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DK0854874T3 - Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse - Google Patents

Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse

Info

Publication number
DK0854874T3
DK0854874T3 DK95932876T DK95932876T DK0854874T3 DK 0854874 T3 DK0854874 T3 DK 0854874T3 DK 95932876 T DK95932876 T DK 95932876T DK 95932876 T DK95932876 T DK 95932876T DK 0854874 T3 DK0854874 T3 DK 0854874T3
Authority
DK
Denmark
Prior art keywords
macrocyclic lactone
processes
preparation
lactone compounds
compound
Prior art date
Application number
DK95932876T
Other languages
English (en)
Inventor
Pharm Inc Nagoya Plan H-Pfizer
Phar Inc Nagoyaplant Y-Pfizer
Phar Inc Nagoya Plant T-Pfizer
Phar Inc Nagoya Plant Y-Pfizer
Pharm Inc Nagoya Plan N-Pfizer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0854874T3 publication Critical patent/DK0854874T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
DK95932876T 1994-11-10 1995-10-13 Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse DK0854874T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9401896 1994-11-10
PCT/IB1995/000870 WO1996015131A1 (en) 1994-11-10 1995-10-13 Macrocyclic lactone compounds and their production process

Publications (1)

Publication Number Publication Date
DK0854874T3 true DK0854874T3 (da) 2003-06-02

Family

ID=1341416

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95932876T DK0854874T3 (da) 1994-11-10 1995-10-13 Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse

Country Status (12)

Country Link
US (2) US6001998A (da)
EP (1) EP0854874B1 (da)
JP (1) JP3061863B2 (da)
AT (1) ATE239024T1 (da)
CA (1) CA2204739C (da)
DE (1) DE69530616T2 (da)
DK (1) DK0854874T3 (da)
ES (1) ES2194054T3 (da)
FI (1) FI971995L (da)
MX (1) MX9703484A (da)
PT (1) PT854874E (da)
WO (1) WO1996015131A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3061863B2 (ja) * 1994-11-10 2000-07-10 ファイザー製薬株式会社 大環状ラクトン化合物及びその製法
EP1383497B1 (en) * 2001-05-02 2008-10-15 Blanchette Rockefeller Neurosciences Institute Carbonic anhydrase activators for enhancing learning and memory
US6551591B1 (en) 2001-09-07 2003-04-22 Essential Therapeutics, Inc. Antibiotics from microbispora
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
AU2005280639A1 (en) * 2004-02-17 2006-03-09 Billy T. Fowler Methods, compositions, and apparatuses for forming macrocyclic compounds
TW200538181A (en) 2004-05-18 2005-12-01 Brni Neurosciences Inst Treatment of depressive disorders
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006091717A1 (en) * 2005-02-24 2006-08-31 Biocern, Inc. Sperm cell separation methods and compositions
WO2006119211A2 (en) * 2005-05-02 2006-11-09 Genaera Corporation Methods and compositions for treating ocular disorders
US20070054890A1 (en) 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
KR20090038478A (ko) 2006-07-28 2009-04-20 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 세포 성장 자극, 시냅스 리모델링 및 장기간 기억 강화 방법
CA2697960A1 (en) * 2006-08-30 2008-03-06 Biocern, Inc. Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
JP6049160B2 (ja) 2006-09-13 2016-12-27 エリクシアー メディカル コーポレイション 大環状ラクトン化合物およびその使用方法
US8088789B2 (en) 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US20090036514A1 (en) 2007-02-09 2009-02-05 Sun Miao-Kun Therapeutic effects of Bryostatins, Bryologs, and other related substances on Ischemia/stroke-induced memory impairment and brain injury
CN101848726A (zh) 2007-02-09 2010-09-29 布朗歇特洛克菲勒神经科学研究所 苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效
US8410066B2 (en) * 2009-05-01 2013-04-02 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
DK2473161T3 (da) * 2009-08-31 2017-09-11 Dr Reddys Laboratories Ltd Topiske formulationer, der omfatter et steroid
CA2804789A1 (en) 2010-07-08 2012-01-12 Daniel L. Alkon Pkc activators and anticoagulant in regimen for treating stroke
CA2808660A1 (en) 2010-08-19 2012-02-23 Blanchette Rockefeller Neurosciences Institute Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators
US10821079B2 (en) 2011-11-13 2020-11-03 Cognitive Research Enterprises, Inc. PKC activators and combinations thereof
WO2016183252A1 (en) 2015-05-11 2016-11-17 Alkon, Daniel, L. Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
RU2629653C1 (ru) * 2016-03-21 2017-08-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет " (ЮЗГУ) Мостовой измеритель параметров двухполюсников
CN107827803A (zh) * 2017-11-28 2018-03-23 绍兴厚普生物科技有限责任公司 一种从发酵液中提取l‑羟脯氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1910715A1 (de) * 1968-03-04 1969-10-09 Stanley Drug Products Inc Antimikrobielle Faktoren und deren Verwendung
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
US5674732A (en) * 1992-04-27 1997-10-07 Pfizer Inc. Rapamycin producer
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
JP3061863B2 (ja) * 1994-11-10 2000-07-10 ファイザー製薬株式会社 大環状ラクトン化合物及びその製法

Also Published As

Publication number Publication date
DE69530616T2 (de) 2004-04-01
FI971995A0 (fi) 1997-05-09
US6187568B1 (en) 2001-02-13
EP0854874A1 (en) 1998-07-29
ES2194054T3 (es) 2003-11-16
DE69530616D1 (de) 2003-06-05
JP3061863B2 (ja) 2000-07-10
EP0854874B1 (en) 2003-05-02
PT854874E (pt) 2003-07-31
WO1996015131A1 (en) 1996-05-23
US6001998A (en) 1999-12-14
CA2204739C (en) 2000-04-04
ATE239024T1 (de) 2003-05-15
JPH11507907A (ja) 1999-07-13
FI971995L (fi) 1997-05-09
MX9703484A (es) 1997-08-30

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