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DE69840035D1 - Chimäres protein welches eine intramolekulare chap zur insulinproduktion - Google Patents

Chimäres protein welches eine intramolekulare chap zur insulinproduktion

Info

Publication number
DE69840035D1
DE69840035D1 DE69840035T DE69840035T DE69840035D1 DE 69840035 D1 DE69840035 D1 DE 69840035D1 DE 69840035 T DE69840035 T DE 69840035T DE 69840035 T DE69840035 T DE 69840035T DE 69840035 D1 DE69840035 D1 DE 69840035D1
Authority
DE
Germany
Prior art keywords
chimeric protein
insulin
intramolecular
imc
chap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69840035T
Other languages
English (en)
Inventor
Zhongru Gan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tonghua Gantech Biotechnology Ltd
Original Assignee
Tonghua Gantech Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4575041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69840035(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tonghua Gantech Biotechnology Ltd filed Critical Tonghua Gantech Biotechnology Ltd
Application granted granted Critical
Publication of DE69840035D1 publication Critical patent/DE69840035D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69840035T 1998-03-31 1998-03-31 Chimäres protein welches eine intramolekulare chap zur insulinproduktion Expired - Lifetime DE69840035D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN1998/000052 WO1999050302A1 (en) 1998-03-31 1998-03-31 Chimeric protein containing an intramolecular chaperone-like sequence and its application to insulin production

Publications (1)

Publication Number Publication Date
DE69840035D1 true DE69840035D1 (de) 2008-10-30

Family

ID=4575041

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69840035T Expired - Lifetime DE69840035D1 (de) 1998-03-31 1998-03-31 Chimäres protein welches eine intramolekulare chap zur insulinproduktion

Country Status (15)

Country Link
US (1) US6924120B1 (de)
EP (1) EP1066328B1 (de)
JP (1) JP4472870B2 (de)
KR (1) KR100554490B1 (de)
CN (1) CN1197876C (de)
AT (1) ATE408631T1 (de)
AU (1) AU765574B2 (de)
BR (1) BR9815788B1 (de)
CA (1) CA2324513C (de)
DE (1) DE69840035D1 (de)
DK (1) DK1066328T3 (de)
ES (1) ES2317665T3 (de)
IL (1) IL138658A0 (de)
MX (1) MXPA00009564A (de)
WO (1) WO1999050302A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069907A1 (en) * 1999-05-14 2000-11-23 Medical Research Council Protein scaffold and its use to multimerise monomeric polypeptides
WO2000069886A2 (en) * 1999-05-14 2000-11-23 Medical Research Council Oligomeric chaperone proteins
GB9913437D0 (en) * 1999-06-09 1999-08-11 Medical Res Council Fusion proteins
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
CA2633554C (en) 2005-12-22 2012-11-13 Genetech, Inc. Recombinant production of heparin binding proteins
AR062069A1 (es) * 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
RU2447149C1 (ru) * 2011-03-24 2012-04-10 Винсорт Менеджемент Инк РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pMSIN4, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД - ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, ШТАММ BL21(DE3)/pMSIN4-ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА
CN102628072B (zh) * 2012-03-20 2013-12-04 甘李药业股份有限公司 一种胰岛素的制备方法
CN103439512B (zh) * 2013-07-30 2014-05-07 通化东宝药业股份有限公司 一种检测特异性重组人胰岛素大肠杆菌残留宿主蛋白的方法
CN112142848A (zh) * 2019-06-26 2020-12-29 中国科学院大连化学物理研究所 一种重组人胰岛素及其纯化制备方法
CN114805610B (zh) * 2022-06-23 2022-10-04 北京惠之衡生物科技有限公司 一种高表达甘精胰岛素前体的重组基因工程菌及其构建方法
CN114805544B (zh) * 2022-06-23 2022-09-09 北京惠之衡生物科技有限公司 一种赖脯胰岛素前体、其重组基因工程菌及其构建方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
NZ199391A (en) 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US5254463A (en) 1981-09-18 1993-10-19 Genentech, Inc. Method for expression of bovine growth hormone
US4665160A (en) * 1982-03-22 1987-05-12 Genentech, Inc. Novel human growth hormone like protein HGH-V encoded in the human genome
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5191063A (en) 1989-05-02 1993-03-02 University Of Medicine And Dentistry Of New Jersey Production of biologically active polypeptides by treatment with an exogenous peptide sequence
US5358857A (en) 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
US5422110A (en) * 1991-10-16 1995-06-06 University Of Saskatchewan Enhanced immunogenicity using leukotoxin chimeras
EP0600372B1 (de) 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
US6316004B1 (en) 1993-06-22 2001-11-13 T. Tikhonenko Chimeric somatostatin containing protein and encoding DNA, plasmids of expression, method for preparing chimeric protein, strain-producers, immunogenic composition, method for increasing the productivity of farm animals
US6001604A (en) 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
ATE350053T1 (de) * 1994-12-29 2007-01-15 Ferring Int Ct Sa Herstellung von humaninsulin
JPH11500308A (ja) * 1995-02-03 1999-01-12 ジー．ディー．サール アンド カンパニー 新規ｃ−ＭＰＬリガンド
US5559128A (en) 1995-04-18 1996-09-24 Merck & Co., Inc. 3-substituted piperidines promote release of growth hormone
SE9504019D0 (sv) 1995-11-13 1995-11-13 Pharmacia Ab Method for production of proteins
AUPO394896A0 (en) 1996-11-29 1997-01-02 May, Peter Andrew John Hose mounting bracket
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
WO2002079251A2 (en) * 2001-04-02 2002-10-10 Novo Nordisk A/S Method for making human insulin precursors

Also Published As

Publication number Publication date
AU6716498A (en) 1999-10-18
MXPA00009564A (es) 2004-03-10
CA2324513C (en) 2013-05-28
CN1197876C (zh) 2005-04-20
ATE408631T1 (de) 2008-10-15
ES2317665T3 (es) 2009-04-16
KR20010042383A (ko) 2001-05-25
CN1291199A (zh) 2001-04-11
IL138658A0 (en) 2001-10-31
JP2004505601A (ja) 2004-02-26
AU765574B2 (en) 2003-09-25
EP1066328B1 (de) 2008-09-17
EP1066328A1 (de) 2001-01-10
JP4472870B2 (ja) 2010-06-02
KR100554490B1 (ko) 2006-03-03
BR9815788B1 (pt) 2013-06-04
BR9815788A (pt) 2000-11-28
EP1066328A4 (de) 2002-06-05
CA2324513A1 (en) 1999-10-07
DK1066328T3 (da) 2009-02-09
US6924120B1 (en) 2005-08-02
WO1999050302A1 (en) 1999-10-07

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