DE69738452D1 - Fusionspolypeptide die eine ige-bindungsdomäne und eine hsa-komponente enthalten und deren diagnostische und therapeutische verwendung - Google Patents

Fusionspolypeptide die eine ige-bindungsdomäne und eine hsa-komponente enthalten und deren diagnostische und therapeutische verwendung

Info

Publication number: DE69738452D1
Authority: DE; Germany
Prior art keywords: diagnostic; binding domain; fusion polypeptides; therapeutic uses; polypeptides containing
Prior art date: 1996-07-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69738452T

Other languages

English (en)

Other versions

DE69738452T2 (de

Inventor

Mary Ellen Digan

Philip Lake

Hermann Gram

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-26

Filing date

1997-07-25

Publication date

2008-02-21

1997-07-25 Application filed by Novartis AG filed Critical Novartis AG

2008-02-21 Publication of DE69738452D1 publication Critical patent/DE69738452D1/de

2008-12-24 Application granted granted Critical

2008-12-24 Publication of DE69738452T2 publication Critical patent/DE69738452T2/de

2017-07-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DE69738452T 1996-07-26 1997-07-25 Fusionspolypeptide die eine ige-bindungsdomäne und eine hsa-komponente enthalten und deren diagnostische und therapeutische verwendung Expired - Lifetime DE69738452T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US690216		1985-01-10
US69021696A	1996-07-26	1996-07-26
PCT/EP1997/004066 WO1998004718A1 (en)	1996-07-26	1997-07-25	Fusion polypeptides comprising an ige-binding domain and a hsa component, and their diagnostic and therapeutic uses

Publications (2)

Publication Number	Publication Date
DE69738452D1 true DE69738452D1 (de)	2008-02-21
DE69738452T2 DE69738452T2 (de)	2008-12-24

Family

ID=24771594

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69738452T Expired - Lifetime DE69738452T2 (de)	1996-07-26	1997-07-25	Fusionspolypeptide die eine ige-bindungsdomäne und eine hsa-komponente enthalten und deren diagnostische und therapeutische verwendung

Country Status (28)

Country	Link
EP (1)	EP0917581B1 (de)
JP (1)	JP3681402B2 (de)
KR (1)	KR100502879B1 (de)
CN (1)	CN1146664C (de)
AR (1)	AR008077A1 (de)
AT (1)	ATE383429T1 (de)
AU (1)	AU722069B2 (de)
BR (1)	BR9710605A (de)
CA (1)	CA2261562C (de)
CO (1)	CO4650184A1 (de)
CZ (1)	CZ297634B6 (de)
DE (1)	DE69738452T2 (de)
ES (1)	ES2300114T3 (de)
HK (1)	HK1020352A1 (de)
ID (1)	ID19420A (de)
IL (2)	IL128094A0 (de)
MY (1)	MY120425A (de)
NO (1)	NO323611B1 (de)
NZ (1)	NZ333908A (de)
PE (1)	PE99498A1 (de)
PL (1)	PL189415B1 (de)
PT (1)	PT917581E (de)
RU (1)	RU2209211C2 (de)
SK (1)	SK7799A3 (de)
TR (1)	TR199900155T2 (de)
TW (1)	TW565571B (de)
WO (1)	WO1998004718A1 (de)
ZA (1)	ZA976666B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9526733D0 (en)	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
EP1056471A4 (de) *	1998-01-29	2001-05-30	Tanox Inc	BEHANDLUNG ATOPISCHER DERMATITIS MIT IgE ANTAGONISTEN
DK1088084T3 (da)	1998-06-15	2007-01-29	Gtc Biotherapeutics Inc	Erythropoietin analog-humant serumalbumin fusionsprotein
EP1208194A2 (de) *	1999-08-09	2002-05-29	Genaissance Pharmaceuticals, Inc.	Isogene arzneimittel-ziele: polymorphismen des gens der immunglobulin e rezeptor i alpha untereinheit
AU2001264563A1 (en)	2000-04-12	2001-10-30	Human Genome Sciences, Inc.	Albumin fusion proteins
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
DE10026998A1 (de) *	2000-05-31	2001-12-13	Fresenius Kabi De Gmbh	Verfahren zur Herstellung einer kosmetischen Zusammensetzung, die humanes Serum Albumin umfasst, welches aus transgenen nicht-menschlichen Säugern erhalten wurde
US7271149B2 (en)	2000-12-07	2007-09-18	Eli Lilly And Company	GLP-1 fusion proteins
TW200526779A (en) *	2001-02-08	2005-08-16	Wyeth Corp	Modified and stabilized GDF propeptides and uses thereof
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
EP2277889B1 (de)	2001-12-21	2014-07-09	Human Genome Sciences, Inc.	Fusionsproteine von Albumin und Interferon beta
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
CN102282168A (zh)	2008-11-18	2011-12-14	梅里麦克制药股份有限公司	人血清白蛋白接头以及其结合物
JP5745431B2 (ja)	2009-02-27	2015-07-08	ノバルティスアーゲー	異種タンパク質を発現する真核生物細胞の選択方法
WO2012169735A2 (ko) *	2011-06-07	2012-12-13	(주)네오팜	FCεRI의 수용성 단편을 포함하는 복합체 및 이를 포함하는 IGE 매개 알레르기성 질환 치료용 조성물
RU2506271C2 (ru) *	2011-06-22	2014-02-10	Учреждение Российской Академии Медицинских Наук Научно-исследовательский институт экспериментальной медицины Северо-западного отделения РАМН (НИИЭМ СЗО РАМН)	РЕКОМБИНАНТНЫЙ ПОЛИПЕПТИД А2, СЕЛЕКТИВНО СВЯЗЫВАЮЩИЙ HSA, РЕКОМБИНАНТНАЯ ДНК pa2, КОДИРУЮЩАЯ HSA-СВЯЗЫВАЮЩУЮ ЧАСТЬ ПОЛИПЕПТИДА A2, ЕГО ПРОДУЦЕНТ - РЕКОМБИНАНТНЫЙ ШТАММ Escherichia coli M15-A2, СОДЕРЖАЩИЙ РЕКОМБИНАНТНУЮ ПЛАЗМИДНУЮ ДНК pQE 32-pa2, ОБЕСПЕЧИВАЮЩУЮ ПОЛУЧЕНИЕ ПОЛИПЕПТИДА A2 И ПРИМЕНЕНИЕ ПОЛИПЕПТИДА А2 ДЛЯ ДИАГНОСТИКИ МИКРОАЛЬБУМИНУРИИ И ВЫДЕЛЕНИЯ HSA ИЗ СЫВОРОТКИ КРОВИ
WO2014036520A1 (en)	2012-08-30	2014-03-06	Merrimack Pharmaceuticals, Inc.	Combination therapies comprising anti-erbb3 agents
US20180139938A1 (en) *	2015-05-04	2018-05-24	Laboratoire Français du Fractionnement et des, Biotechnologies	Transgenic production of fc fusion proteins
EP3192806A1 (de)	2016-01-13	2017-07-19	Affiris AG	Alpha-kette des hochaffinen ige-rezeptors (fceria)
CA3041717A1 (en) *	2016-11-09	2018-05-17	North Carolina State University	Treatment of allergic diseases with chimeric protein
WO2019183437A1 (en)	2018-03-23	2019-09-26	North Carolina State University	Methods and compositions for antibody to high affinity receptor for ige
US20220267396A1 (en) *	2019-07-08	2022-08-25	Progen Co., Ltd.	Novel il-10 variant protein and use thereof
AU2020310003A1 (en)	2019-07-08	2022-01-06	Gi Innovation, Inc.	Polypeptide dimer with high sialic acid content, comprising extracellular domain of alpha subunit of IgE Fc receptor, and pharmaceutical composition comprising same
CN111773392B (zh) *	2020-05-25	2023-04-07	河南省生物工程技术研究中心	一种人血白蛋白/寡核苷酸纳米颗粒及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4962035A (en) *	1987-12-01	1990-10-09	President And Fellows Of Harvard College	DNA encoding IgE receptor alpha-subunit or fragment thereof
GB8909916D0 (en) *	1989-04-29	1989-06-14	Delta Biotechnology Ltd	Polypeptides
CA2059842A1 (en) *	1991-02-11	1992-08-12	Richard A. Chizzonite	Ige-receptor-antibodies

1997
- 1997-07-24 AR ARP970103340A patent/AR008077A1/es active IP Right Grant
- 1997-07-24 PE PE1997000662A patent/PE99498A1/es not_active Application Discontinuation
- 1997-07-24 MY MYPI97003371A patent/MY120425A/en unknown
- 1997-07-25 WO PCT/EP1997/004066 patent/WO1998004718A1/en active IP Right Grant
- 1997-07-25 AU AU42025/97A patent/AU722069B2/en not_active Ceased
- 1997-07-25 BR BR9710605A patent/BR9710605A/pt not_active IP Right Cessation
- 1997-07-25 JP JP50850498A patent/JP3681402B2/ja not_active Expired - Fee Related
- 1997-07-25 CO CO97042651A patent/CO4650184A1/es unknown
- 1997-07-25 NZ NZ333908A patent/NZ333908A/en unknown
- 1997-07-25 RU RU99103326/13A patent/RU2209211C2/ru not_active IP Right Cessation
- 1997-07-25 EP EP97940030A patent/EP0917581B1/de not_active Expired - Lifetime
- 1997-07-25 ZA ZA976666A patent/ZA976666B/xx unknown
- 1997-07-25 ID IDP972592A patent/ID19420A/id unknown
- 1997-07-25 CZ CZ0024699A patent/CZ297634B6/cs not_active IP Right Cessation
- 1997-07-25 CA CA2261562A patent/CA2261562C/en not_active Expired - Fee Related
- 1997-07-25 KR KR10-1999-7000621A patent/KR100502879B1/ko not_active Expired - Fee Related
- 1997-07-25 CN CNB971976597A patent/CN1146664C/zh not_active Expired - Fee Related
- 1997-07-25 IL IL12809497A patent/IL128094A0/xx active IP Right Grant
- 1997-07-25 ES ES97940030T patent/ES2300114T3/es not_active Expired - Lifetime
- 1997-07-25 PT PT97940030T patent/PT917581E/pt unknown
- 1997-07-25 AT AT97940030T patent/ATE383429T1/de active
- 1997-07-25 SK SK77-99A patent/SK7799A3/sk unknown
- 1997-07-25 DE DE69738452T patent/DE69738452T2/de not_active Expired - Lifetime
- 1997-07-25 TR TR1999/00155T patent/TR199900155T2/xx unknown
- 1997-08-08 TW TW086111356A patent/TW565571B/zh not_active IP Right Cessation
1999
- 1999-01-18 IL IL128094A patent/IL128094A/en not_active IP Right Cessation
- 1999-01-25 PL PL97331356A patent/PL189415B1/pl not_active IP Right Cessation
- 1999-01-25 NO NO19990328A patent/NO323611B1/no not_active IP Right Cessation
- 1999-11-24 HK HK99105437A patent/HK1020352A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
TR199900155T2 (xx)	2000-08-21
PL331356A1 (en)	1999-07-05
PL189415B1 (pl)	2005-08-31
ID19420A (id)	1998-07-09
IL128094A (en)	2006-08-20
WO1998004718A1 (en)	1998-02-05
KR100502879B1 (ko)	2005-07-25
PE99498A1 (es)	1999-01-21
NO323611B1 (no)	2007-06-18
JP2000516089A (ja)	2000-12-05
AR008077A1 (es)	1999-12-09
SK7799A3 (en)	1999-07-12
PT917581E (pt)	2008-04-11
NZ333908A (en)	1999-10-28
MY120425A (en)	2005-10-31
KR20000029563A (ko)	2000-05-25
BR9710605A (pt)	1999-08-17
NO990328L (no)	1999-02-19
RU2209211C2 (ru)	2003-07-27
CN1146664C (zh)	2004-04-21
AU722069B2 (en)	2000-07-20
CN1229439A (zh)	1999-09-22
CO4650184A1 (es)	1998-09-03
HK1020352A1 (en)	2000-04-14
CZ297634B6 (cs)	2007-02-21
AU4202597A (en)	1998-02-20
JP3681402B2 (ja)	2005-08-10
CA2261562C (en)	2011-04-05
ES2300114T3 (es)	2008-06-01
ZA976666B (en)	1999-01-25
DE69738452T2 (de)	2008-12-24
ATE383429T1 (de)	2008-01-15
NO990328D0 (no)	1999-01-25
EP0917581A1 (de)	1999-05-26
EP0917581B1 (de)	2008-01-09
IL128094A0 (en)	1999-11-30
CA2261562A1 (en)	1998-02-05
TW565571B (en)	2003-12-11
CZ24699A3 (cs)	1999-04-14

Publication	Publication Date	Title
DE69738452D1 (de)	2008-02-21	Fusionspolypeptide die eine ige-bindungsdomäne und eine hsa-komponente enthalten und deren diagnostische und therapeutische verwendung
DE69706948D1 (de)	2001-10-31	Weichlotwerkstoff und dessen Verwendung in ein elektronisches Bauteil
DE69821463D1 (de)	2004-03-11	Polypropylenharzzusammensetzung und deren verwendung
NO963371D0 (no)	1996-08-13	Hematopoeseprotein samt materialer og fremgangsmåter for fremstilling av det
DE69526969D1 (de)	2002-07-11	Thermoplastische harzzusammensetzung und seine verwendung
DE69806925D1 (de)	2002-09-05	Ligand-aminodextran-markierungsubstanzkonjugate und deren verwendung
DE69729149D1 (de)	2004-06-24	Prozesskassette und Bilderzeugungsgerät mit herausnehmbarer Prozesskassette
DE69718839D1 (de)	2003-03-13	Informationsaufzeichnungsverfahren und Vorrichtung mit Zusatzaufzeichnungsfunktion
KR900009914A (ko)	1990-07-05	근적외선 흡광제 및 이를 이용하여 제조된 표시/기록 물질
DE59506234D1 (de)	1999-07-22	Pigmentzubereitung und deren Verwendung
EP0790826A4 (de)	1998-11-11	Dyhydropyrimidine und deren verwendungen
DE69533336D1 (de)	2004-09-09	Testkarte und ihre anwendung
DE69631240D1 (de)	2004-02-05	Schaltvorrichtung und deren verwendung
DE59802439D1 (de)	2002-01-24	Spiroverbindungen und deren verwendung
DE69401392D1 (de)	1997-02-20	Polypropylen-Harzzusammensetzung und seine Verwendung
DE69817432D1 (de)	2003-10-02	Cycloolefinpolymere und deren Verwendung
DE69807070D1 (de)	2002-09-12	Tocoferol estern und deren verwendung in kosmetika und pharmazie
DE69431350D1 (de)	2002-10-17	Vergiessbares canola-öl und dessen verwendung in nahrungsmitteln
DE69431415D1 (de)	2002-10-31	Kondensator mit drei Anschlüssen und Bauteil mit diesem Kondensator
DE59504919D1 (de)	1999-03-04	Verfahren zur herstellung von ammonium-2-hydroxy-4-(methylthio)-butyrat und dieses enthaltende mischungen in flüssiger form und deren verwendung
DE69519821D1 (de)	2001-02-15	Pulverförmiges Material zur Verwendung beim Wiederstandsschweissen von Aluminiumgegenständen und Wiederstandsschweissen von Aluminiumgegenständen
DE69835007D1 (de)	2006-08-03	Entkoffeinierte mate-extrakte und deren verwendung
DE69637737D1 (de)	2008-12-18	Polyesterzusammensetzung und daraus hergestellte folien
DE69411942D1 (de)	1998-08-27	Mehrschichtenmaterial und eine dieses material enthaltende anordnung
ATE98246T1 (de)	1993-12-15	Substituierte pyrrolizinverbindungen und deren anwendung in der pharmazie.

Legal Events

Date	Code	Title	Description
2009-01-29	8364	No opposition during term of opposition
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2011-06-16	8328	Change in the person/name/address of the agent	Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN