DK0694039T3 - Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning - Google Patents

Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning

Info

Publication number: DK0694039T3
Authority: DK; Denmark
Prior art keywords: benzodiazepine; derivatives; agonistic effect; cck; antagonistic
Prior art date: 1993-04-15

Application number

DK94913580T

Other languages

English (en)

Inventor

Elizabeth Ellen Sugg

Christopher Joseph Aquino

Jerzy Ryszard Szewczyk

Harry Finch

Robin Arthur Ellis Carr

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-15

Filing date

1994-04-14

Publication date

2001-05-21

1994-04-14 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

2001-05-21 Application granted granted Critical

2001-05-21 Publication of DK0694039T3 publication Critical patent/DK0694039T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Crystallography & Structural Chemistry (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Hydrogenated Pyridines (AREA)

DK94913580T 1993-04-15 1994-04-14 Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning DK0694039T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939307833A GB9307833D0 (en)	1993-04-15	1993-04-15	Modulators of cholecystokinin and gastrin
PCT/EP1994/001131 WO1994024149A1 (en)	1993-04-15	1994-04-14	1,5-benzodiazepine derivatives having cck antagonistic or agonistic activity

Publications (1)

Publication Number	Publication Date
DK0694039T3 true DK0694039T3 (da)	2001-05-21

Family

ID=10733915

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94913580T DK0694039T3 (da)	1993-04-15	1994-04-14	Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning

Country Status (34)

Country	Link
US (2)	US5646140A (da)
EP (1)	EP0694039B1 (da)
JP (1)	JP3406317B2 (da)
KR (1)	KR100364948B1 (da)
CN (1)	CN1058487C (da)
AP (2)	AP462A (da)
AT (1)	ATE198894T1 (da)
AU (1)	AU681139B2 (da)
CA (1)	CA2158973C (da)
CZ (1)	CZ286695B6 (da)
DE (1)	DE69426624T2 (da)
DK (1)	DK0694039T3 (da)
EC (1)	ECSP941066A (da)
ES (1)	ES2154674T3 (da)
FI (1)	FI954853L (da)
GB (1)	GB9307833D0 (da)
GR (1)	GR3035641T3 (da)
HK (1)	HK1003943A1 (da)
HU (1)	HU223467B1 (da)
IL (2)	IL109316A (da)
IS (2)	IS4147A (da)
MY (2)	MY112237A (da)
NO (1)	NO311133B1 (da)
NZ (1)	NZ265272A (da)
OA (1)	OA10355A (da)
PE (2)	PE50994A1 (da)
PH (1)	PH30897A (da)
PL (1)	PL178790B1 (da)
PT (1)	PT694039E (da)
RU (1)	RU2135486C1 (da)
SK (1)	SK281211B6 (da)
TW (1)	TW487703B (da)
WO (1)	WO1994024149A1 (da)
ZA (2)	ZA942571B (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0728748B1 (en) *	1993-12-28	2002-03-06	Shionogi & Co., Ltd.	Benzodiazepine derivatives
DE69510545T2 (de) *	1994-04-14	2000-01-13	Glaxo Wellcome Inc	Cck oder gastrin modulierende 5-heterocyclicyl-1,5-benzodiazepine
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PE27497A1 (es) *	1994-04-15	1997-08-07	Glaxo Inc	Derivados de 1,5 benzodiazepina
US5795887A (en) *	1994-04-15	1998-08-18	Glaxo Wellcome Inc.	Method of inducing cholecystokinin agonist activity using 1,4- Benzodiazepine compounds
US5910495A (en) *	1994-10-14	1999-06-08	Glaxo Wellcome Inc.	Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
US5780464A (en) *	1994-10-14	1998-07-14	Glaxo Wellcome Inc.	Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
GB9420747D0 (en) *	1994-10-14	1994-11-30	Glaxo Inc	1,5 benzodiazepine derivatives
GB9420748D0 (en) *	1994-10-14	1994-11-30	Glaxo Inc	1,5 benzodiazepine derivatives
GB9420763D0 (en) *	1994-10-14	1994-11-30	Glaxo Inc	Acetamide derivatives
US5750353A (en) *	1995-12-11	1998-05-12	New England Medical Center Hospitals, Inc.	Assay for non-peptide agonists to peptide hormone receptors
KR100561963B1 (ko)	1995-12-11	2006-11-30	뉴 잉글랜드 메디컬 센터 호스피털스 인코퍼레이티드	펩타이드호르몬수용체리간드의검사방법및용도
CN1130351C (zh) *	1996-12-10	2003-12-10	泽里新药工业株式会社	1,5－苯并二氮杂䓬衍生物
GB2360520B (en)	1997-04-15	2001-11-07	Csir	Intermediates in the synthesis of appetite suppressant steroid glycosides
AR022044A1 (es) *	1999-05-06	2002-09-04	Glaxo Group Ltd	Derivados de 1,5-benzodiazepina
GB2355657B (en)	1999-10-27	2004-07-28	Phytopharm Plc	Inhibitors Of Gastric Acid Secretion
GB2363985B (en)	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en)	2000-08-04	2004-07-27	Lion Bioscience Ag	Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) *	2001-05-29	2002-12-05	Berard Steven O.	Thermally conductive carbon fiber extrusion compounder and method of using same
ATE420644T1 (de) *	2002-02-20	2009-01-15	Abbott Lab	Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1)
US7074805B2 (en) *	2002-02-20	2006-07-11	Abbott Laboratories	Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) *	2003-02-11	2005-08-23	Abbott Laboratories	Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) *	2003-06-12	2006-03-21	Abbott Laboratories	Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
CN1950374A (zh) *	2004-05-25	2007-04-18	辉瑞产品公司	四氮杂苯并[e]甘菊环衍生物及其类似物
CN1333077C (zh) *	2005-04-15	2007-08-22	华南农业大学	缩胆囊素活性片段的串联表达及其应用
MX2009002018A (es) *	2006-08-25	2009-03-05	Abbott Lab	Derivados de indazol que inhiben vanilloide-1 potencial de receptor pasajero (trpv1) y usos de los mismos.
WO2008079683A2 (en) *	2006-12-20	2008-07-03	Abbott Laboratories	N- (5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
JP2011515414A (ja) *	2008-03-20	2011-05-19	アボット・ラボラトリーズ	Ｔｒｐｖ１アンタゴニストである中枢神経系薬剤を作製する方法
CN103102285B (zh) *	2013-01-30	2015-07-29	淮阴师范学院	对氨基苯乙腈的制备方法
EP3071205B1 (en)	2013-11-18	2020-02-05	Forma Therapeutics, Inc.	Benzopiperazine compositions as bet bromodomain inhibitors
NZ720004A (en)	2013-11-18	2020-03-27	Forma Therapeutics Inc	Tetrahydroquinoline compositions as bet bromodomain inhibitors
CN108200760B (zh)	2015-07-22	2022-04-01	英安塔制药有限公司	作为rsv抑制剂的苯并二氮杂䓬衍生物
KR20180114910A (ko)	2016-02-05	2018-10-19	데날리 테라퓨틱스 인크.	수용체-상호작용 단백질 키나제 1의 억제제
PT3552017T (pt)	2016-12-09	2022-05-04	Denali Therapeutics Inc	Compostos úteis como inibidores de ripk1
IL268737B2 (en)	2017-02-16	2024-02-01	Enanta Pharm Inc	Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) *	2017-06-07	2020-08-25	Enanta Pharmaceuticals, Inc.	Aryldiazepine derivatives as RSV inhibitors
US11091501B2 (en)	2017-06-30	2021-08-17	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
US10851115B2 (en)	2017-06-30	2020-12-01	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
MX2020004084A (es)	2017-09-29	2020-07-29	Enanta Pharm Inc	Agentes farmaceuticos como inhibidores del rsv para utilizar en combinacion.
WO2019094920A1 (en)	2017-11-13	2019-05-16	Enanta Pharmaceuticals, Inc.	Azepin-2-one derivatives as rsv inhibitors
US10975094B2 (en)	2018-04-11	2021-04-13	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
CA3133300A1 (en)	2019-03-18	2020-09-24	Enanta Pharmaceuticals, Inc.	Benzodiazepine derivatives as rsv inhibitors
US11179400B2 (en)	2019-04-09	2021-11-23	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
US11505558B1 (en)	2019-10-04	2022-11-22	Enanta Pharmaceuticals, Inc.	Antiviral heterocyclic compounds
UY39032A (es)	2020-01-24	2021-07-30	Enanta Pharm Inc	Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en)	2020-07-07	2022-12-27	Enanta Pharmaceuticals, Inc.	Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en)	2020-10-19	2022-04-28	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as anti-viral agents
EP4463229A1 (en)	2022-01-12	2024-11-20	Denali Therapeutics Inc.	Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide
WO2023211997A1 (en)	2022-04-27	2023-11-02	Enanta Pharmaceuticals, Inc.	Antiviral compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) *	1990-03-13	1992-05-22	Rhone Poulenc Sante	Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) *	1990-10-22	1993-04-27	Merck & Co., Inc.	Benzolactam analogs as antagonists of cck
JP2904941B2 (ja) *	1991-01-28	1999-06-14	出光興産株式会社	スチレン系重合体の精製方法
GEP20001968B (en) *	1992-01-21	2000-03-05	Glaxo Spa	Arilthio Compounds as Antibacterial and Antiviral Agents
DE69510545T2 (de) *	1994-04-14	2000-01-13	Glaxo Wellcome Inc	Cck oder gastrin modulierende 5-heterocyclicyl-1,5-benzodiazepine

1993
- 1993-04-15 GB GB939307833A patent/GB9307833D0/en active Pending
1994
- 1994-01-04 US US08/525,659 patent/US5646140A/en not_active Expired - Lifetime
- 1994-04-11 IS IS4147A patent/IS4147A/is unknown
- 1994-04-11 IS IS4148A patent/IS4148A/is unknown
- 1994-04-12 MY MYPI94000880A patent/MY112237A/en unknown
- 1994-04-12 MY MYPI94000884A patent/MY131569A/en unknown
- 1994-04-12 EC EC1994001066A patent/ECSP941066A/es unknown
- 1994-04-13 PE PE1994240027A patent/PE50994A1/es not_active Application Discontinuation
- 1994-04-13 US US08/522,363 patent/US5585376A/en not_active Expired - Fee Related
- 1994-04-13 AP APAP/P/1994/000634A patent/AP462A/en active
- 1994-04-13 IL IL10931694A patent/IL109316A/en not_active IP Right Cessation
- 1994-04-13 IL IL10931594A patent/IL109315A0/xx unknown
- 1994-04-13 AP APAP/P/1994/000635A patent/AP512A/en active
- 1994-04-13 PE PE1994240028A patent/PE50594A1/es not_active Application Discontinuation
- 1994-04-14 RU RU95117974A patent/RU2135486C1/ru not_active IP Right Cessation
- 1994-04-14 WO PCT/EP1994/001131 patent/WO1994024149A1/en active IP Right Grant
- 1994-04-14 PH PH48093A patent/PH30897A/en unknown
- 1994-04-14 AU AU65676/94A patent/AU681139B2/en not_active Ceased
- 1994-04-14 NZ NZ265272A patent/NZ265272A/en not_active IP Right Cessation
- 1994-04-14 CZ CZ19952675A patent/CZ286695B6/cs not_active IP Right Cessation
- 1994-04-14 AT AT94913580T patent/ATE198894T1/de not_active IP Right Cessation
- 1994-04-14 PT PT94913580T patent/PT694039E/pt unknown
- 1994-04-14 ZA ZA942571A patent/ZA942571B/xx unknown
- 1994-04-14 PL PL94311084A patent/PL178790B1/pl unknown
- 1994-04-14 SK SK1253-95A patent/SK281211B6/sk unknown
- 1994-04-14 HU HU9502978A patent/HU223467B1/hu not_active IP Right Cessation
- 1994-04-14 DK DK94913580T patent/DK0694039T3/da active
- 1994-04-14 CN CN94191773A patent/CN1058487C/zh not_active Expired - Fee Related
- 1994-04-14 EP EP94913580A patent/EP0694039B1/en not_active Expired - Lifetime
- 1994-04-14 ES ES94913580T patent/ES2154674T3/es not_active Expired - Lifetime
- 1994-04-14 DE DE69426624T patent/DE69426624T2/de not_active Expired - Lifetime
- 1994-04-14 KR KR1019950704491A patent/KR100364948B1/ko not_active Expired - Fee Related
- 1994-04-14 ZA ZA942570A patent/ZA942570B/xx unknown
- 1994-04-14 CA CA002158973A patent/CA2158973C/en not_active Expired - Fee Related
- 1994-04-14 JP JP52273494A patent/JP3406317B2/ja not_active Expired - Fee Related
- 1994-05-26 TW TW083104772A patent/TW487703B/zh not_active IP Right Cessation
1995
- 1995-10-12 FI FI954853A patent/FI954853L/fi unknown
- 1995-10-12 OA OA60722A patent/OA10355A/en unknown
- 1995-10-13 NO NO19954090A patent/NO311133B1/no unknown
1998
- 1998-04-16 HK HK98103188A patent/HK1003943A1/xx not_active IP Right Cessation
2001
- 2001-03-27 GR GR20010400488T patent/GR3035641T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PH30897A (en)	1997-12-23
CZ267595A3 (en)	1996-04-17
FI954853A0 (fi)	1995-10-12
ATE198894T1 (de)	2001-02-15
CZ286695B6 (en)	2000-06-14
JPH08508744A (ja)	1996-09-17
PT694039E (pt)	2001-06-29
HU9502978D0 (en)	1995-12-28
GR3035641T3 (en)	2001-06-29
DE69426624D1 (de)	2001-03-01
IL109316A0 (en)	1994-07-31
ZA942571B (en)	1994-11-11
WO1994024149A1 (en)	1994-10-27
US5585376A (en)	1996-12-17
KR100364948B1 (ko)	2003-03-29
MY112237A (en)	2001-05-31
FI954853L (fi)	1995-10-12
AU6567694A (en)	1994-11-08
ZA942570B (en)	1994-11-11
IS4147A (is)	1994-10-16
EP0694039B1 (en)	2001-01-24
HUT74102A (en)	1996-11-28
CN1058487C (zh)	2000-11-15
AP9400634A0 (en)	1994-04-30
AU681139B2 (en)	1997-08-21
PL178790B1 (pl)	2000-06-30
AP512A (en)	1996-07-29
CA2158973A1 (en)	1994-10-27
IL109315A0 (en)	1994-07-31
RU2135486C1 (ru)	1999-08-27
JP3406317B2 (ja)	2003-05-12
AP9400635A0 (en)	1994-04-30
NO954090L (no)	1995-12-13
TW487703B (en)	2002-05-21
CN1120843A (zh)	1996-04-17
DE69426624T2 (de)	2001-06-21
NO954090D0 (no)	1995-10-13
ES2154674T3 (es)	2001-04-16
HK1003943A1 (en)	1998-11-13
SK125395A3 (en)	1996-06-05
HU223467B1 (hu)	2004-07-28
US5646140A (en)	1997-07-08
PE50994A1 (es)	1995-01-06
ECSP941066A (es)	1994-11-16
OA10355A (en)	2001-10-19
EP0694039A1 (en)	1996-01-31
CA2158973C (en)	2006-06-06
IL109316A (en)	1999-03-12
GB9307833D0 (en)	1993-06-02
MY131569A (en)	2007-08-30
NZ265272A (en)	1997-07-27
PL311084A1 (en)	1996-02-05
PE50594A1 (es)	1995-01-06
NO311133B1 (no)	2001-10-15
IS4148A (is)	1994-10-16
SK281211B6 (sk)	2001-01-18
AP462A (en)	1996-02-19

Publication	Publication Date	Title
DK0694039T3 (da)	2001-05-21	Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning
DE69417753D1 (de)	1999-05-12	Wegwerfbare monatsunterhose
FI932402A0 (fi)	1993-05-26	Foerfarande och anordning foer saendning, mottagning och oeverfoering av datasignaler med motsvarande programdatasignaler
DK0876392T3 (da)	2000-11-06	Lacton-derivater af 17.beta.-carboxy, carbothio og amidandrostanforbindelser
DE69223465D1 (de)	1998-01-22	Polymere Zusammensetzungen und Verwendung derselben
FI972864L (fi)	1997-07-04	Lonkkasuojilla varustetut housut
DK0741971T3 (da)	2001-01-29	Biocidsammensætninger omfattende blandinger af halogenpropynylforbindelser og svovlholdige triaziner
ITTO910114A1 (it)	1992-08-19	Composizioni e procedimento di placcatura
MX9205726A (es)	1993-04-01	Derivados de 4'-(n-substituido-n-oxido) estaurosporina.
FI941968A0 (fi)	1994-04-28	Rengas- ja hihnakoostumuksia
DE69413405D1 (de)	1998-10-22	1,5-benzodiazepin-derivate verwendbar als cck oder gastrin antagonisten
FI954852L (fi)	1995-10-12	1,5-bentsodiatsepiinijohdannaisia, joilla on CCK- ja/tai gastriiniantagonistinen aktiivisuus
IT1293642B1 (it)	1999-03-08	Protesi d'anca
FI1215U1 (fi)	1994-02-21	Anlaeggning i samband med styrningen av en vira
DK0776899T3 (da)	2000-07-10	Mellemprodukter og deres anvendelse til fremstilling af N,N'-forbundne bisindolylmaleimider
DE69328467D1 (de)	2000-05-31	Polyamidzusammensetzung und Verwendung
MX9206482A (es)	1993-05-01	1,5-pentanodioles substituidos y procesos para la preparacion de los mismos
DK0810216T3 (da)	2001-07-23	Derivater af 10,11-dihydro-10-oxo-5H-dibenz/b/,f/azepin-5-carboxamid
FR2700675B1 (fr)	1995-03-17	Cartable d'ecolier comportant au moins un element dorsal gonflable.
FR2700926B1 (fr)	1995-04-28	Article d'habillement à ceinture ductile et coulissante.
DK75794A (da)	1995-12-25	Fryseapparat samt anvendelse af samme
KR950000169U (ko)	1995-01-03	허리사이즈가 조절되는 바지
ITMI932019A0 (it)	1993-09-20	Composizione farmaceutica antivirale contenente la 2-ammino 4,6-dicloropirimidina e metisoprinolo
ITMI922323A0 (it)	1992-10-09	Derivati di 4-metossi-n,n'-bis(3-piridinil-metil)-1,3-benzenedicarbossiammide e loro impiego farmacologico
DK18593D0 (da)	1993-02-18	Spaendboesning af ekspansionstypen