DE69824313D1 - Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen - Google Patents

Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen

Info

Publication number: DE69824313D1
Authority: DE; Germany
Prior art keywords: compound; formula; orlistat; pharmaceutical compositions; compositions containing
Prior art date: 1997-12-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69824313T

Other languages

English (en)

Other versions

DE69824313T2 (de

Inventor

John Heal

Christine Jackson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott GmbH and Co KG

Original Assignee

Abbott GmbH and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-24

Filing date

1998-12-16

Publication date

2004-07-08

1998-12-16 Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG

2004-07-08 Application granted granted Critical

2004-07-08 Publication of DE69824313D1 publication Critical patent/DE69824313D1/de

2005-08-25 Publication of DE69824313T2 publication Critical patent/DE69824313T2/de

2018-12-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 title 1
229960001243 orlistat Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 title 1
229960004425 sibutramine Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

DE69824313T 1997-12-24 1998-12-16 Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen Expired - Fee Related DE69824313T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9727131		1997-12-24
GBGB9727131.6A GB9727131D0 (en)	1997-12-24	1997-12-24	Therapeutic agents
PCT/EP1998/008249 WO1999033450A2 (en)	1997-12-24	1998-12-16	Pharmaceutical composition containing sibutramine and orlistat

Publications (2)

Publication Number	Publication Date
DE69824313D1 true DE69824313D1 (de)	2004-07-08
DE69824313T2 DE69824313T2 (de)	2005-08-25

Family

ID=10824083

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69824313T Expired - Fee Related DE69824313T2 (de)	1997-12-24	1998-12-16	Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen

Country Status (26)

Country	Link
US (1)	US6403641B2 (de)
EP (1)	EP1039900B1 (de)
JP (1)	JP2001527036A (de)
KR (1)	KR20010033531A (de)
CN (1)	CN1134257C (de)
AT (1)	ATE268174T1 (de)
AU (1)	AU758181B2 (de)
BG (1)	BG104568A (de)
BR (1)	BR9814498A (de)
CA (1)	CA2315259A1 (de)
CZ (1)	CZ20002392A3 (de)
DE (1)	DE69824313T2 (de)
DK (1)	DK1039900T3 (de)
ES (1)	ES2222001T3 (de)
GB (1)	GB9727131D0 (de)
HK (1)	HK1034446A1 (de)
HU (1)	HUP0300615A3 (de)
IL (1)	IL136733A (de)
NO (1)	NO20003313L (de)
NZ (1)	NZ505686A (de)
PL (1)	PL342099A1 (de)
PT (1)	PT1039900E (de)
SK (1)	SK9492000A3 (de)
TR (1)	TR200001869T2 (de)
UA (1)	UA70310C2 (de)
WO (1)	WO1999033450A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6331571B1 (en)	1998-08-24	2001-12-18	Sepracor, Inc.	Methods of treating and preventing attention deficit disorders
US6974838B2 (en)	1998-08-24	2005-12-13	Sepracor Inc.	Methods of treating or preventing pain using sibutramine metabolites
US6339106B1 (en)	1999-08-11	2002-01-15	Sepracor, Inc.	Methods and compositions for the treatment and prevention of sexual dysfunction
US6476078B2 (en)	1999-08-11	2002-11-05	Sepracor, Inc.	Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
GB9914744D0 (en) *	1999-06-24	1999-08-25	Knoll Ag	Therapeutic agents
US6399826B1 (en)	1999-08-11	2002-06-04	Sepracor Inc.	Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
KR100572785B1 (ko)	2000-07-28	2006-04-19	에프. 호프만-라 로슈 아게	신규한 약학 조성물
WO2002083631A1 (en)	2001-04-13	2002-10-24	Sepracor Inc.	Methods of preparing didesmethylsibutramine and other sibutramine derivatives
US6730319B2 (en) *	2001-06-06	2004-05-04	Hoffmann-La Roche Inc.	Pharmaceutical compositions having depressed melting points
CA2530634A1 (en) *	2003-06-12	2004-12-23	Menachem Rubinstein	Methods of treating obesity and related disorders using tellurium and selenium compounds
US20050131074A1 (en) *	2003-08-04	2005-06-16	Beckman Kristen M.	Methods for treating metabolic syndrome
CN1980682A (zh)	2004-05-10	2007-06-13	丹麦皇家兽医和农业学院	用于控制体重的亚麻子
EP2625968A1 (de)	2007-09-12	2013-08-14	Københavns Universitet	Zusammensetzungen und methoden zur verstärkung der hungerunterdrückung und zum reduzieren der verdaulichkeit der nichtfettenergiesättigung
US20090214682A1 (en) *	2008-02-22	2009-08-27	Heuer Marvin A	Composition and methods for weight loss in a subject
JP5738011B2 (ja) *	2011-03-04	2015-06-17	株式会社ブリヂストン	二次電池の非水電解液用添加剤、二次電池用非水電解液及び非水電解液二次電池
CN102872062A (zh) *	2011-07-13	2013-01-16	鲁南制药集团股份有限公司	一种治疗或预防肥胖症以及代谢综合症的药物组合物
JP2013147488A (ja) *	2011-12-21	2013-08-01	Taisho Pharmaceutical Co Ltd	固形製剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE52768B1 (en)	1981-04-06	1988-02-17	Boots Co Ltd	1-arylcyclobutylalkylamine compounds useful as therapeutic agents
CA1247547A (en) *	1983-06-22	1988-12-28	Paul Hadvary	Leucine derivatives
CA1328881C (en)	1984-12-21	1994-04-26	Pierre Barbier	Process for the manufacture of oxetanones
GB8531071D0 (en)	1985-12-17	1986-01-29	Boots Co Plc	Therapeutic compound
GB8704777D0 (en)	1987-02-28	1987-04-01	Boots Co Plc	Medical treatment
JP2675573B2 (ja)	1988-03-31	1997-11-12	科研製薬株式会社	脳機能改善剤
IE61928B1 (en)	1988-11-29	1994-11-30	Boots Co Plc	Treatment of obesity
TW381025B (en)	1993-08-05	2000-02-01	Hoffmann La Roche	Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
US5459164A (en)	1994-02-03	1995-10-17	Boots Pharmaceuticals, Inc.	Medical treatment

