DK0959888T3 - Anvendelse af det chelerende middel clioquinol til fremstillingen af et farmaceutisk præparat til behandlingen af Alzheimer's sygdom - Google Patents

Anvendelse af det chelerende middel clioquinol til fremstillingen af et farmaceutisk præparat til behandlingen af Alzheimer's sygdom

Info

Publication number: DK0959888T3
Authority: DK; Denmark
Prior art keywords: clioquinol; pharmaceutical composition; alzheimer; disease; preparation
Prior art date: 1996-08-13

Application number

DK97932969T

Other languages

English (en)

Inventor

Nikolas Gerolymatos Panayotis

Original Assignee

Gerolymatos P N Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-13

Filing date

1997-08-08

Publication date

2001-11-05

1997-08-08 Application filed by Gerolymatos P N Sa filed Critical Gerolymatos P N Sa

2001-11-05 Application granted granted Critical

2001-11-05 Publication of DK0959888T3 publication Critical patent/DK0959888T3/da

Links

QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 title abstract 3
229960005228 clioquinol Drugs 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 3
208000024827 Alzheimer disease Diseases 0.000 title 1
239000002738 chelating agent Substances 0.000 title 1
229930003779 Vitamin B12 Natural products 0.000 abstract 1
239000000969 carrier Substances 0.000 abstract 1
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
239000011715 vitamin B12 Substances 0.000 abstract 1
235000019163 vitamin B12 Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK97932969T 1996-08-13 1997-08-08 Anvendelse af det chelerende middel clioquinol til fremstillingen af et farmaceutisk præparat til behandlingen af Alzheimer's sygdom DK0959888T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GR96100286		1996-08-13
PCT/IB1997/000983 WO1998006403A1 (en)	1996-08-13	1997-08-08	Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of alzheimer's disease

Publications (1)

Publication Number	Publication Date
DK0959888T3 true DK0959888T3 (da)	2001-11-05

Family

ID=10942479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97932969T DK0959888T3 (da)	1996-08-13	1997-08-08	Anvendelse af det chelerende middel clioquinol til fremstillingen af et farmaceutisk præparat til behandlingen af Alzheimer's sygdom

Country Status (26)

Country	Link
US (1)	US6001852A (da)
EP (1)	EP0959888B1 (da)
JP (1)	JP2000516606A (da)
KR (1)	KR100489969B1 (da)
CN (1)	CN1114407C (da)
AT (1)	ATE205086T1 (da)
AU (1)	AU720643B2 (da)
BR (1)	BR9711194A (da)
CA (1)	CA2264097C (da)
CZ (2)	CZ295118B6 (da)
DE (1)	DE69706566T2 (da)
DK (1)	DK0959888T3 (da)
ES (1)	ES2162319T3 (da)
HK (1)	HK1022437A1 (da)
HU (1)	HUP9903906A3 (da)
IL (1)	IL128416A (da)
IS (1)	IS1907B (da)
NO (1)	NO990595L (da)
NZ (1)	NZ334124A (da)
PL (1)	PL188838B1 (da)
PT (1)	PT959888E (da)
RU (1)	RU2193406C2 (da)
SI (1)	SI0959888T1 (da)
SK (1)	SK283117B6 (da)
TR (1)	TR199900293T2 (da)
WO (1)	WO1998006403A1 (da)

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US7045531B1 (en)	1997-03-11	2006-05-16	The General Hospital Corporation	Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
EP1007040B1 (en) *	1997-08-21	2002-05-08	P.N. Gerolymatos S.A.	Use of phanquinone for the treatment of alzheimer's disease
AU760140B2 (en) *	1997-10-24	2003-05-08	John P. Blass	Nutritional supplement for cerebral metabolic insufficiencies
US5994323A (en) *	1997-12-31	1999-11-30	P.N. Gerolymatos S.A.	Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof
US20020025944A1 (en) *	2000-04-28	2002-02-28	Bush Ashley I.	Use of clioquinol for the therapy of Alzheimer's disease
US20050112543A1 (en) *	1998-03-11	2005-05-26	The General Hospital Corporation	Method of screening for drugs useful in treating Alzheimer's disease
US6323218B1 (en) *	1998-03-11	2001-11-27	The General Hospital Corporation	Agents for use in the treatment of Alzheimer's disease
US6638711B1 (en)	1999-04-29	2003-10-28	The General Hospital Corporation	Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
WO2000040244A1 (en) *	1999-01-07	2000-07-13	P.N. Gerolymatos S.A.	Use of phanquinone for the treatment or prevention of memory impairment
US6692234B2 (en)	1999-03-22	2004-02-17	Water Management Systems	Pump system with vacuum source
US20040054182A1 (en) *	2000-02-09	2004-03-18	Hideo Kato	1h-imidazopyridine derivatives
FR2818551B1 (fr) *	2000-12-22	2007-06-01	Claude Marc Pierre Hannoun	Utilisation de chelateurs pour le traitement des maladies a prions
US6803379B2 (en) *	2002-06-04	2004-10-12	Jose A. Fernandez-Pol	Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets
AU2002950217A0 (en) *	2002-07-16	2002-09-12	Prana Biotechnology Limited	8- Hydroxy Quinoline Derivatives
KR101122782B1 (ko) *	2002-10-04	2012-04-12	프라나 바이오테크놀로지 리미티드	신경 활성 화합물
US20080063599A1 (en) *	2002-11-18	2008-03-13	Jorge Setoain Quinquer	Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils
US20070037848A1 (en) *	2003-04-03	2007-02-15	Masters Colin L	Treatment of neurological conditions
US20070275943A1 (en) *	2003-11-19	2007-11-29	Acrux Dds Pty Ltd.	Method and Composition for Treatment or Prophylaxis of Amyloidosis Disorders
US20060194723A1 (en) *	2005-02-28	2006-08-31	Rabinoff Michael D	Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement
US8871715B2 (en)	2005-10-14	2014-10-28	Alltech, Inc.	Use of selenium compounds, especially selenium yeasts for altering cognitive function
CN101073584B (zh) *	2005-10-14	2012-10-10	全面技术公司	改变细胞功能的方法和组合物
US8865763B2 (en)	2005-10-14	2014-10-21	Alltech, Inc.	Methods and compositions for altering cell function
BRPI0619249A2 (pt) *	2005-11-30	2011-09-20	Abbott Lab	anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
CN101987849B (zh) *	2006-04-14	2013-05-08	普拉纳生物技术有限公司	治疗与年龄相关的黄斑变性(amd)的方法
EP2046833B9 (en) *	2006-07-14	2014-02-19	AC Immune S.A.	Humanized antibody against amyloid beta
CN101516911B (zh) *	2006-07-14	2016-11-16	Ac免疫有限公司	针对淀粉状蛋白β的人源化抗体
US8613923B2 (en)	2007-06-12	2013-12-24	Ac Immune S.A.	Monoclonal antibody
US8048420B2 (en)	2007-06-12	2011-11-01	Ac Immune S.A.	Monoclonal antibody
US9403902B2 (en)	2007-10-05	2016-08-02	Ac Immune S.A.	Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
ES2332687B1 (es) *	2008-03-13	2011-01-10	Proyecto De Biomedicina Cima, S.L.	Nuevos usos de 4pba y sus sales farmaceuticamente aceptables.
NZ606357A (en)	2010-07-30	2015-05-29	Genentech Inc	Safe and functional humanized anti beta-amyloid antibody
FR2966827B1 (fr)	2010-10-27	2014-08-22	Kimonella Ventures Ltd	Compose peptidique utile pour l'inhibition de la formation de plaques amyloides
KR101802048B1 (ko) *	2013-04-02	2017-12-28	안지 파마슈티컬 코퍼레이션 리미티드	항신경퇴행성제로서의 다작용성 퀴놀린 유도체
JP6461922B2 (ja)	2014-04-24	2019-01-30	想い出創造株式会社	アミロイド線維形成の抑制又は阻害剤
KR20160057500A (ko) *	2014-11-05	2016-05-24	아카데미아 시니카	클리오퀴놀을 포함하는 자폐증 스펙트럼 장애의 치료용 약학적 조성물

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US3174899A (en) *	1960-12-30	1965-03-23	Ciba Geigy Corp	Composition for the management of post antibiotic enteritis
US3178343A (en) *	1962-11-27	1965-04-13	Ciba Geigy Corp	Pharmaceutical compositions and method of using same
DE1617417A1 (de) *	1966-12-08	1971-03-25	Ciba Geigy	Pharmazeutisches Praeparat
DE3932338A1 (de) *	1989-09-28	1991-04-11	Nmi Naturwissenschaftl U Mediz	Verfahren zur praeventiven therapie von morbus alzheimer
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GB9108080D0 (en) *	1991-04-15	1991-06-05	Smithkline Beecham Plc	Pharmaceutical composition
US5206264A (en) *	1991-11-04	1993-04-27	Cypros Pharmaceutical Corporation	Use of disulfiram to prevent cardiovascular damage
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US5505958A (en) *	1994-10-31	1996-04-09	Algos Pharmaceutical Corporation	Transdermal drug delivery device and method for its manufacture

1997
- 1997-08-08 JP JP10509541A patent/JP2000516606A/ja active Pending
- 1997-08-08 EP EP97932969A patent/EP0959888B1/en not_active Expired - Lifetime
- 1997-08-08 SK SK179-99A patent/SK283117B6/sk not_active IP Right Cessation
- 1997-08-08 CZ CZ2003491A patent/CZ295118B6/cs not_active IP Right Cessation
- 1997-08-08 KR KR10-1999-7001196A patent/KR100489969B1/ko not_active IP Right Cessation
- 1997-08-08 PL PL97331822A patent/PL188838B1/pl not_active IP Right Cessation
- 1997-08-08 BR BR9711194-5A patent/BR9711194A/pt not_active Application Discontinuation
- 1997-08-08 RU RU99105213/14A patent/RU2193406C2/ru not_active IP Right Cessation
- 1997-08-08 NZ NZ334124A patent/NZ334124A/xx unknown
- 1997-08-08 DK DK97932969T patent/DK0959888T3/da active
- 1997-08-08 IL IL12841697A patent/IL128416A/en not_active IP Right Cessation
- 1997-08-08 WO PCT/IB1997/000983 patent/WO1998006403A1/en active IP Right Grant
- 1997-08-08 DE DE69706566T patent/DE69706566T2/de not_active Expired - Lifetime
- 1997-08-08 AT AT97932969T patent/ATE205086T1/de not_active IP Right Cessation
- 1997-08-08 PT PT97932969T patent/PT959888E/pt unknown
- 1997-08-08 ES ES97932969T patent/ES2162319T3/es not_active Expired - Lifetime
- 1997-08-08 SI SI9730230T patent/SI0959888T1/xx unknown
- 1997-08-08 CN CN97197919A patent/CN1114407C/zh not_active Expired - Fee Related
- 1997-08-08 CZ CZ1999484A patent/CZ292411B6/cs not_active IP Right Cessation
- 1997-08-08 TR TR1999/00293T patent/TR199900293T2/xx unknown
- 1997-08-08 HU HU9903906A patent/HUP9903906A3/hu unknown
- 1997-08-08 AU AU36324/97A patent/AU720643B2/en not_active Ceased
- 1997-08-08 CA CA002264097A patent/CA2264097C/en not_active Expired - Fee Related
1998
- 1998-02-13 US US09/023,544 patent/US6001852A/en not_active Expired - Lifetime
1999
- 1999-02-09 NO NO990595A patent/NO990595L/no not_active Application Discontinuation
- 1999-02-10 IS IS4972A patent/IS1907B/is unknown
2000
- 2000-03-16 HK HK00101601A patent/HK1022437A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69706566T2 (de)	2002-07-11
PL331822A1 (en)	1999-08-02
ATE205086T1 (de)	2001-09-15
IS4972A (is)	1999-02-10
NZ334124A (en)	2000-10-27
US6001852A (en)	1999-12-14
HK1022437A1 (en)	2000-08-11
PL188838B1 (pl)	2005-04-29
TR199900293T2 (xx)	1999-06-21
SI0959888T1 (en)	2002-10-31
HUP9903906A3 (en)	2001-01-29
KR100489969B1 (ko)	2005-05-17
ES2162319T3 (es)	2001-12-16
AU3632497A (en)	1998-03-06
CZ292411B6 (cs)	2003-09-17
NO316768B1 (no)	1999-04-12
EP0959888B1 (en)	2001-09-05
CZ295118B6 (cs)	2005-05-18
SK17999A3 (en)	1999-09-10
WO1998006403A1 (en)	1998-02-19
KR20000029958A (ko)	2000-05-25
BR9711194A (pt)	2000-01-11
AU720643B2 (en)	2000-06-08
EP0959888A1 (en)	1999-12-01
JP2000516606A (ja)	2000-12-12
CZ48499A3 (cs)	1999-07-14
CN1230115A (zh)	1999-09-29
NO990595L (no)	1999-04-12
IL128416A (en)	2004-06-01
CA2264097A1 (en)	1998-02-19
IL128416A0 (en)	2000-01-31
RU2193406C2 (ru)	2002-11-27
NO990595D0 (no)	1999-02-09
DE69706566D1 (de)	2001-10-11
PT959888E (pt)	2002-02-28
CA2264097C (en)	2007-11-27
HUP9903906A2 (hu)	2000-04-28
SK283117B6 (sk)	2003-02-04
IS1907B (is)	2003-12-16
CN1114407C (zh)	2003-07-16

Publication	Publication Date	Title
DK0959888T3 (da)	2001-11-05	Anvendelse af det chelerende middel clioquinol til fremstillingen af et farmaceutisk præparat til behandlingen af Alzheimer's sygdom
DK1346041T3 (da)	2007-07-02	Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom
MY127980A (en)	2007-01-31	A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
IL133976A0 (en)	2001-04-30	Agents for the treatment of skin disorders
DK0998287T3 (da)	2003-09-01	Anvendelse af levobupivacain
MY111260A (en)	1999-10-30	Pharmaceutical composition for the treatment of nicotine dependence
NO972391D0 (no)	1997-05-26	2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
HK1030885A1 (en)	2001-05-25	The use of isatin and oxindole derivatives in the preparation of a medicament for use in the treatment of mycobacterial disease
GB9103764D0 (en)	1991-04-10	Compositions
DK1007040T3 (da)	2002-08-26	Anvendelsen af phanquinon til behandlingen af Alzheimers sygdom
NO943288L (no)	1995-03-22	Anvendelse av pentoksyfyllin ved fremstilling av farmasöytiske preparater til behandling av granulomatöse og fibroserende lungesykdommer
PT966285E (pt)	2002-12-31	Utilizacao de (+)mefloquina para o tratamento da malaria
ATE360428T1 (de)	2007-05-15	Analgetisches arzneimittel
MX9707642A (es)	1997-12-31	Uso de 2-oxoindol-1-carboxamidas 3-sustituidas y sus sales de base farmaceuticamente aceptables para preparar composiciones para el tratamiento y prevencion de la enfermedad de alzheimer en mamiferos, incluyendo a humanos.
DK0633879T3 (da)	1998-09-28	Enantiomert 1-phenyl-2(2-pyridinyl) ethylamin til behandling af neurodegenerative sygdomme
SE0001916D0 (sv)	2000-05-23	Novel formulation
DK0500953T3 (da)	1997-01-06	Potentiator af antineoplastisk virkning og antineoplastisk middel
BG106151A (en)	2002-05-31	Pharmaceutical complex
SE9602262D0 (sv)	1996-06-06	New use of derivatives of cystine
SE9500897D0 (sv)	1995-03-14	The pharmacological use of certain cystine derivatives
FR2818147B1 (fr)	2005-06-10	Nouvelle application therapeutique d'un derive de la thienyclyclohexylamine
FI972637A0 (fi)	1997-06-19	K-ryhmän vitamiinin käyttö lisäkilpirauhasen liikatoiminnan hoitoon
RS49595B (sr)	2007-06-04	Primena 2-fenil-1,2- benzizoselenazol-3(2h)-ona za izradu farmaceutskog preparata za lečenje alchajmerove bolesti