DE69735552D1 - Pharmazeutische zubereitung zur behandlung der analinkontinenz und analem juckreiz - Google Patents
Pharmazeutische zubereitung zur behandlung der analinkontinenz und analem juckreizInfo
- Publication number
- DE69735552D1 DE69735552D1 DE69735552T DE69735552T DE69735552D1 DE 69735552 D1 DE69735552 D1 DE 69735552D1 DE 69735552 T DE69735552 T DE 69735552T DE 69735552 T DE69735552 T DE 69735552T DE 69735552 D1 DE69735552 D1 DE 69735552D1
- Authority
- DE
- Germany
- Prior art keywords
- anal
- analin
- juckreiz
- continence
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005722 itchiness Effects 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 abstract 1
- 208000034347 Faecal incontinence Diseases 0.000 abstract 1
- 229940123921 Nitric oxide synthase inhibitor Drugs 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 210000000436 anus Anatomy 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- 229940097320 beta blocking agent Drugs 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 210000005072 internal anal sphincter Anatomy 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 239000000236 nitric oxide synthase inhibitor Substances 0.000 abstract 1
- PXGPLTODNUVGFL-UHFFFAOYSA-N prostaglandin F2alpha Natural products CCCCCC(O)C=CC1C(O)CC(O)C1CC=CCCCC(O)=O PXGPLTODNUVGFL-UHFFFAOYSA-N 0.000 abstract 1
- 238000002271 resection Methods 0.000 abstract 1
- 230000000284 resting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9626750 | 1996-12-23 | ||
| GB9626739 | 1996-12-23 | ||
| GBGB9626739.8A GB9626739D0 (en) | 1996-12-23 | 1996-12-23 | Pharmaceutical composition for treating anal incontinence |
| GBGB9626750.5A GB9626750D0 (en) | 1996-12-23 | 1996-12-23 | Pharmaceutical composition for treating anal incontinence |
| GBGB9703309.6A GB9703309D0 (en) | 1997-02-18 | 1997-02-18 | Pharmacuetical composition for treating anal incontinence |
| GB9703309 | 1997-02-18 | ||
| PCT/GB1997/003525 WO1998027971A1 (en) | 1996-12-23 | 1997-12-23 | Pharmaceutical composition for treating fecal incontinence and anal itch |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69735552D1 true DE69735552D1 (de) | 2006-05-11 |
| DE69735552T2 DE69735552T2 (de) | 2007-02-01 |
| DE69735552T3 DE69735552T3 (de) | 2009-08-13 |
Family
ID=27268647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735552T Expired - Lifetime DE69735552T3 (de) | 1996-12-23 | 1997-12-23 | Pharmazeutische zubereitung zur behandlung der analinkontinenz und analem juckreiz |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6635678B1 (de) |
| EP (1) | EP0946155B2 (de) |
| JP (1) | JP4246265B2 (de) |
| AT (1) | ATE320796T1 (de) |
| AU (1) | AU728889C (de) |
| CA (1) | CA2275663C (de) |
| DE (1) | DE69735552T3 (de) |
| DK (1) | DK0946155T4 (de) |
| ES (1) | ES2259806T5 (de) |
| PT (1) | PT946155E (de) |
| WO (1) | WO1998027971A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6156780A (en) * | 1996-10-17 | 2000-12-05 | Milkhaus Laboratory, Inc. | Treatment of fecal incontinence |
| CA2275663C (en) * | 1996-12-23 | 2008-03-18 | Robin Kenneth Stewart Phillips | Pharmaceutical compositions comprising .alpha.-adrenergic agonists for the treatment of fecal incontinence |
| US6627632B2 (en) | 1998-12-14 | 2003-09-30 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| US6395736B1 (en) * | 1998-12-14 | 2002-05-28 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| GB0030580D0 (en) * | 2000-12-15 | 2001-01-31 | Medicare Man Consultancy Ltd | Composition and method |
| GB0130763D0 (en) * | 2001-12-21 | 2002-02-06 | Norgine Res Ltd | Treatment methods |
| WO2003070252A1 (fr) * | 2002-02-22 | 2003-08-28 | Taisho Pharmaceutical Co., Ltd. | Agents antiprurigineux |
| US20040266880A1 (en) * | 2002-02-22 | 2004-12-30 | Fumie Sato | Antipruritics |
| JP3678366B2 (ja) * | 2002-08-09 | 2005-08-03 | 大正製薬株式会社 | 止痒剤 |
| US7737182B2 (en) | 2002-08-09 | 2010-06-15 | Taisho Pharmaceutical Co., Ltd. | Pharmaceuticals for xerosis |
| AU2003301900A1 (en) * | 2002-11-13 | 2004-06-03 | Fumie Sato | Antipruritic drug |
| WO2006041875A1 (en) * | 2004-10-06 | 2006-04-20 | Allergan, Inc. | Novel prostamides for the treatment of glaucoma and related diseases |
| AU2016202290B2 (en) * | 2005-06-17 | 2017-10-05 | Wisconsin Alumni Research Foundation | Topical vasoconstrictor preparations and methods for protecting cells during cancer chemotherapy and radiotherapy |
| AU2014202738B2 (en) * | 2005-06-17 | 2016-05-12 | Wisconsin Alumni Research Foundation | Topical vasoconstrictor preparations and methods for protecting cells during cancer chemotherapy and radiotherapy |
| EP1890732B1 (de) | 2005-06-17 | 2018-03-28 | Wisconsin Alumni Research Foundation | Topische gefässverengende zubereitungen und zellschutzverfahren für chemotherapie und strahlentherapie bei krebs |
| AU2012202731B2 (en) * | 2005-06-17 | 2014-06-19 | Wisconsin Alumni Research Foundation | Topical vasoconstrictor preparations and methods for protecting cells during cancer chemotherapy and radiotherapy |
| WO2007130953A2 (en) | 2006-05-01 | 2007-11-15 | Duodyn Technology, Llc | Apparatus and method for managing incontinence |
| US7828715B2 (en) | 2006-06-29 | 2010-11-09 | Ams Research Corporation | Method of treating anal incontinence |
| JP2010514538A (ja) * | 2007-01-03 | 2010-05-06 | エーエムエス リサーチ コーポレイション | 便失禁処置用スリングの取り付け方法、およびその関連装置 |
| PE20091084A1 (es) * | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
| US20090156891A1 (en) * | 2007-12-12 | 2009-06-18 | Ams Research Corporation | Prolapse and Perineal Repair Concepts |
| CA2742945A1 (en) | 2008-11-10 | 2010-05-14 | Bayer Schering Pharma Aktiengesellschaft | Substituted sulphonamido phenoxybenzamides |
| US8962606B2 (en) | 2009-10-21 | 2015-02-24 | Bayer Intellectual Property Gmbh | Substituted benzosulphonamides |
| WO2011047795A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Substituted benzosulphonamides |
| CA2777071A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Pharma Aktiengesellschaft | Substituted halophenoxybenzamide derivatives |
| US9045429B2 (en) | 2010-10-29 | 2015-06-02 | Bayer Intellectual Property Gmbh | Substituted phenoxypyridines |
| JP6289362B2 (ja) * | 2011-04-26 | 2018-03-07 | アールディーディー ファーマ リミテッド | 肛門直腸疾患の処置のためのオキシメタゾリン |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593261A (en) * | 1976-07-23 | 1981-07-15 | Inveresk Res Int | Controlled release suppository |
| DK339289D0 (da) * | 1989-07-07 | 1989-07-07 | Dak Lab As | Farmaceutisk praeparat |
| DK469989D0 (da) | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
| NL9102142A (nl) | 1991-12-20 | 1993-07-16 | Dagra Pharma Bv | Zetpillen met vertraagde afgifte en werkwijze voor de bereiding daarvan. |
| FR2697162B1 (fr) † | 1992-10-23 | 1995-01-13 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux. |
| EP0692975A4 (de) * | 1993-04-08 | 2000-11-29 | Univ Queensland | Verabreichung eines vaso-aktiven wirkstoffes und eines therapeutischen wirkstoffes |
| GB9422571D0 (en) | 1994-11-09 | 1995-01-04 | Whitehall Lab Ltd | Haemorrihoidal compositions and method of use |
| US5595753A (en) * | 1995-04-14 | 1997-01-21 | President And Fellows Of Harvard College | Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract |
| CA2275663C (en) * | 1996-12-23 | 2008-03-18 | Robin Kenneth Stewart Phillips | Pharmaceutical compositions comprising .alpha.-adrenergic agonists for the treatment of fecal incontinence |
-
1997
- 1997-12-23 CA CA002275663A patent/CA2275663C/en not_active Expired - Fee Related
- 1997-12-23 AT AT97950311T patent/ATE320796T1/de active
- 1997-12-23 DE DE69735552T patent/DE69735552T3/de not_active Expired - Lifetime
- 1997-12-23 AU AU53315/98A patent/AU728889C/en not_active Ceased
- 1997-12-23 EP EP97950311A patent/EP0946155B2/de not_active Expired - Lifetime
- 1997-12-23 WO PCT/GB1997/003525 patent/WO1998027971A1/en active IP Right Grant
- 1997-12-23 DK DK97950311T patent/DK0946155T4/da active
- 1997-12-23 PT PT97950311T patent/PT946155E/pt unknown
- 1997-12-23 JP JP52855098A patent/JP4246265B2/ja not_active Expired - Fee Related
- 1997-12-23 US US09/331,163 patent/US6635678B1/en not_active Expired - Fee Related
- 1997-12-23 ES ES97950311T patent/ES2259806T5/es not_active Expired - Lifetime
-
2003
- 2003-03-18 US US10/389,773 patent/US7928146B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/932,939 patent/US7781444B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0946155B2 (de) | 2009-01-21 |
| US20080058363A1 (en) | 2008-03-06 |
| EP0946155B1 (de) | 2006-03-22 |
| US7781444B2 (en) | 2010-08-24 |
| PT946155E (pt) | 2006-07-31 |
| AU728889B2 (en) | 2001-01-18 |
| ATE320796T1 (de) | 2006-04-15 |
| ES2259806T3 (es) | 2006-10-16 |
| DK0946155T4 (da) | 2009-05-11 |
| JP2001507020A (ja) | 2001-05-29 |
| JP4246265B2 (ja) | 2009-04-02 |
| US7928146B2 (en) | 2011-04-19 |
| DE69735552T3 (de) | 2009-08-13 |
| AU5331598A (en) | 1998-07-17 |
| CA2275663A1 (en) | 1998-07-02 |
| AU728889C (en) | 2001-08-02 |
| ES2259806T5 (es) | 2009-05-01 |
| DK0946155T3 (da) | 2006-07-31 |
| US20030216420A1 (en) | 2003-11-20 |
| DE69735552T2 (de) | 2007-02-01 |
| WO1998027971A1 (en) | 1998-07-02 |
| US6635678B1 (en) | 2003-10-21 |
| CA2275663C (en) | 2008-03-18 |
| EP0946155A1 (de) | 1999-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings |