DK0711289T3 - Piperazinforbindelser til anvendelse i terapi - Google Patents
Piperazinforbindelser til anvendelse i terapiInfo
- Publication number
- DK0711289T3 DK0711289T3 DK94921756T DK94921756T DK0711289T3 DK 0711289 T3 DK0711289 T3 DK 0711289T3 DK 94921756 T DK94921756 T DK 94921756T DK 94921756 T DK94921756 T DK 94921756T DK 0711289 T3 DK0711289 T3 DK 0711289T3
- Authority
- DK
- Denmark
- Prior art keywords
- utility
- compounds
- receptors
- piperazine compounds
- depression
- Prior art date
Links
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010037423 Pulmonary oedema Diseases 0.000 abstract 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
- 206010038678 Respiratory depression Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000008784 apnea Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 102000048260 kappa Opioid Receptors Human genes 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 108020001588 κ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Water Treatment By Sorption (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9833393A | 1993-07-30 | 1993-07-30 | |
| US16987993A | 1993-12-17 | 1993-12-17 | |
| PCT/GB1994/001641 WO1995004051A1 (en) | 1993-07-30 | 1994-07-29 | Piperazine compounds used in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0711289T3 true DK0711289T3 (da) | 2000-11-06 |
Family
ID=26794651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94921756T DK0711289T3 (da) | 1993-07-30 | 1994-07-29 | Piperazinforbindelser til anvendelse i terapi |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5552404A (he) |
| EP (1) | EP0711289B1 (he) |
| JP (1) | JPH09501156A (he) |
| CN (1) | CN1054850C (he) |
| AT (1) | ATE195733T1 (he) |
| AU (1) | AU692788B2 (he) |
| CA (1) | CA2168432C (he) |
| DE (1) | DE69425662T2 (he) |
| DK (1) | DK0711289T3 (he) |
| ES (1) | ES2149881T3 (he) |
| GR (1) | GR3034695T3 (he) |
| HU (1) | HU221726B1 (he) |
| IL (1) | IL110512A (he) |
| MY (1) | MY111348A (he) |
| PT (1) | PT711289E (he) |
| RU (1) | RU2133744C1 (he) |
| TW (1) | TW386081B (he) |
| WO (1) | WO1995004051A1 (he) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US6410537B1 (en) * | 1994-09-09 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
| US6046200A (en) * | 1994-09-09 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9504662D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
| US6359111B1 (en) | 1998-05-28 | 2002-03-19 | Neorx Corporation | Opioid receptor targeting |
| WO1999065932A1 (en) | 1998-06-18 | 1999-12-23 | Sepracor, Inc. | Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors |
| SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| AU2001239896A1 (en) * | 2000-03-16 | 2001-10-03 | Sepracor, Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
| SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0100764D0 (sv) * | 2001-03-07 | 2001-03-07 | Astrazeneca Ab | New assymetric process |
| WO2002080918A1 (fr) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
| CA2446326C (en) | 2001-05-18 | 2010-12-07 | Astrazeneca Ab | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
| US7030124B2 (en) * | 2001-10-29 | 2006-04-18 | Ardent Pharmaceuticals, Inc. | Method of treating depression with delta receptor agonist compounds |
| AU2003214800A1 (en) | 2002-01-02 | 2003-07-24 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
| US8476280B2 (en) | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| ES2298522T3 (es) * | 2002-05-16 | 2008-05-16 | N.V. Organon | Combinacion sinergica de un analgesico opioide y un aine. |
| CN1202843C (zh) * | 2002-06-21 | 2005-05-25 | 天大药业(深圳)有限公司 | 一种戒毒药物组合物及其制备方法和应用 |
| CA2492694A1 (en) * | 2002-07-11 | 2004-01-22 | Toray Industries, Inc. | Therapeutic or prophylactic agent for preventing nausea and vomiting |
| US20050241431A1 (en) * | 2002-09-27 | 2005-11-03 | Continental Teves Ag & Co. Ohg | Adjustable pedal device |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
| US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20090297611A1 (en) * | 2003-07-31 | 2009-12-03 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| TWI317286B (en) | 2003-12-31 | 2009-11-21 | Targeting delivery system | |
| MX2007001240A (es) | 2004-08-02 | 2007-03-23 | Astrazeneca Ab | Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas. |
| US7683168B2 (en) * | 2005-04-14 | 2010-03-23 | Mount Cook Bio Sciences, Inc. | Compositions of novel opioid compounds and method of use thereof |
| DK2081562T3 (en) | 2006-09-20 | 2016-05-30 | Univ Texas | Method of administering volatile anesthetics for regional anesthesia and / or pain relief |
| EP2244737B1 (en) | 2008-01-22 | 2019-04-10 | The Board of Regents of The University of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| CA2724955A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Method of treating anxious major depressive disorder |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2630435A (en) * | 1948-09-09 | 1953-03-03 | Burroughs Wellcome Co | N-benzohydryl-n-methyl piperazines and process of preparing same |
| US4518711A (en) | 1983-05-16 | 1985-05-21 | Gibson-Stephens Institute | Conformationally constrained cyclic enkephalin analogs with delta receptor specificity |
| GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
| IN163948B (he) | 1986-01-17 | 1988-12-10 | Robins Co Inc A H | |
| PH24752A (en) * | 1987-04-16 | 1990-10-01 | Lilly Co Eli | Piperidine opioid antagonists |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| JPH04506072A (ja) * | 1989-06-19 | 1992-10-22 | ザ・ウエルカム・ファウンデーション・リミテッド | 癌治療に有用であり、かつ抗ヒスタミン特性を有する医薬 |
| EP0458160A3 (en) | 1990-05-25 | 1992-03-18 | Sociedad Espanola De Especialidades Farmaco-Terapeuticas, S.A. | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
| SE467304B (sv) * | 1990-10-31 | 1992-06-29 | Kamewa Ab | Styr- och reverseringsanordning foer ett marint straaldriftsaggregat |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
-
1994
- 1994-07-29 RU RU96104351/04A patent/RU2133744C1/ru not_active IP Right Cessation
- 1994-07-29 IL IL11051294A patent/IL110512A/he not_active IP Right Cessation
- 1994-07-29 AU AU72351/94A patent/AU692788B2/en not_active Ceased
- 1994-07-29 PT PT94921756T patent/PT711289E/pt unknown
- 1994-07-29 MY MYPI94001988A patent/MY111348A/en unknown
- 1994-07-29 AT AT94921756T patent/ATE195733T1/de not_active IP Right Cessation
- 1994-07-29 ES ES94921756T patent/ES2149881T3/es not_active Expired - Lifetime
- 1994-07-29 DE DE69425662T patent/DE69425662T2/de not_active Expired - Fee Related
- 1994-07-29 HU HU9501982A patent/HU221726B1/hu not_active IP Right Cessation
- 1994-07-29 EP EP94921756A patent/EP0711289B1/en not_active Expired - Lifetime
- 1994-07-29 JP JP7505665A patent/JPH09501156A/ja not_active Ceased
- 1994-07-29 CN CN94192949A patent/CN1054850C/zh not_active Expired - Fee Related
- 1994-07-29 CA CA002168432A patent/CA2168432C/en not_active Expired - Fee Related
- 1994-07-29 WO PCT/GB1994/001641 patent/WO1995004051A1/en active IP Right Grant
- 1994-07-29 DK DK94921756T patent/DK0711289T3/da active
- 1994-08-02 TW TW083107072A patent/TW386081B/zh not_active IP Right Cessation
-
1995
- 1995-04-28 US US08/431,377 patent/US5552404A/en not_active Expired - Lifetime
-
2000
- 2000-10-27 GR GR20000402382T patent/GR3034695T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU692788B2 (en) | 1998-06-18 |
| AU7235194A (en) | 1995-02-28 |
| HUT72893A (en) | 1996-06-28 |
| MY111348A (en) | 1999-11-30 |
| HU9501982D0 (en) | 1995-09-28 |
| TW386081B (en) | 2000-04-01 |
| IL110512A (he) | 1998-10-30 |
| ATE195733T1 (de) | 2000-09-15 |
| EP0711289A1 (en) | 1996-05-15 |
| DE69425662T2 (de) | 2001-04-12 |
| HU221726B1 (hu) | 2002-12-28 |
| WO1995004051A1 (en) | 1995-02-09 |
| IL110512A0 (en) | 1994-10-21 |
| PT711289E (pt) | 2001-02-28 |
| CN1133593A (zh) | 1996-10-16 |
| RU2133744C1 (ru) | 1999-07-27 |
| CA2168432C (en) | 2004-03-23 |
| JPH09501156A (ja) | 1997-02-04 |
| DE69425662D1 (de) | 2000-09-28 |
| GR3034695T3 (en) | 2001-01-31 |
| EP0711289B1 (en) | 2000-08-23 |
| ES2149881T3 (es) | 2000-11-16 |
| CA2168432A1 (en) | 1995-02-09 |
| US5552404A (en) | 1996-09-03 |
| CN1054850C (zh) | 2000-07-26 |
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