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DK0736303T3 - Interferonopløsning - Google Patents

Interferonopløsning

Info

Publication number
DK0736303T3
DK0736303T3 DK96105142T DK96105142T DK0736303T3 DK 0736303 T3 DK0736303 T3 DK 0736303T3 DK 96105142 T DK96105142 T DK 96105142T DK 96105142 T DK96105142 T DK 96105142T DK 0736303 T3 DK0736303 T3 DK 0736303T3
Authority
DK
Denmark
Prior art keywords
interferon
Prior art date
Application number
DK96105142T
Other languages
Danish (da)
English (en)
Inventor
Guenter Gross
Sabino Del Terzo
Saran Kandakuri Kumar
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0736303T3 publication Critical patent/DK0736303T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
DK96105142T 1995-04-06 1996-03-30 Interferonopløsning DK0736303T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95105166 1995-04-06

Publications (1)

Publication Number Publication Date
DK0736303T3 true DK0736303T3 (da) 2000-01-10

Family

ID=8219166

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96105142T DK0736303T3 (da) 1995-04-06 1996-03-30 Interferonopløsning

Country Status (32)

Country Link
US (1) US5762923A (xx)
EP (1) EP0736303B1 (xx)
JP (1) JP2758154B2 (xx)
KR (1) KR100212346B1 (xx)
CN (1) CN1066065C (xx)
AR (1) AR002932A1 (xx)
AT (1) ATE183650T1 (xx)
AU (1) AU685356B2 (xx)
BR (1) BR9601276A (xx)
CA (1) CA2172664C (xx)
CO (1) CO4750807A1 (xx)
CY (1) CY2194B1 (xx)
CZ (1) CZ287626B6 (xx)
DE (1) DE69603894T2 (xx)
DK (1) DK0736303T3 (xx)
ES (1) ES2136910T3 (xx)
GR (1) GR3031775T3 (xx)
HK (1) HK1012232A1 (xx)
HU (1) HU227643B1 (xx)
IL (1) IL117752A (xx)
MA (1) MA23838A1 (xx)
MY (1) MY113594A (xx)
NO (1) NO316801B1 (xx)
NZ (1) NZ286300A (xx)
PE (1) PE38897A1 (xx)
PL (1) PL183873B1 (xx)
RU (1) RU2113845C1 (xx)
SA (1) SA96160728B1 (xx)
SG (1) SG52806A1 (xx)
TR (1) TR199600287A2 (xx)
TW (1) TW426523B (xx)
ZA (1) ZA962553B (xx)

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US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
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US6180096B1 (en) 1998-03-26 2001-01-30 Schering Corporation Formulations for protection of peg-interferon alpha conjugates
WO1999048535A1 (en) * 1998-03-26 1999-09-30 Schering Corporation Formulations for protection of peg-interferon alpha conjugates
EP1069912B1 (en) * 1998-04-03 2007-07-25 Novartis Vaccines and Diagnostics, Inc. Injectable igf-formulations containing succinate as buffering agent
BR9910505A (pt) 1998-05-15 2001-01-02 Schering Corp Terapia de combinação compreendendo ribavirina e interferon alfa em pacientes cândidos de tratamento antiviral tendo infecção crÈnica por hepatite c
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US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
ES2649840T3 (es) 1998-08-06 2018-01-15 Mountain View Pharmaceuticals, Inc. Uricasa tetramérica aislada
WO2000037096A2 (en) * 1998-12-22 2000-06-29 Schering Corporation Treatment of hepatitis c virus infections with interleukin-10
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
EP1535622B1 (en) 1999-04-08 2008-12-31 Schering Corporation Melanoma therapy
US6362162B1 (en) 1999-04-08 2002-03-26 Schering Corporation CML Therapy
US6923966B2 (en) 1999-04-08 2005-08-02 Schering Corporation Melanoma therapy
US6605273B2 (en) 1999-04-08 2003-08-12 Schering Corporation Renal cell carcinoma treatment
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CN1175901C (zh) * 1999-12-06 2004-11-17 天津华立达生物工程有限公司 一种稳定的干扰素水溶液
CA2405709A1 (en) 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
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WO2005110466A1 (en) 2004-05-17 2005-11-24 Ares Trading S.A. Hydrogel interferon formulations
CN1993138B (zh) * 2004-06-01 2010-12-15 阿雷斯贸易股份有限公司 稳定蛋白质的方法
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MX2007001663A (es) 2004-08-12 2007-04-10 Schering Corp Formulacion de interferon pegilado estable.
KR101149454B1 (ko) 2004-08-24 2012-05-25 간가와 겐지 생리활성 펩티드의 액상 제제
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AU2006295340B2 (en) * 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
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BRPI0721988B1 (pt) * 2007-09-04 2021-07-27 Biosteed Gene Expression Tech. Co., Ltd Interferon alfa 2a modificado por polietileno glicol, método para preparação e uso do mesmo, e composição.
US8597635B2 (en) * 2007-09-04 2013-12-03 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof
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US9138403B2 (en) 2007-12-20 2015-09-22 Merck Serono Sa PEG-interferon-beta formulations
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WO2010151823A1 (en) 2009-06-25 2010-12-29 Savient Pharmaceuticals Inc. Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN102101886A (zh) 2009-12-18 2011-06-22 四川辉阳生命工程股份有限公司 构象改变的重组干扰素晶体、其三维结构及应用
RU2447083C1 (ru) * 2010-07-20 2012-04-10 Закрытое Акционерное Общество "Биокад" НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ
KR101303388B1 (ko) * 2010-10-26 2013-09-03 한미사이언스 주식회사 지속형 인터페론 알파 결합체의 액상 제제
CN102526758B (zh) * 2012-02-23 2013-02-13 北京三元基因工程有限公司 一种聚乙二醇化干扰素稳定的水溶液
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Also Published As

Publication number Publication date
HU9600857D0 (en) 1996-05-28
HUP9600857A2 (en) 1997-08-28
TR199600287A2 (tr) 1997-03-21
SG52806A1 (en) 1998-09-28
CN1066065C (zh) 2001-05-23
JPH08283176A (ja) 1996-10-29
AU5044696A (en) 1996-10-17
TW426523B (en) 2001-03-21
RU2113845C1 (ru) 1998-06-27
MA23838A1 (fr) 1996-12-31
IL117752A0 (en) 1996-08-04
GR3031775T3 (en) 2000-02-29
CN1141808A (zh) 1997-02-05
EP0736303B1 (en) 1999-08-25
CA2172664A1 (en) 1996-10-07
EP0736303A3 (en) 1997-02-26
KR100212346B1 (ko) 1999-08-02
SA96160728B1 (ar) 2005-05-04
CZ99496A3 (en) 1996-10-16
ATE183650T1 (de) 1999-09-15
HU227643B1 (en) 2011-10-28
DE69603894D1 (de) 1999-09-30
US5762923A (en) 1998-06-09
CZ287626B6 (en) 2001-01-17
NO961322L (no) 1996-10-07
CO4750807A1 (es) 1999-03-31
NZ286300A (en) 1997-05-26
NO961322D0 (no) 1996-04-01
PL183873B1 (pl) 2002-07-31
AU685356B2 (en) 1998-01-15
HUP9600857A3 (en) 1998-01-28
ZA962553B (en) 1996-10-07
JP2758154B2 (ja) 1998-05-28
CA2172664C (en) 2000-10-03
MY113594A (en) 2002-04-30
KR960037063A (ko) 1996-11-19
ES2136910T3 (es) 1999-12-01
IL117752A (en) 2000-11-21
CY2194B1 (en) 2002-11-08
EP0736303A2 (en) 1996-10-09
NO316801B1 (no) 2004-05-18
DE69603894T2 (de) 2000-04-20
PE38897A1 (es) 1997-10-04
BR9601276A (pt) 1998-01-13
AR002932A1 (es) 1998-05-27
PL313655A1 (en) 1996-10-14
HK1012232A1 (en) 1999-07-30

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