DK0675878T3 - Nye D-vitaminanaloger - Google Patents
Nye D-vitaminanalogerInfo
- Publication number
- DK0675878T3 DK0675878T3 DK94903741.0T DK94903741T DK0675878T3 DK 0675878 T3 DK0675878 T3 DK 0675878T3 DK 94903741 T DK94903741 T DK 94903741T DK 0675878 T3 DK0675878 T3 DK 0675878T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- compounds
- thiol
- sec
- date
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
- 235000019166 vitamin D Nutrition 0.000 title 1
- 239000011710 vitamin D Substances 0.000 title 1
- 150000003710 vitamin D derivatives Chemical class 0.000 title 1
- 229940046008 vitamin d Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000006324 decarbonylation Effects 0.000 abstract 1
- 238000006606 decarbonylation reaction Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000006552 photochemical reaction Methods 0.000 abstract 1
- JCBJVAJGLKENNC-UHFFFAOYSA-M potassium ethyl xanthate Chemical compound [K+].CCOC([S-])=S JCBJVAJGLKENNC-UHFFFAOYSA-M 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929226877A GB9226877D0 (en) | 1992-12-23 | 1992-12-23 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0675878T3 true DK0675878T3 (da) | 1997-04-28 |
Family
ID=10727157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94903741.0T DK0675878T3 (da) | 1992-12-23 | 1993-12-17 | Nye D-vitaminanaloger |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5554599A (fr) |
| EP (1) | EP0675878B1 (fr) |
| KR (1) | KR100295977B1 (fr) |
| AT (1) | ATE148454T1 (fr) |
| AU (1) | AU668638B2 (fr) |
| CA (1) | CA2146775C (fr) |
| DE (1) | DE69307929T2 (fr) |
| DK (1) | DK0675878T3 (fr) |
| ES (1) | ES2098123T3 (fr) |
| FI (1) | FI108225B (fr) |
| GB (1) | GB9226877D0 (fr) |
| GR (1) | GR3022774T3 (fr) |
| NZ (1) | NZ259317A (fr) |
| RU (1) | RU2136660C1 (fr) |
| WO (1) | WO1994014766A1 (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830885A (en) * | 1992-03-12 | 1998-11-03 | The Johns Hopkins University | Antiproliferative vitamin D3 hybrids |
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| GB9314400D0 (en) * | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
| DK0755922T3 (da) * | 1994-04-11 | 2000-11-13 | Chugai Pharmaceutical Co Ltd | 22-Thiavitamin D3-derivat |
| WO1997024126A1 (fr) * | 1995-12-28 | 1997-07-10 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteurs des metastases de tumeurs malignes |
| US6869940B2 (en) | 1995-12-28 | 2005-03-22 | Chugai Seiyaku Kabushiki Kaisha | Malignant tumor metastasis inhibitors |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6184398B1 (en) | 1996-12-20 | 2001-02-06 | Chugai Seiyaku Kabushiki Kaisha | 16-ene-vitamin D derivatives |
| WO1998028266A1 (fr) | 1996-12-20 | 1998-07-02 | Chugai Seiyaku Kabushiki Kaisha | Derives de vitamine d 16-ene |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| ATE344039T1 (de) | 1999-04-01 | 2006-11-15 | Univ Johns Hopkins | Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung |
| US6703380B2 (en) | 1999-09-29 | 2004-03-09 | Colotech A/S | Prevention of cancer |
| ES2240159T3 (es) | 1999-09-29 | 2005-10-16 | Colotech A/S | Prevencion del cancer colorrectal. |
| WO2001030751A2 (fr) * | 1999-10-25 | 2001-05-03 | Strakan Limited | Utilisations de composes de 1,25-dihydroxy-5,6-trans vitamine d et de leurs derives |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US7074777B2 (en) | 2000-04-19 | 2006-07-11 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivatives |
| AU6428001A (en) | 2000-06-15 | 2001-12-24 | Chugai Pharmaceutical Co Ltd | Vitamin d derivatives |
| DE60231987D1 (de) * | 2001-08-22 | 2009-05-28 | Univ Johns Hopkins | 24-schwefel-substituierte 1-alpha-25-dihydroxy-vitamin-d3-analogen |
| SI1436321T1 (sl) * | 2001-10-19 | 2006-12-31 | Isotechnika Inc | Sinteza analogov ciklosporina |
| CA2488334C (fr) | 2002-06-13 | 2010-12-07 | Johns Hopkins University | Composes de type 24-sulfoximine vitamine d<sb>3</sb> |
| CA2510228C (fr) | 2002-12-18 | 2012-10-30 | Johns Hopkins University | Analogues 25-so2-subsitutes de la 1.alpha.,25-dihydroxyvitamine d3 |
| EA201691980A1 (ru) | 2009-01-27 | 2017-07-31 | БЕРГ ЭлЭлСи | Способы уменьшения побочных эффектов, связанных с химиотерапией |
| KR101880032B1 (ko) | 2009-08-14 | 2018-07-20 | 베르그 엘엘씨 | 탈모증 치료용 비타민 ｄ3 및 이의 유사체들 |
| CA2913543C (fr) | 2013-05-29 | 2024-01-09 | Berg Llc | Prevention ou attenuation de l'alopecie induite par la chimiotherapie au moyen de vitamine d |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2631025B1 (fr) * | 1988-05-04 | 1991-04-12 | Ire Medgenix Sa | Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3 |
| GB8904153D0 (en) * | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| DK0755922T3 (da) * | 1994-04-11 | 2000-11-13 | Chugai Pharmaceutical Co Ltd | 22-Thiavitamin D3-derivat |
-
1992
- 1992-12-23 GB GB929226877A patent/GB9226877D0/en active Pending
-
1993
- 1993-12-17 AT AT94903741T patent/ATE148454T1/de not_active IP Right Cessation
- 1993-12-17 US US08/411,634 patent/US5554599A/en not_active Expired - Fee Related
- 1993-12-17 RU RU95113480A patent/RU2136660C1/ru not_active IP Right Cessation
- 1993-12-17 KR KR1019950701331A patent/KR100295977B1/ko not_active Expired - Fee Related
- 1993-12-17 WO PCT/DK1993/000425 patent/WO1994014766A1/fr active IP Right Grant
- 1993-12-17 EP EP94903741A patent/EP0675878B1/fr not_active Expired - Lifetime
- 1993-12-17 DE DE69307929T patent/DE69307929T2/de not_active Expired - Fee Related
- 1993-12-17 CA CA002146775A patent/CA2146775C/fr not_active Expired - Fee Related
- 1993-12-17 DK DK94903741.0T patent/DK0675878T3/da active
- 1993-12-17 AU AU58087/94A patent/AU668638B2/en not_active Ceased
- 1993-12-17 ES ES94903741T patent/ES2098123T3/es not_active Expired - Lifetime
- 1993-12-17 NZ NZ259317A patent/NZ259317A/en unknown
-
1995
- 1995-06-16 FI FI952972A patent/FI108225B/fi active
-
1997
- 1997-03-07 GR GR970400458T patent/GR3022774T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69307929T2 (de) | 1997-09-04 |
| CA2146775A1 (fr) | 1994-07-07 |
| CA2146775C (fr) | 2005-06-28 |
| GR3022774T3 (en) | 1997-06-30 |
| FI108225B (fi) | 2001-12-14 |
| ATE148454T1 (de) | 1997-02-15 |
| EP0675878B1 (fr) | 1997-01-29 |
| FI952972L (fi) | 1995-06-16 |
| EP0675878A1 (fr) | 1995-10-11 |
| KR950703501A (ko) | 1995-09-20 |
| ES2098123T3 (es) | 1997-04-16 |
| GB9226877D0 (en) | 1993-02-17 |
| DE69307929D1 (de) | 1997-03-13 |
| KR100295977B1 (ko) | 2001-11-14 |
| AU668638B2 (en) | 1996-05-09 |
| US5554599A (en) | 1996-09-10 |
| WO1994014766A1 (fr) | 1994-07-07 |
| NZ259317A (en) | 1997-05-26 |
| FI952972A0 (fi) | 1995-06-16 |
| RU95113480A (ru) | 1997-03-20 |
| AU5808794A (en) | 1994-07-19 |
| RU2136660C1 (ru) | 1999-09-10 |
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