1997
- 1997-12-24 GB GBGB9727131.6A patent/GB9727131D0/en not_active Ceased
1998
- 1998-12-16 NZ NZ505686A patent/NZ505686A/en unknown
- 1998-12-16 WO PCT/EP1998/008249 patent/WO1999033450A2/en not_active Application Discontinuation
- 1998-12-16 AT AT98966345T patent/ATE268174T1/de not_active IP Right Cessation
- 1998-12-16 DK DK98966345T patent/DK1039900T3/da active
- 1998-12-16 UA UA2000074417A patent/UA70310C2/uk unknown
- 1998-12-16 PL PL98342099A patent/PL342099A1/xx unknown
- 1998-12-16 CZ CZ20002392A patent/CZ20002392A3/cs unknown
- 1998-12-16 CN CNB988137399A patent/CN1134257C/zh not_active Expired - Fee Related
- 1998-12-16 AU AU22738/99A patent/AU758181B2/en not_active Ceased
- 1998-12-16 ES ES98966345T patent/ES2222001T3/es not_active Expired - Lifetime
- 1998-12-16 HU HU0300615A patent/HUP0300615A3/hu unknown
- 1998-12-16 US US09/212,249 patent/US6403641B2/en not_active Expired - Fee Related
- 1998-12-16 SK SK949-2000A patent/SK9492000A3/sk unknown
- 1998-12-16 JP JP2000526207A patent/JP2001527036A/ja active Pending
- 1998-12-16 KR KR1020007007034A patent/KR20010033531A/ko not_active Application Discontinuation
- 1998-12-16 CA CA002315259A patent/CA2315259A1/en not_active Abandoned
- 1998-12-16 BR BR9814498-7A patent/BR9814498A/pt not_active IP Right Cessation
- 1998-12-16 IL IL13673398A patent/IL136733A/en not_active IP Right Cessation
- 1998-12-16 PT PT98966345T patent/PT1039900E/pt unknown
- 1998-12-16 TR TR2000/01869T patent/TR200001869T2/xx unknown
- 1998-12-16 DE DE69824313T patent/DE69824313T2/de not_active Expired - Fee Related
- 1998-12-16 EP EP98966345A patent/EP1039900B1/de not_active Expired - Lifetime
2000
- 2000-06-23 NO NO20003313A patent/NO20003313L/no not_active Application Discontinuation
- 2000-06-28 BG BG104568A patent/BG104568A/bg unknown
2001
- 2001-07-13 HK HK01104909A patent/HK1034446A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2273899A (en)	1999-07-19
ES2222001T3 (es)	2005-01-16
CA2315259A1 (en)	1999-07-08
WO1999033450A3 (en)	1999-09-02
NO20003313L (no)	2000-08-11
CZ20002392A3 (cs)	2002-01-16
KR20010033531A (ko)	2001-04-25
PL342099A1 (en)	2001-05-21
NO20003313D0 (no)	2000-06-23
CN1134257C (zh)	2004-01-14
BG104568A (bg)	2001-02-28
SK9492000A3 (en)	2001-07-10
AU758181B2 (en)	2003-03-20
IL136733A0 (en)	2001-06-14
IL136733A (en)	2004-08-31
WO1999033450A2 (en)	1999-07-08
JP2001527036A (ja)	2001-12-25
DK1039900T3 (da)	2004-10-04
US20020010160A1 (en)	2002-01-24
PT1039900E (pt)	2004-09-30
DE69824313T2 (de)	2005-08-25
EP1039900A2 (de)	2000-10-04
ATE268174T1 (de)	2004-06-15
HUP0300615A2 (hu)	2003-07-28
CN1284872A (zh)	2001-02-21
NZ505686A (en)	2002-07-26
BR9814498A (pt)	2000-10-10
UA70310C2 (uk)	2004-10-15
TR200001869T2 (tr)	2000-10-23
EP1039900B1 (de)	2004-06-02
HUP0300615A3 (en)	2005-04-28
HK1034446A1 (en)	2001-10-26
GB9727131D0 (en)	1998-02-25
US6403641B2 (en)	2002-06-11

Publication	Publication Date	Title
DE69824313D1 (de)	2004-07-08	Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen
CY1107391T1 (el)	2010-07-28	Αρυλσυμπυκνωμενες αζαπολυκυκλικες ενωσεις
LU91254I2 (fr)	2006-08-28	Daptomycine et ses dérivés pharmaceutiquement acceptables (cubicinr)
DK0869808T3 (da)	2006-11-13	Anvendelse af Glu-Trp-dipeptider til fremstilling af et lægemiddel til behandling af forskellige tilstande, der involverer neovaskularisation
ES2295609T3 (es)	2008-04-16	Derivados de tiadiazolilpiperazina utiles para tratar o prevenir un dolor.
FI934983A0 (fi)	1993-11-11	Kinuklidinderivat foer behandling av inflammatoriska och gastrointestinala sjukdomar
NO20022014L (no)	2002-06-20	En fast oral kontrollert frigjorende doseringsform inneholdende hydrokodon
GEP20043269B (en)	2004-06-25	Purine Derivatives, Method for Their Production and Composition Containing the Same
DK1346041T3 (da)	2007-07-02	Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom
SE9504661D0 (sv)	1995-12-22	New compounds
DK0503440T3 (da)	1999-01-18	Sumatriptanholdige lægemidler
ATE219363T1 (de)	2002-07-15	Lösliche prodrugs von paclitaxel
WO2005056524A3 (en)	2005-09-22	Therapeutic agents useful for treating pain
TR200103613T2 (tr)	2004-08-23	Burun içinden tatbik edilen morfini içeren farmasötik formülasyonlar ve yöntemler.
LV12291A (lv)	1999-06-20	Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
DK0998287T3 (da)	2003-09-01	Anvendelse af levobupivacain
SE0300908D0 (sv)	2003-03-31	Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
TR200003122T2 (tr)	2001-03-21	Aril bağlı azapolisiklik bileşikler
GEP20043227B (en)	2004-04-26	5HT1 Antagonists for Antidepressant Therapy
ES2111352T3 (es)	1998-03-01	Uso de diester fosfato para el tratamiento de enfermedades retinianas.
BG106180A (en)	2002-08-30	Pharmaceutical composition containing sibutramine and orlistat
NO20031410L (no)	2003-03-27	Anvendelse av distamycinderivater for fremstilling av medikamenter
SE9504662D0 (sv)	1995-12-22	New compounds
BG106209A (en)	2002-09-30	Therapeutic agents
SE0004827D0 (sv)	2000-12-22	Therapeutic compounds

Legal Events

Date	Code	Title	Description
2005-06-30	8364	No opposition during term of opposition
2006-10-12	8339	Ceased/non-payment of the annual fee