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DE69825288D1 - Prodrugs und konjugate von selenolenthaltenden verbindungen und ihre verwendung - Google Patents

Prodrugs und konjugate von selenolenthaltenden verbindungen und ihre verwendung

Info

Publication number
DE69825288D1
DE69825288D1 DE69825288T DE69825288T DE69825288D1 DE 69825288 D1 DE69825288 D1 DE 69825288D1 DE 69825288 T DE69825288 T DE 69825288T DE 69825288 T DE69825288 T DE 69825288T DE 69825288 D1 DE69825288 D1 DE 69825288D1
Authority
DE
Germany
Prior art keywords
selenol
prodrugs
conjugates
containing compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69825288T
Other languages
English (en)
Inventor
C Roberts
H Wilmore
B Cassidy
K Dominick
D Short
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah
Original Assignee
University of Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah filed Critical University of Utah
Application granted granted Critical
Publication of DE69825288D1 publication Critical patent/DE69825288D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
    • C07D293/04—Five-membered rings
    • C07D293/06—Selenazoles; Hydrogenated selenazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69825288T 1997-08-07 1998-08-06 Prodrugs und konjugate von selenolenthaltenden verbindungen und ihre verwendung Expired - Fee Related DE69825288D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5501997P 1997-08-07 1997-08-07
PCT/US1998/016324 WO1999007719A1 (en) 1997-08-07 1998-08-06 Prodrugs and conjugates of thiol- and selenol- containing compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
DE69825288D1 true DE69825288D1 (de) 2004-09-02

Family

ID=21995038

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69835308T Expired - Lifetime DE69835308T2 (de) 1997-08-07 1998-08-06 Prodrugs und Konjugate von Selenoenthaltenden Verbindungen und ihre Verwendung
DE69825288T Expired - Fee Related DE69825288D1 (de) 1997-08-07 1998-08-06 Prodrugs und konjugate von selenolenthaltenden verbindungen und ihre verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69835308T Expired - Lifetime DE69835308T2 (de) 1997-08-07 1998-08-06 Prodrugs und Konjugate von Selenoenthaltenden Verbindungen und ihre Verwendung

Country Status (6)

Country Link
US (1) US6340746B1 (de)
EP (1) EP1003760B1 (de)
AU (1) AU750916C (de)
CA (1) CA2299271C (de)
DE (2) DE69835308T2 (de)
WO (1) WO1999007719A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425635B2 (en) * 1997-08-07 2008-09-16 University Of Utah Research Foundation Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
US6841536B2 (en) * 1997-08-07 2005-01-11 University Of Utah Research Foundation Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US6852353B2 (en) * 2000-08-24 2005-02-08 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
BR0314106A (pt) * 2002-09-11 2005-07-19 Fresenius Kabi De Gmbh Polipeptìdeos hasilados, especialmente eritropoietina hasilada
DE10242076A1 (de) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh HAS-Allergen-Konjugate
AU2003273413A1 (en) * 2002-10-08 2004-05-04 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
EP1653991A2 (de) * 2003-08-08 2006-05-10 Fresenius Kabi Deutschland GmbH Durch oxime als bindungsgruppe verbundene konjugate eines polymers mit einem protein
HRP20110056T1 (hr) * 2003-08-08 2011-02-28 Fresenius Kabi Deutschland Gmbh Konjugati hidroksialkil škroba i g-csf
WO2005014655A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
SG151261A1 (en) * 2004-03-11 2009-04-30 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
CA2598528A1 (en) * 2005-03-11 2006-09-14 Fresenius Kabi Deutschland Gmbh Production of bioactive glycoproteins from inactive starting material
EP1762250A1 (de) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
RS52459B (en) * 2006-02-07 2013-02-28 Shire Human Genetic Therapies Inc. STABILIZED GLUCOCEREBROSIDASE COMPOSITIONS
US9084803B2 (en) 2007-06-29 2015-07-21 Board Of Trustees Of Northern Illinois University Therapeutic uses of glutathione mimics
EP2070950A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2070951A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern
ES2887552T3 (es) 2009-07-28 2021-12-23 Takeda Pharmaceuticals Co Composiciones y métodos para tratar la enfermedad de Gaucher
US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
HUE029018T2 (en) 2011-10-12 2017-02-28 Novartis Ag A method for producing UV absorbing contact lenses by coating
US9623090B2 (en) 2012-03-02 2017-04-18 Shire Human Genetic Therapies, Inc. Compositions and methods for treating type III gaucher disease
CN104871036B (zh) 2012-12-17 2019-12-10 诺华股份有限公司 制备改进的uv吸收性眼用透镜的方法
CA3050119A1 (en) 2017-01-25 2018-08-02 Adare Pharmaceuticals, Inc. Cysteamine prodrugs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5126896A (en) * 1974-08-22 1976-03-05 Funai Yaihin Kogyo Kk Ss inoshirushisuteinno seizoho
FR2313937A1 (fr) * 1975-06-09 1977-01-07 Anvar Medicament a base de 5' thioethers de l'adenosine
FR2354100A2 (fr) * 1976-06-08 1978-01-06 Anvar Medicament a base de 5' thioethers de l'adenosine
US4617189A (en) * 1983-04-14 1986-10-14 Stockel Richard F Use of selenium-containing compounds for negating the toxic effects of platinum compounds used in chemotherapy, and a novel selenium-containing platinum compound and use thereof as an anti-cancer medicine
US5578470A (en) * 1987-01-30 1996-11-26 Nederlandse Organisatie Voor Toegepast Method for preparing thiol compounds with bacterial β-lyase
NL8700240A (nl) * 1987-01-30 1988-08-16 Tno Werkwijze voor het bereiden van thiolverbindingen.
US4868114A (en) * 1987-08-05 1989-09-19 Regents Of The University Of Minnesota Method for elevating glutathione levels
NL9000750A (nl) * 1989-08-23 1991-03-18 Rijksuniversiteit D-mannitol derivaten, werkwijze voor het bereiden van 3-deoxy-d-manno-2-octulonzuur en derivaten daarvan.
FR2693198B1 (fr) * 1992-07-03 1994-09-30 Univ Paris Curie Composés sélénies-glucidiques et leurs procédés de préparation.
DE4328871A1 (de) * 1993-08-27 1995-03-02 Beiersdorf Ag Mittel gegen empfindliche, hyperreaktive Hautzustände, atopische Dermatiden, Pruritus, Psoriasis Prurigo, Photodermatosen und Ichthyosis
US5667791A (en) * 1996-05-31 1997-09-16 Thione International, Inc. X-ray induced skin damage protective composition

Also Published As

Publication number Publication date
EP1003760A4 (de) 2002-07-03
CA2299271A1 (en) 1999-02-18
AU750916B2 (en) 2002-08-01
DE69835308D1 (de) 2006-08-31
US6340746B1 (en) 2002-01-22
DE69835308T2 (de) 2007-08-09
EP1003760A1 (de) 2000-05-31
WO1999007719A1 (en) 1999-02-18
CA2299271C (en) 2009-02-03
AU8898498A (en) 1999-03-01
EP1003760B1 (de) 2004-07-28
AU750916C (en) 2003-05-22

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee