ATE239024T1 - Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung - Google Patents
Macrocyklische lactonverbindungen und verfahren zu ihrer herstellungInfo
- Publication number
- ATE239024T1 ATE239024T1 AT95932876T AT95932876T ATE239024T1 AT E239024 T1 ATE239024 T1 AT E239024T1 AT 95932876 T AT95932876 T AT 95932876T AT 95932876 T AT95932876 T AT 95932876T AT E239024 T1 ATE239024 T1 AT E239024T1
- Authority
- AT
- Austria
- Prior art keywords
- macrocyclic lactone
- production
- lactone compounds
- compound
- lactone compound
- Prior art date
Links
- -1 LACTONE COMPOUNDS Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- XJLSEXAGTJCILF-RXMQYKEDSA-N (R)-nipecotic acid zwitterion Chemical compound OC(=O)[C@@H]1CCCNC1 XJLSEXAGTJCILF-RXMQYKEDSA-N 0.000 abstract 1
- 241000187712 Actinoplanes sp. Species 0.000 abstract 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- 229930182821 L-proline Natural products 0.000 abstract 1
- 230000001857 anti-mycotic effect Effects 0.000 abstract 1
- 239000002543 antimycotic Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9401896 | 1994-11-10 | ||
| PCT/IB1995/000870 WO1996015131A1 (en) | 1994-11-10 | 1995-10-13 | Macrocyclic lactone compounds and their production process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239024T1 true ATE239024T1 (de) | 2003-05-15 |
Family
ID=1341416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95932876T ATE239024T1 (de) | 1994-11-10 | 1995-10-13 | Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6001998A (de) |
| EP (1) | EP0854874B1 (de) |
| JP (1) | JP3061863B2 (de) |
| AT (1) | ATE239024T1 (de) |
| CA (1) | CA2204739C (de) |
| DE (1) | DE69530616T2 (de) |
| DK (1) | DK0854874T3 (de) |
| ES (1) | ES2194054T3 (de) |
| FI (1) | FI971995L (de) |
| MX (1) | MX9703484A (de) |
| PT (1) | PT854874E (de) |
| WO (1) | WO1996015131A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3061863B2 (ja) * | 1994-11-10 | 2000-07-10 | ファイザー製薬株式会社 | 大環状ラクトン化合物及びその製法 |
| EP1383497B1 (de) * | 2001-05-02 | 2008-10-15 | Blanchette Rockefeller Neurosciences Institute | Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung |
| US6551591B1 (en) | 2001-09-07 | 2003-04-22 | Essential Therapeutics, Inc. | Antibiotics from microbispora |
| US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| US20080004332A1 (en) * | 2002-03-07 | 2008-01-03 | Alkon Daniel L | Methods for alzheimer's disease treatment and cognitive enhancement |
| US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| AU2005280639A1 (en) * | 2004-02-17 | 2006-03-09 | Billy T. Fowler | Methods, compositions, and apparatuses for forming macrocyclic compounds |
| TW200538181A (en) | 2004-05-18 | 2005-12-01 | Brni Neurosciences Inst | Treatment of depressive disorders |
| CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| WO2006091717A1 (en) * | 2005-02-24 | 2006-08-31 | Biocern, Inc. | Sperm cell separation methods and compositions |
| WO2006119211A2 (en) * | 2005-05-02 | 2006-11-09 | Genaera Corporation | Methods and compositions for treating ocular disorders |
| US20070054890A1 (en) | 2005-07-29 | 2007-03-08 | Alkon Daniel L | Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning |
| KR20090038478A (ko) | 2006-07-28 | 2009-04-20 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 세포 성장 자극, 시냅스 리모델링 및 장기간 기억 강화 방법 |
| CA2697960A1 (en) * | 2006-08-30 | 2008-03-06 | Biocern, Inc. | Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein |
| US10695327B2 (en) | 2006-09-13 | 2020-06-30 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| JP6049160B2 (ja) | 2006-09-13 | 2016-12-27 | エリクシアー メディカル コーポレイション | 大環状ラクトン化合物およびその使用方法 |
