[go: up one dir, main page]

DE69821650D1 - Phtalazin derivate wirksam als phosphodiesterase 4 inhibitoren - Google Patents

Phtalazin derivate wirksam als phosphodiesterase 4 inhibitoren

Info

Publication number
DE69821650D1
DE69821650D1 DE69821650T DE69821650T DE69821650D1 DE 69821650 D1 DE69821650 D1 DE 69821650D1 DE 69821650 T DE69821650 T DE 69821650T DE 69821650 T DE69821650 T DE 69821650T DE 69821650 D1 DE69821650 D1 DE 69821650D1
Authority
DE
Germany
Prior art keywords
phenyl
alkyl
group
phtalazine
phosphodiesterase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69821650T
Other languages
English (en)
Other versions
DE69821650T2 (de
Inventor
Mauro Napoletano
Gabriele Norcini
Daniela Botta
Giancarlo Grancini
Gabriele Morazzoni
Francesco Santangelo
Herrero Jorge G Siro
Navio Jose Luis Garcia
Julio G Alvarez-Builla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Application granted granted Critical
Publication of DE69821650D1 publication Critical patent/DE69821650D1/de
Publication of DE69821650T2 publication Critical patent/DE69821650T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Lubricants (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69821650T 1997-12-19 1998-12-17 Phtalazin derivate wirksam als phosphodiesterase 4 inhibitoren Expired - Fee Related DE69821650T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI972806 1997-12-19
IT97MI002806A IT1296984B1 (it) 1997-12-19 1997-12-19 Derivati ftalazinici inibitori della fosfodiesterasi 4
PCT/EP1998/008291 WO1999032456A1 (en) 1997-12-19 1998-12-17 Phthalazine derivatives phosphodiesterase 4 inhibitors

Publications (2)

Publication Number Publication Date
DE69821650D1 true DE69821650D1 (de) 2004-03-18
DE69821650T2 DE69821650T2 (de) 2004-12-23

Family

ID=11378396

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69821650T Expired - Fee Related DE69821650T2 (de) 1997-12-19 1998-12-17 Phtalazin derivate wirksam als phosphodiesterase 4 inhibitoren

Country Status (11)

Country Link
US (2) US6589951B1 (de)
EP (1) EP1042300B1 (de)
JP (1) JP2001526270A (de)
AT (1) ATE259356T1 (de)
AU (1) AU2613299A (de)
DE (1) DE69821650T2 (de)
DK (1) DK1042300T3 (de)
ES (1) ES2216354T3 (de)
IT (1) IT1296984B1 (de)
PT (1) PT1042300E (de)
WO (1) WO1999032456A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
ITMI20022739A1 (it) * 2002-12-23 2004-06-24 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4.
FR2868780B1 (fr) 2004-04-13 2008-10-17 Sanofi Synthelabo Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique
CA2593005A1 (en) * 2005-01-03 2006-07-13 Myriad Genetics Inc. Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
US7759337B2 (en) * 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
AU2007221049A1 (en) * 2006-02-28 2007-09-07 Amgen Inc. Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors
US8044041B2 (en) * 2006-11-15 2011-10-25 Forest Laboratories Holdings Limited Phthalazine derivatives as inhibitors of protein kinase
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
US20080254029A1 (en) * 2007-04-11 2008-10-16 Alcon Research, Ltd. Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis
WO2010042646A1 (en) 2008-10-10 2010-04-15 Amgen Inc. Aza- and diaza-phthalazine compounds as p38 map kinase modulators and methods of use thereof
WO2010042649A2 (en) * 2008-10-10 2010-04-15 Amgen Inc. PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF
EP2272831A1 (de) * 2009-06-26 2011-01-12 Prime European Therapeuticals S.p.A. Verfahren zur Herstellung von Arylpyridinylverbindungen
KR20120091037A (ko) * 2009-10-01 2012-08-17 알콘 리서치, 리미티드 올로파타딘 조성물 및 그의 용도
ES2623704T3 (es) 2013-06-24 2017-07-12 Merck Patent Gmbh Derivados de ftalazina.
CN105814022B (zh) * 2013-12-09 2018-09-28 Ucb生物制药私人有限公司 作为tnf活性调节剂的稠合的二环杂芳族衍生物
MX2021007938A (es) 2018-12-28 2022-01-24 Regeneron Pharma Tratamiento de trastornos respiratorios con inhibidores de la araquidonato 15-lipooxigenasa (alox15).

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2063249A (en) * 1979-10-09 1981-06-03 Mitsubishi Yuka Pharma 4-Phenylphthalazine derivatives
AU3102697A (en) * 1996-06-19 1998-01-07 Rhone-Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen

Also Published As

Publication number Publication date
AU2613299A (en) 1999-07-12
EP1042300A1 (de) 2000-10-11
DE69821650T2 (de) 2004-12-23
EP1042300B1 (de) 2004-02-11
JP2001526270A (ja) 2001-12-18
ITMI972806A1 (it) 1999-06-19
IT1296984B1 (it) 1999-08-03
ATE259356T1 (de) 2004-02-15
US6589951B1 (en) 2003-07-08
DK1042300T3 (da) 2004-06-28
ES2216354T3 (es) 2004-10-16
US20040043999A1 (en) 2004-03-04
PT1042300E (pt) 2004-06-30
WO1999032456A1 (en) 1999-07-01

Similar Documents

Publication Publication Date Title
DE69821650D1 (de) Phtalazin derivate wirksam als phosphodiesterase 4 inhibitoren
MY119425A (en) Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to ppar-gamma
DE69327254D1 (de) Substituierte pyrazole als crf antagonisten
DK0424059T3 (da) Anvendelse af substituerede imidazoler
EA199900953A1 (ru) ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ, КАК ИНГИБИТОРЫ p38 КИНАЗЫ
ES8505652A1 (es) Procedimiento para preparar nuevas 1-bencil-aminoalquil-pirrolidinonas
EA199800603A1 (ru) Производные 1-(1,2-дизамещенный пиперидинил)-4-(конденсированный имидазол)-пиперидина
BG99443A (bg) Хербицидни 2-/(4-хетероциклени-феноксиметил)фенокси/ алканоати
TW376385B (en) Watersoluble azole antifungals
WO1999032449A3 (en) Benzazine derivatives as phosphodiesterase 4 inhibitors
ES8602783A1 (es) Un procedimiento para la preparacion de pirazolopiridinas.
EP0299683A3 (de) Heterocyclische olefinische Verbindungen und ihre Verwendung als Aromatasehemmer
ATE216373T1 (de) 2,3-benzodiazepinderivate und deren verwendung als ampa-rezeptoren-hemmer
ES2021941A6 (es) Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles.
NO955192L (no) Imidazol[1,2-aÅpyrazin-4-on, fremstilling derav og medikament inneholdende forbindelsen
ATE72431T1 (de) 5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren.
MY129069A (en) Fused pyrazolone compound which inhibit the release of inflammatory cytokines
Lee et al. Proton magnetic resonance spectra of some tetrazoles, triazoles, and tetrazolium and triazolium salts
ATE85614T1 (de) Psychotropische bizyklische imide.
ATE121401T1 (de) 2-substituierte 4,5-diphenylimidazole.
EP0978515A3 (de) 1-(substituiertes Phenyl)-4-Biphenylmethyl-imidazol-2-on Derivate, deren Herstellung und deren Verwendung als Angiotensin II Antagonisten
ES484616A1 (es) Un procedimiento para preparar nuevos derivados de pirrolil-piridazin-amina
KR890008105A (ko) 1-치환된 이미다졸-5-카르복시산 및 카르복시산 유도체의 합성 방법
Klutchko et al. 4, 5, 6, 7‐Tetrahydro‐1H‐imidazo [4, 5‐c] pyridine‐6‐carboxylic acids (spinacines)
ATE128868T1 (de) Verwendung von oxazolo- 2,3-a>isoindol- und imidazo 2,1-a>isoindol-derivaten als antivirale arzneimittel sowie neue oxazolo 2,3-a>isoindol- derivaten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee