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DE69833460D1 - Rekombinantes allergen mit reduzierter enzymatischer aktivität - Google Patents

Rekombinantes allergen mit reduzierter enzymatischer aktivität

Info

Publication number
DE69833460D1
DE69833460D1 DE69833460T DE69833460T DE69833460D1 DE 69833460 D1 DE69833460 D1 DE 69833460D1 DE 69833460 T DE69833460 T DE 69833460T DE 69833460 T DE69833460 T DE 69833460T DE 69833460 D1 DE69833460 D1 DE 69833460D1
Authority
DE
Germany
Prior art keywords
enzymatic activity
recombinant allergen
reduced enzymatic
allergen
recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69833460T
Other languages
English (en)
Other versions
DE69833460T2 (de
Inventor
Claudine Bruck
Alex Bollen
Paul Jacobs
Marc Massaer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
Original Assignee
GlaxoSmithKline Biologicals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10822365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69833460(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GlaxoSmithKline Biologicals SA filed Critical GlaxoSmithKline Biologicals SA
Publication of DE69833460D1 publication Critical patent/DE69833460D1/de
Application granted granted Critical
Publication of DE69833460T2 publication Critical patent/DE69833460T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69833460T 1997-11-19 1998-11-16 Rekombinantes allergen mit reduzierter enzymatischer aktivität Revoked DE69833460T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9724531 1997-11-19
GBGB9724531.0A GB9724531D0 (en) 1997-11-19 1997-11-19 Novel compounds
PCT/EP1998/007521 WO1999025823A2 (en) 1997-11-19 1998-11-16 Recombinant allergen with reduced enzymatic activity

Publications (2)

Publication Number Publication Date
DE69833460D1 true DE69833460D1 (de) 2006-04-20
DE69833460T2 DE69833460T2 (de) 2006-09-14

Family

ID=10822365

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69833460T Revoked DE69833460T2 (de) 1997-11-19 1998-11-16 Rekombinantes allergen mit reduzierter enzymatischer aktivität

Country Status (8)

Country Link
US (1) US7348009B1 (de)
EP (3) EP1032669B1 (de)
JP (1) JP2001523452A (de)
CA (1) CA2309885A1 (de)
DE (1) DE69833460T2 (de)
ES (1) ES2257825T3 (de)
GB (1) GB9724531D0 (de)
WO (1) WO1999025823A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7878900A (en) 1999-10-15 2001-04-30 Heska Corporation Method for production and use of mite group 1 proteins
GB0014288D0 (en) 2000-06-10 2000-08-02 Smithkline Beecham Biolog Vaccine
GB0120150D0 (en) * 2001-08-17 2001-10-10 Glaxosmithkline Biolog Sa Novel compounds
GB0304424D0 (en) * 2003-02-26 2003-04-02 Glaxosmithkline Biolog Sa Novel compounds
JP2007525155A (ja) * 2003-04-25 2007-09-06 ノボザイムス アクティーゼルスカブ グループ１ダニポリペプチド変異型
WO2005103082A2 (en) * 2004-04-23 2005-11-03 Novozymes A/S Group 1 mite polypeptide variants
ES2349672T3 (es) * 2005-11-24 2011-01-10 Alk-Abello A/S Procedimiento para medir la actividad enzimática de enzima alergénica adsorbida.
US8492099B2 (en) 2005-11-24 2013-07-23 Alk-Abello A/S Method of measuring enzymatic activity of adsorbed allergenic enzyme
JP5263477B2 (ja) * 2007-10-12 2013-08-14 独立行政法人農業生物資源研究所 ダニ抗原米
CA2718994C (en) 2008-03-25 2017-06-13 Bial Industrial Farmaceutica, S.A. Hypoallergenic hybrid proteins of major group 1 and 2 mite allergens for use in the treatment of allergies
CA2903345A1 (en) * 2013-03-19 2014-09-25 Biotech Tools S.A. Allergen preparation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4372945A (en) 1979-11-13 1983-02-08 Likhite Vilas V Antigen compounds
IL61904A (en) 1981-01-13 1985-07-31 Yeda Res & Dev Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same
HUT51332A (en) 1987-01-30 1990-04-28 Smithkline Biolog Process for expressing p.falciparum cirkumsporozoita protein by yeast
GB8913737D0 (en) 1989-06-15 1989-08-02 Univ Birmingham A novel anti-allergy treatment
US5433948A (en) * 1990-02-13 1995-07-18 Thomas; Wayne R. Cloning and sequencing of allergens of dermatophagoides (house dust mite)
PL170980B1 (pl) 1992-06-25 1997-02-28 Smithkline Beecham Biolog Szczepionka PL PL PL PL PL PL PL
US5593877A (en) * 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
DE69405551T3 (de) 1993-03-23 2005-10-20 Smithkline Beecham Biologicals S.A. 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
CA2194761C (en) 1994-07-15 2006-12-19 Arthur M. Krieg Immunomodulatory oligonucleotides
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
GB9516760D0 (en) 1995-08-16 1995-10-18 Sandoz Ltd Organic compounds
US5762943A (en) * 1996-05-14 1998-06-09 Ribi Immunochem Research, Inc. Methods of treating type I hypersensitivity using monophosphoryl lipid A

Also Published As

Publication number Publication date
EP1032669B1 (de) 2006-02-08
JP2001523452A (ja) 2001-11-27
EP1674576A1 (de) 2006-06-28
EP2017342A1 (de) 2009-01-21
CA2309885A1 (en) 1999-05-27
ES2257825T3 (es) 2006-08-01
DE69833460T2 (de) 2006-09-14
EP1032669A2 (de) 2000-09-06
US7348009B1 (en) 2008-03-25
WO1999025823A3 (en) 1999-07-15
GB9724531D0 (en) 1998-01-21
WO1999025823A2 (en) 1999-05-27

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation