DK0489423T3 - Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelsen af disse forbindelser som lægemidler - Google Patents

Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelsen af disse forbindelser som lægemidler

Info

Publication number: DK0489423T3
Authority: DK; Denmark
Prior art keywords: bile acid; acid derivatives; compounds; drugs; processes
Prior art date: 1990-12-06

Application number

DK91120841.1T

Other languages

Danish (da)

English (en)

Inventor

Guenther Dr. Wess G

Werner Dr Kramer

Stefan Dr. Mueller

Horst Dr Neubauer

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-06

Filing date

1991-12-04

Publication date

1997-04-14

1991-12-04 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-04-14 Application granted granted Critical

1997-04-14 Publication of DK0489423T3 publication Critical patent/DK0489423T3/da

Links

HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003613 bile acid Substances 0.000 abstract 3
238000010521 absorption reaction Methods 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000003158 alcohol group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000002860 competitive effect Effects 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
210000000813 small intestine Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Motorcycle And Bicycle Frame (AREA)
Train Traffic Observation, Control, And Security (AREA)

DK91120841.1T 1990-12-06 1991-12-04 Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelsen af disse forbindelser som lægemidler DK0489423T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4038833		1990-12-06

Publications (1)

Publication Number	Publication Date
DK0489423T3 true DK0489423T3 (da)	1997-04-14

Family

ID=6419672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91120841.1T DK0489423T3 (da)	1990-12-06	1991-12-04	Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelsen af disse forbindelser som lægemidler

Country Status (23)

Country	Link
US (1)	US5250524A (fr)
EP (1)	EP0489423B1 (fr)
JP (1)	JP3237882B2 (fr)
KR (1)	KR100221690B1 (fr)
AT (1)	ATE144988T1 (fr)
AU (1)	AU649089B2 (fr)
CA (1)	CA2057099C (fr)
CZ (1)	CZ281075B6 (fr)
DE (1)	DE59108326D1 (fr)
DK (1)	DK0489423T3 (fr)
ES (1)	ES2096614T3 (fr)
FI (1)	FI106800B (fr)
GR (1)	GR3021572T3 (fr)
HR (1)	HRP940751B1 (fr)
HU (2)	HU213402B (fr)
IE (1)	IE914235A1 (fr)
IL (1)	IL100240A (fr)
NO (1)	NO304187B1 (fr)
NZ (1)	NZ240846A (fr)
PT (1)	PT99713B (fr)
SI (1)	SI9111899B (fr)
YU (1)	YU48636B (fr)
ZA (1)	ZA919605B (fr)

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EP4188541B1 (fr)	2020-08-03	2024-12-25	Albireo AB	Composés de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire
WO2022029101A1 (fr)	2020-08-03	2022-02-10	Albireo Ab	Composés de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire
JP2023549226A (ja)	2020-11-12	2023-11-22	アルビレオエービー	進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
AU2021390172A1 (en)	2020-12-04	2023-06-22	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
WO2023216423A1 (fr) *	2022-05-13	2023-11-16	苏州慧疗生物医药科技有限公司	Composé lipidique, composition, préparation et utilisation associées
KR20250022025A (ko)	2022-06-09	2025-02-14	알비레오 에이비	간염 치료
AU2023304672A1 (en)	2022-07-05	2025-01-02	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
AU2023390975A1 (en)	2022-12-09	2025-06-05	Albireo Ab	Asbt inhibitors in the treatment of renal diseases
WO2025146507A1 (fr)	2024-01-05	2025-07-10	Albireo Ab	Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs d'acide biliaire
WO2025146508A1 (fr)	2024-01-05	2025-07-10	Albireo Ab	Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs d'acide biliaire

