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DE69635406D1 - Chemokinrezeptor 88c sowie dessen antikörper - Google Patents

Chemokinrezeptor 88c sowie dessen antikörper

Info

Publication number
DE69635406D1
DE69635406D1 DE69635406T DE69635406T DE69635406D1 DE 69635406 D1 DE69635406 D1 DE 69635406D1 DE 69635406 T DE69635406 T DE 69635406T DE 69635406 T DE69635406 T DE 69635406T DE 69635406 D1 DE69635406 D1 DE 69635406D1
Authority
DE
Germany
Prior art keywords
chemokine receptors
antibodies
modulators
ligands
polynucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69635406T
Other languages
English (en)
Other versions
DE69635406T3 (de
DE69635406T2 (de
Inventor
W Gray
L Schweickart
J Raport
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EUROSCREEN S.A., GOSSELLES, BE
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24302427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69635406(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of DE69635406D1 publication Critical patent/DE69635406D1/de
Application granted granted Critical
Publication of DE69635406T2 publication Critical patent/DE69635406T2/de
Publication of DE69635406T3 publication Critical patent/DE69635406T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69635406.3T 1995-12-20 1996-12-20 Chemokinrezeptor 88c sowie dessen antikörper Expired - Lifetime DE69635406T3 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US575967 1984-02-01
US08/575,967 US6265184B1 (en) 1995-12-20 1995-12-20 Polynucleotides encoding chemokine receptor 88C
US08/661,393 US6268477B1 (en) 1995-12-20 1996-06-07 Chemokine receptor 88-C
US661393 1996-06-07
PCT/US1996/020759 WO1997022698A2 (en) 1995-12-20 1996-12-20 Chemokine receptors 88-2b[ckr-3] and 88c and their antibodies
EP96945669.8A EP0811063B9 (de) 1995-12-20 1996-12-20 Chemokinrezeptor 88c

Publications (3)

Publication Number Publication Date
DE69635406D1 true DE69635406D1 (de) 2005-12-15
DE69635406T2 DE69635406T2 (de) 2006-08-03
DE69635406T3 DE69635406T3 (de) 2014-04-24

Family

ID=24302427

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69638128T Expired - Lifetime DE69638128D1 (de) 1995-12-20 1996-12-20 Verfahren zu Chemokinrezeptor 88C
DE69635406.3T Expired - Lifetime DE69635406T3 (de) 1995-12-20 1996-12-20 Chemokinrezeptor 88c sowie dessen antikörper

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69638128T Expired - Lifetime DE69638128D1 (de) 1995-12-20 1996-12-20 Verfahren zu Chemokinrezeptor 88C

Country Status (17)

Country Link
US (7) US6265184B1 (de)
EP (3) EP1870465B1 (de)
JP (4) JP3288384B2 (de)
CN (2) CN1222617C (de)
AT (2) ATE309349T1 (de)
AU (1) AU730463B2 (de)
BR (1) BR9607300A (de)
CA (1) CA2213331C (de)
CZ (1) CZ261097A3 (de)
DE (2) DE69638128D1 (de)
DK (2) DK0811063T3 (de)
ES (2) ES2255716T5 (de)
HU (1) HUP9801127A3 (de)
NO (2) NO973800L (de)
PL (2) PL192294B1 (de)
SK (1) SK112897A3 (de)
WO (1) WO1997022698A2 (de)

