DE69839767D1 - Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten - Google Patents

Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten

Info

Publication number: DE69839767D1
Authority: DE; Germany
Prior art keywords: keto; prostaglandin; compounds; endothelin antagonists; endothelin
Prior art date: 1997-11-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69839767T

Other languages

English (en)

Inventor

Ryuji Ueno

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sucampo GmbH

Original Assignee

Sucampo GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-28

Filing date

1998-11-16

Publication date

2008-09-04

1998-11-16 Application filed by Sucampo GmbH filed Critical Sucampo GmbH

2008-09-04 Application granted granted Critical

2008-09-04 Publication of DE69839767D1 publication Critical patent/DE69839767D1/de

2018-11-17 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

VXPBDCBTMSKCKZ-XQHNHVHJSA-N 15-dehydro-prostaglandin E1 Chemical class CCCCCC(=O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O VXPBDCBTMSKCKZ-XQHNHVHJSA-N 0.000 title abstract 2
102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
208000033386 Buerger disease Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010043540 Thromboangiitis obliterans Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69839767T 1997-11-28 1998-11-16 Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten Expired - Lifetime DE69839767D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP32783297		1997-11-28
PCT/JP1998/005143 WO1999027934A1 (fr)	1997-11-28	1998-11-16	Antagoniste d'endotheline

Publications (1)

Publication Number	Publication Date
DE69839767D1 true DE69839767D1 (de)	2008-09-04

Family

ID=18203488

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69839767T Expired - Lifetime DE69839767D1 (de)	1997-11-28	1998-11-16	Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten

Country Status (16)

Country	Link
US (1)	US6197821B1 (de)
EP (1)	EP0978284B1 (de)
JP (1)	JP4319256B2 (de)
KR (1)	KR100648868B1 (de)
CN (1)	CN1206997C (de)
AT (1)	ATE401894T1 (de)
AU (1)	AU739343B2 (de)
CA (1)	CA2279267C (de)
DE (1)	DE69839767D1 (de)
DK (1)	DK0978284T3 (de)
ES (1)	ES2310013T3 (de)
NO (1)	NO328460B1 (de)
NZ (1)	NZ336960A (de)
PT (1)	PT978284E (de)
TW (1)	TW592701B (de)
WO (1)	WO1999027934A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0212233A (pt) *	2001-08-31	2004-10-05	Sucampo Ag	Abridor de canal de cloreto
AR037524A1 (es) *	2001-11-14	2004-11-17	Sucampo Ag	Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
TWI263505B (en) *	2001-11-19	2006-10-11	Sucampo Ag	Pharmaceutical composition comprising a C1C-2 channel opener
KR20120045051A (ko) *	2002-12-27	2012-05-08	수캄포 아게	복부 불쾌감 치료용 프로스타글랜딘의 유도체
US20040225014A1 (en) *	2003-02-14	2004-11-11	Sucampo Ag	Method for treating ocular hypertension and glaucoma
PL1841433T3 (pl) *	2005-01-27	2012-07-31	Sucampo Ag	Kompozycja do leczenia zaburzeń ośrodkowego układu nerwowego
ES2355518T3 (es)	2005-03-04	2011-03-28	Sucampo Ag	Procedimiento y composición para el tratamiento de enfermedades vasculares periféricas.
CA2819844C (en) *	2006-02-07	2015-09-15	R-Tech Ueno, Ltd.	Prostaglandin derivatives
AU2007223469B2 (en) *	2006-02-28	2012-06-07	Sucampo Ag	Method and composition for treating chronic obstructive pulmonary disease
KR20080111137A (ko) *	2006-04-13	2008-12-22	액테리온 파마슈티칼 리미티드	초기 단계 특발성 폐 섬유증을 위한 엔도텔린 수용체 대항제
JP2010519177A (ja) *	2007-02-27	2010-06-03	スキャンポ・アーゲー	ミトコンドリアを保護するための組成物および方法
US20090082442A1 (en) *	2007-09-26	2009-03-26	Protia, Llc	Deuterium-enriched lubiprostone
CN102050808B (zh) *	2009-11-02	2014-03-12	上海天伟生物制药有限公司	一种前列腺素中间体的制备方法
CA2784933A1 (en) *	2009-12-18	2011-06-23	Apotex Pharmachem Inc.	Processes for the purification of lubiprostone
CN104557845B (zh) *	2015-01-13	2020-12-22	齐鲁制药有限公司	一种鲁比前列酮化合物的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3853951A (en)	1971-07-14	1974-12-10	American Cyanamid Co	Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en)	1972-02-11	1977-04-19	American Cyanamid Company	3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
US3981868A (en)	1973-05-31	1976-09-21	American Cyanamid Company	Derivatives of 9-oxo-13-trans-prostenoic acid amides
CA1323364C (en) *	1987-01-28	1993-10-19	Ryuzo Ueno	Prostaglandins e and anti ulcer agents containing same
US5362751A (en)	1988-05-11	1994-11-08	Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo	Tracheobronchodilator using 16-substituted PGEs
JP2597649B2 (ja) *	1988-05-11	1997-04-09	株式会社上野製薬応用研究所	気管・気管支拡張剤
ES2055051T3 (es) *	1988-05-23	1994-08-16	Ueno Seiyaku Oyo Kenkyujo Kk	Un metodo para la fabricacion de un medicamento eficaz para aumentar la presion sanguinea.
JPH0232031A (ja) *	1988-07-22	1990-02-01	Nippon Steel Chem Co Ltd	イソプロピル化ｐ‐ターフェニル類の製造法
CA2027814C (en) *	1989-10-20	1996-07-30	Ryuji Ueno	Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds
CA2030344C (en) *	1989-11-22	2000-04-18	Ryuji Ueno	Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
CA2030345C (en) *	1989-11-22	1998-12-08	Ryuji Ueno	Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2030346C (en) *	1989-11-22	2000-04-11	Ryuji Ueno	Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
CA2039420C (en)	1990-04-04	1996-12-10	Ryuji Ueno	Treatment of cataract with 15-keto-prostaglandin compounds
EP0455448B1 (de) *	1990-05-01	1998-12-09	R-Tech Ueno Ltd.	Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten
CA2046069C (en)	1990-07-10	2002-04-09	Ryuji Ueno	Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
ES2093774T3 (es) *	1991-03-14	1997-01-01	R Tech Ueno Ltd	Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.
CN101085756B (zh)	1996-06-10	2011-03-02	苏坎波公司	内皮素拮抗剂
JPH107574A (ja)	1996-06-17	1998-01-13	R Tec Ueno:Kk	エンドセリン拮抗剤

1998
- 1998-11-16 US US09/355,270 patent/US6197821B1/en not_active Expired - Lifetime
- 1998-11-16 WO PCT/JP1998/005143 patent/WO1999027934A1/ja active IP Right Grant
- 1998-11-16 AU AU10537/99A patent/AU739343B2/en not_active Ceased
- 1998-11-16 KR KR1019997006752A patent/KR100648868B1/ko not_active Expired - Fee Related
- 1998-11-16 CA CA002279267A patent/CA2279267C/en not_active Expired - Fee Related
- 1998-11-16 NZ NZ336960A patent/NZ336960A/en not_active IP Right Cessation
- 1998-11-16 DE DE69839767T patent/DE69839767D1/de not_active Expired - Lifetime
- 1998-11-16 DK DK98953058T patent/DK0978284T3/da active
- 1998-11-16 AT AT98953058T patent/ATE401894T1/de active
- 1998-11-16 ES ES98953058T patent/ES2310013T3/es not_active Expired - Lifetime
- 1998-11-16 JP JP53056099A patent/JP4319256B2/ja not_active Expired - Fee Related
- 1998-11-16 PT PT98953058T patent/PT978284E/pt unknown
- 1998-11-16 CN CNB988035863A patent/CN1206997C/zh not_active Expired - Fee Related
- 1998-11-16 EP EP98953058A patent/EP0978284B1/de not_active Expired - Lifetime
- 1998-11-17 TW TW087118975A patent/TW592701B/zh not_active IP Right Cessation
1999
- 1999-07-27 NO NO19993647A patent/NO328460B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT978284E (pt)	2008-10-07
CA2279267C (en)	2010-01-12
AU739343B2 (en)	2001-10-11
KR100648868B1 (ko)	2006-11-24
CN1206997C (zh)	2005-06-22
KR20000070508A (ko)	2000-11-25
EP0978284A1 (de)	2000-02-09
NO328460B1 (no)	2010-02-22
CN1251040A (zh)	2000-04-19
AU1053799A (en)	1999-06-16
JP4319256B2 (ja)	2009-08-26
EP0978284B1 (de)	2008-07-23
EP0978284A4 (de)	2001-07-18
CA2279267A1 (en)	1999-06-10
HK1025521A1 (en)	2000-11-17
TW592701B (en)	2004-06-21
US6197821B1 (en)	2001-03-06
NO993647L (no)	1999-09-27
ES2310013T3 (es)	2008-12-16
WO1999027934A1 (fr)	1999-06-10
NO993647D0 (no)	1999-07-27
DK0978284T3 (da)	2008-10-27
ATE401894T1 (de)	2008-08-15
NZ336960A (en)	2001-02-23

Publication	Publication Date	Title
DE69839767D1 (de)	2008-09-04	Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten
FI20030162A7 (fi)	2003-02-03	Uusia yhdisteitä
DE69006131D1 (de)	1994-03-03	Substituierte Chinazolinone als Angiotensin II-Antagonisten.
CY1105836T1 (el)	2011-02-02	12, 13-τροποποιημενα παραγωγα εποθιλονης
CO4940465A1 (es)	2000-07-24	Sal mesilato trihidrato de 5-(2-(4-(1,2-benzoisotiazol-3- il)-1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona
LV12639B (lv)	2001-09-20	Bifenilsulfonamidi ka duali angiotenzina un endotelina receptoru antagonisti
ATE464299T1 (de)	2010-04-15	Neues phenylalaninderivat
ES2175066T3 (es)	2002-11-16	Antagonistas triciclicos de la vasopresina.
ATE305781T1 (de)	2005-10-15	Non-peptidische vasopressin via antagonisten
EA200000381A1 (ru)	2000-10-30	Препарат 2-метил-тиено-бензодиазепина
DE69714698D1 (de)	2002-09-19	Endothelin-antagonisten
ATE225351T1 (de)	2002-10-15	Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittel
TR199901710T2 (xx)	1999-09-21	IL-8 resept�r antagonistleri.
CY1106444T1 (el)	2011-10-12	17b-νιτρο-11β-αρυλοστepοειδη και παραγωγα αυτων ως ορμονικοι αγωνιστες ή ανταγωνιστες
EA200201138A1 (ru)	2003-06-26	Пептид, модулирующий рецептор тромбопоэтина
BR9813214A (pt)	2000-08-29	Antagonista de receptor vitronectina
DE69610316D1 (de)	2000-10-19	Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste
TR200100885T2 (tr)	2001-08-21	2-Metil-tieno-benzodiazepin formülasyonu
EA200000198A1 (ru)	2000-10-30	2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов
TR199901761T2 (xx)	1999-10-21	IL-8 resept�r antagonistleri.
EA200401137A1 (ru)	2005-04-28	Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора
ATE257706T1 (de)	2004-01-15	Endothelin antagonist und renin-angiotensin system hemmer als kombinationspräparate
NO20000518L (no)	2000-03-31	2-acylaminopropanaminer som takykininreseptorantagonister
ATE172205T1 (de)	1998-10-15	Zyklische neurokinin a - antagonisten
ATE238791T1 (de)	2003-05-15	Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure als mukolytikum

Legal Events

Date	Code	Title	Description
2009-08-13	8364	No opposition during term of opposition