DE69918671D1 - Optische papillarzirkulation verbesserende mittel - Google Patents
Optische papillarzirkulation verbesserende mittelInfo
- Publication number
- DE69918671D1 DE69918671D1 DE69918671T DE69918671T DE69918671D1 DE 69918671 D1 DE69918671 D1 DE 69918671D1 DE 69918671 T DE69918671 T DE 69918671T DE 69918671 T DE69918671 T DE 69918671T DE 69918671 D1 DE69918671 D1 DE 69918671D1
- Authority
- DE
- Germany
- Prior art keywords
- optic nerve
- nerve head
- papillar
- optical
- circulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000004087 circulation Effects 0.000 title abstract 3
- 239000004129 EU approved improving agent Substances 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 210000003733 optic disk Anatomy 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- JQSAYKKFZOSZGJ-UHFFFAOYSA-N 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine Chemical compound COC1=C(OC)C(OC)=CC=C1CN1CCN(C(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CC1 JQSAYKKFZOSZGJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010067013 Normal tension glaucoma Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 abstract 1
- 229950007692 lomerizine Drugs 0.000 abstract 1
- 201000002978 low tension glaucoma Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1683198 | 1998-01-29 | ||
| JP1683198 | 1998-01-29 | ||
| JP25237598 | 1998-09-07 | ||
| JP25237598 | 1998-09-07 | ||
| PCT/JP1999/000202 WO1999038515A1 (fr) | 1998-01-29 | 1999-01-21 | Agents ameliorant la circulation optique papillaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69918671D1 true DE69918671D1 (de) | 2004-08-19 |
| DE69918671T2 DE69918671T2 (de) | 2005-07-28 |
Family
ID=26353257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69918671T Expired - Fee Related DE69918671T2 (de) | 1998-01-29 | 1999-01-21 | Optische papillarzirkulation verbessernde mittel |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6387910B1 (de) |
| EP (1) | EP1051973B1 (de) |
| JP (1) | JP4456269B2 (de) |
| KR (1) | KR100585299B1 (de) |
| CN (1) | CN1149086C (de) |
| AT (1) | ATE270890T1 (de) |
| DE (1) | DE69918671T2 (de) |
| ES (1) | ES2224597T3 (de) |
| PT (1) | PT1051973E (de) |
| TW (1) | TW461815B (de) |
| WO (1) | WO1999038515A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9365553B2 (en) * | 2010-05-27 | 2016-06-14 | Aska Pharmaceutical Co., Ltd. | Heterocyclic compound and H1 receptor antagonist |
| CN109580836A (zh) * | 2018-12-31 | 2019-04-05 | 辰欣药业股份有限公司 | 一种盐酸洛美利嗪原料及制剂有关物质的检测方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60222472A (ja) * | 1984-03-30 | 1985-11-07 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
| WO1990006123A1 (en) | 1988-12-05 | 1990-06-14 | Houston Biotechnology Incorporated | Therapeutic use of calcium entry blockers in retinal or optic nerve dysfunction |
| FR2669132A1 (fr) * | 1990-11-09 | 1992-05-15 | Guerin James | Dispositif de memorisation d'informations connectable a un ordinateur. |
| EP0639986A1 (de) | 1992-05-13 | 1995-03-01 | Alcon Laboratories, Inc. | Topischeopthalmische zusammensetzungen, die eine kombination von calcium-antagonisten mit bekannten antiglaukommitteln enthalten |
-
1999
- 1999-01-21 ES ES99900647T patent/ES2224597T3/es not_active Expired - Lifetime
- 1999-01-21 EP EP99900647A patent/EP1051973B1/de not_active Expired - Lifetime
- 1999-01-21 CN CNB998045942A patent/CN1149086C/zh not_active Expired - Fee Related
- 1999-01-21 US US09/601,231 patent/US6387910B1/en not_active Expired - Fee Related
- 1999-01-21 JP JP2000529248A patent/JP4456269B2/ja not_active Expired - Fee Related
- 1999-01-21 PT PT99900647T patent/PT1051973E/pt unknown
- 1999-01-21 AT AT99900647T patent/ATE270890T1/de not_active IP Right Cessation
- 1999-01-21 KR KR1020007008272A patent/KR100585299B1/ko not_active Expired - Fee Related
- 1999-01-21 WO PCT/JP1999/000202 patent/WO1999038515A1/ja active IP Right Grant
- 1999-01-21 DE DE69918671T patent/DE69918671T2/de not_active Expired - Fee Related
- 1999-01-22 TW TW088100938A patent/TW461815B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1051973A1 (de) | 2000-11-15 |
| DE69918671T2 (de) | 2005-07-28 |
| CN1149086C (zh) | 2004-05-12 |
| TW461815B (en) | 2001-11-01 |
| WO1999038515A1 (fr) | 1999-08-05 |
| JP4456269B2 (ja) | 2010-04-28 |
| PT1051973E (pt) | 2004-11-30 |
| ES2224597T3 (es) | 2005-03-01 |
| ATE270890T1 (de) | 2004-07-15 |
| EP1051973B1 (de) | 2004-07-14 |
| KR100585299B1 (ko) | 2006-06-01 |
| CN1295475A (zh) | 2001-05-16 |
| US6387910B1 (en) | 2002-05-14 |
| EP1051973A4 (de) | 2002-02-06 |
| KR20010024889A (ko) | 2001-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: N.V. ORGANON, OSS, NL |
|
| 8339 | Ceased/non-payment of the annual fee |