|
US6150328A
(en)
|
1986-07-01 |
2000-11-21 |
Genetics Institute, Inc. |
BMP products
|
|
US7393682B1
(en)
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
|
US6465239B1
(en)
|
1993-03-19 |
2002-10-15 |
The John Hopkins University School Of Medicine |
Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
|
|
US7566768B1
(en)
|
1995-10-26 |
2009-07-28 |
The Johns Hopkins University School Of Medicine |
Promyostatin peptides and methods of using same
|
|
US5827733A
(en)
|
1993-03-19 |
1998-10-27 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-8 (GDF-8) and polynucleotides encoding same
|
|
US6607884B1
(en)
|
1993-03-19 |
2003-08-19 |
The Johns Hopkins University School Of Medicine |
Methods of detecting growth differentiation factor-8
|
|
EP1770161A3
(en)
|
1993-05-12 |
2008-04-23 |
Genetics Institute, LLC |
BMP-11 compositions
|
|
US6291206B1
(en)
|
1993-09-17 |
2001-09-18 |
Genetics Institute, Inc. |
BMP receptor proteins
|
|
ATE319823T1
(de)
|
1993-12-07 |
2006-03-15 |
Inst Genetics Llc |
Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen
|
|
US7332575B2
(en)
|
1994-03-18 |
2008-02-19 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
|
|
US20030167492A1
(en)
*
|
1994-07-08 |
2003-09-04 |
Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
|
|
US6008434A
(en)
|
1994-07-08 |
1999-12-28 |
Johns Hopkins University School Of Medicine |
Growth differentiation factor-11 transgenic mice
|
|
US5846770A
(en)
*
|
1994-11-22 |
1998-12-08 |
Genetics Institute, Inc. |
DNA molecules encoding human chordin
|
|
US6524802B1
(en)
*
|
1996-03-29 |
2003-02-25 |
The Johns Hopkins University School Of Medicine |
Methods of detecting growth differentiation factor-14
|
|
US5965403A
(en)
|
1996-09-18 |
1999-10-12 |
Genetics Institute, Inc. |
Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
|
|
US7041641B2
(en)
|
1997-03-20 |
2006-05-09 |
Stryker Corporation |
Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
|
|
US20010016646A1
(en)
|
1998-03-20 |
2001-08-23 |
David C. Rueger |
Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
|
|
EP0985149A1
(en)
|
1997-05-30 |
2000-03-15 |
Creative Biomolecules, Inc. |
Methods for evaluating tissue morphogenesis and activity
|
|
US6696260B1
(en)
*
|
1997-08-01 |
2004-02-24 |
The Johns Hopkins University School Of Medicine |
Methods to identify growth differentiation factor (GDF) binding proteins
|
|
US6891082B2
(en)
*
|
1997-08-01 |
2005-05-10 |
The Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a truncated activintype II receptor
|
|
US20020052026A1
(en)
|
1997-10-08 |
2002-05-02 |
Steven M. Vicik |
Methods of refolding proteins
|
|
WO1999024057A2
(en)
*
|
1997-11-07 |
1999-05-20 |
Genetics Inst |
Neuronal uses of bmp-11
|
|
US6027917A
(en)
|
1997-12-10 |
2000-02-22 |
Genetics Institute, Inc. |
Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
|
|
WO1999040181A1
(en)
*
|
1998-02-05 |
1999-08-12 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-8
|
|
US6369201B1
(en)
*
|
1998-02-19 |
2002-04-09 |
Metamorphix International, Inc. |
Myostatin multimers
|
|
US7147839B2
(en)
|
1998-05-29 |
2006-12-12 |
Curis, Inc. |
Methods for evaluating tissue morphogenesis and activity
|
|
AU765832B2
(en)
*
|
1998-07-28 |
2003-10-02 |
Johns Hopkins University School Of Medicine, The |
Growth differentiation factor-11
|
|
EP1147413B1
(en)
*
|
1999-01-21 |
2006-04-05 |
Metamorphix, Inc. |
Growth differentiation factor inhibitors and uses therefor
|
|
US6727224B1
(en)
|
1999-02-01 |
2004-04-27 |
Genetics Institute, Llc. |
Methods and compositions for healing and repair of articular cartilage
|
|
US6555374B1
(en)
*
|
1999-08-19 |
2003-04-29 |
Artecel Sciences, Inc. |
Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
|
|
DK1223990T3
(da)
|
1999-10-15 |
2004-11-29 |
Inst Genetics Llc |
Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
|
|
TWI329129B
(en)
*
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
|
KR100420798B1
(ko)
*
|
2001-02-10 |
2004-03-02 |
(주)알에이싸이언스 |
펩타이드 벡터
|
|
EP1399023B1
(en)
|
2001-06-01 |
2008-04-30 |
Wyeth |
COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9;
|
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
US6798160B2
(en)
*
|
2001-11-02 |
2004-09-28 |
Honda Giken Kogyo Kabushiki Kaisha |
Electric working machine
|
|
GB2385052A
(en)
|
2002-02-05 |
2003-08-13 |
Leuven K U Res & Dev |
Treatment of spondyloarthropathies
|
|
KR20040094709A
(ko)
|
2002-02-21 |
2004-11-10 |
와이어쓰 |
폴리스타틴 도메인을 포함하는 단백질
|
|
BR0307871A
(pt)
*
|
2002-02-21 |
2005-04-12 |
Wyeth Corp |
Proteìnas contendo domìnio de folistatina
|
|
US20040172667A1
(en)
|
2002-06-26 |
2004-09-02 |
Cooper Richard K. |
Administration of transposon-based vectors to reproductive organs
|
|
US7527966B2
(en)
|
2002-06-26 |
2009-05-05 |
Transgenrx, Inc. |
Gene regulation in transgenic animals using a transposon-based vector
|
|
ATE461275T1
(de)
*
|
2002-09-16 |
2010-04-15 |
Univ Johns Hopkins |
Metalloproteaseaktivierung von myostatin und verfahren zur modulation der myostatinaktivität
|
|
AR047392A1
(es)
|
2002-10-22 |
2006-01-18 |
Wyeth Corp |
Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
|
|
US20040223966A1
(en)
*
|
2002-10-25 |
2004-11-11 |
Wolfman Neil M. |
ActRIIB fusion polypeptides and uses therefor
|
|
KR20060026860A
(ko)
*
|
2003-06-02 |
2006-03-24 |
와이어쓰 |
신경근 장애의 치료를 위한, 코르티코스테로이드와 조합된미오스타틴 (gdf8) 저해제의 용도
|
|
CN101897974B
(zh)
|
2003-09-12 |
2013-09-25 |
惠氏公司 |
用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂
|
|
WO2005062881A2
(en)
*
|
2003-12-24 |
2005-07-14 |
Transgenrx, Inc. |
Gene therapy using transposon-based vectors
|
|
US8372419B2
(en)
|
2004-03-10 |
2013-02-12 |
Scil Technology Gmbh |
Coated implants, their manufacturing and use thereof
|
|
EP1740609A2
(en)
|
2004-04-27 |
2007-01-10 |
Research Development Foundation |
Antagonism of tgf-beta superfamily receptor signaling
|
|
EP1763362B1
(en)
|
2004-05-25 |
2011-07-06 |
Stryker Corporation |
Use of op-1 for treating cartilage defects
|
|
US20060034831A1
(en)
*
|
2004-08-12 |
2006-02-16 |
Wyeth |
Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors
|
|
US7473678B2
(en)
|
2004-10-14 |
2009-01-06 |
Biomimetic Therapeutics, Inc. |
Platelet-derived growth factor compositions and methods of use thereof
|
|
BRPI0609439A2
(pt)
*
|
2005-03-23 |
2010-04-06 |
Wyeth Corp |
detecção de uma resposta imunológica a agentes moduladores de gdf-8
|
|
CA2601667A1
(en)
*
|
2005-03-23 |
2006-09-28 |
Wyeth |
Detection of gdf-8 modulating agents
|
|
ES2533464T3
(es)
|
2005-10-06 |
2015-04-10 |
Eli Lilly And Company |
Anticuerpos anti-miostatina
|
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
|
US8147860B2
(en)
|
2005-12-06 |
2012-04-03 |
Etex Corporation |
Porous calcium phosphate bone material
|
|
WO2007092622A2
(en)
|
2006-02-09 |
2007-08-16 |
Biomimetic Therapeutics, Inc. |
Compositions and methods for treating bone
|
|
JP5219359B2
(ja)
|
2006-02-21 |
2013-06-26 |
日東電工株式会社 |
反射性及び/又は遮光性を有する粘着テープ又はシート、および液晶表示装置
|
|
CA2652549A1
(en)
|
2006-05-17 |
2007-12-13 |
Stryker Corporation |
Use of a soluble morphogenic protein complex for treating cartilage defects
|
|
WO2008005427A2
(en)
|
2006-06-30 |
2008-01-10 |
Biomimetic Therapeutics, Inc. |
Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
|
|
US9161967B2
(en)
|
2006-06-30 |
2015-10-20 |
Biomimetic Therapeutics, Llc |
Compositions and methods for treating the vertebral column
|
|
US8524265B2
(en)
|
2006-08-17 |
2013-09-03 |
Warsaw Orthopedic, Inc. |
Medical implant sheets useful for tissue regeneration
|
|
CN101511871B
(zh)
*
|
2006-09-05 |
2012-07-18 |
伊莱利利公司 |
抗肌肉生长抑制因子抗体
|
|
AU2007234612B2
(en)
|
2006-12-14 |
2013-06-27 |
Johnson & Johnson Regenerative Therapeutics, Llc |
Protein stabilization formulations
|
|
ES2447516T3
(es)
|
2006-12-21 |
2014-03-12 |
Stryker Corporation |
Formulaciones de liberación sostenida que comprenden cristales BMP-7
|
|
US7678764B2
(en)
|
2007-06-29 |
2010-03-16 |
Johnson & Johnson Regenerative Therapeutics, Llc |
Protein formulations for use at elevated temperatures
|
|
WO2009020744A1
(en)
|
2007-08-07 |
2009-02-12 |
Johnson & Johnson Regenerative Therapeutics, Llc |
Protein formulations comprising gdf-5 in aqueous acidic solution
|
|
PE20091163A1
(es)
*
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
JP2011514331A
(ja)
|
2008-02-13 |
2011-05-06 |
キース フルスカ, |
血管硬化症の治療における使用のためのbmp−7
|
|
EP2276458A1
(en)
|
2008-04-14 |
2011-01-26 |
Advanced Technologies and Regenerative Medicine, LLC |
Liquid buffered gdf-5 formulations
|
|
US8216997B2
(en)
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
|
BRPI0918611B8
(pt)
|
2008-09-09 |
2021-06-22 |
Biomimetic Therapeutics Inc |
composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit
|
|
WO2010036978A2
(en)
|
2008-09-25 |
2010-04-01 |
Transgenrx, Inc. |
Novel vectors for production of growth hormone
|
|
WO2010036976A2
(en)
|
2008-09-25 |
2010-04-01 |
Transgenrx, Inc. |
Novel vectors for production of antibodies
|
|
CN102369016A
(zh)
|
2009-02-12 |
2012-03-07 |
史赛克公司 |
用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用
|
|
SG173634A1
(en)
|
2009-02-12 |
2011-09-29 |
Stryker Corp |
COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS
|
|
US20120148539A1
(en)
|
2009-03-24 |
2012-06-14 |
Moulay Hicham Alaoui-Ismaili |
Methods and Compositions for Tissue Engineering
|
|
US8609127B2
(en)
|
2009-04-03 |
2013-12-17 |
Warsaw Orthopedic, Inc. |
Medical implant with bioactive material and method of making the medical implant
|
|
EP2417263B1
(en)
|
2009-04-09 |
2015-09-23 |
ProteoVec Holding L.L.C. |
Production of proteins using transposon-based vectors
|
|
EP3845239A1
(en)
*
|
2009-06-08 |
2021-07-07 |
Acceleron Pharma Inc. |
Use of anti-actriib proteins for increasing thermogenic adipocytes
|
|
US20110002897A1
(en)
|
2009-06-11 |
2011-01-06 |
Burnham Institute For Medical Research |
Directed differentiation of stem cells
|
|
WO2010151426A1
(en)
|
2009-06-12 |
2010-12-29 |
Acceleron Pharma Inc. |
Truncated actriib-fc fusion proteins
|
|
WO2011031856A1
(en)
|
2009-09-09 |
2011-03-17 |
Stryker Corporation |
Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
|
|
EP2352750B1
(en)
|
2009-09-17 |
2012-06-13 |
Stryker Corporation |
Buffers for controlling the ph of bone morphogenetic proteins
|
|
JP2013514811A
(ja)
|
2009-12-22 |
2013-05-02 |
ストライカー コーポレイション |
免疫原性が抑制されたbmp−7変異体
|
|
CN102811622A
(zh)
|
2010-02-22 |
2012-12-05 |
生物模拟治疗公司 |
用于治疗腱病的血小板衍生生长因子组合物和方法
|
|
WO2014012101A1
(en)
|
2012-07-13 |
2014-01-16 |
Trustees Of Tufts College |
Silk powder compaction for production of constructs with high mechanical strength and stiffness
|
|
EP3608419B1
(en)
*
|
2012-10-24 |
2025-03-26 |
Celgene Corporation |
Biomarker for use in treating anemia
|
|
CN104981250A
(zh)
*
|
2012-10-24 |
2015-10-14 |
细胞基因公司 |
用于治疗贫血的方法
|
|
NZ707477A
(en)
|
2012-11-02 |
2019-09-27 |
Celgene Corp |
Activin-actrii antagonists and uses for treating bone and other disorders
|
|
EP2956545A4
(en)
*
|
2013-02-15 |
2016-07-20 |
Joslin Diabetes Ct |
THYMUSREGENERATION
|
|
EP2983694B1
(en)
|
2013-04-08 |
2022-06-22 |
President and Fellows of Harvard College |
Compositions for rejuvenating skeletal muscle stem cells
|
|
US20160287667A1
(en)
*
|
2013-11-08 |
2016-10-06 |
President And Fellows Of Harvard College |
Methods and compositions for rejuvenating neuromuscular junctions
|
|
BR112017005730B1
(pt)
|
2014-09-26 |
2023-12-12 |
Somalogic Operating Co., Inc |
Método para triagem de um indivíduo quanto ao risco de um evento cardiovascular ou para predizer a probabilidade que um indivíduo tenha tal evento
|
|
CA3005158A1
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Anti-pro/latent-myostatin antibodies and uses thereof
|
|
WO2017015622A2
(en)
*
|
2015-07-22 |
2017-01-26 |
Scholar Rock, Inc |
Gdf11 binding proteins and uses thereof
|
|
RS66913B1
(sr)
|
2015-09-15 |
2025-07-31 |
Scholar Rock Inc |
Anti-pro/latentna antitela miostatina i njihova upotreba
|
|
JP7025021B2
(ja)
|
2015-10-26 |
2022-02-24 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
還元多糖および酸化多糖ならびにそれらの使用の方法
|
|
CN109310742B
(zh)
|
2016-01-06 |
2022-12-02 |
哈佛学院校长同事会 |
使用gdf11的治疗防止体重增加、提高葡萄糖耐量并减轻脂肪肝
|
|
EP3400240A2
(en)
|
2016-01-08 |
2018-11-14 |
Scholar Rock, Inc. |
Anti-pro/latent myostatin antibodies and methods of use thereof
|
|
LT3368069T
(lt)
|
2016-06-13 |
2020-12-10 |
Scholar Rock, Inc. |
Miostatino inhibitorių naudojimas, ir kombinuotas gydymas
|
|
EP4218817A3
(en)
|
2017-01-06 |
2023-09-06 |
Scholar Rock, Inc. |
Methods for treating metabolic diseases by inhibiting myostatin activation
|
|
WO2024138076A1
(en)
|
2022-12-22 |
2024-06-27 |
Scholar Rock, Inc. |
Selective and potent inhibitory antibodies of myostatin activation
|