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US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US20040151719A1 (en) * 1995-06-06 2004-08-05 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US6025154A (en) * 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
ATE427488T1 (de) * 1995-06-07 2009-04-15 Progenics Pharm Inc Monoklonaler antikírper fur die inhibierung von hiv-1-hullgykoprotein-vermittelte membranfusion
US6265184B1 (en) 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
US7118859B2 (en) * 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
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DK1482042T3 (da) * 1996-03-01 2009-06-15 Euroscreen Sa Aktive og inaktive CC-kemokinreceptorer og nukleinsyremolekyler der koder for receptoren
US6344545B1 (en) * 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US7858298B1 (en) * 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
EP0915969A4 (de) 1996-04-02 2002-04-17 Progenics Pharm Inc Unterdrückung der infektion von cd4+ zellen durch hiv
US6271347B1 (en) * 1996-04-26 2001-08-07 Merck & Co., Inc. Eosinophil eotaxin receptor
AU2813297A (en) * 1996-04-26 1997-11-19 Incyte Pharmaceuticals, Inc. Mammalian mixed lymphocyte receptors, chemokine receptors {mmlr-ccr}
EP1012190A4 (de) * 1996-04-26 2004-04-28 Merck & Co Inc Eotaxinrezeptor aus Eosinophilen
US5939320A (en) * 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US6258527B1 (en) 1996-05-20 2001-07-10 The Aaron Diamond Aids Research Center Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
AU3375697A (en) * 1996-05-28 1998-01-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cc chemokine receptor 5, antibodies thereto, transgenic animals
US20040086528A1 (en) * 1996-06-14 2004-05-06 Progenics Pharmaceuticals, Inc. Uses of a chemokine receptor for inhibiting HIV-1 infection
US6057102A (en) * 1996-08-08 2000-05-02 The Aaron Diamond Aids Research Center HIV coreceptor mutants
US6388055B1 (en) 1996-10-03 2002-05-14 Smithkline Beecham Corporation Mouse CC-CKR5 receptor polypeptide
US6528625B1 (en) * 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
US6153431A (en) * 1997-05-30 2000-11-28 Fond Mondiale Rech & Prev Sida Human immunodeficiency virus co-receptor variants associated with resistance to virus infection
US6465237B1 (en) * 1997-07-01 2002-10-15 Millennium Pharmaceuticals, Inc. Cloning and characterization of a human adenylyl cyclase
US6989435B2 (en) 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6204024B1 (en) * 1997-09-12 2001-03-20 Akzo Nobel N.V. CCR5 RNA transcription based amplification assay
US6287805B1 (en) 1998-03-20 2001-09-11 Millennium Pharmaceuticals, Inc. Nucleic acid molecules of the protein-coupled heptahelical receptor superfamily and uses therefor
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US20080015348A1 (en) * 1998-12-16 2008-01-17 Progenics Pharmaceuticals, Inc. Nucleic acids encoding polypeptides of anti-CCR5 antibodies
US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
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CN1227265C (zh) * 2000-02-09 2005-11-16 人类基因组科学公司 抗ccr5的抗体
US6692922B2 (en) 2000-08-15 2004-02-17 The Board Of Trustees Of The Leland Stanford Junior University Method for identifying agents which modulate chemokine “MEC”-induced functions of CCR3
US7138119B2 (en) * 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
US7175988B2 (en) * 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7060273B2 (en) * 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US20030104496A1 (en) * 2001-11-30 2003-06-05 Cytokinetics, Inc. Novel motor protein of P. falciparum and methods for its use
US7393934B2 (en) * 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
CN100575482C (zh) * 2002-01-18 2009-12-30 津莫吉尼蒂克斯公司 新的细胞因子zcytor17配体
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
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US7094848B2 (en) * 2003-05-13 2006-08-22 Exxonmobil Chemical Patents Inc. Olefin polymerization catalyst system
JP2008507255A (ja) * 2004-03-12 2008-03-13 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０
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ES2450929T3 (es) 2004-10-29 2014-03-25 Topigen Pharmaceuticals Inc. Oligonucleótidos antisentido para tratar la alergia y la proliferación de las células neoplásicas
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US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
DE102013200909A1 (de) * 2013-01-22 2014-07-24 Robert Bosch Gmbh Brennstoffeinspritzanlage mit einer Brennstoff führenden Komponente, einem Brennstoffeinspritzventil und einem Verbindungselement
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (de) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
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US5939320A (en) 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
AU3375697A (en) 1996-05-28 1998-01-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cc chemokine receptor 5, antibodies thereto, transgenic animals
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US5994515A (en) * 1996-06-25 1999-11-30 Trustees Of The University Of Pennsylvania Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same

Also Published As

Publication number Publication date
ATE309349T1 (de) 2005-11-15
AU730463B2 (en) 2001-03-08
DE69638128D1 (de) 2010-04-01
CA2213331C (en) 2011-09-27
HUP9801127A2 (hu) 1998-08-28
US6265184B1 (en) 2001-07-24
AU1689297A (en) 1997-07-14
NO20052202D0 (no) 2005-05-04
US20040230037A1 (en) 2004-11-18
WO1997022698A2 (en) 1997-06-26
DE69635406T3 (de) 2014-04-24
US6268477B1 (en) 2001-07-31
JP2001264324A (ja) 2001-09-26
JP3288384B2 (ja) 2002-06-04
CN1183805A (zh) 1998-06-03
EP1642975A3 (de) 2006-04-12
MX9706316A (es) 1997-11-29
US20050260565A1 (en) 2005-11-24
NO973800D0 (no) 1997-08-19
EP1642975A2 (de) 2006-04-05
US20020150888A1 (en) 2002-10-17
ES2255716T3 (es) 2006-07-01
EP1870465A3 (de) 2008-04-23
ES2341371T3 (es) 2010-06-18
US7662548B2 (en) 2010-02-16
NO973800L (no) 1997-10-20
PL192294B1 (pl) 2006-09-29
PL192071B1 (pl) 2006-08-31
NO327506B1 (no) 2009-07-27
EP0811063B1 (de) 2005-11-09
EP1870465A2 (de) 2007-12-26
NO20052202L (no) 1997-10-20
BR9607300A (pt) 1997-11-25
EP0811063B2 (de) 2013-12-04
PL321937A1 (en) 1998-01-05
DK1870465T3 (da) 2010-05-17
DK0811063T3 (da) 2006-04-10
CZ261097A3 (cs) 1998-06-17
ATE458052T1 (de) 2010-03-15
WO1997022698A3 (en) 1997-09-12
ES2255716T5 (es) 2014-03-21
EP1870465B1 (de) 2010-02-17
DE69635406T2 (de) 2006-08-03
JPH11503028A (ja) 1999-03-23
EP0811063B9 (de) 2014-04-23
JP2001029089A (ja) 2001-02-06
HUP9801127A3 (en) 2000-12-28
CN1827646A (zh) 2006-09-06
JP2009065976A (ja) 2009-04-02
US20080032336A1 (en) 2008-02-07
EP0811063A2 (de) 1997-12-10
CA2213331A1 (en) 1997-06-26
US6797811B1 (en) 2004-09-28
CN1222617C (zh) 2005-10-12
SK112897A3 (en) 1998-07-08

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