DK0668272T3 - Fremgangsmåde til fremstilling af tetrazolylforbindelser - Google Patents
Fremgangsmåde til fremstilling af tetrazolylforbindelserInfo
- Publication number
- DK0668272T3 DK0668272T3 DK95101055T DK95101055T DK0668272T3 DK 0668272 T3 DK0668272 T3 DK 0668272T3 DK 95101055 T DK95101055 T DK 95101055T DK 95101055 T DK95101055 T DK 95101055T DK 0668272 T3 DK0668272 T3 DK 0668272T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- tetrazolyl compound
- tetrazolyl compounds
- tetrazolyl
- protected
- Prior art date
Links
- 125000003831 tetrazolyl group Chemical group 0.000 title 1
- -1 N-protected tetrazolyl compound Chemical class 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP823394 | 1994-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0668272T3 true DK0668272T3 (da) | 2000-09-18 |
Family
ID=11687442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95101055T DK0668272T3 (da) | 1994-01-28 | 1995-01-26 | Fremgangsmåde til fremstilling af tetrazolylforbindelser |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5578733A (da) |
| EP (1) | EP0668272B1 (da) |
| AT (1) | ATE194603T1 (da) |
| CA (1) | CA2141175C (da) |
| DE (1) | DE69517832T2 (da) |
| DK (1) | DK0668272T3 (da) |
| ES (1) | ES2147798T3 (da) |
| GR (1) | GR3034464T3 (da) |
| PT (1) | PT668272E (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002043709A1 (fr) | 2000-12-01 | 2002-06-06 | Takeda Chemical Industries, Ltd. | Procede de production d'une preparation contenant une substance bioactive |
| EP1444988A4 (en) | 2001-11-13 | 2007-04-25 | Takeda Pharmaceutical | CANCER AGENT |
| WO2003074008A2 (en) * | 2002-03-01 | 2003-09-12 | Merck & Co., Inc. | Aminoalkylphosphonates and related compounds as edg receptor agonists |
| EP1511739B1 (en) * | 2003-03-17 | 2008-04-30 | Teva Pharmaceutical Industries Ltd. | Polymorphs of valsartan |
| AU2003230193A1 (en) * | 2003-03-27 | 2004-10-18 | Hetero Drugs Limited | Novel crystalline forms of candesartan cilexetil |
| WO2004094391A2 (en) | 2003-04-21 | 2004-11-04 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of valsartan and intermediates thereof |
| CZ297016B6 (cs) * | 2003-08-27 | 2006-08-16 | Zentiva, A.S. | Zpusob odstranování trifenylmethanové chránicí skupiny z 1-trityl-5-(4'-subst. aminomethyl-1,1' -bifenyl-2-yl)-1H-tetrazolu a zpusob výroby draselné soli losartanu, irbesartanu a valsartanu s jeho pouzitím |
| CA2542499A1 (en) * | 2003-10-16 | 2005-04-28 | Teva Pharmaceutical Industries Ltd. | Preparation of candesartan cilexetil |
| WO2005051928A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | Process for production of tetrazolyl compounds |
| EP1713795A2 (en) * | 2004-02-11 | 2006-10-25 | Teva Pharmaceutical Industries Ltd. | Candesartan cilexetil polymorphs |
| MXPA06012702A (es) * | 2004-05-05 | 2007-04-02 | Teva Pharma | Preparacion de candesartan cilexetil de alta pureza. |
| WO2005123720A1 (en) * | 2004-06-18 | 2005-12-29 | Ranbaxy Laboratories Limited | Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof |
| EP1655298A1 (en) * | 2004-11-03 | 2006-05-10 | LEK Pharmaceuticals d.d. | Novel polymorph forms of candesartan cilexetil |
| EP1812423A1 (en) * | 2004-11-11 | 2007-08-01 | LEK Pharmaceuticals D.D. | Process for the synthesis of tetrazoles |
| CA2590894A1 (en) * | 2005-01-14 | 2006-07-20 | Teva Pharmaceutical Industries Ltd. | Preparation of crude candesartan cilexetil |
| US20070082055A1 (en) * | 2005-05-10 | 2007-04-12 | Ziv Kurgan | Stable micronized candesartan cilexetil and methods for preparing thereof |
| EP1896455A2 (en) | 2005-06-06 | 2008-03-12 | Medichem, S.A. | Process for the preparation of tetrazolyl compounds |
| EP1816131A1 (en) * | 2006-02-06 | 2007-08-08 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of olmesartan medoxomil |
| WO2007017135A2 (en) * | 2005-07-29 | 2007-02-15 | Krka | Process for the preparation of olmesartan medoxomil |
| SI22127A (sl) | 2005-10-07 | 2007-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo kandesartan cileksetila |
| CZ299265B6 (cs) * | 2005-10-20 | 2008-05-28 | Zentiva, A. S. | Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu) |
| ITTO20060560A1 (it) * | 2006-07-27 | 2008-01-28 | S I M S S R L | Composti intermedi per la preparazione di antagonisti dell¿angiotensina ii |
| WO2008012371A1 (en) * | 2006-07-28 | 2008-01-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of amorphous and crystalline forms of candesartan cilexetil using column chromatography |
| EP2170868A1 (en) * | 2007-07-11 | 2010-04-07 | Alembic Limited | An improved process for the preparation of candesartan cilexetil |
| MX2011012460A (es) | 2009-05-20 | 2012-04-20 | Ranbaxy Lab Ltd | Proceso para la preparacion de olmesartan medoxomil. |
| WO2011080684A1 (en) | 2009-12-31 | 2011-07-07 | Ranbaxy Laboratories Limited | Process for the preparation of candesartan cilexetil |
| WO2011092666A1 (en) | 2010-01-29 | 2011-08-04 | Ranbaxy Laboratories Limited | An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof |
| KR101251741B1 (ko) | 2010-12-16 | 2013-04-05 | 동화약품주식회사 | 칸데사르탄실렉세틸의 개선된 제조방법 |
| CN103396408A (zh) * | 2013-08-13 | 2013-11-20 | 河南华商药业有限公司 | 坎地沙坦酯中杂质b的制备方法 |
| CN109851612A (zh) * | 2019-01-30 | 2019-06-07 | 浙江省食品药品检验研究院 | 一种坎地沙坦酯晶体及其制备方法 |
| CN109776503A (zh) * | 2019-01-30 | 2019-05-21 | 浙江省食品药品检验研究院 | 一种坎地沙坦酯晶体及其制备方法 |
| CN109627234A (zh) * | 2019-01-30 | 2019-04-16 | 浙江省食品药品检验研究院 | 一种坎地沙坦酯晶体及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| GB9017480D0 (en) * | 1990-08-09 | 1990-09-26 | Ici Plc | Chemical process |
| TW209213B (da) * | 1991-08-21 | 1993-07-11 | Yamanouchi Pharma Co Ltd | |
| IL103020A (en) * | 1991-09-10 | 1998-10-30 | Tanabe Seiyaku Co | 3-(1,1'-Biphenyl-4-yl-methyl)-4,5,6,7-tetrahydro-3h-imidazo Ú4,5-c¾ pyridine-4-carboxylic acids their preparation and pharmaceutical compositions containing them |
| DE4132632A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Substituierte imidazolyl-propensaeurederivate |
| EP0550313A1 (fr) * | 1991-12-30 | 1993-07-07 | Synthelabo | Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse |
| DE4212748A1 (de) * | 1992-04-16 | 1993-10-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
-
1995
- 1995-01-26 DK DK95101055T patent/DK0668272T3/da active
- 1995-01-26 DE DE69517832T patent/DE69517832T2/de not_active Expired - Lifetime
- 1995-01-26 ES ES95101055T patent/ES2147798T3/es not_active Expired - Lifetime
- 1995-01-26 PT PT95101055T patent/PT668272E/pt unknown
- 1995-01-26 AT AT95101055T patent/ATE194603T1/de active
- 1995-01-26 EP EP95101055A patent/EP0668272B1/en not_active Expired - Lifetime
- 1995-01-26 CA CA002141175A patent/CA2141175C/en not_active Expired - Lifetime
- 1995-01-27 US US08/378,825 patent/US5578733A/en not_active Expired - Lifetime
-
1996
- 1996-08-16 US US08/697,010 patent/US5763619A/en not_active Expired - Lifetime
-
2000
- 2000-09-21 GR GR20000402153T patent/GR3034464T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0668272A3 (en) | 1995-08-30 |
| CA2141175C (en) | 2006-12-12 |
| DE69517832T2 (de) | 2000-11-09 |
| EP0668272B1 (en) | 2000-07-12 |
| US5578733A (en) | 1996-11-26 |
| EP0668272A2 (en) | 1995-08-23 |
| GR3034464T3 (en) | 2000-12-29 |
| ES2147798T3 (es) | 2000-10-01 |
| CA2141175A1 (en) | 1995-07-29 |
| US5763619A (en) | 1998-06-09 |
| PT668272E (pt) | 2000-10-31 |
| ATE194603T1 (de) | 2000-07-15 |
| DE69517832D1 (de) | 2000-08-17 |
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