DE69825608D1 - Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren - Google Patents

Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Info

Publication number: DE69825608D1
Authority: DE; Germany
Prior art keywords: cycloheptapyridine; benzo; protein transferase; transferase inhibitors; farnesyl protein
Prior art date: 1997-06-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69825608T

Other languages

English (en)

Other versions

DE69825608T2 (de

Inventor

F Rane

W Remiszewski

J Doll

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-17

Filing date

1998-06-15

Publication date

2004-09-16

1998-06-15 Application filed by Schering Corp filed Critical Schering Corp

2004-09-16 Publication of DE69825608D1 publication Critical patent/DE69825608D1/de

2005-08-04 Application granted granted Critical

2005-08-04 Publication of DE69825608T2 publication Critical patent/DE69825608T2/de

2018-06-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE69825608T 1997-06-17 1998-06-15 Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren Expired - Lifetime DE69825608T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/877,366 US5939416A (en)	1997-06-17	1997-06-17	Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US877366		1997-06-17
PCT/US1998/011505 WO1998057970A1 (en)	1997-06-17	1998-06-15	Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Publications (2)

Publication Number	Publication Date
DE69825608D1 true DE69825608D1 (de)	2004-09-16
DE69825608T2 DE69825608T2 (de)	2005-08-04

Family

ID=25369837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69825608T Expired - Lifetime DE69825608T2 (de)	1997-06-17	1998-06-15	Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Country Status (12)

Country	Link
US (1)	US5939416A (de)
EP (1)	EP1019400B1 (de)
JP (1)	JP3258342B2 (de)
CN (1)	CN1119345C (de)
AR (1)	AR012990A1 (de)
AT (1)	ATE273307T1 (de)
AU (1)	AU8253398A (de)
CA (1)	CA2293711C (de)
DE (1)	DE69825608T2 (de)
ES (1)	ES2221989T3 (de)
WO (1)	WO1998057970A1 (de)
ZA (1)	ZA985211B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6524832B1 (en) *	1994-02-04	2003-02-25	Arch Development Corporation	DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en)	1997-12-22	2003-10-14	Schering Corporation	Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en)	1998-12-18	2001-08-07	Schering Corporation	Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en)	1999-04-09	2001-11-13	Schering Corporation	Methods of inducing cancer cell death and tumor regression
CA2429720C (en)	2000-11-29	2009-12-29	Schering Corporation	Tricyclic compounds useful for the inhibition of farnesyl protein transferase
US20050272068A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	UCH-L1 expression and cancer therapy
US20050288298A1 (en) *	2004-03-18	2005-12-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
US20070148660A1 (en) *	2005-06-16	2007-06-28	The Regents Of The University Of California	Treatment of maladaptive substance use with H-ras antagonists
US8232402B2 (en)	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US8343996B2 (en)	2008-11-13	2013-01-01	Astrazeneca Ab	Azaquinolinone derivatives and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5089496A (en) *	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5721236A (en) *	1993-10-15	1998-02-24	Schering Corporation	Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5700806A (en) *	1995-03-24	1997-12-23	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
HUP0000121A2 (hu) *	1996-09-13	2001-04-28	Schering Corp.	Farnezil-protein transzferáz triciklusos inhibitorai, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
CA2266014A1 (en) *	1996-09-13	1998-03-19	Schering Corporation	Tricyclic compounds useful for inhibition of farnesyl protein transferase

1997
- 1997-06-17 US US08/877,366 patent/US5939416A/en not_active Expired - Fee Related
1998
- 1998-06-15 ZA ZA985211A patent/ZA985211B/xx unknown
- 1998-06-15 AT AT98932715T patent/ATE273307T1/de not_active IP Right Cessation
- 1998-06-15 CN CN98808188A patent/CN1119345C/zh not_active Expired - Fee Related
- 1998-06-15 ES ES98932715T patent/ES2221989T3/es not_active Expired - Lifetime
- 1998-06-15 JP JP50450099A patent/JP3258342B2/ja not_active Expired - Fee Related
- 1998-06-15 CA CA002293711A patent/CA2293711C/en not_active Expired - Fee Related
- 1998-06-15 AU AU82533/98A patent/AU8253398A/en not_active Abandoned
- 1998-06-15 WO PCT/US1998/011505 patent/WO1998057970A1/en active IP Right Grant
- 1998-06-15 DE DE69825608T patent/DE69825608T2/de not_active Expired - Lifetime
- 1998-06-15 EP EP98932715A patent/EP1019400B1/de not_active Expired - Lifetime
- 1998-06-16 AR ARP980102860A patent/AR012990A1/es unknown

Also Published As

Publication number	Publication date
AR012990A1 (es)	2000-11-22
JP3258342B2 (ja)	2002-02-18
US5939416A (en)	1999-08-17
ES2221989T3 (es)	2005-01-16
CN1119345C (zh)	2003-08-27
EP1019400B1 (de)	2004-08-11
ATE273307T1 (de)	2004-08-15
JP2000513034A (ja)	2000-10-03
CA2293711C (en)	2004-08-24
WO1998057970A1 (en)	1998-12-23
AU8253398A (en)	1999-01-04
EP1019400A1 (de)	2000-07-19
CA2293711A1 (en)	1998-12-23
CN1267302A (zh)	2000-09-20
ZA985211B (en)	1998-12-15
DE69825608T2 (de)	2005-08-04

Publication	Publication Date	Title
ATE215541T1 (de)	2002-04-15	(imidazol-5-yl)methyl-2-chinolinoderivate als farnesyl protein transferase inhibitoren
NO996571L (no)	2000-02-23	Inhibitorer for farnesyl-protein-transferase
ATE185341T1 (de)	1999-10-15	4,9-ethano-benzo(f)isoindolderivate als farnesyl transferase inhibitoren
EE9800262A (et)	1999-02-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
DE69728676D1 (de)	2004-05-19	Substituierte 6,6-heterobicyclische derivate
DE69907964D1 (de)	2003-06-18	1,2-annelierte chinolinderivate
DK1019395T3 (da)	2002-05-06	Farnesyltransferasehæmmende 2-quinolonderivater
ATE435861T1 (de)	2009-07-15	12,13-cyclopropan-epothilonderivate
DE69736711D1 (de)	2006-11-02	Substituierte 6,5-heterobicyclische-derivate
PT1000048E (pt)	2003-03-31	Derivados substituidos do 1,2,3,4-tetrahidronaftaleno
ATE214381T1 (de)	2002-03-15	Thiazole derivate als protein kinase c inhibitoren
DE69725465D1 (de)	2003-11-13	6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren
ATE231847T1 (de)	2003-02-15	Substituierte 1,2,3,4- tetrahydronaphthalinderivate
PT921125E (pt)	2002-06-28	Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
ATE387448T1 (de)	2008-03-15	4,5-pyrazinoxindole als proteinkinasehemmer
DE69825608D1 (de)	2004-09-16	Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren
ATE273299T1 (de)	2004-08-15	Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung
ATE240317T1 (de)	2003-05-15	Indolderivate als pkc-inhibitoren
NO20003825L (no)	2000-07-26	1,3,4 - oxadiazolonderivater
NO20012961D0 (no)	2001-06-15	Trisykliske farnesylproteintransferase-inhibitorer
DE69622415D1 (de)	2002-08-22	12H-Dibenzo[d,g][1,3]dioxocin Derivate
ATE214367T1 (de)	2002-03-15	Farnesyl transferase inhibitoren
DE69807477D1 (de)	2002-10-02	Benzo[5,6]cyclohepta[1,2-b]pyridine derivate als farnesyl protein transferase inhibitoren
DE69709869D1 (de)	2002-02-28	BENZO[g]CHINOLIN DERIVATE

Legal Events

Date	Code	Title	Description
2006-07-27	8364	No opposition during term of opposition