DE69635579D1 - Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit - Google Patents
Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeitInfo
- Publication number
- DE69635579D1 DE69635579D1 DE69635579T DE69635579T DE69635579D1 DE 69635579 D1 DE69635579 D1 DE 69635579D1 DE 69635579 T DE69635579 T DE 69635579T DE 69635579 T DE69635579 T DE 69635579T DE 69635579 D1 DE69635579 D1 DE 69635579D1
- Authority
- DE
- Germany
- Prior art keywords
- genes
- permissive
- environmentally
- environment
- microorganisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- 244000005700 microbiome Species 0.000 abstract 5
- 230000035899 viability Effects 0.000 abstract 5
- 108700005090 Lethal Genes Proteins 0.000 abstract 4
- 229960005486 vaccine Drugs 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 230000001105 regulatory effect Effects 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108700039887 Essential Genes Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000607142 Salmonella Species 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47378995A | 1995-06-07 | 1995-06-07 | |
| PCT/US1996/009774 WO1996040947A1 (en) | 1995-06-07 | 1996-06-07 | Recombinant bacterial system with environmentally limited viability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69635579D1 true DE69635579D1 (de) | 2006-01-19 |
Family
ID=23880978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69635579T Expired - Lifetime DE69635579D1 (de) | 1995-06-07 | 1996-06-07 | Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6610529B1 (de) |
| EP (1) | EP0832255B1 (de) |
| JP (1) | JPH11507532A (de) |
| AT (1) | ATE312934T1 (de) |
| AU (1) | AU711618B2 (de) |
| CA (1) | CA2222761A1 (de) |
| DE (1) | DE69635579D1 (de) |
| WO (1) | WO1996040947A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69635579D1 (de) * | 1995-06-07 | 2006-01-19 | Univ St Louis | Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit |
| AU2233397A (en) * | 1996-03-13 | 1997-10-01 | Takara Shuzo Co., Ltd. | Plasmid |
| JP2000509270A (ja) * | 1996-04-19 | 2000-07-25 | ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン | ヒスチジンタグ付きインチミン、ならびに免疫応答を刺激し、標的能力を有する抗原担体としてインチミンを使用する方法 |
| US6537558B2 (en) | 1997-03-31 | 2003-03-25 | Megan Health, Inc. | Methods of producing and using virulence attenuated poxR mutant bacteria |
| US6099848A (en) * | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| AU782566B2 (en) * | 1999-06-25 | 2005-08-11 | Wyeth Holdings Corporation | Production of the lipidated form of the peptidoglycan-associated lipoproteins of gram-negative bacteria |
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US6780405B1 (en) | 2000-04-28 | 2004-08-24 | Avant Immunotherapeutics, Inc. | Regulated antigen delivery system (RADS) |
| GB0012233D0 (en) * | 2000-05-19 | 2000-07-12 | Devgen Nv | Vector constructs |
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| AU2003250250B2 (en) | 2002-06-19 | 2008-02-14 | Intrexon Actobiotics Nv | Methods and means to promote gut absorption |
| US8748126B2 (en) | 2005-11-29 | 2014-06-10 | Actogenix N.V. | Induction of mucosal tolerance to antigens |
| US8354258B2 (en) | 2005-12-14 | 2013-01-15 | The Invention Science Fund I, Llc | Diatom device |
| US8734823B2 (en) * | 2005-12-14 | 2014-05-27 | The Invention Science Fund I, Llc | Device including altered microorganisms, and methods and systems of use |
| US9061075B2 (en) | 2005-12-14 | 2015-06-23 | The Invention Science Fund I, Llc | Bone delivery device |
| US20110172826A1 (en) * | 2005-12-14 | 2011-07-14 | Amodei Dario G | Device including altered microorganisms, and methods and systems of use |
| US8900865B2 (en) | 2005-12-14 | 2014-12-02 | The Invention Science Fund I, Llc | Blood brain barrier device |
| US8682619B2 (en) * | 2005-12-14 | 2014-03-25 | The Invention Science Fund I, Llc | Device including altered microorganisms, and methods and systems of use |
| US9005944B2 (en) | 2005-12-14 | 2015-04-14 | The Invention Science Fund I, Llc | Bone cell delivery device |
| US8852916B2 (en) * | 2010-01-22 | 2014-10-07 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with microorganisms |
| US7855062B2 (en) | 2005-12-14 | 2010-12-21 | The Invention Science Fund I, Llc | Bone cell delivery device |
| US8278094B2 (en) | 2005-12-14 | 2012-10-02 | The Invention Science Fund I, Llc | Bone semi-permeable device |
| US20080124355A1 (en) * | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| CA2675297C (en) | 2007-01-25 | 2019-05-07 | Actogenix Nv | Treatment of immune disease by mucosal delivery of antigens |
| CA2684742C (en) * | 2007-04-24 | 2014-07-08 | Celldex Therapeutics, Inc. | V. cholerae hyperexpressing recombinant cholera toxin b subunit showing dual immunogenicity |
| WO2009025888A2 (en) | 2007-05-10 | 2009-02-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety |
| EP2152883A4 (de) * | 2007-05-10 | 2010-10-27 | Univ Arizona | Rekombinante bakterien mit vektoren zur expression von nukleinsäuresequenzencodierenden antigenen |
| US8465755B2 (en) | 2007-10-05 | 2013-06-18 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against enteric pathogens |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| DK2853269T3 (da) | 2008-05-19 | 2019-08-05 | Advaxis Inc | Dobbelt indgivelsessystem til heterologe antigener, der omfatter en rekombinant Listeria-stamme svækket ved mutation af dal/dat og deletion af ActA, der omfatter et nukleinsyremolekyle, der koder for et listeriolysin O-prostataspecifikt antigenfusionsprotein |
| EA201170493A1 (ru) * | 2008-09-26 | 2011-10-31 | Амбркс, Инк. | Микроорганизмы и вакцины, зависимые от репликации неприродных аминокислот |
| WO2010045620A1 (en) | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
| US9163219B2 (en) | 2009-04-14 | 2015-10-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Single expression vector for generation of a virus with a segmented genome |
| US8551749B2 (en) | 2009-04-23 | 2013-10-08 | The Invention Science Fund I, Llc | Device including bone cage and method for treatment of disease in a subject |
| WO2010135563A1 (en) | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium and methods of antigen and nucleic acid delivery |
| US9045742B2 (en) | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| US9062297B2 (en) | 2010-01-13 | 2015-06-23 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Yersinia pestis vaccine |
| EP2526185A4 (de) | 2010-01-22 | 2013-07-24 | Univ Arizona | Bakterium mit einer regulierten rfah-nukleinsäure |
| WO2011150421A2 (en) | 2010-05-28 | 2011-12-01 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium to decrease tumor growth |
| WO2012003460A2 (en) | 2010-07-02 | 2012-01-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Compositions and methods for bacterial lysis and neutral lipid production |
| US9226958B2 (en) | 2010-10-01 | 2016-01-05 | University Of Georgia Research Foundation, Inc. | Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| WO2012054693A1 (en) * | 2010-10-22 | 2012-04-26 | Trudeau Institute | Uses of yersinia yope peptide, gene, and subparts thereof as a plague vaccine component and assays for yersinia pestis-specific t cells |
| WO2012087483A1 (en) * | 2010-11-24 | 2012-06-28 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium comprising a toxin/antitoxin system |
| US20120107888A1 (en) * | 2011-02-17 | 2012-05-03 | Qteros, Inc. | Modulation of fermentation products through vitamin supplementation |
| AU2012229218B2 (en) | 2011-03-11 | 2017-03-02 | Advaxis, Inc. | Listeria-based adjuvants |
| KR20140134695A (ko) | 2012-03-12 | 2014-11-24 | 어드박시스, 인크. | 리스테리아 백신 치료 후 억제 세포 기능 저해 |
| US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
| US9605267B2 (en) | 2012-08-02 | 2017-03-28 | University Of Central Florida Research Foundation, Inc. | Compositions and methods for genetic constructs |
| EP2994537A4 (de) * | 2013-03-15 | 2017-07-05 | Microbial Robotics, LLC | Zusammensetzungen, systeme und verfahren zum schutz genetisch veränderter organismen gegen unberechtigte verwendung oder freisetzung in die umgebung |
| US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
| WO2017184565A1 (en) | 2016-04-20 | 2017-10-26 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for nucleic acid expression and protein secretion in bacteroides |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11566238B2 (en) | 2016-12-15 | 2023-01-31 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating growth of a genetically modified gut bacterial cell |
| CA3084954A1 (en) | 2017-12-05 | 2019-06-13 | BioPlx, Inc. | Methods and compositions to prevent microbial infection |
| US20210393711A1 (en) | 2018-10-11 | 2021-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Bacteria expressing single chain antibodies against toll-like receptors |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| MX2023011505A (es) * | 2021-04-05 | 2023-12-14 | Univ Maryland | Vacuna contra la salmonela. |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968619A (en) * | 1976-09-27 | 1990-11-06 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4190495A (en) | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4506013A (en) * | 1980-10-03 | 1985-03-19 | Eli Lilly And Company | Stabilizing and selecting recombinant DNA host cells |
| US4650761A (en) * | 1981-11-27 | 1987-03-17 | Eli Lilly And Company | Method for stabilizing and selecting recombinant DNA containing host cell |
| US4436815A (en) * | 1981-11-27 | 1984-03-13 | Eli Lilly And Company | Method for stabilizing and selecting recombinant DNA containing host cells |
| US5702916A (en) * | 1982-09-16 | 1997-12-30 | Gx Biosystems A/S | Biological Containment |
| US5190931A (en) | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5387744A (en) * | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| US5855880A (en) * | 1987-06-04 | 1999-01-05 | Washington University | Avirulent microbes and uses therefor |
| US5468485A (en) * | 1987-06-04 | 1995-11-21 | Washington University | Avirulent microbes and uses therefor |
| US5294441A (en) * | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| DE3853683T2 (de) | 1987-10-07 | 1995-08-31 | Univ Washington | Verfahren zur erhaltung eines erwünschten rekombinanten gens in einer genetischen zellpopulation. |
| US5185431A (en) * | 1988-08-31 | 1993-02-09 | Eisai Co., Ltd. | Recombinant natural killer cell activator |
| DE3936408A1 (de) * | 1989-11-02 | 1991-05-08 | Merck Patent Gmbh | Ueberexpression von proteinen in rekombinanten wirtszellen |
| IE892893A1 (en) * | 1990-03-11 | 1991-09-25 | Charles O Kane | Phage-like bacteriocins |
| WO1992009684A1 (en) * | 1990-11-21 | 1992-06-11 | Washington University | Recombinant avirulent salmonella antifertility vaccines |
| US5599537A (en) * | 1990-12-18 | 1997-02-04 | The General Hospital Corporation | Salmonella virulence genes |
| US5843426A (en) * | 1990-12-18 | 1998-12-01 | The General Hospital Corporation | Salmonella vaccines |
| US5695983A (en) * | 1990-12-18 | 1997-12-09 | The General Hospital Corporation | Salmonella vaccines |
| US5589380A (en) * | 1992-06-05 | 1996-12-31 | University Of Maryland At Baltimore | Isolated DNA molecule encoding SHET1 of Shigella flexneri 2a and mutant Shigella flexneri 2a |
| AU683454B2 (en) * | 1993-02-22 | 1997-11-13 | General Hospital Corporation, The | Heterologous antigens in live cell vaccine strains |
| KR960703172A (ko) * | 1993-11-18 | 1996-06-19 | 스티븐 제이. 멘토 | 조건적으로 치사적인 유전자를 활용하기 위한 조성물 및 방법(Compositions and methods for utilizing conditionally lethal genes) |
| US5733760A (en) * | 1994-08-05 | 1998-03-31 | Virus Research Institute | Salmonella vectors encoding truncated pag fusion protein, method of making, and uses thereof |
| US5681745A (en) * | 1995-05-01 | 1997-10-28 | Trustees Of Boston University | Biotin-binding containment systems |
| DE69635579D1 (de) * | 1995-06-07 | 2006-01-19 | Univ St Louis | Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit |
| WO1998022575A2 (en) * | 1996-11-22 | 1998-05-28 | Human Genome Sciences, Inc. | Nucleotide sequence of escherichia coli pathogenicity islands |
| US6024961A (en) * | 1997-11-14 | 2000-02-15 | Washington University | Recombinant avirulent immunogenic S typhi having rpos positive phenotype |
| US6780405B1 (en) * | 2000-04-28 | 2004-08-24 | Avant Immunotherapeutics, Inc. | Regulated antigen delivery system (RADS) |
| WO2002096195A1 (en) * | 2001-05-31 | 2002-12-05 | Enteromed, Inc. | Treatment or replacement therapy using transgenic stem cells delivered to the gut |
| US20030082511A1 (en) * | 2001-09-25 | 2003-05-01 | Brown Steven J. | Identification of modulatory molecules using inducible promoters |
-
1996
- 1996-06-07 DE DE69635579T patent/DE69635579D1/de not_active Expired - Lifetime
- 1996-06-07 AU AU61664/96A patent/AU711618B2/en not_active Ceased
- 1996-06-07 JP JP9501998A patent/JPH11507532A/ja not_active Ceased
- 1996-06-07 AT AT96919292T patent/ATE312934T1/de not_active IP Right Cessation
- 1996-06-07 EP EP96919292A patent/EP0832255B1/de not_active Expired - Lifetime
- 1996-06-07 WO PCT/US1996/009774 patent/WO1996040947A1/en active IP Right Grant
- 1996-06-07 CA CA002222761A patent/CA2222761A1/en not_active Abandoned
- 1996-12-06 US US08/761,769 patent/US6610529B1/en not_active Expired - Lifetime
-
1998
- 1998-07-22 US US09/120,970 patent/US7871604B1/en not_active Expired - Fee Related
-
2003
- 2003-07-15 US US10/620,777 patent/US20040208897A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE312934T1 (de) | 2005-12-15 |
| AU711618B2 (en) | 1999-10-21 |
| WO1996040947A1 (en) | 1996-12-19 |
| AU6166496A (en) | 1996-12-30 |
| EP0832255A1 (de) | 1998-04-01 |
| EP0832255B1 (de) | 2005-12-14 |
| US6610529B1 (en) | 2003-08-26 |
| CA2222761A1 (en) | 1996-12-19 |
| JPH11507532A (ja) | 1999-07-06 |
| US7871604B1 (en) | 2011-01-18 |
| US20040208897A1 (en) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |