T1 (es)	2000-11-01
NO20000700D0 (no)	2000-02-11
UA75862C2 (uk)	2006-06-15
US8436148B2 (en)	2013-05-07
CN1267307A (zh)	2000-09-20
EE200000073A (da)	2000-10-16
US20060154294A1 (en)	2006-07-13
KR20010022900A (ko)	2001-03-26
DE69841175D1 (de)	2009-11-05
HUP0003533A2 (hu)	2001-01-29
NO20000700L (no)	2000-04-14
ES2149149T3 (es)	2009-12-01
EP1003781B1 (en)	2009-09-23
US7799541B2 (en)	2010-09-21
WO1999009063A1 (en)	1999-02-25
JP2001514876A (ja)	2001-09-18
SK1762000A3 (en)	2000-09-12
US7101689B2 (en)	2006-09-05
ATE443719T1 (de)	2009-10-15
AU8746098A (en)	1999-03-08
US20100010200A1 (en)	2010-01-14
IL125463A0 (en)	1999-03-12
PL338647A1 (en)	2000-11-06
IL134523A0 (en)	2001-04-30
IL134523A (en)	2011-09-27
US6605280B1 (en)	2003-08-12
KR100687388B1 (ko)	2007-02-26
CA2298855A1 (en)	1999-02-25
EP1003781A1 (en)	2000-05-31
IL122134A0 (en)	1998-04-05

Publication	Publication Date	Title
DK1003781T3 (da)	2010-01-25	Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse
ATA898A (de)	2003-02-15	Snowboard - einstiegsbindung
EE200000148A (et)	2001-02-15	Kay - uus immuunsüsteemi valk
NO983364L (no)	1999-01-25	Konsensusproteiner
DK0875252T3 (da)	2005-04-25	Formuleringer af aktiveret protein C
DK0954588T3 (da)	2007-05-14	OB fusionsprotein-sammensætninger og fremgangsmåder
LTPA2010013I1 (lt)	2021-05-25	Osteoprotegeriną rišantys baltymai ir receptoriai
DE69735926D1 (de)	2006-06-29	Interleukin-18 Rezeptorproteine
DK1005652T3 (da)	2006-10-30	Bindingsassay under anvendelse af antigener indlejret i termoplast
NO982296D0 (no)	1998-05-20	Triaromatiske forbindelser, preparater inneholdende disse og deres anvendelse
ATA144897A (de)	1998-11-15	Wirbelsäulen-prothese
DE69705017D1 (de)	2001-07-05	Medikamente bindendes Protein
NO995062D0 (no)	1999-10-15	<Beta>-anyloidpeptid-bindende proteiner og polynuldeotider som kodes for samme
NO20006192D0 (no)	2000-12-06	Angiostatin-bindingsprotein
NO20005547D0 (no)	2000-11-03	Myelinbasiske proteinpeptider og anvendelser derav
NO991227D0 (no)	1999-03-12	PTX-sensitive G-proteiner, deres fremstilling og bruk
ATA73796A (de)	1998-12-15	Snowboardbindung
DE59509523D1 (de)	2001-09-20	Snowboardbindung
DE60013052D1 (de)	2004-09-23	NADE bindende Proteine
ZA987310B (en)	2000-08-14	Interleukin-18 binding proteins, their preparation and use.
IL121639A0 (en)	1998-02-08	Interleukin-18 binding proteins their preparation and use
ATA116597A (de)	1998-12-15	Skibindung
AU2003200442A1 (en)	2003-04-10	Interleukin-18 binding proteins, their preparation and use
DE59809617D1 (de)	2003-10-23	Skibindung
ATA9397A (de)	1999-02-15	Skibindung