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DE69819311D1 - Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase - Google Patents

Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase

Info

Publication number
DE69819311D1
DE69819311D1 DE69819311T DE69819311T DE69819311D1 DE 69819311 D1 DE69819311 D1 DE 69819311D1 DE 69819311 T DE69819311 T DE 69819311T DE 69819311 T DE69819311 T DE 69819311T DE 69819311 D1 DE69819311 D1 DE 69819311D1
Authority
DE
Germany
Prior art keywords
fructose
bisphosphatase
inhibitors
benzimidazol
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69819311T
Other languages
English (en)
Other versions
DE69819311T2 (de
Inventor
Rao Kasibhatla
Raja Reddy
D Erion
Qun Dang
R Scarlato
Rami Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabasis Therapeutics Inc
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Application granted granted Critical
Publication of DE69819311D1 publication Critical patent/DE69819311D1/de
Publication of DE69819311T2 publication Critical patent/DE69819311T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69819311T 1997-03-07 1998-03-06 Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase Expired - Fee Related DE69819311T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4062797P 1997-03-07 1997-03-07
US40627P 1997-03-07
PCT/US1998/004498 WO1998039343A1 (en) 1997-03-07 1998-03-06 Novel benzimidazole inhibitors of fructose-1,6-bisphosphatase

Publications (2)

Publication Number Publication Date
DE69819311D1 true DE69819311D1 (de) 2003-12-04
DE69819311T2 DE69819311T2 (de) 2004-07-29

Family

ID=21912034

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69819311T Expired - Fee Related DE69819311T2 (de) 1997-03-07 1998-03-06 Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase

Country Status (11)

Country Link
US (2) US6110903A (de)
EP (1) EP0970095B1 (de)
JP (1) JP2001515482A (de)
AT (1) ATE253073T1 (de)
AU (1) AU6691498A (de)
DE (1) DE69819311T2 (de)
DK (1) DK0970095T3 (de)
ES (1) ES2210728T3 (de)
PT (1) PT970095E (de)
WO (1) WO1998039343A1 (de)
ZA (1) ZA981936B (de)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
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US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
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KR20070029196A (ko) * 2004-06-08 2007-03-13 메타베이시스 테라퓨틱스, 인크. 고리 에스테르의 루이스 산 매개 합성
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AU6691498A (en) 1998-09-22
US6399782B1 (en) 2002-06-04
JP2001515482A (ja) 2001-09-18
WO1998039343A1 (en) 1998-09-11
DE69819311T2 (de) 2004-07-29
EP0970095A1 (de) 2000-01-12
ZA981936B (en) 1999-09-06
DK0970095T3 (da) 2004-03-08
PT970095E (pt) 2004-03-31
EP0970095B1 (de) 2003-10-29
ATE253073T1 (de) 2003-11-15
US6110903A (en) 2000-08-29

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