[go: up one dir, main page]

DK0567271T3 - Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf - Google Patents

Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf

Info

Publication number
DK0567271T3
DK0567271T3 DK93302937.3T DK93302937T DK0567271T3 DK 0567271 T3 DK0567271 T3 DK 0567271T3 DK 93302937 T DK93302937 T DK 93302937T DK 0567271 T3 DK0567271 T3 DK 0567271T3
Authority
DK
Denmark
Prior art keywords
treatment
substituted alkyl
applications
preparation
alkyl
Prior art date
Application number
DK93302937.3T
Other languages
Danish (da)
English (en)
Inventor
Koichi Kojima
Hitoshi Kurata
Koki Ishibashi
Takakazu Hamada
Hiroyoshi Horikoshi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of DK0567271T3 publication Critical patent/DK0567271T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
DK93302937.3T 1992-04-20 1993-04-15 Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf DK0567271T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9981692 1992-04-20
JP32804392 1992-12-08

Publications (1)

Publication Number Publication Date
DK0567271T3 true DK0567271T3 (da) 1998-02-16

Family

ID=26440917

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93302937.3T DK0567271T3 (da) 1992-04-20 1993-04-15 Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf

Country Status (25)

Country Link
US (3) US5536714A (cs)
EP (2) EP0567271B1 (cs)
JP (1) JP2514778B2 (cs)
KR (1) KR0146680B1 (cs)
CN (2) CN1041095C (cs)
AT (1) ATE154937T1 (cs)
AU (1) AU656852B2 (cs)
CA (1) CA2094300C (cs)
CZ (2) CZ284206B6 (cs)
DE (1) DE69311837T2 (cs)
DK (1) DK0567271T3 (cs)
ES (1) ES2105108T3 (cs)
FI (1) FI931765L (cs)
GR (1) GR3024896T3 (cs)
HK (1) HK1000303A1 (cs)
HU (1) HU219579B (cs)
ID (1) ID18576A (cs)
IL (1) IL105478A (cs)
MX (1) MX9302300A (cs)
NO (1) NO304891B1 (cs)
NZ (1) NZ247449A (cs)
PH (1) PH31052A (cs)
RU (2) RU2097387C1 (cs)
TW (2) TW401420B (cs)
ZA (1) ZA932732B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1259419B (it) * 1991-05-24 1996-03-18 Erba Carlo Spa Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
CA2134231A1 (en) * 1992-04-30 1993-11-11 Dennis Alan Holt 17.alpha. and 17.alpha.-substituted estra-1,3,5(10)-triene-3-carboxylic acid
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
GB9224148D0 (en) * 1992-11-18 1993-01-06 Smithkline Beecham Corp Compounds
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
ATE227122T1 (de) * 1993-09-03 2002-11-15 Smithkline Beecham Corp Stabilisierte tablettenformulierung
GB9324371D0 (en) * 1993-11-26 1994-01-12 Erba Carlo Spa Side chain fluoro substituted 3-carboxysteroids
GB9411103D0 (en) * 1994-06-03 1994-07-27 Smithkline Beecham Corp Compounds
GB9415183D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 3-carboxysteroids with a fluorinated side-chain
AU8779898A (en) * 1997-08-11 1999-03-01 Weider Nutrition International, Inc. Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors
US5879711A (en) * 1997-11-07 1999-03-09 Sequeira; Joel A. Stable antiandrogenic gel composition
EP1079859B1 (en) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US7258850B2 (en) * 1999-05-04 2007-08-21 Aradigm Corporation Methods and compositions for treating erectile dysfunction
US6428769B1 (en) 1999-05-04 2002-08-06 Aradigm Corporation Acute testosterone administration
EP1434786A4 (en) * 2001-10-03 2009-03-25 Merck & Co Inc ANDROSTAN-17-BETA-CARBOXAMIDE AS MODULATORS OF THE ANDROGEN RECEPTOR
US20060148725A1 (en) * 2001-12-21 2006-07-06 The Miriam Hospital Selective 11beta HSD inhibitors and methods of use thereof
WO2003059267A2 (en) * 2001-12-21 2003-07-24 Rhode Island Hospital SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF
CA2524165A1 (en) * 2003-04-29 2004-11-11 The Miriam Hospital Selective testicular 11.beta.-hsd inhibitors and methods of use thereof
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
US7604386B2 (en) * 2005-11-18 2009-10-20 Federal-Mogul World Wide, Inc Lamp assembly having a socket made from high temperature plastic
CN102316902B (zh) 2009-02-20 2014-09-24 to-BBB控股股份有限公司 基于谷胱甘肽的药物递送系统
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US8563728B2 (en) * 2009-07-09 2013-10-22 Aurobindo Pharma Ltd. Process for the preparation of Dutasteride
CN111362999B (zh) * 2020-03-16 2022-03-29 江苏联环药业股份有限公司 一种爱普列特杂质及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
IL74365A (en) * 1984-02-27 1990-07-26 Merck & Co Inc 17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US4946834A (en) * 1988-12-23 1990-08-07 Smithkline Beecham Corporation Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5137882A (en) * 1990-06-11 1992-08-11 Holt Dennis A Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
WO1992018132A1 (en) * 1991-04-17 1992-10-29 Merck & Co., Inc. Pharmaceutical combination for the treatment of benign prostatic hyperplasia comtaining a 5 alpha-reductase inhibitor
US5196411A (en) * 1991-08-16 1993-03-23 Merck & Co., Inc. 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors

Also Published As

Publication number Publication date
EP0567271A3 (en) 1994-11-23
HUT64558A (en) 1994-01-28
CA2094300C (en) 2003-01-28
HU219579B (hu) 2001-05-28
EP0567271B1 (en) 1997-07-02
US5536714A (en) 1996-07-16
PH31052A (en) 1998-02-03
EP0725074A3 (en) 1996-11-20
US5717088A (en) 1998-02-10
EP0567271A2 (en) 1993-10-27
AU656852B2 (en) 1995-02-16
JP2514778B2 (ja) 1996-07-10
RU2114861C1 (ru) 1998-07-10
US5760025A (en) 1998-06-02
ES2105108T3 (es) 1997-10-16
FI931765A0 (fi) 1993-04-19
CZ67893A3 (en) 1994-01-19
DE69311837D1 (de) 1997-08-07
FI931765L (fi) 1993-10-21
AU3698493A (en) 1993-10-21
CZ90097A3 (cs) 1998-07-15
NZ247449A (en) 1995-02-24
NO931401L (no) 1993-10-21
GR3024896T3 (en) 1998-01-30
RU95101838A (ru) 1997-01-10
ZA932732B (en) 1993-10-28
CZ283791B6 (cs) 1998-06-17
TW238312B (cs) 1995-01-11
IL105478A (en) 1998-03-10
IL105478A0 (en) 1993-08-18
CA2094300A1 (en) 1993-10-21
JPH06279487A (ja) 1994-10-04
MX9302300A (es) 1994-03-31
TW401420B (en) 2000-08-11
CN1195666A (zh) 1998-10-14
NO931401D0 (no) 1993-04-16
CZ284206B6 (cs) 1998-09-16
HU9301155D0 (en) 1993-07-28
NO304891B1 (no) 1999-03-01
KR930021654A (ko) 1993-11-22
HK1000303A1 (en) 1998-02-20
DE69311837T2 (de) 1998-02-12
CN1083070A (zh) 1994-03-02
EP0725074A2 (en) 1996-08-07
ID18576A (id) 1998-04-23
ATE154937T1 (de) 1997-07-15
KR0146680B1 (ko) 1998-08-01
RU2097387C1 (ru) 1997-11-27
CN1041095C (zh) 1998-12-09

Similar Documents

Publication Publication Date Title
DK0567271T3 (da) Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
DK0484094T3 (da) Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse
DK0552329T3 (da) Methylen-oxindol-derivater og fremgangsmåde til deres fremstilling
EP1175208A4 (en) COMPOSITION FOR PREVENTION OR TREATMENT OF DEMENTIA CONTAINING A HYDROXYCINNAMIC ACID DERIVATIVE OR AN EXTRACT OF AN ANGELICAE SPECIES CONTAINING SAID ACID
BG104569A (en) Substituted 2-benzylamino-2-phenyl-acetamide compounds
DK164915C (da) Anvendelse af 17beta-methoxycarbonyl-4-aza-4-methyl-5alfa-androst-1-en-3-on til fremstilling af et topisk praeparat
EP0711164A1 (en) 4-AZA-PREGNAN-5-ALPHA REDUCTASE ISOZYM 1 INHIBITORS
AU2287499A (en) Azetidinecarboxamide derivatives for treating cns disorders
NO964522L (no) Fremgangmåte ved fremstilling av 5,6-dihydroksy-2-amino-1,2,3,4-tetrahydronaftalenderivater
AU4355696A (en) Substituted amidinonaphthyl ester derivatives
MX9800705A (es) Compuestos heterociclicos, composiciones para tratar isquemia de miocardio que los contiene, y procedimiento para su preparacion.
AU2178199A (en) Azetidinecarboxamide derivatives for the treatment of cns disorders
DK1049670T3 (da) Azetidincarboxamidderivater til behandling af CNS-lidelser
WO2000034247A3 (de) Verfahren zur herstellung von pyrazolylbenzoylderivaten sowie neue pyrazolylbenzoylderivate
IT1265256B1 (it) 4-alchil e 4-alchenil delta-3-cefem solfoni