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IT1210874B (it) *	1982-04-15	1989-09-29	Istituto Chemioterapico	Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo.
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1991
- 1991-12-04 NZ NZ240846A patent/NZ240846A/en unknown
- 1991-12-04 AT AT91120841T patent/ATE144988T1/de not_active IP Right Cessation
- 1991-12-04 FI FI915719A patent/FI106800B/fi active
- 1991-12-04 DE DE59108326T patent/DE59108326D1/de not_active Expired - Lifetime
- 1991-12-04 DK DK91120841.1T patent/DK0489423T3/da active
- 1991-12-04 EP EP91120841A patent/EP0489423B1/fr not_active Expired - Lifetime
- 1991-12-04 ES ES91120841T patent/ES2096614T3/es not_active Expired - Lifetime
- 1991-12-04 IL IL10024091A patent/IL100240A/en not_active IP Right Cessation
- 1991-12-04 US US07/802,413 patent/US5250524A/en not_active Expired - Lifetime
- 1991-12-05 ZA ZA919605A patent/ZA919605B/xx unknown
- 1991-12-05 CZ CS913697A patent/CZ281075B6/cs not_active IP Right Cessation
- 1991-12-05 AU AU88849/91A patent/AU649089B2/en not_active Ceased
- 1991-12-05 NO NO914792A patent/NO304187B1/no not_active IP Right Cessation
- 1991-12-05 JP JP34837791A patent/JP3237882B2/ja not_active Expired - Lifetime
- 1991-12-05 HU HU913817A patent/HU213402B/hu not_active IP Right Cessation
- 1991-12-05 CA CA002057099A patent/CA2057099C/fr not_active Expired - Lifetime
- 1991-12-05 IE IE423591A patent/IE914235A1/en not_active Application Discontinuation
- 1991-12-06 KR KR1019910022269A patent/KR100221690B1/ko not_active Expired - Fee Related
- 1991-12-06 SI SI9111899A patent/SI9111899B/sl unknown
- 1991-12-06 YU YU189991A patent/YU48636B/sh unknown
- 1991-12-06 PT PT99713A patent/PT99713B/pt active IP Right Grant
1994
- 1994-10-25 HR HR940751A patent/HRP940751B1/xx not_active IP Right Cessation
1995
- 1995-06-29 HU HU95P/P00553P patent/HU211900A9/hu unknown
1996
- 1996-11-07 GR GR960402941T patent/GR3021572T3/el unknown

Also Published As

Publication number	Publication date
EP0489423A1 (fr)	1992-06-10
HU211900A9 (en)	1996-01-29
AU649089B2 (en)	1994-05-12
NO304187B1 (no)	1998-11-09
FI915719L (fi)	1992-06-07
NO914792L (no)	1992-06-09
PT99713B (pt)	1999-05-31
YU189991A (sh)	1995-10-03
US5250524A (en)	1993-10-05
CA2057099A1 (fr)	1992-06-07
YU48636B (sh)	1999-03-04
EP0489423B1 (fr)	1996-11-06
NO914792D0 (no)	1991-12-05
IL100240A0 (en)	1992-09-06
AU8884991A (en)	1992-06-11
ATE144988T1 (de)	1996-11-15
ES2096614T3 (es)	1997-03-16
ZA919605B (en)	1992-08-26
KR920012108A (ko)	1992-07-25
HU913817D0 (en)	1992-02-28
GR3021572T3 (en)	1997-02-28
IL100240A (en)	1995-10-31
CZ281075B6 (cs)	1996-06-12
DE59108326D1 (de)	1996-12-12
HRP940751B1 (en)	2000-12-31
NZ240846A (en)	1994-04-27
HU213402B (en)	1997-06-30
SI9111899B (sl)	2000-06-30
JPH05294988A (ja)	1993-11-09
FI106800B (fi)	2001-04-12
KR100221690B1 (ko)	1999-10-01
HUT62599A (en)	1993-05-28
SI9111899A (sl)	1998-04-30
JP3237882B2 (ja)	2001-12-10
CS369791A3 (en)	1992-06-17
PT99713A (pt)	1992-10-30
FI915719A0 (fi)	1991-12-04
HRP940751A2 (en)	1997-04-30
IE914235A1 (en)	1992-06-17
CA2057099C (fr)	2005-05-17

Publication	Publication Date	Title
DK0489423T3 (da)	1997-04-14	Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelsen af disse forbindelser som lægemidler
NO923944D0 (no)	1992-10-09	Derivater og analoger av 2-deoksy-2,3-didehydro-n-acetyl-neuraminsyre og anvendelse av disse som virusmotvirkende midler
FI942075L (fi)	1994-11-09	Sappihappojohdannaisten tetratsolijohdannaisia, menetelmä niiden valmistamiseksi ja näiden yhdisteiden käyttö lääkeaineina
NO883073L (no)	1989-01-11	3-desmetyl-mevalonsyrederivater, fremgangsmaate for fremstilling av dem, farmasoeytiske preparater paa basis av disse forbindelsene, deres anvendelse saavel som mellomprodukter.
LU90192I2 (fr)	1998-03-02	Desirudine et ses sels et dérivés pharmaceutiquement acceptables (revasc)
NO302474B1 (no)	1998-03-09	Sakarinderivater, farmasöytisk sammensetning og anvendelse derav
PT93246A (pt)	1990-08-31	Processo para a preparacao de compostos pirrolicos substituidos e de composicoes farmaceuticas que os contem
DK162883D0 (da)	1983-04-13	N-glucosylerede carboxylsyreamidderivater, fremgangsmade til fremstilling heraf samt deres anvendelse til pavirkning af organismens egen forsvarsmekanisme
ES2110414T3 (es)	1998-02-16	Derivados de sacarina utiles como inhibidores de enzimas proteoliticas y su preparacion.
ATE131471T1 (de)	1995-12-15	An fette gebundene aminosäuren, peptide oder deren derivate
ATE157879T1 (de)	1997-09-15	Transformierte erythrozyten, verfahren zu deren herstellung, und ihre verwendung in pharmazeutischen zusammensetzungen
DK199789D0 (da)	1989-04-25	Anvendelse af et phenylquinolincarboxylsyrederivat eller et farmaceutisk egnet salt deraf til fremstilling af et topisk farmaceutisk praeparat til behandling af hud- og/eller slimepithelsygdomme
DK162439C (da)	1992-03-23	Imidazol-2-ylthioalkansyrer og derivater deraf, fremgangsmaader til deres fremstilling samt farmaceutiske praeparater indeholdende disse
DK482185A (da)	1986-04-23	Peptider, deres fremstilling og anvendelse som laegemidler
DK383388D0 (da)	1988-07-08	3-demethyl-4-fluor-mevalonsyrederivater, deres fremstilling, farmaceutiske praeparater deraf, deres anvendelse og mellemprodukter til deres fremstilling
DK0411268T3 (da)	1995-08-14	Dibenzo(1,5)dioxocin-5-on-derivater, deres anvendelse i lægemidler og fremgangsmåde til deres fremstilling
DK161833C (da)	1992-01-20	Analogifremgangsmaade til fremstilling af n-(vinblastinoyl-23)-derivater af aminosyrer eller farmaceutisk acceptable syreadditionssalte deraf
ATE86974T1 (de)	1993-04-15	(2-cyan-2-oximinoacetyl)-aminosaeure-derivate.
ES2087421T3 (es)	1996-07-16	Acidos (1's)-hidroxialquiloxapenem-3-carboxilicos y su uso como inhibidor de la betalactamasa.
FI910330A7 (fi)	1991-07-24	3-L(5-tiokso-L-prolyyli)tiatsolidiini-4-karboksyylihappo ja sen johdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
GT199100061A (es)	1993-03-02	Derivados de acido acetico
DE59203987D1 (de)	1995-11-16	Verfahren zur Reinigung von Tetrahydropyran-4-carbonsäureestern.
AR013096A1 (es)	2000-12-13	Sal de adicion de acido maleico de 5-(2-etil-2-h-tetrazol-5-il)-1-metil- 1,2,3,6-tetrahidropiridina, composicion farmaceutica que la contiene, su usoen terapia y metodo de preparacion de la misma.