DE69911238D1 - Indolderivate und ihre verwendung als serotoninrezeptor-liganden - Google Patents
Indolderivate und ihre verwendung als serotoninrezeptor-ligandenInfo
- Publication number
- DE69911238D1 DE69911238D1 DE69911238T DE69911238T DE69911238D1 DE 69911238 D1 DE69911238 D1 DE 69911238D1 DE 69911238 T DE69911238 T DE 69911238T DE 69911238 T DE69911238 T DE 69911238T DE 69911238 D1 DE69911238 D1 DE 69911238D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- hydrogen
- seroton
- receptor ligands
- indolder derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003446 ligand Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9825413 | 1998-11-19 | ||
| GBGB9825413.9A GB9825413D0 (en) | 1998-11-19 | 1998-11-19 | Pharmaceutical compounds |
| PCT/GB1999/003836 WO2000031074A2 (en) | 1998-11-19 | 1999-11-18 | Indole derivatives and their use as serotonin receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69911238D1 true DE69911238D1 (de) | 2003-10-16 |
| DE69911238T2 DE69911238T2 (de) | 2004-07-01 |
Family
ID=10842732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69911238T Expired - Fee Related DE69911238T2 (de) | 1998-11-19 | 1999-11-18 | Indolderivate und ihre verwendung als serotoninrezeptor-liganden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6329366B1 (de) |
| EP (1) | EP1131321B1 (de) |
| JP (1) | JP2002530405A (de) |
| AT (1) | ATE249457T1 (de) |
| AU (1) | AU1170300A (de) |
| CA (1) | CA2351526A1 (de) |
| DE (1) | DE69911238T2 (de) |
| ES (1) | ES2207344T3 (de) |
| GB (1) | GB9825413D0 (de) |
| WO (1) | WO2000031074A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844338B2 (en) | 2000-05-18 | 2005-01-18 | Eli Lilly And Company | Piperidyindoles as serotonin receptor ligands |
| GB2362381A (en) * | 2000-05-18 | 2001-11-21 | Lilly Co Eli | Pharmaceutically active indolyl-piperidines |
| DK1294710T3 (da) * | 2000-06-14 | 2005-10-03 | Lundbeck & Co As H | Indolderivater, der er egnede til behandlingen af CNS-lidelser |
| UA74830C2 (en) * | 2000-06-14 | 2006-02-15 | Lundbeck & Co As H | Indole derivatives being useful for the treatment of cns disorders, a pharmaceutical composition and a method for the treatment of diseases |
| AR028685A1 (es) * | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
| PL364580A1 (en) | 2001-03-29 | 2004-12-13 | Bristol-Myers Squibb Company | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors |
| DE10157673A1 (de) * | 2001-11-24 | 2003-06-05 | Merck Patent Gmbh | Verwendung von N-(Indolcarbonyl-)piperazinderivaten |
| TWI391387B (zh) * | 2004-05-12 | 2013-04-01 | Eisai R&D Man Co Ltd | 具有哌啶環之吲哚衍生物 |
| US20080119518A1 (en) * | 2005-02-04 | 2008-05-22 | Yuichi Suzuki | 1-(Piperidin-4- Yl)-1H-Indole Derivatives |
| JP4932717B2 (ja) * | 2005-05-11 | 2012-05-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピペリジン環を有するインドール誘導体の製造方法 |
| AU2006244914A1 (en) * | 2005-05-11 | 2006-11-16 | Eisai R & D Management Co., Ltd. | Crystal of indole derivative having piperidine ring and process for production thereof |
| EP1880995B1 (de) * | 2005-05-11 | 2011-12-21 | Eisai R&D Management Co., Ltd. | Verfahren zur herstellung eines indolderivats mit einem piperidinring |
| JPWO2006121104A1 (ja) * | 2005-05-11 | 2008-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピペリジン環を有するインドール誘導体の結晶およびその製法 |
| CL2007003590A1 (es) * | 2006-12-12 | 2008-02-29 | Wyeth Corp | Compuestos derivados de aril sulfamida; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en prevencion y tratamiento de sintomas vasomotrices, disfuncion sexual, transtornos gastrointestinales, transt |
| WO2008073958A2 (en) | 2006-12-12 | 2008-06-19 | Wyeth | Substituted benzothiadiazinedioxide derivatives and methods of their use |
| PL392436A1 (pl) * | 2010-09-17 | 2012-03-26 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Pochodne arylosulfonamidów do leczenia chorób odśrodkowego układu nerwowego |
| CN109896984A (zh) * | 2019-03-27 | 2019-06-18 | 南通宝凯化工有限公司 | 一种二甲氨基磺酰氯的生产工艺 |
| CN115109060A (zh) * | 2022-07-18 | 2022-09-27 | 湖南警察学院 | 铜催化α-溴羰基炔和马来酰亚胺串联环化选择性合成喹啉-2-酮的方法 |
| CN115093368B (zh) * | 2022-07-18 | 2024-06-18 | 湖南警察学院 | 铜催化α-溴羰基炔环化/氧化切断制备喹啉-2,4-二酮衍生物的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4359468A (en) | 1981-02-25 | 1982-11-16 | Boehringer Ingelheim Ltd. | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
| DE19500689A1 (de) * | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
| GB9700895D0 (en) | 1997-01-17 | 1997-03-05 | Lilly Co Eli | Pharmaceutical compounds |
| AU8743098A (en) * | 1997-08-22 | 1999-03-16 | Eli Lilly And Company Limited | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands |
| GB9810886D0 (en) | 1998-05-13 | 1998-07-22 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1998
- 1998-11-19 GB GBGB9825413.9A patent/GB9825413D0/en not_active Ceased
-
1999
- 1999-11-18 CA CA002351526A patent/CA2351526A1/en not_active Abandoned
- 1999-11-18 EP EP99972634A patent/EP1131321B1/de not_active Expired - Lifetime
- 1999-11-18 US US09/442,904 patent/US6329366B1/en not_active Expired - Fee Related
- 1999-11-18 DE DE69911238T patent/DE69911238T2/de not_active Expired - Fee Related
- 1999-11-18 ES ES99972634T patent/ES2207344T3/es not_active Expired - Lifetime
- 1999-11-18 AU AU11703/00A patent/AU1170300A/en not_active Abandoned
- 1999-11-18 JP JP2000583902A patent/JP2002530405A/ja active Pending
- 1999-11-18 AT AT99972634T patent/ATE249457T1/de not_active IP Right Cessation
- 1999-11-18 WO PCT/GB1999/003836 patent/WO2000031074A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2351526A1 (en) | 2000-06-02 |
| WO2000031074A3 (en) | 2000-09-14 |
| JP2002530405A (ja) | 2002-09-17 |
| GB9825413D0 (en) | 1999-01-13 |
| EP1131321B1 (de) | 2003-09-10 |
| US6329366B1 (en) | 2001-12-11 |
| ATE249457T1 (de) | 2003-09-15 |
| WO2000031074A2 (en) | 2000-06-02 |
| ES2207344T3 (es) | 2004-05-16 |
| AU1170300A (en) | 2000-06-13 |
| DE69911238T2 (de) | 2004-07-01 |
| EP1131321A2 (de) | 2001-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |