DK0382276T3 - Ethere af 1-benzyl-3-hydroxymethyl-indazol med alifatiske 2-hydroxysyrer - Google Patents

Ethere af 1-benzyl-3-hydroxymethyl-indazol med alifatiske 2-hydroxysyrer

Info

Publication number: DK0382276T3
Authority: DK; Denmark
Prior art keywords: indazole; hydroxymethyl; ethers; benzyl; aliphatic
Prior art date: 1989-02-07

Application number

DK90200167.6T

Other languages

English (en)

Inventor

Bruno Silvestrini

Leandro Baiocchi

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-07

Filing date

1990-01-23

Publication date

1996-01-15

1990-01-23 Application filed by Acraf filed Critical Acraf

1996-01-15 Application granted granted Critical

1996-01-15 Publication of DK0382276T3 publication Critical patent/DK0382276T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DK90200167.6T 1989-02-07 1990-01-23 Ethere af 1-benzyl-3-hydroxymethyl-indazol med alifatiske 2-hydroxysyrer DK0382276T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8947620A IT1230441B (it)	1989-02-07	1989-02-07	Eteri della serie dell'indazolo

Publications (1)

Publication Number	Publication Date
DK0382276T3 true DK0382276T3 (da)	1996-01-15

Family

ID=11261479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90200167.6T DK0382276T3 (da)	1989-02-07	1990-01-23	Ethere af 1-benzyl-3-hydroxymethyl-indazol med alifatiske 2-hydroxysyrer

Country Status (36)

Country	Link
US (2)	US4999367A (da)
EP (1)	EP0382276B1 (da)
JP (1)	JP2870925B2 (da)
KR (1)	KR0145525B1 (da)
CN (2)	CN1046505C (da)
AR (1)	AR247386A1 (da)
AT (1)	ATE127115T1 (da)
AU (1)	AU624895B2 (da)
BG (1)	BG50273A3 (da)
CA (1)	CA2009503C (da)
CZ (1)	CZ280121B6 (da)
DD (2)	DD295363A5 (da)
DE (2)	DE382276T1 (da)
DK (1)	DK0382276T3 (da)
EG (1)	EG19170A (da)
ES (1)	ES2020171T3 (da)
FI (1)	FI102678B (da)
GE (1)	GEP19971030B (da)
GR (2)	GR910300073T1 (da)
HU (1)	HU204793B (da)
IL (1)	IL93132A (da)
IN (1)	IN170957B (da)
IT (1)	IT1230441B (da)
LT (1)	LT3604B (da)
LV (1)	LV10612B (da)
NZ (1)	NZ232258A (da)
PE (1)	PE25091A1 (da)
PH (1)	PH26552A (da)
PL (2)	PL163720B1 (da)
PT (1)	PT93067B (da)
RO (1)	RO106252B1 (da)
RU (3)	RU2066318C1 (da)
SK (1)	SK278441B6 (da)
UA (1)	UA26852C2 (da)
YU (1)	YU47943B (da)
ZA (1)	ZA90644B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1253703B (it) *	1991-04-22	1995-08-23	Angelini Francesco Ist Ricerca	Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) *	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) *	1997-11-26	1999-08-24	Intel Corporation	Two-transistor DRAM cell for logic process technology
US7514463B2 (en)	2004-08-20	2009-04-07	University Of Kansas	Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it)	2006-11-24	2008-05-25	Acraf	Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
PT2254869T (pt)	2008-03-07	2017-07-18	Acraf	Novos derivados de 1-benzil-3-hidroximetilindazole e suas utilizações no tratamento de doenças com base na expressão de cx3cr1 e p40
AU2009221063B2 (en)	2008-03-07	2013-03-21	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
MX2010009625A (es)	2008-03-07	2010-09-28	Acraf	Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
CA2766235C (en)	2009-08-03	2017-04-04	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S.P.A.	Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
JP2015523546A (ja)	2012-05-01	2015-08-13	トランスレイタムメディカスインコーポレイテッド	失明性疾患を処置および診断するための方法
US8999292B2 (en)	2012-05-01	2015-04-07	Translatum Medicus Inc.	Methods for treating and diagnosing blinding eye diseases
EP2850062B1 (en)	2012-05-18	2017-07-19	Sanofi	Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
JP6257596B2 (ja)	2012-05-18	2018-01-10	サノフイ	ピラゾール誘導体およびｌｐａｒ５アンタゴニストとしてのその使用
CN108047136B (zh) *	2017-12-20	2021-07-09	长春普华制药股份有限公司	一种苄达酸的精制方法
US11753382B2 (en)	2019-06-25	2023-09-12	Translatum Medicus Inc.	Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) *	2021-10-19	2022-01-14	吕梁学院	一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL28032A (en) *	1966-08-29	1971-08-25	Acraf	Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) *	1969-01-29	1969-09-30	Acraf	Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it)	1980-07-29	1986-06-25	Acraf	Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it)	1981-11-27	1988-01-28	Acraf	Trattamento della cataratta
IT1194564B (it)	1983-04-18	1988-09-22	Acraf	Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it)	1986-08-01	1988-12-06	Acraf	Metodo per il tratamento di lenti a contatto

1989
- 1989-02-07 IT IT8947620A patent/IT1230441B/it active
1990
- 1990-01-22 IL IL9313290A patent/IL93132A/en not_active IP Right Cessation
- 1990-01-23 ES ES90200167T patent/ES2020171T3/es not_active Expired - Lifetime
- 1990-01-23 AT AT90200167T patent/ATE127115T1/de not_active IP Right Cessation
- 1990-01-23 EP EP90200167A patent/EP0382276B1/en not_active Expired - Lifetime
- 1990-01-23 DE DE199090200167T patent/DE382276T1/de active Pending
- 1990-01-23 DE DE69021902T patent/DE69021902T2/de not_active Expired - Lifetime
- 1990-01-23 DK DK90200167.6T patent/DK0382276T3/da active
- 1990-01-24 US US07/470,118 patent/US4999367A/en not_active Expired - Lifetime
- 1990-01-26 NZ NZ232258A patent/NZ232258A/en unknown
- 1990-01-29 ZA ZA90644A patent/ZA90644B/xx unknown
- 1990-01-30 PE PE1990164654A patent/PE25091A1/es unknown
- 1990-01-30 IN IN81/CAL/90A patent/IN170957B/en unknown
- 1990-02-02 AU AU49066/90A patent/AU624895B2/en not_active Expired
- 1990-02-05 PL PL90283638A patent/PL163720B1/pl unknown
- 1990-02-05 YU YU20690A patent/YU47943B/sh unknown
- 1990-02-05 RO RO144074A patent/RO106252B1/ro unknown
- 1990-02-05 PL PL90285287A patent/PL163730B1/pl unknown
- 1990-02-06 RU SU904743128A patent/RU2066318C1/ru active
- 1990-02-06 FI FI900577A patent/FI102678B/fi active IP Right Grant
- 1990-02-06 AR AR90316095A patent/AR247386A1/es active
- 1990-02-06 EG EG6290A patent/EG19170A/xx active
- 1990-02-06 HU HU90689A patent/HU204793B/hu unknown
- 1990-02-06 PT PT93067A patent/PT93067B/pt active IP Right Grant
- 1990-02-06 SK SK563-90A patent/SK278441B6/sk not_active IP Right Cessation
- 1990-02-06 JP JP2027007A patent/JP2870925B2/ja not_active Expired - Lifetime
- 1990-02-06 PH PH40002A patent/PH26552A/en unknown
- 1990-02-06 UA UA4743128A patent/UA26852C2/uk unknown
- 1990-02-06 CZ CS90563A patent/CZ280121B6/cs not_active IP Right Cessation
- 1990-02-06 BG BG091122A patent/BG50273A3/xx unknown
- 1990-02-07 DD DD90342349A patent/DD295363A5/de unknown
- 1990-02-07 KR KR1019900001453A patent/KR0145525B1/ko not_active IP Right Cessation
- 1990-02-07 DD DD90337657A patent/DD291995A5/de unknown
- 1990-02-07 CN CN90100599A patent/CN1046505C/zh not_active Expired - Fee Related
- 1990-02-07 CA CA002009503A patent/CA2009503C/en not_active Expired - Lifetime
- 1990-12-20 US US07/632,117 patent/US5112986A/en not_active Expired - Lifetime
1991
- 1991-06-05 RU SU914895526A patent/RU2055071C1/ru active
- 1991-06-05 RU SU914895540A patent/RU2044729C1/ru active
- 1991-11-15 GR GR91300073T patent/GR910300073T1/el unknown
1993
- 1993-06-22 LV LVP-93-647A patent/LV10612B/lv unknown
- 1993-07-26 GE GEAP19931214A patent/GEP19971030B/en unknown
- 1993-08-17 LT LTIP872A patent/LT3604B/lt not_active IP Right Cessation
- 1993-09-15 CN CN93117740A patent/CN1034016C/zh not_active Expired - Fee Related
1995
- 1995-11-22 GR GR950403284T patent/GR3018165T3/el unknown

Also Published As

Publication number	Publication date
EP0382276A3 (en)	1990-12-12
LTIP872A (en)	1995-03-27
AU4906690A (en)	1990-08-16
CN1044810A (zh)	1990-08-22
PL163730B1 (pl)	1994-04-29
GR910300073T1 (en)	1991-11-15
GR3018165T3 (en)	1996-02-29
JP2870925B2 (ja)	1999-03-17
SK56390A3 (en)	1997-05-07
IT1230441B (it)	1991-10-23
RU2066318C1 (ru)	1996-09-10
CN1034016C (zh)	1997-02-12
HU204793B (en)	1992-02-28
LV10612B (en)	1995-08-20
KR0145525B1 (ko)	1998-08-17
IT8947620A0 (it)	1989-02-07
FI900577A0 (fi)	1990-02-06
EP0382276A2 (en)	1990-08-16
ES2020171A4 (es)	1991-08-01
CA2009503C (en)	2000-04-11
IL93132A0 (en)	1990-11-05
LT3604B (en)	1995-12-27
US5112986A (en)	1992-05-12
DD291995A5 (de)	1991-07-18
ES2020171T3 (es)	1995-12-01
JPH02240065A (ja)	1990-09-25
IL93132A (en)	1994-05-30
PH26552A (en)	1992-08-19
RO106252B1 (ro)	1993-03-31
RU2055071C1 (ru)	1996-02-27
HUT53088A (en)	1990-09-28
CA2009503A1 (en)	1990-08-07
CN1046505C (zh)	1999-11-17
US4999367A (en)	1991-03-12
DE382276T1 (de)	1991-11-28
KR900012913A (ko)	1990-09-03
FI102678B1 (fi)	1999-01-29
GEP19971030B (en)	1997-06-13
EP0382276B1 (en)	1995-08-30
YU20690A (sh)	1992-07-20
NZ232258A (en)	1991-06-25
CZ56390A3 (en)	1995-06-14
SK278441B6 (en)	1997-05-07
ATE127115T1 (de)	1995-09-15
RU2044729C1 (ru)	1995-09-27
PE25091A1 (es)	1991-08-17
AU624895B2 (en)	1992-06-25
UA26852C2 (uk)	1999-12-29
CN1088201A (zh)	1994-06-22
AR247386A1 (es)	1994-12-29
PT93067A (pt)	1990-08-31
LV10612A (lv)	1995-04-20
DD295363A5 (de)	1991-10-31
HU900689D0 (en)	1990-04-28
DE69021902T2 (de)	1996-05-23
DE69021902D1 (de)	1995-10-05
IN170957B (da)	1992-06-20
YU47943B (sh)	1996-07-24
CZ280121B6 (cs)	1995-11-15
ZA90644B (en)	1991-01-30
PT93067B (pt)	1995-12-29
BG50273A3 (en)	1992-06-15
PL163720B1 (pl)	1994-04-29
EG19170A (en)	1994-11-30
FI102678B (fi)	1999-01-29

Publication	Publication Date	Title
DK0382276T3 (da)	1996-01-15	Ethere af 1-benzyl-3-hydroxymethyl-indazol med alifatiske 2-hydroxysyrer
DK180790A (da)	1991-01-29	Fremstilling af farmaceutisk praeparat
DK148885D0 (da)	1985-04-02	Stabilt praeparat af interleukin-2
DK199384D0 (da)	1984-04-18	Balle af straa eller hoe
AR240408A1 (es)	1990-04-30	Pelota de basquetbol
DK0485436T3 (da)	1995-04-10	Fremgangsmåde til fremstilling af et næringsmiddel med reduceret fedtstofindhold
DK196986D0 (da)	1986-04-30	Fremstilling af polysaccharider
DK0482094T3 (da)	1994-11-21	Fremgangsmåde til fremstilling af et næringsmiddel med reduceret fedtstofindhold
DK363887A (da)	1988-01-15	Anvendelse af bromcruptin
DK427787A (da)	1988-02-19	Komponenter af plastmateriale
DK529583D0 (da)	1983-11-18	Enzymatisk fremstilling af l-serin
DK141090D0 (da)	1990-06-08	Fremstilling af human prourokinase
DK420185A (da)	1986-03-18	Anvendelse af somatostatinanaloge
DK88091D0 (da)	1991-05-10	Fremstilling af pentansyrederivater
DK0387654T3 (da)	1994-11-14	Fremgangsmåde til fremstilling af alkylenglycolmonosorbater
DK541487A (da)	1987-10-16	Sammenfoejning af materialer
DK105089A (da)	1989-03-03	Fremstilling af bis(amin-holdige)benzendioler
DK73687A (da)	1987-08-15	Hydroxaminsyrer af 7-oxabicycloheptansubstituerede ethere
DK487289D0 (da)	1989-10-04	Omestring af phospholipider
DK135387D0 (da)	1987-03-17	Fremstilling af proteiner
ID1049B (id)	1996-10-29	Komposisi batangan deterjen
DK519287A (da)	1988-04-04	Praeparat med thrombolytisk virkning
DK345683D0 (da)	1983-07-28	Fremstilling af 2-t-butyl-5-chlorpyrimidin
DK321986A (da)	1987-06-22	Fremstilling af proteiner
DK512687D0 (da)	1987-09-29	Fremstilling af proteiner