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DE69939106D1 - Verfahren zur Herstellung von ED-71 - Google Patents

Verfahren zur Herstellung von ED-71

Info

Publication number
DE69939106D1
DE69939106D1 DE69939106T DE69939106T DE69939106D1 DE 69939106 D1 DE69939106 D1 DE 69939106D1 DE 69939106 T DE69939106 T DE 69939106T DE 69939106 T DE69939106 T DE 69939106T DE 69939106 D1 DE69939106 D1 DE 69939106D1
Authority
DE
Germany
Prior art keywords
vitamin
derivatives
protective group
represents hydrogen
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939106T
Other languages
English (en)
Inventor
Susumi Hatakeyama
Hiroyoshi Watanabe
Akira Kawase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69939106D1 publication Critical patent/DE69939106D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/44Halogenated unsaturated alcohols containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69939106T 1998-02-24 1999-02-23 Verfahren zur Herstellung von ED-71 Expired - Lifetime DE69939106D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4229598 1998-02-24
PCT/JP1999/000796 WO1999043645A1 (fr) 1998-02-24 1999-02-23 Derives de 24-hydroxyvitamine d

Publications (1)

Publication Number Publication Date
DE69939106D1 true DE69939106D1 (de) 2008-08-28

Family

ID=12632059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939106T Expired - Lifetime DE69939106D1 (de) 1998-02-24 1999-02-23 Verfahren zur Herstellung von ED-71

Country Status (6)

Country Link
EP (1) EP1061070B1 (de)
JP (2) JP4357114B2 (de)
AT (1) ATE401303T1 (de)
AU (1) AU2549099A (de)
DE (1) DE69939106D1 (de)
WO (1) WO1999043645A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE341533T1 (de) * 1998-02-27 2006-10-15 Chugai Pharmaceutical Co Ltd Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position
EP1812011A1 (de) 2004-11-12 2007-08-01 Bioxell S.p.a. Kombinierte verwendung von vitamin-d-derivaten und antiproliferativen mitteln zur behandlung von blasenkrebs
WO2008062871A1 (fr) 2006-11-22 2008-05-29 Shiseido Company Ltd. Procédé de production d'une poudre de fines particules d'oxyde de zinc et de cosmétiques contenant la poudre
BRPI0916600B1 (pt) 2008-07-18 2020-09-15 Basf Se Processo para a preparação de partículas de zno modificadas, partículas de zno modificadas, processo para a incorporação de partículas de zno modificadas em materiais, e, uso de partículas de zno modificadas
BR112013009647A2 (pt) 2010-10-25 2016-07-12 Teijin Pharma Ltd derivado de vitamina, composição farmacêutica, agente terapêutico, e, composto
TW201406380A (zh) * 2012-04-24 2014-02-16 Teijin Pharma Ltd 次發性副甲狀腺機能亢進症治療劑
ES2969990T3 (es) * 2019-05-13 2024-05-23 Faes Farma Sa Procedimiento y productos intermedios para la preparación de eldecalcitol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108048A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
JPS5846507B2 (ja) * 1978-12-26 1983-10-17 帝人株式会社 1α,24(R),25↓−トリヒドロキシコレカルシフエロ−ルの製造法
JPS58208223A (ja) * 1982-05-28 1983-12-03 Kureha Chem Ind Co Ltd 抗腫瘍剤
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
JPH0780773B2 (ja) * 1986-06-05 1995-08-30 中外製薬株式会社 新規ビタミンd▲下3▼誘導体を有効成分とする医薬
DE69433220T2 (de) * 1993-07-09 2004-08-19 Laboratoire Theramex Neue strukturelle Vitamin D Derivate
JP3712077B2 (ja) * 1995-05-12 2005-11-02 株式会社クラレ ヒドロインダン−4−オール誘導体およびその製造方法
JPH11130711A (ja) * 1997-10-24 1999-05-18 Teijin Ltd 1α,24,25−トリヒドロキシビタミンD3類の合成中間体およびその製造法
ATE341533T1 (de) * 1998-02-27 2006-10-15 Chugai Pharmaceutical Co Ltd Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position

Also Published As

Publication number Publication date
EP1061070A1 (de) 2000-12-20
AU2549099A (en) 1999-09-15
JP4990937B2 (ja) 2012-08-01
EP1061070B1 (de) 2008-07-16
ATE401303T1 (de) 2008-08-15
WO1999043645A1 (fr) 1999-09-02
JP4357114B2 (ja) 2009-11-04
EP1061070A4 (de) 2005-03-30
JP2009256361A (ja) 2009-11-05

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