[go: up one dir, main page]

DK0723546T3 - 1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser - Google Patents

1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser

Info

Publication number
DK0723546T3
DK0723546T3 DK94929537T DK94929537T DK0723546T3 DK 0723546 T3 DK0723546 T3 DK 0723546T3 DK 94929537 T DK94929537 T DK 94929537T DK 94929537 T DK94929537 T DK 94929537T DK 0723546 T3 DK0723546 T3 DK 0723546T3
Authority
DK
Denmark
Prior art keywords
alkyl
halo
cyano
hydroxy
optionally substituted
Prior art date
Application number
DK94929537T
Other languages
Danish (da)
English (en)
Inventor
David J Heal
Fernandez Maria Isab Fernandez
Bruce G Sargent
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Application granted granted Critical
Publication of DK0723546T3 publication Critical patent/DK0723546T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DK94929537T 1993-10-13 1994-10-12 1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser DK0723546T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939321162A GB9321162D0 (en) 1993-10-13 1993-10-13 Therapeutic agents
PCT/EP1994/003364 WO1995010521A1 (en) 1993-10-13 1994-10-12 Therapeutic agents

Publications (1)

Publication Number Publication Date
DK0723546T3 true DK0723546T3 (da) 2000-05-01

Family

ID=10743505

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94929537T DK0723546T3 (da) 1993-10-13 1994-10-12 1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser

Country Status (31)

Country Link
US (1) US5753665A (de)
EP (1) EP0723546B1 (de)
JP (1) JPH09503771A (de)
CN (1) CN1040537C (de)
AT (1) ATE188966T1 (de)
AU (1) AU679573B2 (de)
BG (1) BG62405B1 (de)
BR (1) BR9407812A (de)
CA (1) CA2173857A1 (de)
CZ (1) CZ106996A3 (de)
DE (1) DE69422724T2 (de)
DK (1) DK0723546T3 (de)
ES (1) ES2142413T3 (de)
FI (1) FI961630A (de)
GB (1) GB9321162D0 (de)
GR (1) GR3032480T3 (de)
HU (1) HUT74580A (de)
IL (1) IL111259A (de)
IN (1) IN179169B (de)
MY (1) MY112110A (de)
NO (1) NO306509B1 (de)
NZ (1) NZ274500A (de)
PL (1) PL177920B1 (de)
PT (1) PT723546E (de)
RO (1) RO117020B1 (de)
RU (1) RU2136684C1 (de)
SK (1) SK282329B6 (de)
TW (1) TW372237B (de)
UA (1) UA42738C2 (de)
WO (1) WO1995010521A1 (de)
ZA (1) ZA947949B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506382D0 (en) * 1995-03-29 1995-05-17 Boots Co Plc Pharmaceutical compositions
GB9507348D0 (en) * 1995-04-08 1995-05-31 Knoll Ag Therapeutic agents
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
EP0915875B1 (de) * 1996-07-25 2003-04-09 MERCK SHARP & DOHME LTD. Substituierte Triazolo-Pyridazin-Derivate als Liganden von GABA-Rezeptoren
GB9617727D0 (en) * 1996-08-23 1996-10-02 Knoll Ag Process
GB9626746D0 (en) * 1996-12-23 1997-02-12 Knoll Ag Process
DE19706337A1 (de) * 1997-02-19 1998-08-20 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Estern
DE19706336A1 (de) * 1997-02-19 1998-08-20 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Alkoholen
DE19707008A1 (de) * 1997-02-21 1998-08-27 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Alkoholen
AU760688B2 (en) 1998-10-16 2003-05-22 Merck Sharp & Dohme Limited Pyrazolo-triazine derivatives as ligands for GABA receptors
GB9906130D0 (en) * 1999-03-18 1999-05-12 Knoll Ag Compounds for use in therapy
GB9906124D0 (en) * 1999-03-18 1999-05-12 Knoll Ag Therapeutic agent
GB9906126D0 (en) * 1999-03-18 1999-05-12 Knoll Ag Pharmaceutical formulations
GB9914743D0 (en) * 1999-06-24 1999-08-25 Knoll Ag Therapeutic agents
AU7306201A (en) * 2000-06-30 2002-01-14 American Home Prod Substituted-triazolopyrimidines as anticancer agents
WO2005080320A1 (en) 2004-02-13 2005-09-01 Warner-Lambert Company Llc Androgen receptor modulators
EP1737813A1 (de) 2004-04-13 2007-01-03 Warner-Lambert Company LLC Androgenmodulatoren
EP1740533A1 (de) 2004-04-22 2007-01-10 Warner-Lambert Company LLC Androgenmodulatoren
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
PT2328414E (pt) * 2008-08-29 2014-03-17 Concert Pharmaceuticals Inc Derivados de triazol-piridazina substituídos
WO2010112485A1 (en) 2009-04-01 2010-10-07 Neurosearch A/S SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
WO2010112486A1 (en) * 2009-04-01 2010-10-07 Neurosearch A/S SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
EP2414364A1 (de) * 2009-04-01 2012-02-08 NeuroSearch A/S Substituierte [1,2,4]triazolo[1,5-a] pyrimidine und deren verwendung als kaliumkanalmodulatoren
CA3138307A1 (en) 2019-05-13 2020-11-19 Ecolab Usa Inc. 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE46306B1 (en) * 1977-02-11 1983-05-04 Ici Ltd Safeguarded toxic chemical compositions containing an emetic
WO1989001478A1 (en) * 1987-08-07 1989-02-23 The Australian National University ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present

Also Published As

Publication number Publication date
IL111259A0 (en) 1995-03-30
EP0723546B1 (de) 2000-01-19
CN1135754A (zh) 1996-11-13
DE69422724T2 (de) 2000-09-07
MY112110A (en) 2001-04-30
PL177920B1 (pl) 2000-01-31
ZA947949B (en) 1996-01-23
BG62405B1 (bg) 1999-10-29
AU7855494A (en) 1995-05-04
BR9407812A (pt) 1997-05-06
RO117020B1 (ro) 2001-09-28
CZ106996A3 (en) 1996-09-11
HUT74580A (en) 1997-01-28
PT723546E (pt) 2000-04-28
NZ274500A (en) 1997-06-24
NO961435D0 (no) 1996-04-11
US5753665A (en) 1998-05-19
AU679573B2 (en) 1997-07-03
IL111259A (en) 1998-02-08
DE69422724D1 (de) 2000-02-24
CA2173857A1 (en) 1995-04-20
FI961630A0 (fi) 1996-04-12
ES2142413T3 (es) 2000-04-16
SK43796A3 (en) 1996-10-02
NO961435L (no) 1996-06-10
GR3032480T3 (en) 2000-05-31
PL313970A1 (en) 1996-08-05
EP0723546A1 (de) 1996-07-31
UA42738C2 (uk) 2001-11-15
BG100485A (bg) 1996-11-29
JPH09503771A (ja) 1997-04-15
GB9321162D0 (en) 1993-12-01
WO1995010521A1 (en) 1995-04-20
SK282329B6 (sk) 2002-01-07
HU9600959D0 (en) 1996-06-28
IN179169B (de) 1997-09-06
FI961630A (fi) 1996-04-12
ATE188966T1 (de) 2000-02-15
TW372237B (en) 1999-10-21
NO306509B1 (no) 1999-11-15
RU2136684C1 (ru) 1999-09-10
CN1040537C (zh) 1998-11-04

Similar Documents

Publication Publication Date Title
DK0723546T3 (da) 1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser
ES2113081T3 (es) 1,4-benzotiazepinas utiles como agentes neurologicos.
UA66825C2 (uk) Азаполіциклічні сполуки, конденсовані з арилом, фармацевтична композиція, спосіб лікування та спосіб зниження нікотинової залежності
GEP20033029B (en) Substituted 1,8-Naphthyridin-4(1H)-Ones as Phosphodiesterase 4 Inhibitors
DK0674512T3 (da) Anvendelse af riluzol ved behandling af neurologiske skader knyttet til traumer
BG101110A (en) Substituted pyrimidine compounds and their application
MX2007000051A (es) Derivados de pirimidina fusionados y composiciones de los mismos como moduladores del receptor cxcr3, utiles en la prevencion y tratamiento de trastornos y enfermedades inflamatorias e inmunoregulatorias.
PL313941A1 (en) Alkoxyalkyl carbamates of imidazo /1,2-a/ pyrimidines
CA2148194A1 (en) Cyclopeptides of the formula i
AU3582095A (en) Isothiourea derivatives as no synthase inhibitors
TW200726769A (en) Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates
AR032653A1 (es) Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos.
RO105807B1 (ro) Procedeu de preparare a unor agenti terapeutici
ZA943241B (en) Therapeutic agents
TW359667B (en) Tetralines
IE894039L (en) Therapeutic agents
CA2347939A1 (en) Composition for the treatment of rheumatism, hepatitis or pancreatitis
IL104478A (en) N-5-protected 2,5-diamino-4, 6-dichloropyrimidines and processes for their preparation
JO1833B1 (en) Therapeutic agents
WO2001032650A3 (en) Alkaline salts of n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-n'-isonicotinoylhydrazide, possess for their preparation, and pharmaceutical composition based on these salts
MXPA01009384A (es) Composiciones farmaceuticas que comprenden un derivado de pirimidina y ciclodextrina.