DE69908756D1 - Matrix-metalloproteinase-inhibitoren - Google Patents
Matrix-metalloproteinase-inhibitorenInfo
- Publication number
- DE69908756D1 DE69908756D1 DE69908756T DE69908756T DE69908756D1 DE 69908756 D1 DE69908756 D1 DE 69908756D1 DE 69908756 T DE69908756 T DE 69908756T DE 69908756 T DE69908756 T DE 69908756T DE 69908756 D1 DE69908756 D1 DE 69908756D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- group
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 title 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006686 (C1-C24) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9804504.0A GB9804504D0 (en) | 1998-03-03 | 1998-03-03 | Matrix metalloproteinase inhibitors |
| GB9804504 | 1998-03-03 | ||
| PCT/DK1999/000072 WO1999044989A1 (en) | 1998-03-03 | 1999-02-23 | Matrix metalloproteinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69908756D1 true DE69908756D1 (de) | 2003-07-17 |
| DE69908756T2 DE69908756T2 (de) | 2004-04-29 |
Family
ID=10827909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69908756T Expired - Fee Related DE69908756T2 (de) | 1998-03-03 | 1999-02-23 | Matrix-metalloproteinase-inhibitoren |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6277876B1 (de) |
| EP (1) | EP1060161B1 (de) |
| JP (1) | JP2002505320A (de) |
| KR (1) | KR20010034168A (de) |
| CN (1) | CN1205181C (de) |
| AT (1) | ATE242764T1 (de) |
| AU (1) | AU741867B2 (de) |
| CA (1) | CA2317502A1 (de) |
| DE (1) | DE69908756T2 (de) |
| DK (1) | DK1060161T3 (de) |
| ES (1) | ES2201668T3 (de) |
| GB (1) | GB9804504D0 (de) |
| HK (1) | HK1033666A1 (de) |
| HU (1) | HUP0100564A3 (de) |
| NZ (1) | NZ505458A (de) |
| PL (1) | PL342667A1 (de) |
| PT (1) | PT1060161E (de) |
| RU (1) | RU2205825C2 (de) |
| WO (1) | WO1999044989A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2504460A1 (en) * | 2002-11-12 | 2004-05-27 | Peter G. Klimko | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| EP2287326A1 (de) | 2003-08-08 | 2011-02-23 | Arriva Pharmaceuticals, Inc. | Verfahren zur Protein-Produktion in Hefe |
| GB0319917D0 (en) * | 2003-08-23 | 2003-09-24 | British Biotech Pharm | Metalloproteinase inhibitors |
| DE602004032548D1 (de) | 2003-08-23 | 2011-06-16 | Merck Serono Sa | Derivate von hydroxamsäure als metalloproteinaseinhibitoren |
| WO2005086915A2 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743587A (en) | 1985-09-10 | 1988-05-10 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| KR927003520A (ko) | 1990-12-03 | 1992-12-18 | 죤 에드워드 베리만 | 펩티딜(peptidyl) 유도체 |
| GB9423914D0 (en) | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
-
1998
- 1998-03-03 GB GBGB9804504.0A patent/GB9804504D0/en not_active Ceased
-
1999
- 1999-02-23 WO PCT/DK1999/000072 patent/WO1999044989A1/en not_active Application Discontinuation
- 1999-02-23 AT AT99904732T patent/ATE242764T1/de not_active IP Right Cessation
- 1999-02-23 KR KR1020007007791A patent/KR20010034168A/ko not_active Application Discontinuation
- 1999-02-23 EP EP99904732A patent/EP1060161B1/de not_active Expired - Lifetime
- 1999-02-23 DE DE69908756T patent/DE69908756T2/de not_active Expired - Fee Related
- 1999-02-23 CA CA002317502A patent/CA2317502A1/en not_active Abandoned
- 1999-02-23 AU AU25125/99A patent/AU741867B2/en not_active Ceased
- 1999-02-23 PT PT99904732T patent/PT1060161E/pt unknown
- 1999-02-23 PL PL99342667A patent/PL342667A1/xx not_active Application Discontinuation
- 1999-02-23 DK DK99904732T patent/DK1060161T3/da active
- 1999-02-23 ES ES99904732T patent/ES2201668T3/es not_active Expired - Lifetime
- 1999-02-23 CN CNB998025933A patent/CN1205181C/zh not_active Expired - Fee Related
- 1999-02-23 RU RU2000124933/04A patent/RU2205825C2/ru not_active IP Right Cessation
- 1999-02-23 NZ NZ505458A patent/NZ505458A/xx unknown
- 1999-02-23 US US09/623,428 patent/US6277876B1/en not_active Expired - Fee Related
- 1999-02-23 JP JP2000534533A patent/JP2002505320A/ja active Pending
- 1999-02-23 HU HU0100564A patent/HUP0100564A3/hu unknown
-
2001
- 2001-06-19 HK HK01104217A patent/HK1033666A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9804504D0 (en) | 1998-04-29 |
| US6277876B1 (en) | 2001-08-21 |
| PL342667A1 (en) | 2001-07-02 |
| HUP0100564A3 (en) | 2003-07-28 |
| HUP0100564A2 (hu) | 2001-07-30 |
| AU2512599A (en) | 1999-09-20 |
| HK1033666A1 (en) | 2001-09-14 |
| KR20010034168A (ko) | 2001-04-25 |
| DK1060161T3 (da) | 2003-10-06 |
| DE69908756T2 (de) | 2004-04-29 |
| EP1060161A1 (de) | 2000-12-20 |
| CA2317502A1 (en) | 1999-09-10 |
| WO1999044989A1 (en) | 1999-09-10 |
| NZ505458A (en) | 2002-10-25 |
| ES2201668T3 (es) | 2004-03-16 |
| PT1060161E (pt) | 2003-10-31 |
| JP2002505320A (ja) | 2002-02-19 |
| EP1060161B1 (de) | 2003-06-11 |
| CN1205181C (zh) | 2005-06-08 |
| CN1289323A (zh) | 2001-03-28 |
| RU2205825C2 (ru) | 2003-06-10 |
| ATE242764T1 (de) | 2003-06-15 |
| AU741867B2 (en) | 2001-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT1314184B1 (it) | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo | |
| NZ505968A (en) | Sulfonylamino derivatives which inhibit matrix- degrading metallproteinases | |
| MXPA04000411A (es) | Tiazolidinonas arilo sustituidas y uso de las mismas. | |
| IS6309A (is) | Kínasólínafleiður | |
| KR970704699A (ko) | 아미노산 아미드 유도체, 그 제조방법, 농원예용 살균제 및 살균방법 | |
| BR9909490A (pt) | Composições desinfetantes e processos para desinfetar superfìcies | |
| BR9911932A (pt) | Composto | |
| DE69705480D1 (de) | Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung | |
| KR920014810A (ko) | 항균제 | |
| ID26622A (id) | Senyawa-senyawa pengganti 2-benzylamino-2-phenyl-acetamide | |
| ATE369187T1 (de) | Stabilisierung kosmetischer oder dermatologischer zubereitungen, welche repellent-wirkstoffe enthalten | |
| DK1060161T3 (da) | Matrixmetalloproteinaseinhibitorer | |
| DE60014394D1 (de) | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha | |
| MXPA03000547A (es) | Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares. | |
| KR920014818A (ko) | 항균제 | |
| EP0420803A3 (en) | Benzo-1,2,3-thiadiazole derivatives and their use for protecting plants against diseases | |
| PT1175429E (pt) | Derivados halo de 9-desoxo-9a-aza-9a-homoeritromicina a | |
| DE69909811T2 (de) | Substituierte isoxazolylthiophenverbindungen | |
| ES2098346T3 (es) | Inhibidores de la dihidrofolato reductasa de pneumocystis carinii. | |
| IL159548A0 (en) | Use of thiazole derivatives for preparing a medicine for protecting mitochondria | |
| ES2059685T3 (es) | Acilaminoalquilpiridinamidas inhibidoras de metastasis tumoral. | |
| DE68910090D1 (de) | Verwendung heterozyklischer Amide zur Verhinderung der Tumormetastasierung. | |
| MXPA06000651A (es) | Uso de derivados de indazol para el tratamiento de dolor neuropatico. | |
| KR950704243A (ko) | 아세트아미드 유도체(acetamide derivative) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |