DK0583271T3 - Arylmorpholin, fremstilling og anvendelse - Google Patents

Arylmorpholin, fremstilling og anvendelse

Info

Publication number: DK0583271T3
Authority: DK; Denmark
Prior art keywords: manufacture; human; aryl morpholine; morpholine; aryl
Prior art date: 1991-04-23

Application number

DK92908819T

Other languages

English (en)

Inventor

James Leroy Kelley

Nariman Bomanshaw Mehta

Grady Evan Boswell

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-23

Filing date

1992-04-22

Publication date

1999-07-26

1992-04-22 Application filed by Wellcome Found filed Critical Wellcome Found

1999-07-26 Application granted granted Critical

1999-07-26 Publication of DK0583271T3 publication Critical patent/DK0583271T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Photoreceptors In Electrophotography (AREA)
Compositions Of Macromolecular Compounds (AREA)

DK92908819T 1991-04-23 1992-04-22 Arylmorpholin, fremstilling og anvendelse DK0583271T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919108629A GB9108629D0 (en)	1991-04-23	1991-04-23	Heterocyclic pharmaceutical compounds,preparation and use
PCT/GB1992/000733 WO1992018489A1 (en)	1991-04-23	1992-04-22	Arylmorpholine, preparation and use

Publications (1)

Publication Number	Publication Date
DK0583271T3 true DK0583271T3 (da)	1999-07-26

Family

ID=10693740

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92908819T DK0583271T3 (da)	1991-04-23	1992-04-22	Arylmorpholin, fremstilling og anvendelse

Country Status (17)

Country	Link
US (2)	US5648347A (da)
EP (1)	EP0583271B1 (da)
JP (1)	JP3130040B2 (da)
AT (1)	ATE173252T1 (da)
AU (1)	AU668863B2 (da)
CA (1)	CA2108967C (da)
DE (1)	DE69227583T2 (da)
DK (1)	DK0583271T3 (da)
ES (1)	ES2124256T3 (da)
FI (1)	FI934680A0 (da)
GB (1)	GB9108629D0 (da)
HU (1)	HU219458B (da)
IE (1)	IE921260A1 (da)
NZ (1)	NZ242421A (da)
PT (1)	PT100415B (da)
WO (1)	WO1992018489A1 (da)
ZA (1)	ZA922910B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9108629D0 (en) *	1991-04-23	1991-06-12	Wellcome Found	Heterocyclic pharmaceutical compounds,preparation and use
US7098206B2 (en) *	1998-01-21	2006-08-29	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
HRP20051024A2 (hr)	1998-01-21	2006-04-30	Glaxo Group Limited	Farmaceutski aktivni morfolinol
US6998400B2 (en)	1998-01-22	2006-02-14	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
US6855820B2 (en) *	1999-01-20	2005-02-15	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
US6734213B2 (en)	1999-01-20	2004-05-11	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
FR2796069B3 (fr) *	1999-07-09	2001-08-24	Sanofi Synthelabo	Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
EA009589B1 (ru) *	2002-12-10	2008-02-28	Пфайзер Инк.	Производные морфолина для применения в качестве агонистов допамина при лечении половой дисфункции
US7323462B2 (en)	2002-12-10	2008-01-29	Pfizer Inc.	Morpholine dopamine agonists
GB0228787D0 (en) *	2002-12-10	2003-01-15	Pfizer Ltd	Morpholine dopamine agonists
EP2571859B1 (en)	2010-05-21	2015-07-22	Research Triangle Institute	1-phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
WO2011146850A1 (en) *	2010-05-21	2011-11-24	Research Triangle Institute	Phenylmorpholines and analogues thereof
CN105949142B (zh) *	2016-05-21	2018-03-27	南华大学	具有抗抑郁活性的单一手性化合物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2997469A (en) *		1961-08-22		Preparation of substituted
GB851311A (en) *	1958-04-02	1960-10-12	Geigy Ag J R	Morpholine compounds and their production
US3117967A (en) *	1962-04-02	1964-01-14	Smith Kline French Lab	2-biphenylyl-2-hydroxy-morpholinium halides
GB1336732A (en) *	1970-10-28	1973-11-07	Istituto Gentili Spa Pisa	Diethanolamine derivatives
IE50355B1 (en) *	1979-10-20	1986-04-02	Wyeth John & Brother Ltd	Morpholine derivatives
FR2517305B1 (fr) *	1981-12-01	1985-10-25	Lafon Labor	Nouveaux derives de 2-phenyl-morpholine et leur utilisation en therapeutique
FR2553410B1 (fr) *	1983-10-14	1986-05-16	Lafon Labor	Nouveaux derives de 2-tolyl-morpholine utiles en therapeutique
FR2553411B1 (fr) *	1983-10-14	1986-08-01	Lafon Labor	Derives de 2-halogenophenyl-morpholine, procede de preparation et utilisation en therapeutique
FR2553413B1 (fr) *	1983-10-17	1986-03-21	Lafon Labor	Derives de 4-alkyl-2-hydroxy-3-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8417170D0 (en) *	1984-07-05	1984-08-08	Wellcome Found	Heterocyclic pharmaceutical compounds
US4803200A (en) *	1987-10-02	1989-02-07	A. H. Robins Company, Incorporated	Substituted dialkanolamines, sulfur analogs and condensed 1,4-oxazine derivatives thereof in viral disease treatment
GB8924528D0 (en) *	1989-10-31	1989-12-20	Wellcome Found	Heterocyclic pharmaceutical compounds,preparation and use
GB9108629D0 (en) *	1991-04-23	1991-06-12	Wellcome Found	Heterocyclic pharmaceutical compounds,preparation and use

1991
- 1991-04-23 GB GB919108629A patent/GB9108629D0/en active Pending
1992
- 1992-04-22 IE IE126092A patent/IE921260A1/en not_active IP Right Cessation
- 1992-04-22 ZA ZA922910A patent/ZA922910B/xx unknown
- 1992-04-22 CA CA002108967A patent/CA2108967C/en not_active Expired - Fee Related
- 1992-04-22 HU HU9303000A patent/HU219458B/hu not_active IP Right Cessation
- 1992-04-22 ES ES92908819T patent/ES2124256T3/es not_active Expired - Lifetime
- 1992-04-22 NZ NZ242421A patent/NZ242421A/en unknown
- 1992-04-22 AT AT92908819T patent/ATE173252T1/de not_active IP Right Cessation
- 1992-04-22 DK DK92908819T patent/DK0583271T3/da active
- 1992-04-22 PT PT100415A patent/PT100415B/pt not_active IP Right Cessation
- 1992-04-22 DE DE69227583T patent/DE69227583T2/de not_active Expired - Fee Related
- 1992-04-22 EP EP92908819A patent/EP0583271B1/en not_active Expired - Lifetime
- 1992-04-22 AU AU15753/92A patent/AU668863B2/en not_active Ceased
- 1992-04-22 FI FI934680A patent/FI934680A0/fi not_active IP Right Cessation
- 1992-04-22 JP JP04508053A patent/JP3130040B2/ja not_active Expired - Fee Related
- 1992-04-22 WO PCT/GB1992/000733 patent/WO1992018489A1/en not_active Ceased
1995
- 1995-05-19 US US08/444,609 patent/US5648347A/en not_active Expired - Fee Related
1997
- 1997-03-28 US US08/828,935 patent/US5760224A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH06506675A (ja)	1994-07-28
PT100415B (pt)	1999-08-31
FI934680A7 (fi)	1993-10-22
WO1992018489A1 (en)	1992-10-29
EP0583271A1 (en)	1994-02-23
HU219458B (hu)	2001-04-28
HUT70531A (en)	1995-10-30
AU668863B2 (en)	1996-05-23
EP0583271B1 (en)	1998-11-11
ES2124256T3 (es)	1999-02-01
US5760224A (en)	1998-06-02
PT100415A (pt)	1993-06-30
DE69227583D1 (de)	1998-12-17
FI934680L (fi)	1993-10-22
ATE173252T1 (de)	1998-11-15
NZ242421A (en)	1994-10-26
JP3130040B2 (ja)	2001-01-31
FI934680A0 (fi)	1993-10-22
IE921260A1 (en)	1992-11-04
CA2108967C (en)	2002-10-08
AU1575392A (en)	1992-11-17
DE69227583T2 (de)	1999-04-01
HU9303000D0 (en)	1994-01-28
ZA922910B (en)	1994-01-24
CA2108967A1 (en)	1992-10-24
GB9108629D0 (en)	1991-06-12
US5648347A (en)	1997-07-15

Publication	Publication Date	Title
SE9504661D0 (sv)	1995-12-22	New compounds
ES2141957T3 (es)	2000-04-01	Uso de raloxifeno y sus analogos para la produccion de un medicamento para el tratamiento de enfermedades virales.
SE9604786D0 (sv)	1996-12-20	New compounds
ATE165510T1 (de)	1998-05-15	Methode zur hemmung der proliferation weiche muskelzellen und der restenose
DK0583271T3 (da)	1999-07-26	Arylmorpholin, fremstilling og anvendelse
DK0652002T3 (da)	2001-04-17	Anvendelse af 2-phenyl-3-aroylebenzothiophener til fremstilling af et medikament til hæmning af brusknedbrydning
RU94045271A (ru)	1996-10-10	Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера
SE9504662D0 (sv)	1995-12-22	New compounds
EA199700136A1 (ru)	1997-12-30	Способы ингибирования экзогенных эстрогенов
ES2104938T3 (es)	1997-10-16	Metodo de inhibir la fibrosis.
MY133438A (en)	2007-11-30	Morpholinobenzamide salts
DK0769945T3 (da)	2003-06-10	Brug af 2-phenyl-3-aroylbenzothiophenderivater til fremstilling af et medikament til behandling af knogler og knoglebrud
SE9603284D0 (sv)	1996-09-10	New compounds
LV11524A (lv)	1996-10-20	Benzidamina izmantosana TNF izsaukto patologisko stavoklu arstesana
SE7806469L (sv)	1979-12-02	Antihypertensiva kompositioner
DK0772438T3 (da)	1999-11-01	Anvendelse af benzothiophener til fremstilling af et medikament til reduktion af ardannelse under sårheling
NO970784L (no)	1997-02-20	Fremgangsmåte for opprettholdelse av tenner og oralt ben
ATE56445T1 (de)	1990-09-15	Pharmacologisch aktive propionylanilide.
MX9709536A (es)	1998-03-29	Metodo para reducir el factor de transcripcion bef-1.