| US8088789B2 (en) | 2006-09-13 | 2012-01-03 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US20090036514A1 (en) | 2007-02-09 | 2009-02-05 | Sun Miao-Kun | Therapeutic effects of Bryostatins, Bryologs, and other related substances on Ischemia/stroke-induced memory impairment and brain injury |
| CN101848726A (zh) | 2007-02-09 | 2010-09-29 | 布朗歇特洛克菲勒神经科学研究所 | 苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效 |
| US8410066B2 (en) * | 2009-05-01 | 2013-04-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors |
| DK2473161T3 (en) * | 2009-08-31 | 2017-09-11 | Dr Reddys Laboratories Ltd | TOPICAL FORMULATIONS INCLUDING A STEROID |
| CA2804789A1 (en) | 2010-07-08 | 2012-01-12 | Daniel L. Alkon | Pkc activators and anticoagulant in regimen for treating stroke |
| CA2808660A1 (en) | 2010-08-19 | 2012-02-23 | Blanchette Rockefeller Neurosciences Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
| US10821079B2 (en) | 2011-11-13 | 2020-11-03 | Cognitive Research Enterprises, Inc. | PKC activators and combinations thereof |
| WO2016183252A1 (en) | 2015-05-11 | 2016-11-17 | Alkon, Daniel, L. | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| RU2629653C1 (ru) * | 2016-03-21 | 2017-08-30 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет " (ЮЗГУ) | Мостовой измеритель параметров двухполюсников |
| CN107827803A (zh) * | 2017-11-28 | 2018-03-23 | 绍兴厚普生物科技有限责任公司 | 一种从发酵液中提取l‑羟脯氨酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1910715A1 (de) * | 1968-03-04 | 1969-10-09 | Stanley Drug Products Inc | Antimikrobielle Faktoren und deren Verwendung |
| US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| US5674732A (en) * | 1992-04-27 | 1997-10-07 | Pfizer Inc. | Rapamycin producer |
| CA2106034A1 (en) * | 1992-09-24 | 1994-03-25 | Ralph J. Russo | 21-norrapamycin |
| JP3061863B2 (ja) * | 1994-11-10 | 2000-07-10 | ファイザー製薬株式会社 | 大環状ラクトン化合物及びその製法 |
-
1995
- 1995-10-13 JP JP8515869A patent/JP3061863B2/ja not_active Expired - Lifetime
- 1995-10-13 DK DK95932876T patent/DK0854874T3/da active
- 1995-10-13 ES ES95932876T patent/ES2194054T3/es not_active Expired - Lifetime
- 1995-10-13 US US08/836,213 patent/US6001998A/en not_active Expired - Fee Related
- 1995-10-13 PT PT95932876T patent/PT854874E/pt unknown
- 1995-10-13 EP EP95932876A patent/EP0854874B1/de not_active Expired - Lifetime
- 1995-10-13 WO PCT/IB1995/000870 patent/WO1996015131A1/en active IP Right Grant
- 1995-10-13 CA CA002204739A patent/CA2204739C/en not_active Expired - Fee Related
- 1995-10-13 MX MX9703484A patent/MX9703484A/es not_active IP Right Cessation
- 1995-10-13 DE DE69530616T patent/DE69530616T2/de not_active Expired - Fee Related
- 1995-10-13 AT AT95932876T patent/ATE239024T1/de not_active IP Right Cessation
-
1997
- 1997-05-09 FI FI971995A patent/FI971995L/fi not_active IP Right Cessation
-
1999
- 1999-08-20 US US09/378,062 patent/US6187568B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69530616T2 (de) | 2004-04-01 |
| FI971995A0 (fi) | 1997-05-09 |
| US6187568B1 (en) | 2001-02-13 |
| EP0854874A1 (de) | 1998-07-29 |
| DK0854874T3 (da) | 2003-06-02 |
| ES2194054T3 (es) | 2003-11-16 |
| DE69530616D1 (de) | 2003-06-05 |
| JP3061863B2 (ja) | 2000-07-10 |
| EP0854874B1 (de) | 2003-05-02 |
| PT854874E (pt) | 2003-07-31 |
| WO1996015131A1 (en) | 1996-05-23 |
| US6001998A (en) | 1999-12-14 |
| CA2204739C (en) | 2000-04-04 |
| JPH11507907A (ja) | 1999-07-13 |
| FI971995L (fi) | 1997-05-09 |
| MX9703484A (es) | 1997-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0854874 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |