DK0506792T3 - Insulinpræparat, der indeholder nikotinsyre eller nikotinamid - Google Patents

Insulinpræparat, der indeholder nikotinsyre eller nikotinamid

Info

Publication number: DK0506792T3
Authority: DK; Denmark
Prior art keywords: nicotinic acid; nicotinamide; pct; preparation containing; insulin preparation
Prior art date: 1989-12-21

Application number

DK91901711.1T

Other languages

English (en)

Inventor

Klavs Holger Jorgensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-20

Publication date

1995-10-09

1989-12-21 Priority claimed from DK654389A external-priority patent/DK654389D0/da

1990-01-10 Priority claimed from DK7190A external-priority patent/DK7190D0/da

1990-12-20 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1995-10-09 Application granted granted Critical

1995-10-09 Publication of DK0506792T3 publication Critical patent/DK0506792T3/da

Links

DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title abstract 5
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title abstract 3
235000005152 nicotinamide Nutrition 0.000 title abstract 3
239000011570 nicotinamide Substances 0.000 title abstract 3
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
229960003966 nicotinamide Drugs 0.000 title abstract 2
229960003512 nicotinic acid Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
235000001968 nicotinic acid Nutrition 0.000 abstract 1
239000011664 nicotinic acid Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Pyridine Compounds (AREA)

DK91901711.1T 1989-12-21 1990-12-20 Insulinpræparat, der indeholder nikotinsyre eller nikotinamid DK0506792T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK654389A DK654389D0 (da)	1989-12-21	1989-12-21	Laegemiddel
DK7190A DK7190D0 (da)	1990-01-10	1990-01-10	Laegemiddel

Publications (1)

Publication Number	Publication Date
DK0506792T3 true DK0506792T3 (da)	1995-10-09

Family

ID=26063239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91901711.1T DK0506792T3 (da)	1989-12-21	1990-12-20	Insulinpræparat, der indeholder nikotinsyre eller nikotinamid

Country Status (10)

Country	Link
US (1)	US5382574A (da)
EP (1)	EP0506792B1 (da)
JP (1)	JP3122128B2 (da)
AT (1)	ATE122567T1 (da)
AU (1)	AU641721B2 (da)
CA (1)	CA2070814A1 (da)
DE (1)	DE69019534T2 (da)
DK (1)	DK0506792T3 (da)
ES (1)	ES2072596T3 (da)
WO (1)	WO1991009617A1 (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3562195A (en) *	1994-10-04	1996-04-26	Novo Nordisk A/S	Preparations containing aspb28 human insulin and nicotinamide
US5830999A (en) *	1995-01-26	1998-11-03	Regents Of The University Of California	Stabilization of insulin through ligand binding interations
EP0880969A1 (en) *	1997-05-28	1998-12-02	Applied Research Systems ARS Holdings N.V.	Pharmaceutical compositions of peptides having low solubility in physiological medium
CN1317967A (zh)	1998-09-17	2001-10-17	伊莱利利公司	蛋白质制剂
US6573237B2 (en)	2001-03-16	2003-06-03	Eli Lilly And Company	Protein formulations
PL2107069T3 (pl) *	2003-08-05	2013-06-28	Novo Nordisk As	Nowe pochodne insuliny
CA2568134A1 (en) *	2004-05-24	2005-12-08	New York University	Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
US9737511B2 (en) *	2004-05-24	2017-08-22	Geoffrey C. GURTNER	Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
DK1969004T3 (da) *	2005-12-28	2011-11-28	Novo Nordisk As	Insulinsammensætninger og metode til at lave en sammensætning
CN101677947B (zh) *	2007-06-13	2013-07-17	诺沃-诺迪斯克有限公司	包含胰岛素衍生物的药物制剂
US10098857B2 (en)	2008-10-10	2018-10-16	The Board Of Trustees Of The Leland Stanford Junior University	Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
US9603904B2 (en) *	2008-10-30	2017-03-28	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
US9018190B2 (en)	2009-03-27	2015-04-28	Adocia	Functionalized oligosaccharides
FR2943538B1 (fr)	2009-03-27	2011-05-20	Adocia	Formulation a action rapide d'insuline recombinante humaine
AU2013203134B2 (en) *	2009-06-26	2016-05-12	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and an amino acid
EP2340033B1 (en) *	2009-06-26	2013-10-09	Novo Nordisk A/S	PREPARATION COMPRISING INSULIN, NICOTINAMIDE AND Arginine
BR112013010345A2 (pt)	2010-10-27	2017-07-25	Novo Nordisk As	tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
US20130331320A1 (en)	2010-12-14	2013-12-12	Novo Nordisk A/S	Fast-acting insulin in combination with long-acting insulin
BR112013014856A2 (pt)	2010-12-14	2016-10-18	Novo Nordisk As	preparação compreendendo insulina, nicotinamida e um aminoácido
US20130231281A1 (en)	2011-11-02	2013-09-05	Adocia	Rapid acting insulin formulation comprising an oligosaccharide
WO2013130935A1 (en) *	2012-03-02	2013-09-06	Genentech, Inc.	Amido-benzyl sulfoxide derivatives
WO2013130943A1 (en) *	2012-03-02	2013-09-06	Genentech, Inc.	Alkyl-and di-substituted amido-benzyl sulfonamide derivatives
JP6224586B2 (ja) *	2012-07-10	2017-11-01	武田薬品工業株式会社	注射用製剤
EP2919804B1 (fr)	2012-11-13	2018-01-31	Adocia	Formulation à action rapide d'insuline comprenant un composé anionique substitué
WO2014177623A1 (en)	2013-04-30	2014-11-06	Novo Nordisk A/S	Novel administration regime
US20150273022A1 (en) *	2014-02-10	2015-10-01	Biodel Inc.	Stabilized ultra-rapid-acting insulin formulations
AR099569A1 (es) *	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
WO2015131902A1 (en) *	2014-03-07	2015-09-11	Jørgensen Klavs Holger	Novel fast acting insulin preparations
US9795678B2 (en)	2014-05-14	2017-10-24	Adocia	Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3020947B1 (fr)	2014-05-14	2018-08-31	Adocia	Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
KR20180038049A (ko) *	2015-08-25	2018-04-13	노보 노르디스크 에이/에스	신규한 인슐린 유도체 및 그것의 의학적 사용
EP3341401A1 (en) *	2015-08-25	2018-07-04	Novo Nordisk A/S	Novel insulin derivatives and the medical uses hereof
FR3043557B1 (fr)	2015-11-16	2019-05-31	Adocia	Composition a action rapide d'insuline comprenant un citrate substitue
GB201607918D0 (en)	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
EP3518893A1 (en)	2016-09-29	2019-08-07	Arecor Limited	Novel formulations
EP3574007A1 (en)	2017-01-30	2019-12-04	Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)	Novel igfr-like 2 receptor and uses thereof
GB201707189D0 (en)	2017-05-05	2017-06-21	Arecor Ltd	Novel formulations
GB201707188D0 (en)	2017-05-05	2017-06-21	Arecor Ltd	Novel formulations
GB201707187D0 (en) *	2017-05-05	2017-06-21	Arecor Ltd	Novel formulations
US11331288B2 (en)	2017-09-14	2022-05-17	The Board Of Trustees Of The Leland Stanford Junior University	Conditioning irradiated tissue for increasing vascularity
EP3773473A1 (en)	2018-04-04	2021-02-17	Arecor Limited	Medical infusion pump system for the delivery of an insulin compound
EP3773472A1 (en)	2018-04-04	2021-02-17	Arecor Limited	Medical infusion pump system for the delivery of an insulin compound
US12357562B2 (en)	2018-04-04	2025-07-15	Arecor Limited	Injection pen system for the delivery of an insulin compound
TWI829687B (zh)	2018-05-07	2024-01-21	丹麥商諾佛儂迪克股份有限公司	包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
FR3083985A1 (fr)	2018-07-23	2020-01-24	Adocia	Dispositif pour injecter une solution d'insuline(s)
WO2019243627A1 (fr)	2018-06-23	2019-12-26	Adocia	Dispositif pour injecter une solution d'insuline(s)
FR3083984A1 (fr)	2018-07-23	2020-01-24	Adocia	Dispositif pour injecter une solution d'insuline(s)
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
EP3996679B1 (en)	2019-07-12	2023-09-06	Novo Nordisk A/S	High concentration insulin formulation
HUE067827T2 (hu)	2019-12-11	2024-11-28	Novo Nordisk As	Új inzulin analógok és alkalmazásaik
GB202004814D0 (en)	2020-04-01	2020-05-13	Arecor Ltd	Novel formulations
AR131148A1 (es)	2022-11-26	2025-02-19	Obshchestvo S Ogranichennoy Otvetstvennostyu «Geropharm»	Composiciones de insulina de acción rápida (variantes de las mismas)
EP4628092A1 (en)	2022-12-04	2025-10-08	OOO "Geropharm"	Insulin aspart composition (embodiments)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2179384A (en) *	1937-04-05	1939-11-07	Univ Alberta	Therapeutic composition and process of making it
US2538018A (en) *	1944-04-04	1951-01-16	Nordisk Insulinlab	Crystalline product of insulin and alkaline protein and process of making it
US2793977A (en) *	1951-08-31	1957-05-28	Caspe Saul	Compositions and method for reducing blood sugar concentration
DK116527B (da) *	1967-03-01	1970-01-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1603639A (en) *	1978-05-26	1981-11-25	Haggar H	Composition for application to the hair and scalp
CA1299102C (en) *	1987-06-15	1992-04-21	Steven G. Ayre	Insulin potentiation therapy
US5155096A (en) *	1987-06-15	1992-10-13	Garcia Y Bellon Donato P	Method for potentiation of a therapeutic agent
AU2523588A (en) *	1987-10-08	1989-05-02	Andor Bilas	Mixture of substances for stabilyzing metabolism

1990
- 1990-12-20 DK DK91901711.1T patent/DK0506792T3/da active
- 1990-12-20 WO PCT/DK1990/000335 patent/WO1991009617A1/en not_active Ceased
- 1990-12-20 AU AU70471/91A patent/AU641721B2/en not_active Ceased
- 1990-12-20 AT AT91901711T patent/ATE122567T1/de not_active IP Right Cessation
- 1990-12-20 JP JP03502033A patent/JP3122128B2/ja not_active Expired - Fee Related
- 1990-12-20 US US07/849,448 patent/US5382574A/en not_active Expired - Fee Related
- 1990-12-20 DE DE69019534T patent/DE69019534T2/de not_active Expired - Fee Related
- 1990-12-20 CA CA002070814A patent/CA2070814A1/en not_active Abandoned
- 1990-12-20 EP EP91901711A patent/EP0506792B1/en not_active Expired - Lifetime
- 1990-12-20 ES ES91901711T patent/ES2072596T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5382574A (en)	1995-01-17
AU641721B2 (en)	1993-09-30
DE69019534D1 (de)	1995-06-22
AU7047191A (en)	1991-07-24
JPH05502234A (ja)	1993-04-22
EP0506792B1 (en)	1995-05-17
EP0506792A1 (en)	1992-10-07
JP3122128B2 (ja)	2001-01-09
DE69019534T2 (de)	1995-09-21
ES2072596T3 (es)	1995-07-16
WO1991009617A1 (en)	1991-07-11
CA2070814A1 (en)	1991-06-22
ATE122567T1 (de)	1995-06-15

Publication	Publication Date	Title
DK0506792T3 (da)	1995-10-09	Insulinpræparat, der indeholder nikotinsyre eller nikotinamid
TR27525A (tr)	1995-06-07	Propenoik asit türevleri, hazirlanmalarina mahsus usuller ve fungisid olarak kullanimlari.
NO904584D0 (no)	1990-10-23	Preparater inneholdende hyaluronsyreforbindelser samt fremgangsmaate for fremstilling derav.
DK0473333T3 (da)	1997-09-08	Modificeret polydextrose og fremgangsmåde til fremstilling heraf
AR244674A1 (es)	1993-11-30	Procedimiento para preparar derivados de acidos 3,4-dihidro-3-tioxo-2h-1,4-bensoxa (o tia)zin-4-aceticos.
FI875233A7 (fi)	1988-05-29	Nya heteroaromatiska aminderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning.
NO875358L (no)	1988-06-23	6-benzoksazinyl- og 6-benzotiazinyl-2,3,4,5-tetrahydropyridazin-3-oner og fremgangsmaate for deres fremstilling.
ATE64526T1 (de)	1991-07-15	Zubereitung von pregnanolol in einer stabilen oel- in-wasser-emulsion.
NO870512D0 (no)	1987-02-10	1,4-benzoksazinderivater og fremgangsmaate for deres fremstilling.
DE69225410D1 (de)	1998-06-10	Herstellung von n-acetylneuraminsäure-derivaten
FI894027A0 (fi)	1989-08-28	Rotator foer kranburna arbetsredskap, i synnerhet traedbearbetningsaggregat.
IT1205115B (it)	1989-03-15	Metodo per preparare poliammidi aromatiche e polibenzossazoli
DK62288A (da)	1988-08-16	Substituerede 2,6-substituerede pyridinforbindelser og herbicide praeparater indeholdende disse forbindelser
FI831619A7 (fi)	1983-11-19	2(1H)-pyridinoni-johdannaiset, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet.
FI882921L (fi)	1988-06-17	Protaminzink-insulinpreparat.
DK0482108T3 (da)	1996-07-22	Substituerede 2-imidazoliner samt fremstilling og anvendelse deraf
FI893877A7 (fi)	1990-03-01	Platina(IV)diamiinikompleksi, menetelmä tämän yhdisteen valmistamiseksi, kasvaimen vastaista vaikutusta omaava valmiste, joka sisältää antiyhdisteen, ja kasvaimen vastaista vaikutusta omaavat muotoillut valmisteet
FI883680L (fi)	1989-02-07	Foerfarande foer behandling av illamaoende med vissa substituerade fenylalkylamino (och aminosyra) derivat.
DK4287A (da)	1987-07-08	Polyfluoralkylthiomethyl-forbindelser, fremgangsmaade til fremstilling deraf og anvendelse af saadanneforbindelser som overfladeaktive midler
DK62388A (da)	1988-08-10	Substituerede 2,6-substituerede pyridinforbindelser og herbicide praeparater indeholdende disse forbindelser
FI873800A7 (fi)	1987-09-01	Nor-kolaanihappojohdannaiset, menetelmä niiden valmistamiseksi, niiden käyttö sekä niitä sisältävät farmaseuttiset seokset.
NO870834D0 (no)	1987-02-27	Glysero-3(2)-fosfo-l-serinderivater og salter derav, fremgangsmaater for fremstilling derav og farmasoeytiske preparater inneholdende derivatene.
FI874085A7 (fi)	1988-03-20	Menetelmä 2,3,5,6-tetraklooripyridiinin valmistamiseksi.
IL82409A0 (en)	1987-11-30	Nicotinic acid derivatives,their preparation and their use as fungicides
FI890303L (fi)	1989-01-20	Analogiamenetelmä happea kuljettavan, vesiliukoisen hemoglobiinikompleksin valmistamiseksi