DK0414421T3 - 1-Oxa-2-oxo-8-azaspiro(4,5)decan-derivater, fremgangsmåder til deres fremstilling samt farmaceutiske præparater med indhold deraf - Google Patents
1-Oxa-2-oxo-8-azaspiro(4,5)decan-derivater, fremgangsmåder til deres fremstilling samt farmaceutiske præparater med indhold derafInfo
- Publication number
- DK0414421T3 DK0414421T3 DK90308784.9T DK90308784T DK0414421T3 DK 0414421 T3 DK0414421 T3 DK 0414421T3 DK 90308784 T DK90308784 T DK 90308784T DK 0414421 T3 DK0414421 T3 DK 0414421T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- alkyl
- halogen atoms
- alkoxy
- oxa
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- SEUNTAIZLCAWDW-UHFFFAOYSA-N 1-oxa-8-azaspiro[4.5]decan-2-one Chemical class O1C(=O)CCC11CCNCC1 SEUNTAIZLCAWDW-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000496 anti-anoxic effect Effects 0.000 abstract 1
- 230000000141 anti-hypoxic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000006931 brain damage Effects 0.000 abstract 1
- 231100000874 brain damage Toxicity 0.000 abstract 1
- 208000029028 brain injury Diseases 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- DIOQZVSQGTUSAI-NJFSPNSNSA-N decane Chemical class CCCCCCCCC[14CH3] DIOQZVSQGTUSAI-NJFSPNSNSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU894095A HU204530B (en) | 1989-08-10 | 1989-08-10 | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
SG96294A SG96294G (en) | 1989-08-10 | 1994-07-16 | 1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0414421T3 true DK0414421T3 (da) | 1994-05-16 |
Family
ID=26317733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90308784.9T DK0414421T3 (da) | 1989-08-10 | 1990-08-09 | 1-Oxa-2-oxo-8-azaspiro(4,5)decan-derivater, fremgangsmåder til deres fremstilling samt farmaceutiske præparater med indhold deraf |
Country Status (23)
Country | Link |
---|---|
US (1) | US5118687A (no) |
EP (1) | EP0414421B1 (no) |
JP (1) | JPH0749431B2 (no) |
KR (1) | KR940006635B1 (no) |
AT (1) | ATE103920T1 (no) |
AU (1) | AU622039B2 (no) |
BG (1) | BG60436B2 (no) |
DD (1) | DD299429A5 (no) |
DE (1) | DE69007904T2 (no) |
DK (1) | DK0414421T3 (no) |
ES (1) | ES2052180T3 (no) |
FI (1) | FI93455C (no) |
HK (1) | HK145994A (no) |
HR (1) | HRP920778A2 (no) |
HU (2) | HU204530B (no) |
IE (1) | IE64911B1 (no) |
IL (1) | IL95320A (no) |
NO (1) | NO177962C (no) |
NZ (1) | NZ234848A (no) |
PL (3) | PL163431B1 (no) |
SG (1) | SG96294G (no) |
SI (1) | SI9011538A (no) |
ZA (1) | ZA906302B (no) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
EP1223990B1 (en) * | 1999-10-15 | 2004-07-28 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
RU2257202C2 (ru) * | 2000-12-01 | 2005-07-27 | Соболев Дмитрий Владимирович | Натриевая соль поли(парадигидрокси- парафенилен)тиосульфокислоты в качестве регулятора метаболизма клеток и антигипоксанта, фармацевтическая композиция на ее основе |
KR20020091462A (ko) * | 2001-05-30 | 2002-12-06 | 삼성광주전자 주식회사 | 원료 굳음 방지기능을 갖는 자동판매기 및 그 제어방법 |
GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR96352E (fr) * | 1967-12-29 | 1972-06-16 | Science Union & Cie | Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation. |
BE790675A (fr) * | 1971-10-29 | 1973-04-27 | Science Union & Cie | Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane |
EP0189370A3 (de) * | 1985-01-16 | 1988-01-27 | Sandoz Ag | Spiro-dioxolane, -dithiolane und -oxothiolane |
KR940003491B1 (ko) * | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
HU204529B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
-
1989
- 1989-08-10 HU HU894095A patent/HU204530B/hu not_active IP Right Cessation
-
1990
- 1990-08-09 DK DK90308784.9T patent/DK0414421T3/da active
- 1990-08-09 DE DE69007904T patent/DE69007904T2/de not_active Expired - Fee Related
- 1990-08-09 IL IL9532090A patent/IL95320A/en not_active IP Right Cessation
- 1990-08-09 KR KR1019900012256A patent/KR940006635B1/ko not_active Expired - Fee Related
- 1990-08-09 ES ES90308784T patent/ES2052180T3/es not_active Expired - Lifetime
- 1990-08-09 AU AU60807/90A patent/AU622039B2/en not_active Ceased
- 1990-08-09 NZ NZ234848A patent/NZ234848A/en unknown
- 1990-08-09 SI SI9011538A patent/SI9011538A/sl unknown
- 1990-08-09 IE IE288490A patent/IE64911B1/en not_active IP Right Cessation
- 1990-08-09 EP EP90308784A patent/EP0414421B1/en not_active Expired - Lifetime
- 1990-08-09 NO NO903512A patent/NO177962C/no unknown
- 1990-08-09 AT AT90308784T patent/ATE103920T1/de not_active IP Right Cessation
- 1990-08-09 DD DD90343361A patent/DD299429A5/de not_active IP Right Cessation
- 1990-08-09 JP JP2209358A patent/JPH0749431B2/ja not_active Expired - Lifetime
- 1990-08-09 ZA ZA906302A patent/ZA906302B/xx unknown
- 1990-08-10 PL PL90291701A patent/PL163431B1/pl unknown
- 1990-08-10 FI FI903972A patent/FI93455C/fi not_active IP Right Cessation
- 1990-08-10 PL PL90286440A patent/PL163370B1/pl unknown
- 1990-08-10 PL PL90291702A patent/PL163593B1/pl unknown
- 1990-08-10 US US07/566,275 patent/US5118687A/en not_active Expired - Fee Related
-
1992
- 1992-10-01 HR HRP-1538/90A patent/HRP920778A2/hr not_active Application Discontinuation
-
1993
- 1993-12-02 BG BG098261A patent/BG60436B2/bg unknown
-
1994
- 1994-07-16 SG SG96294A patent/SG96294G/en unknown
- 1994-10-12 HU HU94P/P00036P patent/HU210072A9/hu unknown
- 1994-12-22 HK HK145994A patent/HK145994A/en not_active IP Right Cessation
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