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DK0419099T3 - Proteiner med antikoagulationsegenskaber - Google Patents

Proteiner med antikoagulationsegenskaber

Info

Publication number
DK0419099T3
DK0419099T3 DK90309834.1T DK90309834T DK0419099T3 DK 0419099 T3 DK0419099 T3 DK 0419099T3 DK 90309834 T DK90309834 T DK 90309834T DK 0419099 T3 DK0419099 T3 DK 0419099T3
Authority
DK
Denmark
Prior art keywords
proteins
inhibitors
factor
anticoagulant properties
inhibit
Prior art date
Application number
DK90309834.1T
Other languages
English (en)
Inventor
George P Vlasuk
Lloyd H Waxman
Victor M Garsky
Michael P Neeper
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0419099T3 publication Critical patent/DK0419099T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK90309834.1T 1989-09-07 1990-09-07 Proteiner med antikoagulationsegenskaber DK0419099T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40403389A 1989-09-07 1989-09-07
US49830790A 1990-03-23 1990-03-23
US56516490A 1990-08-13 1990-08-13

Publications (1)

Publication Number Publication Date
DK0419099T3 true DK0419099T3 (da) 1996-03-11

Family

ID=27410566

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90309834.1T DK0419099T3 (da) 1989-09-07 1990-09-07 Proteiner med antikoagulationsegenskaber

Country Status (8)

Country Link
EP (1) EP0419099B1 (da)
JP (1) JP3034926B2 (da)
AT (1) ATE133962T1 (da)
AU (1) AU639257B2 (da)
CA (1) CA2024697A1 (da)
DE (1) DE69025247T2 (da)
DK (1) DK0419099T3 (da)
IE (1) IE70759B1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
US5278144A (en) * 1990-09-04 1994-01-11 Cor Therapeutics, Inc. Antithrombosis agents
DE4136087A1 (de) * 1991-10-31 1993-05-06 Basf Ag, 6700 Ludwigshafen, De Neues thrombininhibitorisches protein aus zecken
US5321010A (en) * 1991-12-10 1994-06-14 Merck & Co., Inc. Proteins for inhibiting adhesion of platelets to collagen
WO1994012204A1 (en) * 1992-12-01 1994-06-09 Merck & Co., Inc. Anticoagulant proteins
AU7868394A (en) * 1993-10-29 1995-05-22 Merck & Co., Inc. Antithrombotic proteins
ATE346928T1 (de) 1994-10-18 2006-12-15 Dendreon Corp Aus nematoden extrahierte serinprotease- inhibitoren und die koagulation hemmende proteine
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US6245741B1 (en) 1998-05-19 2001-06-12 Washington University Protein Z-dependent protease inhibitor
ES2543588T3 (es) 2002-12-03 2015-08-20 Pharmacyclics Llc Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa
EP1931733A4 (en) 2005-09-28 2009-11-25 Biovascular Inc METHOD AND COMPOSITIONS FOR BLOCKING THROMBOZYTE AND CELL ADHESION, CELL MIGRATION AND IGNITION
CN111205354B (zh) * 2020-01-22 2021-01-22 天津科技大学 一种提高异源蛋白分泌量的信号肽突变体及其构建方法与用途

Also Published As

Publication number Publication date
ATE133962T1 (de) 1996-02-15
DE69025247T2 (de) 1996-09-12
CA2024697A1 (en) 1991-03-08
EP0419099B1 (en) 1996-02-07
IE903245A1 (en) 1991-03-13
AU639257B2 (en) 1993-07-22
JPH03178997A (ja) 1991-08-02
JP3034926B2 (ja) 2000-04-17
EP0419099A1 (en) 1991-03-27
IE70759B1 (en) 1996-12-30
AU6224790A (en) 1991-03-14
DE69025247D1 (de) 1996-03-21

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